A must-have reference for both general physicians and advanced practice providers, Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant provides trusted, time-tested guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. The fully revised 12th Edition is an ideal resource for every stage of practice and remains the most comprehensive, multidisciplinary text in the field. Drs. Richard J. Martin and Avroy A. Fanaroff from Rainbow Babies and Children’s Hospital bring you up to date with everything from diagnosis and treatment selection through post-treatment strategies and management of complications—all with a dual focus on neonatology and perinatology, and all designed to help you improve the quality of life and long-term outcomes of your patients.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Contributors - p. iii 7. Preface - p. gxxii 8. List of Illustrations - p. gxxii 9. List of Tables - p. gxxii 10. Volume 1 - p. gxxii 11. Part 1: The Field of Neonatal-Perinatal Medicine - p. gxxii 12. Chapter 1: Growth of Neonatal-Perinatal Medicine—A Historical Perspective - p. gxxii 13. Chapter 2: Epidemiology for Neonatologists - p. g16 14. Chapter 3: Big Data for the Smallest Patients—What We Can Learn From Neonatal Database Research - p. g26 15. Chapter 4: Medical Ethics in Neonatal Care - p. g35 16. Chapter 5: Improving the Quality, Safety, and Equity of Neonatal Intensive Care for Infants and Families - p. g59 17. Chapter 6: Importance of Simulation in Neonatology - p. g93 18. Chapter 7: Perinatal and Neonatal Care in Developing Countries - p. g105 19. Chapter 8: Social and Economic Contributors to Neonatal Outcome in the United States - p. g127 20. Part 2: The Fetus - p. g145 21. Chapter 9: Genetic Aspects of Perinatal Disease and Prenatal Diagnosis - p. g145 22. Chapter 10: Perinatal Ultrasound - p. g168 23. Chapter 11: Estimation of Fetal Well-Being - p. g209 24. Chapter 12: Surgical Treatment of the Fetus - p. g224 25. Chapter 13: Adverse Exposures to the Fetus - p. g238 26. Chapter 14: Fetal Growth Restriction: A Complex Interplay Between the Intrauterine and Maternal Environment - p. g256 27. Chapter 15: Developmental Origins of Health and Disease - p. g271 28. Part 3: Pregnancy Disorders and Their Impact on the Fetus - p. g285 29. Chapter 16: Hypertensive Disorders of Pregnancy - p. g285 30. Chapter 17: Pregnancy Complicated by Diabetes Mellitus - p. g304 31. Chapter 18: Obstetric Management of Prematurity - p. g315 32. Chapter 19: Fetal Effects of Autoimmune Disease - p. g345 33. Chapter 20: Multiple Gestation: Fetal and Maternal Considerations - p. g359 34. Chapter 21: Post-Term Pregnancy - p. g370 35. Chapter 22: Immune and Nonimmune Hydrops Fetalis - p. g379 36. Chapter 23: Amniotic Fluid Volume - p. g393 37. Chapter 24: Perinatal Infections and Chorioamnionitis - p. g411 38. Chapter 25: Placental Pathology - p. g423 39. Part 4: The Delivery Room - p. g431 40. Chapter 26: Anesthesia for Labor and Delivery - p. g431 41. Chapter 27: Physical Examination of the Healthy Newborn - p. g431 42. Chapter 28: Birth Injuries - p. g473 43. Chapter 29: Congenital Anomalies - p. g473 44. Part 5: Resuscitation of the Newborn - p. g526 45. Chapter 30: Overview and Initial Management of Delivery Room Resuscitation - p. g526 46. Chapter 31: Role of Positive Pressure Ventilation in Neonatal Resuscitation - p. g526 47. Chapter 32: Oxygen Therapy in Neonatal Resuscitation - p. g526 48. Chapter 33: Chest Compression, Medications, and Special Problems in Neonatal Resuscitation - p. g567 49. Chapter 34: Role of Umbilical Cord Management in Neonatal Resuscitation - p. g567 50. Part 6: The Physical Environment in Neonatal