Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare.
1. Epigenetics and Metabolomics - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xv 7. Preface - p. xxi 8. Chapter 1 Metabolomics techniques: A brief update - p. 1 9. Chapter 2 Integration of epigenomics and metabolomics: From biomarkers discovery to personalized medicine - p. 31 10. Chapter 3 Aging-associated changes in metabolic regulation of epigenetic modifications and gene expression - p. 75 11. Chapter 4 Epigenetic and metabolic changes in traumatic brain injury - p. 97 12. Chapter 5 Metabolic regulation in urological tumors: Interplay with epigenetics and epitranscriptomics - p. 107 13. Chapter 6 Multiomics approach for precision wellness - p. 147 14. Chapter 7 Oncogene: An epigenetic regulation - p. 181 15. Chapter 8 Epigenetic regulations in gastrointestine: Implications on sensitivity to ionizing radiation, inflammatory diseases, and cancer development - p. 199 16. Chapter 9 Epigenetics of epithelial to mesenchymal transition (EMT) in cancer - p. 237 17. Chapter 10 Nutrients seminal role in the development and epigenetic reprogramming during the first 1000 days of life - p. 265 18. Chapter 11 Epigenetic mechanisms of hepatocellular carcinoma progression: Potential therapeutic opportunities - p. 279 19. Chapter 12 Translational epigenetics in neurodegenerative diseases - p. 297 20. Chapter 13 Host-epigenetics-microbiota: A tripartite interaction in health and disease - p. 315 21. Chapter 14 Epigenetics in cardiovascular complications - p. 329 22. Chapter 15 Epigenetics and viral infectious diseases - p. 353 23. Chapter 16 Metabolic profiling leading to clinical phenomics: From bench to bedside - p. 371 24. Chapter 17 Epigenetic insights for wound healing mechanism - p. 383 25. Chapter 18 Role of metabolomics to investigate combined effect of radiation and burn - p. 401 26. Chapter 19 Advances and prospects of epigenetics in plants - p. 421 27. Index - p. 445
Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare.
1. Epigenetics and Metabolomics - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xv 7. Preface - p. xxi 8. Chapter 1 Metabolomics techniques: A brief update - p. 1 9. Chapter 2 Integration of epigenomics and metabolomics: From biomarkers discovery to personalized medicine - p. 31 10. Chapter 3 Aging-associated changes in metabolic regulation of epigenetic modifications and gene expression - p. 75 11. Chapter 4 Epigenetic and metabolic changes in traumatic brain injury - p. 97 12. Chapter 5 Metabolic regulation in urological tumors: Interplay with epigenetics and epitranscriptomics - p. 107 13. Chapter 6 Multiomics approach for precision wellness - p. 147 14. Chapter 7 Oncogene: An epigenetic regulation - p. 181 15. Chapter 8 Epigenetic regulations in gastrointestine: Implications on sensitivity to ionizing radiation, inflammatory diseases, and cancer development - p. 199 16. Chapter 9 Epigenetics of epithelial to mesenchymal transition (EMT) in cancer - p. 237 17. Chapter 10 Nutrients seminal role in the development and epigenetic reprogramming during the first 1000 days of life - p. 265 18. Chapter 11 Epigenetic mechanisms of hepatocellular carcinoma progression: Potential therapeutic opportunities - p. 279 19. Chapter 12 Translational epigenetics in neurodegenerative diseases - p. 297 20. Chapter 13 Host-epigenetics-microbiota: A tripartite interaction in health and disease - p. 315 21. Chapter 14 Epigenetics in cardiovascular complications - p. 329 22. Chapter 15 Epigenetics and viral infectious diseases - p. 353 23. Chapter 16 Metabolic profiling leading to clinical phenomics: From bench to bedside - p. 371 24. Chapter 17 Epigenetic insights for wound healing mechanism - p. 383 25. Chapter 18 Role of metabolomics to investigate combined effect of radiation and burn - p. 401 26. Chapter 19 Advances and prospects of epigenetics in plants - p. 421 27. Index - p. 445
