Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.
Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.
1. Chapter 1 Introduction—Epigenetic regulations in organ specific disorders - p. 1 2. Chapter 2 Higher-order chromatin structure and gene regulation - p. 11 3. Chapter 3 Molecular and structural interactions between epigenetic regulators - p. 33 4. Chapter 4 Epigenetic regulation of necrosis and pyknosis - p. 51 5. Chapter 5 HDAC inhibition in cancer - p. 63 6. Chapter 6 Epigenetic signatures that maintain stemness in pluripotent and mesenchymal stem cells - p. 99 7. Chapter 7 Epigenetic modifications and alternative pre-mRNA splicing in cancer - p. 123 8. Chapter 8 Epigenetics of T cell-mediated immunological responses - p. 149 9. Chapter 9 Epigenetic modifications and regulation in infection - p. 181 10. Chapter 10 Epigenetics of aging - p. 213 11. Chapter 11 Epigenetic regulation mediated by diets - p. 235 12. Chapter 12 Epigenetic regulations in neurological disorders - p. 269 13. Chapter 13 Epigenetics of Disorders Affecting the Anterior Segment of Eye - p. 311 14. Chapter 14 Epigenetic regulations in fat depots - p. 327 15. Chapter 15 Epigenetic changes in periodontal tissues - p. 341 16. Chapter 16 Epigenetics of the pathogenic myofibroblast in lung disease - p. 353 17. Chapter 17 Epigenetic mechanisms in cardiovascular diseases - p. 393 18. Chapter 18 Epigenetics of NAFLD and NASH - p. 423 19. Chapter 19 Role of histone modifications in the development of acute kidney injury - p. 447 20. Chapter 20 Epigenetic regulation of chronic kidney disease development following prenatal maternal stress - p. 465 21. Chapter 21 Epigenetic modifications and regulations in gastrointestinal diseases - p. 497 22. Chapter 22 Epigenetics of radiation-induced GI damage: Role of protein modifications - p. 545 23. Chapter 23 Epigenetic modulations in age-associated bone disorders - p. 565 24. Chapter 24 Epigenetic regulations in inflammatory diseases - p. 585 25. Chapter 25 Epigenetic drug discovery: Recent advances through structure-activity relationships and phenotypic profiling studies - p. 615 26. Index - p. 631
Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.
Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.
1. Chapter 1 Introduction—Epigenetic regulations in organ specific disorders - p. 1 2. Chapter 2 Higher-order chromatin structure and gene regulation - p. 11 3. Chapter 3 Molecular and structural interactions between epigenetic regulators - p. 33 4. Chapter 4 Epigenetic regulation of necrosis and pyknosis - p. 51 5. Chapter 5 HDAC inhibition in cancer - p. 63 6. Chapter 6 Epigenetic signatures that maintain stemness in pluripotent and mesenchymal stem cells - p. 99 7. Chapter 7 Epigenetic modifications and alternative pre-mRNA splicing in cancer - p. 123 8. Chapter 8 Epigenetics of T cell-mediated immunological responses - p. 149 9. Chapter 9 Epigenetic modifications and regulation in infection - p. 181 10. Chapter 10 Epigenetics of aging - p. 213 11. Chapter 11 Epigenetic regulation mediated by diets - p. 235 12. Chapter 12 Epigenetic regulations in neurological disorders - p. 269 13. Chapter 13 Epigenetics of Disorders Affecting the Anterior Segment of Eye - p. 311 14. Chapter 14 Epigenetic regulations in fat depots - p. 327 15. Chapter 15 Epigenetic changes in periodontal tissues - p. 341 16. Chapter 16 Epigenetics of the pathogenic myofibroblast in lung disease - p. 353 17. Chapter 17 Epigenetic mechanisms in cardiovascular diseases - p. 393 18. Chapter 18 Epigenetics of NAFLD and NASH - p. 423 19. Chapter 19 Role of histone modifications in the development of acute kidney injury - p. 447 20. Chapter 20 Epigenetic regulation of chronic kidney disease development following prenatal maternal stress - p. 465 21. Chapter 21 Epigenetic modifications and regulations in gastrointestinal diseases - p. 497 22. Chapter 22 Epigenetics of radiation-induced GI damage: Role of protein modifications - p. 545 23. Chapter 23 Epigenetic modulations in age-associated bone disorders - p. 565 24. Chapter 24 Epigenetic regulations in inflammatory diseases - p. 585 25. Chapter 25 Epigenetic drug discovery: Recent advances through structure-activity relationships and phenotypic profiling studies - p. 615 26. Index - p. 631
