In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies.
Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease.
1. Title of Book - p. ii 2. Cover image - p. ii 3. Title page - p. ii 4. Table of Contents - p. ii 5. Front Matter - p. i 6. Copyright - p. iii 7. Contributors - p. xvii 8. Preface - p. xxiii 9. Chapter 1. Perspectives and future directions of translational epigenetics in personalized and precision medicine - p. 6 10. Chapter 2. Translational epigenetics in precision medicine of colorectal cancer - p. 19 11. Chapter 3. Epigenetics in precision medicine of breast cancer - p. 43 12. Chapter 4. Epigenetics and precision medicine in prostate cancer - p. 89 13. Chapter 5. Epigenetics and precision medicine in lung cancer - p. 126 14. Chapter 6. Epigenetics and precision medicine in bone and soft tissue sarcomas - p. 147 15. Chapter 7. Epigenetics and precision medicine in skin diseases - p. 193 16. Chapter 8. Epigenetic biomarker and drug development in gynecological cancers - p. 233 17. Chapter 9. Epigenetics in precision medicine of pancreatic cancer - p. 257 18. Chapter 10. Epigenetics and personalized medicine of brain cancer - p. 302 19. Chapter 11. Epigenetics and precision medicine in diabetes and obesity prevention and management - p. 335 20. Chapter 12. Epigenetics in precision medicine of cardiovascular disease - p. 353 21. Chapter 13. Sperm epigenetics: The future of precision medicine in male infertility - p. 369 22. Chapter 14. Epigenetic in precision medicine in autoimmune and inflammatory-mediated disorders - p. 382 23. Chapter 15. Epigenetics and precision medicine in allergic diseases - p. 407 24. Chapter 16. Epigenetics in spine curvature disorders - p. 449 25. Chapter 17. Methylated circulating tumor DNA biomarkers for the blood-based detection of cancer signals - p. 471 26. Chapter 18. Dietary regulation of miRNA in precision medicine of lung cancer - p. 521 27. Chapter 19. Epigenetic biomarkers in male infertility and its potential use in assisted reproductive technology - p. 548 28. Index - p. 573
In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies.
Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease.
1. Title of Book - p. ii 2. Cover image - p. ii 3. Title page - p. ii 4. Table of Contents - p. ii 5. Front Matter - p. i 6. Copyright - p. iii 7. Contributors - p. xvii 8. Preface - p. xxiii 9. Chapter 1. Perspectives and future directions of translational epigenetics in personalized and precision medicine - p. 6 10. Chapter 2. Translational epigenetics in precision medicine of colorectal cancer - p. 19 11. Chapter 3. Epigenetics in precision medicine of breast cancer - p. 43 12. Chapter 4. Epigenetics and precision medicine in prostate cancer - p. 89 13. Chapter 5. Epigenetics and precision medicine in lung cancer - p. 126 14. Chapter 6. Epigenetics and precision medicine in bone and soft tissue sarcomas - p. 147 15. Chapter 7. Epigenetics and precision medicine in skin diseases - p. 193 16. Chapter 8. Epigenetic biomarker and drug development in gynecological cancers - p. 233 17. Chapter 9. Epigenetics in precision medicine of pancreatic cancer - p. 257 18. Chapter 10. Epigenetics and personalized medicine of brain cancer - p. 302 19. Chapter 11. Epigenetics and precision medicine in diabetes and obesity prevention and management - p. 335 20. Chapter 12. Epigenetics in precision medicine of cardiovascular disease - p. 353 21. Chapter 13. Sperm epigenetics: The future of precision medicine in male infertility - p. 369 22. Chapter 14. Epigenetic in precision medicine in autoimmune and inflammatory-mediated disorders - p. 382 23. Chapter 15. Epigenetics and precision medicine in allergic diseases - p. 407 24. Chapter 16. Epigenetics in spine curvature disorders - p. 449 25. Chapter 17. Methylated circulating tumor DNA biomarkers for the blood-based detection of cancer signals - p. 471 26. Chapter 18. Dietary regulation of miRNA in precision medicine of lung cancer - p. 521 27. Chapter 19. Epigenetic biomarkers in male infertility and its potential use in assisted reproductive technology - p. 548 28. Index - p. 573
