From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure‐based discovery and development of mGlu5 NAMs, and much more.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xi 6. Preface - p. page_xiii 7. Chapter One: The computational modeling of allosteric modulation of metabotropic glutamate receptors - p. page_xvii 8. Chapter Two: Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators - p. page_33 9. Chapter Three: The function and allosteric control of the human sweet taste receptor - p. page_58 10. Chapter Four: The different aspects of the GABAB receptor allosteric modulation - p. page_82 11. Chapter Five: RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors - p. page_113 12. Chapter Six: Strategies and considerations of G-protein-coupled receptor photopharmacology - p. page_141 13. Chapter Seven: Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP: A novel tool to probe GLP-1R pharmacology - p. page_172 14. Chapter Eight: Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations - p. page_191 15. Chapter Nine: Allosteric modulation of muscarinic receptors in alcohol and substance use disorders - p. page_232 16. Chapter Ten: M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease? - p. page_275
From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure‐based discovery and development of mGlu5 NAMs, and much more.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xi 6. Preface - p. page_xiii 7. Chapter One: The computational modeling of allosteric modulation of metabotropic glutamate receptors - p. page_xvii 8. Chapter Two: Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators - p. page_33 9. Chapter Three: The function and allosteric control of the human sweet taste receptor - p. page_58 10. Chapter Four: The different aspects of the GABAB receptor allosteric modulation - p. page_82 11. Chapter Five: RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors - p. page_113 12. Chapter Six: Strategies and considerations of G-protein-coupled receptor photopharmacology - p. page_141 13. Chapter Seven: Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP: A novel tool to probe GLP-1R pharmacology - p. page_172 14. Chapter Eight: Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations - p. page_191 15. Chapter Nine: Allosteric modulation of muscarinic receptors in alcohol and substance use disorders - p. page_232 16. Chapter Ten: M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease? - p. page_275
