Febrile seizures are the most common seizures in infants and children worldwide, This fact provides strong impetus to study and understand them and their consequences, and consider their treatment. These topics were the focus of the first edition of this book.
The 20 years since the publication of this first edition have witnessed an explosion of new information about febrile seizures, meriting this new edition. Key advances have been made in the genetics and neurobiological underpinnings of febrile seizures and especially the very long fever-related seizures called febrile status epilepticus. The role of neuroinflammatory factors in the emergence of these seizures and their consequences, the demonstration of unique clinical and neuroradiological aspects of febrile status epilepticus, and the prospect of predictive (bio)markers to identify and characterize cognitive and epilepsy outcomes are exciting and important. In this edition, the authors and editors tackle these developments in chapters addressing the questions of parents, physicians, allied health care professionals and basic and translational scientists.
1. Title of Book - p. Cover 2. Cover image - p. Cover 3. Title page - p. ii 4. Table of Contents - p. iv 5. Copyright - p. iv 6. Contributors - p. xiii 7. Part I: Epidemiology of febrile seizures - p. xvi 8. Chapter 1. The incidence and prevalence of febrile seizures and febrile status epilepticus - p. 13 9. Part II: Genetic and acquired syndromes associated with febrile seizures - p. 28 10. Chapter 2. The evolving genetic landscape of febrile seizures and GEFS + - p. 31 11. SCN1A and Dravet syndrome - p. 43 12. Ion channels and febrile seizures: It’s not just SCN1A - p. 67 13. Part III: Febrile status epilepticus - p. 91 14. Chapter 5. Neuroimmunologic aspects of febrile status epilepticus - p. 102 15. Chapter 6. Febrile status epilepticus and its consequences: Insights from the “Consequences of Febrile Status Epilepticus in Childhood” (FEBSTAT) study - p. 115 16. Chapter 7. The role of febrile seizures in directing surgical therapies for temporal lobe epilepsy - p. 121 17. Chapter 8. Cognitive outcomes of febrile status epilepticus - p. 143 18. Part IV: The neurobiology of FS and FSE: Experimental approaches - p. 151 19. Chapter 9. Why do febrile seizures involve specifically the developing brain? - p. 155 20. Chapter 10. Contributions of cytokines to febrile seizures - p. 179 21. Chapter 11. Experimental models of febrile seizures and febrile status epilepticus - p. 199 22. Part V: The neurobiology of FSE-induced epilepsy and cognitive deficits: Experimental approaches - p. 217 23. Chapter 12. Febrile status epilepticus-related epilepsy: Neuroinflammation and epigenetics - p. 221 24. Chapter 13. MicroRNAs and epigenetic processes in FSE-provoked epilepsy - p. 235 25. Chapter 14. From prolonged febrile seizures to epilepsy: Potential contribution of HCN channels - p. 258 26. Chapter 15. Cognitive consequences of experimental febrile status epilepticus - p. 273 27. Part VI: Clinical and translational implications of FSE - p. 288 28. Chapter 16. MRI for assessing the impact of febrile status epilepticus and predicting outcomes - p. 291 29. Chapter 17. EEG for assessing the impact of febrile status epilepticus and predicting outcomes - p. 303 30. Part VII: Management of febrile seizures and FSE: Past, present, and future - p. 311 31. Chapter 18. Evaluation and practical management: Approach to simple and complex febrile seizures - p. 315 32. Chapter 19. What do we tell parents of a child with simple or complex febrile seizures? - p. 329 33. Chapter 20. The future of FS, FSE, and their epileptogenic and cognitive outcomes - p. 341 34. Index - p. 345
Febrile seizures are the most common seizures in infants and children worldwide, This fact provides strong impetus to study and understand them and their consequences, and consider their treatment. These topics were the focus of the first edition of this book.
The 20 years since the publication of this first edition have witnessed an explosion of new information about febrile seizures, meriting this new edition. Key advances have been made in the genetics and neurobiological underpinnings of febrile seizures and especially the very long fever-related seizures called febrile status epilepticus. The role of neuroinflammatory factors in the emergence of these seizures and their consequences, the demonstration of unique clinical and neuroradiological aspects of febrile status epilepticus, and the prospect of predictive (bio)markers to identify and characterize cognitive and epilepsy outcomes are exciting and important. In this edition, the authors and editors tackle these developments in chapters addressing the questions of parents, physicians, allied health care professionals and basic and translational scientists.
1. Title of Book - p. Cover 2. Cover image - p. Cover 3. Title page - p. ii 4. Table of Contents - p. iv 5. Copyright - p. iv 6. Contributors - p. xiii 7. Part I: Epidemiology of febrile seizures - p. xvi 8. Chapter 1. The incidence and prevalence of febrile seizures and febrile status epilepticus - p. 13 9. Part II: Genetic and acquired syndromes associated with febrile seizures - p. 28 10. Chapter 2. The evolving genetic landscape of febrile seizures and GEFS + - p. 31 11. SCN1A and Dravet syndrome - p. 43 12. Ion channels and febrile seizures: It’s not just SCN1A - p. 67 13. Part III: Febrile status epilepticus - p. 91 14. Chapter 5. Neuroimmunologic aspects of febrile status epilepticus - p. 102 15. Chapter 6. Febrile status epilepticus and its consequences: Insights from the “Consequences of Febrile Status Epilepticus in Childhood” (FEBSTAT) study - p. 115 16. Chapter 7. The role of febrile seizures in directing surgical therapies for temporal lobe epilepsy - p. 121 17. Chapter 8. Cognitive outcomes of febrile status epilepticus - p. 143 18. Part IV: The neurobiology of FS and FSE: Experimental approaches - p. 151 19. Chapter 9. Why do febrile seizures involve specifically the developing brain? - p. 155 20. Chapter 10. Contributions of cytokines to febrile seizures - p. 179 21. Chapter 11. Experimental models of febrile seizures and febrile status epilepticus - p. 199 22. Part V: The neurobiology of FSE-induced epilepsy and cognitive deficits: Experimental approaches - p. 217 23. Chapter 12. Febrile status epilepticus-related epilepsy: Neuroinflammation and epigenetics - p. 221 24. Chapter 13. MicroRNAs and epigenetic processes in FSE-provoked epilepsy - p. 235 25. Chapter 14. From prolonged febrile seizures to epilepsy: Potential contribution of HCN channels - p. 258 26. Chapter 15. Cognitive consequences of experimental febrile status epilepticus - p. 273 27. Part VI: Clinical and translational implications of FSE - p. 288 28. Chapter 16. MRI for assessing the impact of febrile status epilepticus and predicting outcomes - p. 291 29. Chapter 17. EEG for assessing the impact of febrile status epilepticus and predicting outcomes - p. 303 30. Part VII: Management of febrile seizures and FSE: Past, present, and future - p. 311 31. Chapter 18. Evaluation and practical management: Approach to simple and complex febrile seizures - p. 315 32. Chapter 19. What do we tell parents of a child with simple or complex febrile seizures? - p. 329 33. Chapter 20. The future of FS, FSE, and their epileptogenic and cognitive outcomes - p. 341 34. Index - p. 345
