The first title in the new Case-Based Approach to Diagnosis series, Gastrointestinal Pathology and Liver Metastasis offers a practical, real-world approach to this complex area of surgical pathology. Actual cases, highlighted by hundreds of high-quality clinical and histologic photographs, help you learn and retain key information, including which pathologic findings are clinically significant and which are not. Useful as both an everyday bench-side reference and as an authoritative review for certification and recertification exams, this new volume uses diagnostically relevant cases to teach how to evaluate and interpret even the most challenging lesions.
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Dedications - p. v 5. Contributors - p. vi 6. Preface - p. x 7. Contents - p. xi 8. Part 1 Esophagus - p. p1 9. 1.1 Eosinophilic Esophagitis Versus Reflux Esophagitis - p. 1 10. 1.2 Lymphocytic Esophagitis Versus Candida Esophagitis Versus Lichen Planus Esophagitis - p. 7 11. 1.3 Candida Esophagitis Versus Other Neutrophil-Predominant Esophagitis - p. 12 12. 1.4 Viral Esophagitis Versus Pill and Corrosive Esophagitis - p. 15 13. 1.5 Epidermoid Metaplasia Versus Glycogenic Acanthosis - p. 19 14. 1.6 Melanosis or Melanocytosis (“Brown” Esophagus) Versus Acute Necrosis (“Black” Esophagus) - p. 22 15. 1.7 Columnar-Lined Esophagus Versus Barrett’s Esophagus - p. 25 16. 1.8 Multilayered Epithelium Versus Barrett’s Esophagus - p. 29 17. 1.9 Ancillary Stains for the Diagnosis of Barrett’s Esophagus - p. 30 18. 1.10 Barrett’s Esophagus Versus Carditis With Intestinal Metaplasia - p. 33 19. 1.11 Reactive Changes Versus Dysplasia (Including “Crypt Dysplasia”) in Barrett’s Esophagus - p. 36 20. 1.12 Low-Grade Versus High-Grade Conventional Dysplasia - p. 39 21. 1.13 Conventional Versus Foveolar Dysplasia - p. 41 22. 1.14 p53 Immunohistochemistry for Diagnosis of Dysplasia in Barrett’s Esophagus - p. 43 23. 1.15 High-Grade Dysplasia Versus Intramucosal Adenocarcinoma - p. 46 24. 1.16 Early Adenocarcinoma Reporting in Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection Specimens - p. 48 25. 1.17 Esophageal Adenocarcinoma Variants - p. 51 26. 1.18 Grading and Management of Squamous Dysplasia - p. 54 27. 1.19 Typical and Variant Squamous Cell Carcinoma - p. 57 28. 1.20 Giant Fibrovascular Polyp Versus Atypical Lipomatous Tumor - p. 60 29. 1.21 Leiomyoma Versus Granular Cell Tumor - p. 63 30. 1.22 Poorly Differentiated and Undifferentiated Esophageal Carcinomas - p. 66 31. 1.23 Diagnostic Challenges in Post-neoadjuvant Esophageal Cancer Resection Specimens - p. 70 32. 1.24 Esophageal Adenocarcinoma Versus Salivary Gland–Type Tumors - p. 74 33. 1.25 Primary Versus Secondary Esophageal Carcinomas - p. 77 34. Part 2 Stomach - p. p81 35. 2.1 Normal Stomach Versus Chronic Gastritis - p. 81 36. 2.2 Chronic Gastritis Versus Reactive Gastropathy - p. 86 37. 2.3 Helicobacter Pylori Gastritis: To Stain or Not to Stain - p. 88 38. 2.4 Autoimmune Gastritis Versus Helicobacter Gastritis - p. 93 39. 