Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies.
In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.
1. Essentials of Pharmatoxicology in Drug Research, Volume 1 - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Dedication - p. Page v 7. List of contributors - p. Page v 8. List of Illustrations - p. Page ix 9. List of Tables - p. Page x 10. Chapter 1 : Understanding pharmacotoxicology - p. Page x 11. Chapter 2 : Toxicology in drug research - p. Page 24 12. Chapter 3 : Role of microRNAs in toxicology - p. Page 50 13. Chapter 4 : Exosomes as mediators of chemical-induced toxicity - p. Page 88 14. Chapter 5 : Drug-induced oxidative stress as a mechanism of toxicity - p. Page 108 15. Chapter 6 : Role of “toxicant-induced loss of tolerance” in the emergence of disease - p. Page 129 16. Chapter 7 : Types of cellular responses to chemical toxicants - p. Page 164 17. Chapter 8 : Toxicant-induced injury and tissue repair - p. Page 198 18. Chapter 9 : Computer-aided technologies in drug discovery and toxicity prediction - p. Page 233 19. Chapter 10 : Predicting toxicity from chemical structure of a drug compound - p. Page 252 20. Chapter 11 : Toxicokinetics and organ-specific toxicity - p. Page 264 21. Chapter 12 : Drug-induced nephrotoxicity and its biomarkers - p. Page 283 22. Chapter 13 : Mechanism of drug-induced neurotoxicity and its management - p. Page 312 23. Chapter 14 : Thermal processing and food-related toxicants - p. Page 335 24. Chapter 15 : Medication errors and approaches for its prevention - p. Page 364 25. Chapter 16 : Understanding the bioaccumulation of pharmaceuticals and personal care products - p. Page 389 26. Chapter 17 : Toxicity of dental materials and ways to screen their biosafety - p. Page 427 27. Chapter 18 : Clinical detoxification of the body from chemical toxicants - p. Page 461 28. Chapter 19 : Molecular mechanisms of the chemopreventive role of dietary phytochemicals - p. Page 500 29. Chapter 20 : Toxicity labels - p. Page 524 30. Chapter 21 : Toxic potential indicator - p. Page 550 31. Chapter 22 : Concept of pharmacotherapy and managed care in clinical interventions - p. Page 568 32. Chapter 23 : Understanding the connection between dietary supplementation and inadvertent doping - p. Page 595 33. Chapter 24 : Cells and tissue-based models as a rational substitute in toxicity testing - p. Page 620 34. Chapter 25 : Regulatory agencies for toxicological studies - p. Page 662 35. Chapter 26 : Key challenges for toxicologists in the 21st century - p. Page 699 36. Index - p. Page 715
Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies.
In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.
1. Essentials of Pharmatoxicology in Drug Research, Volume 1 - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Dedication - p. Page v 7. List of contributors - p. Page v 8. List of Illustrations - p. Page ix 9. List of Tables - p. Page x 10. Chapter 1 : Understanding pharmacotoxicology - p. Page x 11. Chapter 2 : Toxicology in drug research - p. Page 24 12. Chapter 3 : Role of microRNAs in toxicology - p. Page 50 13. Chapter 4 : Exosomes as mediators of chemical-induced toxicity - p. Page 88 14. Chapter 5 : Drug-induced oxidative stress as a mechanism of toxicity - p. Page 108 15. Chapter 6 : Role of “toxicant-induced loss of tolerance” in the emergence of disease - p. Page 129 16. Chapter 7 : Types of cellular responses to chemical toxicants - p. Page 164 17. Chapter 8 : Toxicant-induced injury and tissue repair - p. Page 198 18. Chapter 9 : Computer-aided technologies in drug discovery and toxicity prediction - p. Page 233 19. Chapter 10 : Predicting toxicity from chemical structure of a drug compound - p. Page 252 20. Chapter 11 : Toxicokinetics and organ-specific toxicity - p. Page 264 21. Chapter 12 : Drug-induced nephrotoxicity and its biomarkers - p. Page 283 22. Chapter 13 : Mechanism of drug-induced neurotoxicity and its management - p. Page 312 23. Chapter 14 : Thermal processing and food-related toxicants - p. Page 335 24. Chapter 15 : Medication errors and approaches for its prevention - p. Page 364 25. Chapter 16 : Understanding the bioaccumulation of pharmaceuticals and personal care products - p. Page 389 26. Chapter 17 : Toxicity of dental materials and ways to screen their biosafety - p. Page 427 27. Chapter 18 : Clinical detoxification of the body from chemical toxicants - p. Page 461 28. Chapter 19 : Molecular mechanisms of the chemopreventive role of dietary phytochemicals - p. Page 500 29. Chapter 20 : Toxicity labels - p. Page 524 30. Chapter 21 : Toxic potential indicator - p. Page 550 31. Chapter 22 : Concept of pharmacotherapy and managed care in clinical interventions - p. Page 568 32. Chapter 23 : Understanding the connection between dietary supplementation and inadvertent doping - p. Page 595 33. Chapter 24 : Cells and tissue-based models as a rational substitute in toxicity testing - p. Page 620 34. Chapter 25 : Regulatory agencies for toxicological studies - p. Page 662 35. Chapter 26 : Key challenges for toxicologists in the 21st century - p. Page 699 36. Index - p. Page 715
