Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field.
In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease.
Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field.
A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of vitamin D, as opposed to searching through thousands of journal articles Chapters written by the most prominent and well-published names in the field
1. Chapter 1 : Book introduction: Major trends in vitamin D research - p. Page xxvi 2. Chapter 2 : Evolution of human skin pigmentation and vitamin D - p. Page 7 3. Chapter 3 : Photobiology of vitamin D - p. Page 21 4. Chapter 4 : The activating enzymes of vitamin D metabolism (25- and 1α-hydroxylases) - p. Page 40 5. Chapter 5 : CYP24A1: structure, function, and physiological role - p. Page 65 6. Chapter 6 : Alternative pathways for vitamin D metabolism - p. Page 80 7. Chapter 7 : Vitamin D–binding protein - p. Page 104 8. Chapter 8 : Regulation of renal vitamin D metabolism - p. Page 130 9. Chapter 9 : Regulation of extra-renal synthesis of 1,25(OH)2D - p. Page 151 10. Chapter 10 : Structural basis for ligand activity in vitamin D receptor - p. Page 178 11. Chapter 11 : Genome-wide perspectives on vitamin D receptor actions - p. Page 208 12. Chapter 12 : Vitamin D, chromatin, and epigenetics - p. Page 225 13. Chapter 13 : The diverse genomic mechanisms of action of the vitamin D receptor - p. Page 238 14. Chapter 14 : Vitamin D and microRNAs - p. Page 253 15. Chapter 15 : Pathway based-analysis of transcriptomic data from vitamin D studies - p. Page 284 16. Chapter 16 : Vitamin D and the kidney - p. Page 298 17. Chapter 17 : Vitamin D and the calcium-sensing receptor - p. Page 320 18. Chapter 18 : Regulation of intestinal calcium and phosphate absorption by vitamin D - p. Page 353 19. Chapter 19 : Vitamin D and FGF23 - p. Page 378 20. Chapter 20 : Osteoclastogenesis and vitamin D - p. Page 392 21. Chapter 21 : Vitamin D activity in osteoblasts and osteocytes - p. Page 406 22. Chapter 22 : Cartilage - p. Page 415 23. Chapter 23 : Vitamin D and bone: an integrated approach - p. Page 430 24. Chapter 24 : Vitamin D in dentoalveolar and oral health - p. Page 448 25. Chapter 25 : Role of vitamin D in skin and hair biology - p. Page 475 26. Chapter 26 : Vitamin D and the cardiovascular system - p. Page 503 27. Chapter 27 : Vitamin D, brain development and function - p. Page 528 28. Chapter 28 : Vitamin D, VDR, and adipose tissue: focus on cellular mechanisms - p. Page 555 29. Chapter 29 : Vitamin D and skeletal muscle - p. Page 581 30. Chapter 30 : Understanding vitamin D from mouse knockout models - p. Page 603 31. Chapter 31 : Pharmacology and pharmacokinetics of vitamin D - p. Page 625 32. Chapter 32 : Vitamin D as a modifier of genomic function and phenotypic expression during pregnancy - p. Page 658 33. Chapter 33 : The role of vitamin D physiology in regulating calcium and bone metabolism in mother and child: pregnancy, lactation, postweaning, fetus, and neonate - p. Page 686 34. Chapter 34 : Vitamin D and the placenta - p. Page 742 35. Chapter 35 : Consequences of perinatal vitamin D deficiency on later bone health - p. Page 773 36. Chapter 36 : Adolescence and acquisition of peak bone mass - p. Page 793 37. Chapter 37 : The role of vitamin D in orthopedic surgery - p. Page 824 38. Chapter 38 : Vitamin D and muscle performance in athletes and older adults - p. Page 845 39. Chapter 39 : Role in reproductive biology and dysfunction in women - p. Page 862 40. Chapter 40 : Vitamin D, reproductive endocrinology, and male reproductive organ function in health and disease - p. Page 884 41. Chapter 41 : Vitamin D and the renin–angiotensin system - p. Page 918 42. Chapter 42 : Vitamin D: presence and function in the eye - p. Page 944 43. Chapter 43 : Adult vitamin D deficiency and adverse brain outcomes - p. Page 973 44. Chapter 44 : Vitamin D and the lung - p. Page 990 45. Chapter 45 : Design and synthesis of vitamin D analogs - p. Page 1008 46. Chapter 46 : Structure function relationships of VDR ligands - p. Page 1025 47. Chapter 47 : Modulating vitamin D receptor–coregulator binding with small molecules - p. Page 1047 48. Chapter 48 : Mass spectrometry assays of vitamin D metabolites - p. Page 1058 49. Chapter 49 : Measurement and quality assessment of total and free 25-hydroxyvitamin D - p. Page 1081 50. Chapter 50 : Vitamin D tissue distribution by mass spectrometry imaging - p. Page 1109 51. Index for Volume 1 - p. Page 1126
Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field.