Care - p. g588 51. Chapter 35: Thermal Environment of the Intensive Care Nursery - p. g588 52. Chapter 36: Optimization of the Neonatal Intensive Care Unit Environment - p. g602 53. Part 7: Provisions for Neonatal Care - p. g615 54. Chapter 37: Neonatal Cardiorespiratory Monitoring - p. g615 55. Chapter 38: Diagnostic Imaging of the Neonate - p. g632 56. Chapter 39: Anesthesia in the Neonate - p. g662 57. Chapter 40: Care of Periviable Micropreemies: The Japanese Perspective - p. g684 58. Chapter 41: The Late Preterm Infant - p. g701 59. Chapter 42: Nutritional Support for the Preterm Infant - p. g717 60. Chapter 43: Support for the Family - p. g736 61. Chapter 44: Perinatal Palliative Care - p. g749 62. Part 8: Developmental Pharmacology - p. g761 63. Chapter 45: Principles of Drug Use in the Fetus and Neonate - p. g761 64. Chapter 46: Principles of Drug Use During Lactation - p. g778 65. Chapter 47: Pharmacokinetics in Neonatal Medicine - p. g778 66. Chapter 48: Infants of Substance-Using Mothers - p. g800 67. Part 9: The Immune System - p. g814 68. Chapter 49: Developmental Immunology - p. g814 69. Chapter 50: Postnatal Bacterial Infections - p. g855 70. Chapter 51: Fungal and Protozoal Infections of the Neonate - p. g876 71. Chapter 52: Viral Infections in the Neonate - p. g913 72. Part 10: The Central Nervous System - p. g971 73. Chapter 53: Normal and Abnormal Brain Development - p. g971 74. Chapter 54: Cerebral White Matter Damage and Encephalopathy of Prematurity - p. g1009 75. Chapter 55: Intracranial Hemorrhage and Stroke in the Neonate - p. g1029 76. Chapter 56: Hypoxic-Ischemic Encephalopathy - p. g1054 77. Chapter 57: Seizures in Neonates - p. g1082 78. Chapter 58: Hypotonia and Neuromuscular Disease in the Neonate - p. g1113 79. Chapter 59: Disorders in Head Shape and Size - p. g1130 80. Chapter 60: Spinal Dysraphisms - p. g1143 81. Chapter 61: Hearing Loss in the Newborn Infant - p. g1152 82. Chapter 62: Early Childhood Neurodevelopmental Outcomes of High-Risk Neonates - p. g1162 83. Volume 2 - p. g1184 84. Part 11: The Respiratory System - p. g1184 85. Chapter 63: Lung Development and Maturation - p. g1184 86. Chapter 64: Assessment of Neonatal Pulmonary Function - p. g1207 87. Chapter 65: Respiratory Distress Syndrome in the Neonate - p. g1223 88. Chapter 66: Assisted Ventilation and Its Complications - p. g1237 89. Chapter 67: Spectrum of Neonatal Respiratory Disorders - p. g1267 90. Chapter 68: Apnea, Bradycardia, Hypoxemia, and the Foundation of Respiratory Control - p. g1299 91. Chapter 69: Upper Airway Lesions in the Neonate - p. g1315 92. Chapter 70: Bronchopulmonary Dysplasia in the Neonate - p. g1328 93. Chapter 71: Postneonatal Respiratory Morbidity - p. g1342 94. Part 12: The Cardiovascular System - p. g1353 95. Chapter 72: Cardiac Embryology - p. g1353 96. Chapter 73: Pulmonary Vascular Development - p. g1369 97. Chapter 74: Prenatal Diagnosis of Congenital Heart Disease - p. g1384 98. Chapter 75: Patent Ductus Arteriosus - p. g1399 99. Chapter 76: Congenital Defects of the Cardiovascular System - p. g1408 100. Chapter 77: Unique Neonatal Cardiovascular Problems - p. g1430 101. Chapter 78: Disorders of Cardiac Rhythm and Conduction in Newborns - p. g1448 102. Chapter 79: Neonatal Management of Congenital Heart Disease - p. g1468 103. Part 13: The Blood and Hematopoietic System - p. g1495 104. Chapter 80: The Hemostatic System - p. g1495 105. Chapter 81: Red Blood Cell Disorders in the Fetus and Neonate - p. g1517 106. Chapter 82: White Blood Cells and Immune Disorders - p. g1550 107. Chapter 83: Neoplasms in the Neonate - p. g1562 108. Chapter 84: Blood Component Therapy for the