Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain focuses on the role of miRNAs in neurogenesis, gliogenesis, neuronal network formation, and the cell biology of forebrain development. The important role miRNAs play in neuronal maturation, neocortex function, and in some neurodevelopmental disorders is discussed, as are the computational challenges and methods used in the identification of miRNA targets.
This book is a valuable reference for neuroscientists who wish to better understand the role of miRNAs in complex processes. It is of strong interest to those working to develop enabling technologies to detect and monitor miRNA expression and function, and to evaluate its roles in neural progenitor proliferation/differentiation, neuronal plasticity, and learning and memory.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xiii 6. Preface - p. xvii 7. Acknowledgments - p. xxi 8. Chapter 1. Making and Maintaining microRNAs in Animals - p. 1 9. Chapter 2. Essentials of miRNA-dependent Control of mRNA Translation and decay, miRNA Targeting Principles, and Methods for Target Identification - p. 19 10. Chapter 3. Computational Challenges and -omics Approaches for the Identification of microRNAs and Targets - p. 39 11. Chapter 4. Methodological Challenges in Functional Investigation and Therapeutic Use of microRNAs - p. 61 12. Chapter 5. The Cell Biology of Neural Stem and Progenitor Cells and Neocortex Expansion in Development and Evolution - p. 81 13. Chapter 6. miRNA-Dependent and Independent Functions of the Microprocessor in the Regulation of Neural Stem Cell Biology - p. 101 14. Chapter 7. Epigenetic Regulation of Neurogenesis by microRNAs - p. 119 15. Chapter 8. miRNAs in Mammalian Adult Olfactory Neurogenesis - p. 137 16. Chapter 9. microRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Hippocampus-dependent Cognition and Related Disorders? - p. 155 17. Chapter 10. Transcriptional and Epigenetic Control of Astrogliogenesis - p. 177 18. Chapter 11. microRNAs in Oligodendrocyte Myelination and Repair in the Central Nervous System - p. 197 19. Chapter 12. miRNA in Neuronal Networks Maturation and Plasticity - p. 211 20. Chapter 13. Small RNA Dysregulation in Neurocognitive and Neuropsychiatric Disorders - p. 225 21. Chapter 14. Circular RNAs Expression, Function, and Regulation in Neural Systems - p. 247 22. Chapter 15. Comparative Functions of miRNAs in Embryonic Neurogenesis and Neuronal Network Formation - p. 265 23. Chapter 16. microRNA and Neocortical Evolution - p. 283 24. Index - p. 301
Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain focuses on the role of miRNAs in neurogenesis, gliogenesis, neuronal network formation, and the cell biology of forebrain development. The important role miRNAs play in neuronal maturation, neocortex function, and in some neurodevelopmental disorders is discussed, as are the computational challenges and methods used in the identification of miRNA targets.
This book is a valuable reference for neuroscientists who wish to better understand the role of miRNAs in complex processes. It is of strong interest to those working to develop enabling technologies to detect and monitor miRNA expression and function, and to evaluate its roles in neural progenitor proliferation/differentiation, neuronal plasticity, and learning and memory.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xiii 6. Preface - p. xvii 7. Acknowledgments - p. xxi 8. Chapter 1. Making and Maintaining microRNAs in Animals - p. 1 9. Chapter 2. Essentials of miRNA-dependent Control of mRNA Translation and decay, miRNA Targeting Principles, and Methods for Target Identification - p. 19 10. Chapter 3. Computational Challenges and -omics Approaches for the Identification of microRNAs and Targets - p. 39 11. Chapter 4. Methodological Challenges in Functional Investigation and Therapeutic Use of microRNAs - p. 61 12. Chapter 5. The Cell Biology of Neural Stem and Progenitor Cells and Neocortex Expansion in Development and Evolution - p. 81 13. Chapter 6. miRNA-Dependent and Independent Functions of the Microprocessor in the Regulation of Neural Stem Cell Biology - p. 101 14. Chapter 7. Epigenetic Regulation of Neurogenesis by microRNAs - p. 119 15. Chapter 8. miRNAs in Mammalian Adult Olfactory Neurogenesis - p. 137 16. Chapter 9. microRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Hippocampus-dependent Cognition and Related Disorders? - p. 155 17. Chapter 10. Transcriptional and Epigenetic Control of Astrogliogenesis - p. 177 18. Chapter 11. microRNAs in Oligodendrocyte Myelination and Repair in the Central Nervous System - p. 197 19. Chapter 12. miRNA in Neuronal Networks Maturation and Plasticity - p. 211 20. Chapter 13. Small RNA Dysregulation in Neurocognitive and Neuropsychiatric Disorders - p. 225 21. Chapter 14. Circular RNAs Expression, Function, and Regulation in Neural Systems - p. 247 22. Chapter 15. Comparative Functions of miRNAs in Embryonic Neurogenesis and Neuronal Network Formation - p. 265 23. Chapter 16. microRNA and Neocortical Evolution - p. 283 24. Index - p. 301
