Epigenetic Regulations in Gastrointestinal Cancers offers a comprehensive exploration of the genomic and epigenomic alterations that underpin the aggressive nature of gastrointestinal (GI) cancers. . By synthesizing the latest research and insights into the role of the tumor microenvironment and cellular signaling pathways, this book aims to elucidate the multifaceted nature of GI cancer neoplasia and propose innovative therapeutic strategies. Addressing critical challenges in GI cancer research and treatment, this book serves as a vital resource for researchers and clinicians striving to bridge the gap between basic research and clinical application. It tackles the complexities of GI cancer mechanisms by integrating knowledge from diverse fields, thereby providing a holistic understanding essential for effective therapeutic development. Through real-world case studies and expert contributions, the book highlights successful treatment regimens that leverage epigenetic insights, thereby fostering dialogue among multidisciplinary teams and promoting collaborative approaches to cancer care. Moreover, the book emphasizes the importance of staying abreast of rapid advancements in the field of cancer research. With contributions from leading experts and an accompanying online platform featuring interactive resources, readers will have access to the latest insights and developments in GI cancer research. By identifying specific epigenetic targets and innovative strategies for overcoming treatment resistance, this book aspires to enhance patient outcomes in GI cancers and contribute to the ongoing evolution of personalized medicine in oncology.
1. Title of Book - p. i 2. Cover Image - p. i 3. Title Page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. Contributors - p. xiii 8. Editors biography - p. xv 9. Preface - p. xvii 10. Chapter 1 Epigenetics of GI cancers - p. 1 11. Chapter 2 Overview of epigenetic changes in cancer-related to gastrointestinal systems - p. 7 12. Chapter 3 Epigenetic change-based cancer development in the gastrointestinal gastric, pancreatic, and colorectal cancers - p. 29 13. Chapter 4 Epigenetics in gastrointestinal cancers - p. 53 14. Chapter 5 Targeting methylation and acetylation in colon cancer - p. 61 15. Chapter 6 Epigenetics in angiogenesis, gastrointestinal cancer progression and its clinical significance - p. 81 16. Chapter 7 Non-coding RNAs - p. 99 17. Chapter 8 The roles of non-coding RNA-encoded functional peptides in gastrointestinal cancer - p. 113 18. Chapter 9 Targeting methylation and acetylation in colon cancer - p. 143 19. Chapter 10 Deciphering the crosstalk between single-cell sequencing and gastrointestinal cancer - p. 153 20. Chapter 11 Exosome-derived biomarkers and therapies - p. 167 21. Chapter 12 Therapeutic challenges and advances in the management of colorectal cancer overcoming resistance mechanisms and exploring future directions - p. 177 22. Chapter 13 Current and emerging epigenetic therapies and future directions - p. 185 23. Chapter 14 Phytochemicals as epigenetic modulators in gastrointestinal cancer - p. 201 24. Chapter 15 Epigenetics and metabolic involvement in regeneration: An overview - p. 213 25. Chapter 16 The role of DNA methyltransferase genes in cancers: A systematic review and meta-analysis of DNMT1 and DNMT3B gene polymorphisms - p. 229 26. Chapter 17 Epigenetic and post-transcriptional regulators of colon cancer formation vs progression: invasion and metastasis - p. 255 27. Chapter 18 Role of the microbiome on epigenetic changes in pancreatic and colon cancers - p. 273 28. Chapter 19 DNA methylation and histone modifications in gastrointestinal cancers - p. 285 29. Chapter 20 Epigenetic mechanisms in colorectal cancer: Preclinical studies to clinical implications - p. 303 30. Chapter 21 DNA methylation and histone modification in liver cancer - p. 313 31. Index - p. 325
Epigenetic Regulations in Gastrointestinal Cancers offers a comprehensive exploration of the genomic and epigenomic alterations that underpin the aggressive nature of gastrointestinal (GI) cancers. . By synthesizing the latest research and insights into the role of the tumor microenvironment and cellular signaling pathways, this book aims to elucidate the multifaceted nature of GI cancer neoplasia and propose innovative therapeutic strategies. Addressing critical challenges in GI cancer research and treatment, this book serves as a vital resource for researchers and clinicians striving to bridge the gap between basic research and clinical application. It tackles the complexities of GI cancer mechanisms by integrating knowledge from diverse fields, thereby providing a holistic understanding essential for effective therapeutic development. Through real-world case studies and expert contributions, the book highlights successful treatment regimens that leverage epigenetic insights, thereby fostering dialogue among multidisciplinary teams and promoting collaborative approaches to cancer care. Moreover, the book emphasizes the importance of staying abreast of rapid advancements in the field of cancer research. With contributions from leading experts and an accompanying online platform featuring interactive resources, readers will have access to the latest insights and developments in GI cancer research. By identifying specific epigenetic targets and innovative strategies for overcoming treatment resistance, this book aspires to enhance patient outcomes in GI cancers and contribute to the ongoing evolution of personalized medicine in oncology.
1. Title of Book - p. i 2. Cover Image - p. i 3. Title Page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. Contributors - p. xiii 8. Editors biography - p. xv 9. Preface - p. xvii 10. Chapter 1 Epigenetics of GI cancers - p. 1 11. Chapter 2 Overview of epigenetic changes in cancer-related to gastrointestinal systems - p. 7 12. Chapter 3 Epigenetic change-based cancer development in the gastrointestinal gastric, pancreatic, and colorectal cancers - p. 29 13. Chapter 4 Epigenetics in gastrointestinal cancers - p. 53 14. Chapter 5 Targeting methylation and acetylation in colon cancer - p. 61 15. Chapter 6 Epigenetics in angiogenesis, gastrointestinal cancer progression and its clinical significance - p. 81 16. Chapter 7 Non-coding RNAs - p. 99 17. Chapter 8 The roles of non-coding RNA-encoded functional peptides in gastrointestinal cancer - p. 113 18. Chapter 9 Targeting methylation and acetylation in colon cancer - p. 143 19. Chapter 10 Deciphering the crosstalk between single-cell sequencing and gastrointestinal cancer - p. 153 20. Chapter 11 Exosome-derived biomarkers and therapies - p. 167 21. Chapter 12 Therapeutic challenges and advances in the management of colorectal cancer overcoming resistance mechanisms and exploring future directions - p. 177 22. Chapter 13 Current and emerging epigenetic therapies and future directions - p. 185 23. Chapter 14 Phytochemicals as epigenetic modulators in gastrointestinal cancer - p. 201 24. Chapter 15 Epigenetics and metabolic involvement in regeneration: An overview - p. 213 25. Chapter 16 The role of DNA methyltransferase genes in cancers: A systematic review and meta-analysis of DNMT1 and DNMT3B gene polymorphisms - p. 229 26. Chapter 17 Epigenetic and post-transcriptional regulators of colon cancer formation vs progression: invasion and metastasis - p. 255 27. Chapter 18 Role of the microbiome on epigenetic changes in pancreatic and colon cancers - p. 273 28. Chapter 19 DNA methylation and histone modifications in gastrointestinal cancers - p. 285 29. Chapter 20 Epigenetic mechanisms in colorectal cancer: Preclinical studies to clinical implications - p. 303 30. Chapter 21 DNA methylation and histone modification in liver cancer - p. 313 31. Index - p. 325
