Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease.
1. Epigenetics in Cardiovascular Disease - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xvii 7. Preface - p. xxi 8. Chapter 1 The ever-growing burden of cardiovascular disease - p. 1 9. Chapter 2 Epigenetics concepts: An overview - p. 19 10. Chapter 3 From classical signaling pathways to the nucleus - p. 41 11. Chapter 4 DNA methylation in heart failure - p. 55 12. Chapter 5 Histone modifications in cardiovascular disease initiation and progression - p. 77 13. Chapter 6 RNA modifications in cardiovascular disease—An experimental and computational perspective - p. 113 14. Chapter 7 Regulatory RNAs in cardiovascular disease - p. 127 15. Chapter 8 Regulation of splicing in cardiovascular disease - p. 163 16. Chapter 9 Cardiac transcriptomic remodeling in metabolic syndrome - p. 187 17. Chapter 10 Sex differences in epigenetics mechanisms of cardiovascular disease - p. 213 18. Chapter 11 Epigenetics in cardiac development and human induced pluripotent stem cells - p. 235 19. Chapter 12 Peripheral blood DNA and RNA biomarkers of cardiovascular disease in clinical practice - p. 261 20. Chapter 13 Epigenetics and physical exercise - p. 283 21. Chapter 14 Long noncoding RNAs and circular RNAs as heart failure biomarkers - p. 303 22. Chapter 15 Artificial intelligence in clinical decision-making for diagnosis of cardiovascular disease using epigenetics mechanisms - p. 327 23. Chapter 16 Therapeutic strategies for modulating epigenetic mechanisms in cardiovascular disease - p. 349 24. Chapter 17 Single-cell RNA sequencing in cardiovascular science - p. 377 25. Chapter 18 Good laboratory and experimental practices for microRNA analysis in cardiovascular research - p. 395 26. Chapter 19 Analytical challenges in microRNA biomarker development: Best practices for analyzing microRNAs in cell-free biofluids - p. 415 27. Chapter 20 Concept of biological reference materials for RNA analysis in cardiovascular disease - p. 431 28. Chapter 21 Unbiased bioinformatics analysis of microRNA transcriptomics datasets and network theoretic target prediction - p. 441 29. Conclusions and perspectives: The present and future of epigenetics in cardiovascular disease - p. 459 30. Index - p. 463
Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease.
1. Epigenetics in Cardiovascular Disease - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xvii 7. Preface - p. xxi 8. Chapter 1 The ever-growing burden of cardiovascular disease - p. 1 9. Chapter 2 Epigenetics concepts: An overview - p. 19 10. Chapter 3 From classical signaling pathways to the nucleus - p. 41 11. Chapter 4 DNA methylation in heart failure - p. 55 12. Chapter 5 Histone modifications in cardiovascular disease initiation and progression - p. 77 13. Chapter 6 RNA modifications in cardiovascular disease—An experimental and computational perspective - p. 113 14. Chapter 7 Regulatory RNAs in cardiovascular disease - p. 127 15. Chapter 8 Regulation of splicing in cardiovascular disease - p. 163 16. Chapter 9 Cardiac transcriptomic remodeling in metabolic syndrome - p. 187 17. Chapter 10 Sex differences in epigenetics mechanisms of cardiovascular disease - p. 213 18. Chapter 11 Epigenetics in cardiac development and human induced pluripotent stem cells - p. 235 19. Chapter 12 Peripheral blood DNA and RNA biomarkers of cardiovascular disease in clinical practice - p. 261 20. Chapter 13 Epigenetics and physical exercise - p. 283 21. Chapter 14 Long noncoding RNAs and circular RNAs as heart failure biomarkers - p. 303 22. Chapter 15 Artificial intelligence in clinical decision-making for diagnosis of cardiovascular disease using epigenetics mechanisms - p. 327 23. Chapter 16 Therapeutic strategies for modulating epigenetic mechanisms in cardiovascular disease - p. 349 24. Chapter 17 Single-cell RNA sequencing in cardiovascular science - p. 377 25. Chapter 18 Good laboratory and experimental practices for microRNA analysis in cardiovascular research - p. 395 26. Chapter 19 Analytical challenges in microRNA biomarker development: Best practices for analyzing microRNAs in cell-free biofluids - p. 415 27. Chapter 20 Concept of biological reference materials for RNA analysis in cardiovascular disease - p. 431 28. Chapter 21 Unbiased bioinformatics analysis of microRNA transcriptomics datasets and network theoretic target prediction - p. 441 29. Conclusions and perspectives: The present and future of epigenetics in cardiovascular disease - p. 459 30. Index - p. 463
