In this issue of Hematology/Oncology Clinics, guest editors Drs. Edward J. Benz, Jr. and Vijay G. Sankaran bring their considerable expertise to the topic of Thalassemia. Top experts in the field provide an overview of the history, epidemiology, pathogenic mechanisms, and clinical management of the thalassemia syndromes.
Contains 16 practice-oriented topics including molecular basis and genetic modifiers of thalassemia; fetal hemoglobin in thalassemia; clinical complications and their management; iron chelation in thalassemia; fertility and pregnancy in women with transfusion-dependent thalassemia; gene therapy and genome editing in thalassemia; emerging medical therapies for thalassemia; and more.
Provides in-depth clinical reviews on thalassemia, offering actionable insights for clinical practice.
Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
1. Introduction to the Thalassemia Syndromes: Molecular Medicine’s Index Case - p. 245 2. The Need for Translational Epidemiology in Beta Thalassemia Syndromes: A Thalassemia International Federation Perspective - p. 261 3. Molecular Basis and Genetic Modifiers of Thalassemia - p. 273 4. Fetal Hemoglobin Regulation in Beta-Thalassemia - p. 301 5. Clinical Classification, Screening, and Diagnosis in Beta-Thalassemia and Hemoglobin E/Beta-Thalassemia - p. 313 6. The Clinical Phenotypes of Alpha Thalassemia - p. 327 7. Pathogenic Mechanisms in Thalassemia I: Ineffective Erythropoiesis and Hypercoagulability - p. 341 8. Pathogenic Mechanisms in Thalassemia II: Iron Overload - p. 353 9. Clinical Complications and Their Management - p. 365 10. Clinical Challenges with Iron Chelation in Beta Thalassemia - p. 379 11. Fertility and Pregnancy in Women with Transfusion-Dependent Thalassemia - p. 393 12. Hematopoietic Stem Cell Transplantation in Thalassemia - p. 413 13. Gene Therapy and Gene Editing for β-Thalassemia - p. 433 14. Emerging Therapies in β-Thalassemia - p. 449
In this issue of Hematology/Oncology Clinics, guest editors Drs. Edward J. Benz, Jr. and Vijay G. Sankaran bring their considerable expertise to the topic of Thalassemia. Top experts in the field provide an overview of the history, epidemiology, pathogenic mechanisms, and clinical management of the thalassemia syndromes.
Contains 16 practice-oriented topics including molecular basis and genetic modifiers of thalassemia; fetal hemoglobin in thalassemia; clinical complications and their management; iron chelation in thalassemia; fertility and pregnancy in women with transfusion-dependent thalassemia; gene therapy and genome editing in thalassemia; emerging medical therapies for thalassemia; and more.
Provides in-depth clinical reviews on thalassemia, offering actionable insights for clinical practice.
Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
1. Introduction to the Thalassemia Syndromes: Molecular Medicine’s Index Case - p. 245 2. The Need for Translational Epidemiology in Beta Thalassemia Syndromes: A Thalassemia International Federation Perspective - p. 261 3. Molecular Basis and Genetic Modifiers of Thalassemia - p. 273 4. Fetal Hemoglobin Regulation in Beta-Thalassemia - p. 301 5. Clinical Classification, Screening, and Diagnosis in Beta-Thalassemia and Hemoglobin E/Beta-Thalassemia - p. 313 6. The Clinical Phenotypes of Alpha Thalassemia - p. 327 7. Pathogenic Mechanisms in Thalassemia I: Ineffective Erythropoiesis and Hypercoagulability - p. 341 8. Pathogenic Mechanisms in Thalassemia II: Iron Overload - p. 353 9. Clinical Complications and Their Management - p. 365 10. Clinical Challenges with Iron Chelation in Beta Thalassemia - p. 379 11. Fertility and Pregnancy in Women with Transfusion-Dependent Thalassemia - p. 393 12. Hematopoietic Stem Cell Transplantation in Thalassemia - p. 413 13. Gene Therapy and Gene Editing for β-Thalassemia - p. 433 14. Emerging Therapies in β-Thalassemia - p. 449