Neonate - p. g1570 109. Part 14: The Gastrointestinal Tract - p. g1593 110. Chapter 85: Development of the Neonatal Gastrointestinal Tract - p. g1593 111. Chapter 86: Gastrointestinal Reflux and Motility in the Neonate - p. g1604 112. Chapter 87: Disorders of Digestion in the Neonate - p. g1611 113. Chapter 88: Selected Gastrointestinal Anomalies in the Neonate - p. g1623 114. Chapter 89: Neonatal Necrotizing Enterocolitis - p. g1652 115. Part 15: Metabolic and Endocrine Disorders - p. g1664 116. Chapter 90: Disorders of Carbohydrate Metabolism in the Neonate - p. g1664 117. Chapter 91: Disorders of Calcium, Phosphorus, and Magnesium Metabolism in the Neonate - p. g1695 118. Chapter 92: Thyroid Disorders in the Neonate - p. g1726 119. Chapter 93: Disorders of Sex Development - p. g1748 120. Chapter 94: Inborn Errors of Metabolism - p. g1787 121. Part 16: Neonatal Jaundice and Liver Disease - p. g1868 122. Chapter 95: Neonatal Jaundice and Liver Disease - p. g1868 123. Part 17: The Kidney and Urinary Tract - p. g1942 124. Chapter 96: Fluid, Electrolytes, and Acid-Base Homeostasis - p. g1942 125. Chapter 97: The Kidney and Urinary Tract of the Neonate - p. g1963 126. Part 18: The Skin - p. g1988 127. Chapter 98: The Skin of the Neonate - p. g1988 128. Part 19: The Eye - p. g2025 129. Chapter 99: Examination and Common Problems in the Neonatal Eye - p. g2025 130. Chapter 100: Retinopathy of Prematurity - p. g2061 131. Part 20: Neonatal Orthopedics - p. g2070 132. Chapter 101: Musculoskeletal Disorders in Neonates - p. g2070 133. Chapter 102: Bone and Joint Infections in Neonates - p. g2070 134. Chapter 103: Congenital Abnormalities of the Upper and Lower Extremities and Spine - p. g2086 135. Appendices - p. g2107 136. Therapeutic Agents - p. g2107 137. Tables of Normal Values - p. g2107 138. Index - p. g2107
A must-have reference for both general physicians and advanced practice providers, Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant provides trusted, time-tested guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. The fully revised 12th Edition is an ideal resource for every stage of practice and remains the most comprehensive, multidisciplinary text in the field. Drs. Richard J. Martin and Avroy A. Fanaroff from Rainbow Babies and Children’s Hospital bring you up to date with everything from diagnosis and treatment selection through post-treatment strategies and management of complications—all with a dual focus on neonatology and perinatology, and all designed to help you improve the quality of life and long-term outcomes of your patients.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Contributors - p. iii 7. Preface - p. gxxii 8. List of Illustrations - p. gxxii 9. List of Tables - p. gxxii 10. Volume 1 - p. gxxii 11. Part 1: The Field of Neonatal-Perinatal Medicine - p. gxxii 12. Chapter 1: Growth of Neonatal-Perinatal Medicine—A Historical Perspective - p. gxxii 13. Chapter 2: Epidemiology for Neonatologists - p. g16 14. Chapter 3: Big Data for the Smallest Patients—What We Can Learn From Neonatal Database Research - p. g26 15. Chapter 4: Medical Ethics in Neonatal Care - p. g35 16. Chapter 5: Improving the Quality, Safety, and Equity of Neonatal Intensive Care for Infants and Families - p. g59 17. Chapter 6: Importance of Simulation in Neonatology - p. g93 18. Chapter 7: Perinatal and Neonatal Care in Developing Countries - p. g105 19. Chapter 8: Social and Economic Contributors to Neonatal Outcome in the United States - p. g127 20. Part 2: The Fetus - p. g145 21. Chapter 9: Genetic Aspects of Perinatal Disease and Prenatal Diagnosis - p. g145 22. Chapter 10: Perinatal Ultrasound - p. g168 23. Chapter 11: Estimation of Fetal Well-Being - p. g209 24. Chapter 12: Surgical Treatment of the Fetus - p. g224 25. Chapter 13: Adverse Exposures to the Fetus - p. g238 26. Chapter 14: Fetal Growth Restriction: A Complex Interplay Between the Intrauterine and Maternal Environment - p. g256 27. Chapter 15: Developmental Origins of Health and Disease - p. g271 28. Part 3: Pregnancy Disorders and Their Impact on the Fetus - p. g285 29. Chapter 16: Hypertensive Disorders of Pregnancy - p. g285 30. Chapter 17: Pregnancy Complicated by Diabetes Mellitus - p. g304 31. Chapter 18: Obstetric Management of Prematurity - p. g315 32. Chapter 19: Fetal Effects of Autoimmune Disease - p. g345 33. Chapter 20: Multiple Gestation: Fetal and Maternal Considerations - p. g359 34. Chapter 21: Post-Term Pregnancy - p. g370 35. Chapter 22: Immune and Nonimmune Hydrops Fetalis - p. g379 36. Chapter 23: Amniotic Fluid Volume - p. g393 37. Chapter 24: Perinatal Infections and Chorioamnionitis - p. g411 38. Chapter 25: Placental Pathology - p. g423 39. Part 4: The Delivery Room - p. g431 40. Chapter 26: Anesthesia for Labor and Delivery - p. g431 41. Chapter 27: Physical Examination of the Healthy Newborn - p. g431 42. Chapter 28: Birth Injuries - p. g473 43. Chapter 29: Congenital Anomalies - p. g473 44. Part 5: Resuscitation of the Newborn - p. g526 45. Chapter 30: Overview and Initial Management of Delivery Room Resuscitation - p. g526 46. Chapter 31: Role of Positive Pressure Ventilation in Neonatal Resuscitation - p. g526 47. Chapter 32: Oxygen Therapy in Neonatal Resuscitation - p. g526 48. Chapter 33: Chest Compression, Medications, and Special Problems in Neonatal Resuscitation - p. g567 49. Chapter 34: Role of Umbilical Cord Management in Neonatal Resuscitation - p. g567 50. Part 6: The Physical Environment in Neonatal Care - p. g588 51. Chapter 35: Thermal Environment of the Intensive Care Nursery - p. g588 52. Chapter 36: Optimization of the Neonatal Intensive Care Unit Environment - p. g602 53. Part 7: Provisions for Neonatal Care - p. g615 54. Chapter 37: Neonatal Cardiorespiratory Monitoring - p. g615 55. Chapter 38: Diagnostic Imaging of the Neonate - p. g632 56. Chapter 39: Anesthesia in the Neonate - p. g662 57. Chapter 40: Care of Periviable Micropreemies: The Japanese Perspective - p. g684 58. Chapter 41: The Late Preterm Infant - p. g701 59. Chapter 42: Nutritional Support for the Preterm Infant - p. g717 60. Chapter 43: Support for the Family - p. g736 61. Chapter 44: Perinatal Palliative Care - p. g749 62. Part 8: Developmental Pharmacology - p. g761 63. Chapter 45: Principles of Drug Use in the Fetus and Neonate - p. g761 64. Chapter 46: Principles of Drug Use During Lactation - p. g778 65. Chapter 47: Pharmacokinetics in Neonatal Medicine - p. g778 66. Chapter 48: Infants of Substance-Using Mothers - p. g800 67. Part 9: The Immune System - p. g814 68. Chapter 49: Developmental Immunology - p. g814 69. Chapter 50: Postnatal Bacterial Infections - p. g855 70. Chapter 51: Fungal and Protozoal Infections of the Neonate - p. g876 71. Chapter 52: Viral Infections in the Neonate - p. g913 72. Part 10: The Central Nervous System - p. g971 73. Chapter 53: Normal and Abnormal Brain Development - p. g971 74. Chapter 54: Cerebral White Matter Damage and Encephalopathy of Prematurity - p. g1009 75. Chapter 55: Intracranial Hemorrhage and Stroke in the Neonate - p. g1029 76. Chapter 56: Hypoxic-Ischemic Encephalopathy - p. g1054 77. Chapter 57: Seizures in Neonates - p. g1082 78. Chapter 58: Hypotonia and Neuromuscular Disease in the Neonate - p. g1113 79. Chapter 59: Disorders in Head Shape and Size - p. g1130 