Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school.
By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. List of contributors - p. xvii 7. About the editors - p. xxi 8. Preface - p. xxiii 9. Acknowledgments - p. xxv 10. Chapter 1. Molecular mechanisms of cell death - p. 1 11. Chapter 2. Acute and chronic inflammation induces disease pathogenesis - p. 19 12. Chapter 3. Infection and host response - p. 33 13. Chapter 4. Neoplasia - p. 55 14. Chapter 5. Basic concepts in human molecular genetics - p. 81 15. Chapter 6. Understanding human disease in the post-genomic era - p. 101 16. Chapter 7. The human transcriptome: implications for understanding, diagnosing, and treating human disease - p. 113 17. Chapter 8. The human epigenome—implications for the understanding of human disease - p. 139 18. Chapter 9. Clinical proteomics and molecular pathology - p. 149 19. Chapter 10. Integrative systems biology - p. 165 20. Chapter 11. Pathology: the clinical description of human disease - p. 177 21. Chapter 12. Understanding molecular pathogenesis: the biological basis of human disease and implications for improved treatment of human disease - p. 191 22. Chapter 13. Integration of molecular and cellular pathogenesis - a bioinformatics approach - p. 201 23. Chapter 14. Molecular basis of cardiovascular disease - p. 209 24. Chapter 15. Molecular basis of hemostatic and thrombotic diseases - p. 229 25. Chapter 16. Molecular basis of lymphoid and myeloid diseases - p. 247 26. Chapter 17. Molecular basis of diseases of immunity - p. 271 27. Chapter 18. Molecular basis of pulmonary disease - p. 285 28. Chapter 19. Molecular basis of diseases of the gastrointestinal tract - p. 323 29. Chapter 20. Molecular basis of liver disease - p. 345 30. Chapter 21. Molecular basis of diseases of the exocrine pancreas - p. 367 31. Chapter 22. Molecular basis of diseases of the endocrine system - p. 381 32. Chapter 23. Molecular basis of gynecologic diseases - p. 409 33. Chapter 24. Molecular basis of kidney disease - p. 425 34. Chapter 25. Molecular pathogenesis of prostate cancer - p. 441 35. Chapter 26. Molecular biology of breast cancer - p. 449 36. Chapter 27. Molecular basis of skin disease - p. 463 37. Chapter 28. Molecular basis of bone diseases - p. 495 38. Chapter 29. Molecular basis of diseases of the nervous system - p. 509 39. Chapter 30. Molecular diagnosis of human disease - p. 549 40. Chapter 31. Molecular assessment of human diseases in the clinical laboratory - p. 563 41. Chapter 32. Pharmacogenomics and personalized medicine in the treatment of human diseases - p. 579 42. Index - p. 591
Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school.
By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. List of contributors - p. xvii 7. About the editors - p. xxi 8. Preface - p. xxiii 9. Acknowledgments - p. xxv 10. Chapter 1. Molecular mechanisms of cell death - p. 1 11. Chapter 2. Acute and chronic inflammation induces disease pathogenesis - p. 19 12. Chapter 3. Infection and host response - p. 33 13. Chapter 4. Neoplasia - p. 55 14. Chapter 5. Basic concepts in human molecular genetics - p. 81 15. Chapter 6. Understanding human disease in the post-genomic era - p. 101 16. Chapter 7. The human transcriptome: implications for understanding, diagnosing, and treating human disease - p. 113 17. Chapter 8. The human epigenome—implications for the understanding of human disease - p. 139 18. Chapter 9. Clinical proteomics and molecular pathology - p. 149 19. Chapter 10. Integrative systems biology - p. 165 20. Chapter 11. Pathology: the clinical description of human disease - p. 177 21. Chapter 12. Understanding molecular pathogenesis: the biological basis of human disease and implications for improved treatment of human disease - p. 191 22. Chapter 13. Integration of molecular and cellular pathogenesis - a bioinformatics approach - p. 201 23. Chapter 14. Molecular basis of cardiovascular disease - p. 209 24. Chapter 15. Molecular basis of hemostatic and thrombotic diseases - p. 229 25. Chapter 16. Molecular basis of lymphoid and myeloid diseases - p. 247 26. Chapter 17. Molecular basis of diseases of immunity - p. 271 27. Chapter 18. Molecular basis of pulmonary disease - p. 285 28. Chapter 19. Molecular basis of diseases of the gastrointestinal tract - p. 323 29. Chapter 20. Molecular basis of liver disease - p. 345 30. Chapter 21. Molecular basis of diseases of the exocrine pancreas - p. 367 31. Chapter 22. Molecular basis of diseases of the endocrine system - p. 381 32. Chapter 23. Molecular basis of gynecologic diseases - p. 409 33. Chapter 24. Molecular basis of kidney disease - p. 425 34. Chapter 25. Molecular pathogenesis of prostate cancer - p. 441 35. Chapter 26. Molecular biology of breast cancer - p. 449 36. Chapter 27. Molecular basis of skin disease - p. 463 37. Chapter 28. Molecular basis of bone diseases - p. 495 38. Chapter 29. Molecular basis of diseases of the nervous system - p. 509 39. Chapter 30. Molecular diagnosis of human disease - p. 549 40. Chapter 31. Molecular assessment of human diseases in the clinical laboratory - p. 563 41. Chapter 32. Pharmacogenomics and personalized medicine in the treatment of human diseases - p. 579 42. Index - p. 591