In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease.
Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field.
A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of vitamin D, as opposed to searching through thousands of journal articles Chapters written by the most prominent and well-published names in the field
1. Chapter 1 : Book introduction: Major trends in vitamin D research - p. Page xxvi 2. Chapter 2 : Evolution of human skin pigmentation and vitamin D - p. Page 7 3. Chapter 3 : Photobiology of vitamin D - p. Page 21 4. Chapter 4 : The activating enzymes of vitamin D metabolism (25- and 1α-hydroxylases) - p. Page 40 5. Chapter 5 : CYP24A1: structure, function, and physiological role - p. Page 65 6. Chapter 6 : Alternative pathways for vitamin D metabolism - p. Page 80 7. Chapter 7 : Vitamin D–binding protein - p. Page 104 8. Chapter 8 : Regulation of renal vitamin D metabolism - p. Page 130 9. Chapter 9 : Regulation of extra-renal synthesis of 1,25(OH)2D - p. Page 151 10. Chapter 10 : Structural basis for ligand activity in vitamin D receptor - p. Page 178 11. Chapter 11 : Genome-wide perspectives on vitamin D receptor actions - p. Page 208 12. Chapter 12 : Vitamin D, chromatin, and epigenetics - p. Page 225 13. Chapter 13 : The diverse genomic mechanisms of action of the vitamin D receptor - p. Page 238 14. Chapter 14 : Vitamin D and microRNAs - p. Page 253 15. Chapter 15 : Pathway based-analysis of transcriptomic data from vitamin D studies - p. Page 284 16. Chapter 16 : Vitamin D and the kidney - p. Page 298 17. Chapter 17 : Vitamin D and the calcium-sensing receptor - p. Page 320 18. Chapter 18 : Regulation of intestinal calcium and phosphate absorption by vitamin D - p. Page 353 19. Chapter 19 : Vitamin D and FGF23 - p. Page 378 20. Chapter 20 : Osteoclastogenesis and vitamin D - p. Page 392 21. Chapter 21 : Vitamin D activity in osteoblasts and osteocytes - p. Page 406 22. Chapter 22 : Cartilage - p. Page 415 23. Chapter 23 : Vitamin D and bone: an integrated approach - p. Page 430 24. Chapter 24 : Vitamin D in dentoalveolar and oral health - p. Page 448 25. Chapter 25 : Role of vitamin D in skin and hair biology - p. Page 475 26. Chapter 26 : Vitamin D and the cardiovascular system - p. Page 503 27. Chapter 27 : Vitamin D, brain development and function - p. Page 528 28. Chapter 28 : Vitamin D, VDR, and adipose tissue: focus on cellular mechanisms - p. Page 555 29. Chapter 29 : Vitamin D and skeletal muscle - p. Page 581 30. Chapter 30 : Understanding vitamin D from mouse knockout models - p. Page 603 31. Chapter 31 : Pharmacology and pharmacokinetics of vitamin D - p. Page 625 32. Chapter 32 : Vitamin D as a modifier of genomic function and phenotypic expression during pregnancy - p. Page 658 33. Chapter 33 : The role of vitamin D physiology in regulating calcium and bone metabolism in mother and child: pregnancy, lactation, postweaning, fetus, and neonate - p. Page 686 34. Chapter 34 : Vitamin D and the placenta - p. Page 742 35. Chapter 35 : Consequences of perinatal vitamin D deficiency on later bone health - p. Page 773 36. Chapter 36 : Adolescence and acquisition of peak bone mass - p. Page 793 37. Chapter 37 : The role of vitamin D in orthopedic surgery - p. Page 824 38. Chapter 38 : Vitamin D and muscle performance in athletes and older adults - p. Page 845 39. Chapter 39 : Role in reproductive biology and dysfunction in women - p. Page 862 40. Chapter 40 : Vitamin D, reproductive endocrinology, and male reproductive organ function in health and disease - p. Page 884 41. Chapter 41 : Vitamin D and the renin–angiotensin system - p. Page 918 42. Chapter 42 : Vitamin D: presence and function in the eye - p. Page 944 43. Chapter 43 : Adult vitamin D deficiency and adverse brain outcomes - p. Page 973 44. Chapter 44 : Vitamin D and the lung - p. Page 990 45. Chapter 45 : Design and synthesis of vitamin D analogs - p. Page 1008 46. Chapter 46 : Structure function relationships of VDR ligands - p. Page 1025 47. Chapter 47 : Modulating vitamin D receptor–coregulator binding with small molecules - p. Page 1047 48. Chapter 48 : Mass spectrometry assays of vitamin D metabolites - p. Page 1058 49. Chapter 49 : Measurement and quality assessment of total and free 25-hydroxyvitamin D - p. Page 1081 50. Chapter 50 : Vitamin D tissue distribution by mass spectrometry imaging - p. Page 1109 51. Index for Volume 1 - p. Page 1126