80. Chapter 60: Spinal Dysraphisms - p. g1143 81. Chapter 61: Hearing Loss in the Newborn Infant - p. g1152 82. Chapter 62: Early Childhood Neurodevelopmental Outcomes of High-Risk Neonates - p. g1162 83. Volume 2 - p. g1184 84. Part 11: The Respiratory System - p. g1184 85. Chapter 63: Lung Development and Maturation - p. g1184 86. Chapter 64: Assessment of Neonatal Pulmonary Function - p. g1207 87. Chapter 65: Respiratory Distress Syndrome in the Neonate - p. g1223 88. Chapter 66: Assisted Ventilation and Its Complications - p. g1237 89. Chapter 67: Spectrum of Neonatal Respiratory Disorders - p. g1267 90. Chapter 68: Apnea, Bradycardia, Hypoxemia, and the Foundation of Respiratory Control - p. g1299 91. Chapter 69: Upper Airway Lesions in the Neonate - p. g1315 92. Chapter 70: Bronchopulmonary Dysplasia in the Neonate - p. g1328 93. Chapter 71: Postneonatal Respiratory Morbidity - p. g1342 94. Part 12: The Cardiovascular System - p. g1353 95. Chapter 72: Cardiac Embryology - p. g1353 96. Chapter 73: Pulmonary Vascular Development - p. g1369 97. Chapter 74: Prenatal Diagnosis of Congenital Heart Disease - p. g1384 98. Chapter 75: Patent Ductus Arteriosus - p. g1399 99. Chapter 76: Congenital Defects of the Cardiovascular System - p. g1408 100. Chapter 77: Unique Neonatal Cardiovascular Problems - p. g1430 101. Chapter 78: Disorders of Cardiac Rhythm and Conduction in Newborns - p. g1448 102. Chapter 79: Neonatal Management of Congenital Heart Disease - p. g1468 103. Part 13: The Blood and Hematopoietic System - p. g1495 104. Chapter 80: The Hemostatic System - p. g1495 105. Chapter 81: Red Blood Cell Disorders in the Fetus and Neonate - p. g1517 106. Chapter 82: White Blood Cells and Immune Disorders - p. g1550 107. Chapter 83: Neoplasms in the Neonate - p. g1562 108. Chapter 84: Blood Component Therapy for the Neonate - p. g1570 109. Part 14: The Gastrointestinal Tract - p. g1593 110. Chapter 85: Development of the Neonatal Gastrointestinal Tract - p. g1593 111. Chapter 86: Gastrointestinal Reflux and Motility in the Neonate - p. g1604 112. Chapter 87: Disorders of Digestion in the Neonate - p. g1611 113. Chapter 88: Selected Gastrointestinal Anomalies in the Neonate - p. g1623 114. Chapter 89: Neonatal Necrotizing Enterocolitis - p. g1652 115. Part 15: Metabolic and Endocrine Disorders - p. g1664 116. Chapter 90: Disorders of Carbohydrate Metabolism in the Neonate - p. g1664 117. Chapter 91: Disorders of Calcium, Phosphorus, and Magnesium Metabolism in the Neonate - p. g1695 118. Chapter 92: Thyroid Disorders in the Neonate - p. g1726 119. Chapter 93: Disorders of Sex Development - p. g1748 120. Chapter 94: Inborn Errors of Metabolism - p. g1787 121. Part 16: Neonatal Jaundice and Liver Disease - p. g1868 122. Chapter 95: Neonatal Jaundice and Liver Disease - p. g1868 123. Part 17: The Kidney and Urinary Tract - p. g1942 124. Chapter 96: Fluid, Electrolytes, and Acid-Base Homeostasis - p. g1942 125. Chapter 97: The Kidney and Urinary Tract of the Neonate - p. g1963 126. Part 18: The Skin - p. g1988 127. Chapter 98: The Skin of the Neonate - p. g1988 128. Part 19: The Eye - p. g2025 129. Chapter 99: Examination and Common Problems in the Neonatal Eye - p. g2025 130. Chapter 100: Retinopathy of Prematurity - p. g2061 131. Part 20: Neonatal Orthopedics - p. g2070 132. Chapter 101: Musculoskeletal Disorders in Neonates - p. g2070 133. Chapter 102: Bone and Joint Infections in Neonates - p. g2070 134. Chapter 103: Congenital Abnormalities of the Upper and Lower Extremities and Spine - p. g2086 135. Appendices - p. g2107 136. Therapeutic Agents - p. g2107 137. Tables of Normal Values - p. g2107 138. Index - p. g2107
