Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic
mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the
evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress
disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding
stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of
recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments
in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical
effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or
development and across the life span. The book concludes by looking at possible transgenerational stress-induced
epigenetic alterations on future offspring and important areas of research for public health, along with the potential for
epigenetic therapeutics or “epidrugs.
1. Epigenetics of Stress and Stress Disorders - p. ii 2. Cover - p. ii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xiii 7. Foreword - p. xvii 8. Acknowledgments - p. xix 9. Chapter 1 The physiology of stress and the human body’s response to stress - p. 1 10. Chapter 2 Posttraumatic stress disorder: Diagnosis, measurement, and assessment - p. 19 11. Chapter 3 Nikola Tesla: An autobiographical case study of trauma and resilience - p. 27 12. Chapter 4 Management of posttraumatic stress disorder - p. 37 13. Chapter 5 Depression and epigenetics: Epidemiology, pathophysiology, diagnosis, and assessment - p. 51 14. Chapter 6 Depression management and pharmacoepigenetics - p. 67 15. Chapter 7 Psychotherapy for stress disorders: A military perspective - p. 85 16. Chapter 8 How stress affects gene expression through epigenetic modifications - p. 99 17. Chapter 9 Proposed effect of epigenetic alterations on stress-related disorders - p. 119 18. Chapter 10 PTSD and physiology: The long-term effects of PTSD and relation to epigenetics, physical health, and chronic diseases - p. 137 19. Chapter 11 Epigenomic biomarkers of posttraumatic stress disorder - p. 163 20. Chapter 12 Adversity across time: Do sensitive periods across the life span determine adversity-induced epigenetic changes? - p. 179 21. Chapter 13 PTSD, telomeres, and aging - p. 193 22. Chapter 14 Accelerated aging in mood disorders - p. 207 23. Chapter 15 Epigenetics, stress, and depression - p. 225 24. Chapter 16 Capturing the epigenome: Differences among blood, saliva, and brain samples - p. 239 25. Chapter 17 Posttraumatic stress disorder, major depressive disorder, and noncoding RNAs - p. 257 26. Chapter 18 MicroRNAs in posttraumatic stress disorder - p. 285 27. Chapter 19 Potential transgenerational epigenetic effects of prolonged stress and psychological trauma - p. 307 28. Chapter 20 Targeting epigenetics as future treatments of trauma- and stress-or-related disorders. Epidrugs and epinutraceuticals - p. 317 29. Index - p. 393
Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic
mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the
evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress
disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding
stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of
recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments
in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical
effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or
development and across the life span. The book concludes by looking at possible transgenerational stress-induced
epigenetic alterations on future offspring and important areas of research for public health, along with the potential for
epigenetic therapeutics or “epidrugs.
1. Epigenetics of Stress and Stress Disorders - p. ii 2. Cover - p. ii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xiii 7. Foreword - p. xvii 8. Acknowledgments - p. xix 9. Chapter 1 The physiology of stress and the human body’s response to stress - p. 1 10. Chapter 2 Posttraumatic stress disorder: Diagnosis, measurement, and assessment - p. 19 11. Chapter 3 Nikola Tesla: An autobiographical case study of trauma and resilience - p. 27 12. Chapter 4 Management of posttraumatic stress disorder - p. 37 13. Chapter 5 Depression and epigenetics: Epidemiology, pathophysiology, diagnosis, and assessment - p. 51 14. Chapter 6 Depression management and pharmacoepigenetics - p. 67 15. Chapter 7 Psychotherapy for stress disorders: A military perspective - p. 85 16. Chapter 8 How stress affects gene expression through epigenetic modifications - p. 99 17. Chapter 9 Proposed effect of epigenetic alterations on stress-related disorders - p. 119 18. Chapter 10 PTSD and physiology: The long-term effects of PTSD and relation to epigenetics, physical health, and chronic diseases - p. 137 19. Chapter 11 Epigenomic biomarkers of posttraumatic stress disorder - p. 163 20. Chapter 12 Adversity across time: Do sensitive periods across the life span determine adversity-induced epigenetic changes? - p. 179 21. Chapter 13 PTSD, telomeres, and aging - p. 193 22. Chapter 14 Accelerated aging in mood disorders - p. 207 23. Chapter 15 Epigenetics, stress, and depression - p. 225 24. Chapter 16 Capturing the epigenome: Differences among blood, saliva, and brain samples - p. 239 25. Chapter 17 Posttraumatic stress disorder, major depressive disorder, and noncoding RNAs - p. 257 26. Chapter 18 MicroRNAs in posttraumatic stress disorder - p. 285 27. Chapter 19 Potential transgenerational epigenetic effects of prolonged stress and psychological trauma - p. 307 28. Chapter 20 Targeting epigenetics as future treatments of trauma- and stress-or-related disorders. Epidrugs and epinutraceuticals - p. 317 29. Index - p. 393