2.5 Iron Pill Gastropathy Versus Other Gastric Siderosis - p. 98 40. 2.6 Doxycycline Injury Versus Nonspecific Erosion - p. 100 41. 2.7 Lanthanum Injury Versus Other Histiocytic Infiltration - p. 102 42. 2.8 Lymphocytic Versus Collagenous Gastritis - p. 105 43. 2.9 Gastric Biopsy With Increase in Eosinophils - p. 108 44. 2.10 Acute Gastritis With Ulcer Versus Cytomegalovirus Gastritis - p. 110 45. 2.11 Acute Gastritis With Ulcer Versus Adenovirus Gastritis - p. 113 46. 2.12 Phlegmonous Gastritis - p. 115 47. 2.13 Chronic Gastritis With Intestinal Metaplasia: To Type or Not to Type - p. 117 48. 2.14 Chronic Gastritis With Reactive Changes Versus Intestinal-Type Dysplasia - p. 121 49. 2.15 Chronic Gastritis With Reactive Changes Versus Foveolar Dysplasia - p. 125 50. 2.16 High-Grade Dysplasia Versus Intramucosal Adenocarcinoma - p. 128 51. 2.17 Hyperplastic Polyp Versus Fundic Gland Polyp - p. 130 52. 2.18 Hyperplastic Polyp With Dysplasia Versus Intestinal-Type Adenoma - p. 133 53. 2.19 Pyloric Gland Adenoma Versus Foveolar-Type Adenoma - p. 135 54. 2.20 Oxyntic Gland Adenoma Versus Other Adenomas - p. 139 55. 2.21 Hyperplastic Polyp Versus Peutz-Jeghers Polyp - p. 142 56. 2.22 Multiple Fundic Polyps Versus Gastric Adenocarcinoma and Proximal Polyposis of the Stomach - p. 144 57. 2.23 Gastric Adenocarcinoma: Intestinal Versus Diffuse Type - p. 147 58. 2.24 Lymphocyte-Rich/Epstein-Barr Virus-Positive Versus Mismatch Repair Deficient Adenocarcinoma - p. 151 59. 2.25 Hepatoid Carcinoma Versus Poorly-Differentiated Adenocarcinoma - p. 155 60. 2.26 Enteroblastic Adenocarcinoma Versus Conventional Adenocarcinoma - p. 158 61. 2.27 Signet Ring Cell Carcinoma Versus Pseudo Signet Ring Cells - p. 161 62. 2.28 Signet Ring Cell Carcinoma: Sporadic Versus Familial - p. 164 63. 2.29 Signet Ring Cell Carcinoma: Primary Versus Metastatic - p. 168 64. 2.30 Sarcomatoid Carcinoma Versus Sarcoma - p. 171 65. 2.31 Gastroblastoma Versus Adenocarcinoma - p. 173 66. 2.32 Gastric Adenocarcinoma With HER2 Staining - p. 175 67. 2.33 Gastric Adenocarcinoma With Programmed Cell Death Ligand 1 Staining - p. 178 68. 2.34 Well-Differentiated Neuroendocrine Tumor in Autoimmune Gastritis (Type 1) Versus Neuroendocrine Hyperplasia - p. 181 69. 2.35 Well-Differentiated Neuroendocrine Tumor: Sporadic (Type 3) Versus Other Types (Types 1 and 2) and Neuroendocrine Carcinoma - p. 184 70. Part 3 Small Intestine - p. p189 71. 3.1 Gastric Heterotopia Versus Neoplasm - p. 189 72. 3.2 Pediatric Small Intestinal Biopsies in Intractable Diarrhea - p. 193 73. 3.3 Small Bowel Disorders: Celiac Disease and Mimics - p. 197 74. 3.4 Small Bowel Infection: Protozoal, Microsporidial, Viral - p. 208 75. 3.5 Macrophage Infiltrates: Infectious Versus Non-Infectious Etiologies - p. 214 76. 3.6 Heterotopic Pancreas Versus Neoplasm - p. 220 77. 3.7 Active Ileitis With Crystals Versus Crohn’s Disease - p. 223 78. 3.8 Adenoma With High-Grade Dysplasia Versus Invasive Adenocarcinoma - p. 226 79. 3.9 Pyloric Gland Adenoma Versus Brunner Gland Hamartoma - p. 229 80. 3.10 Dystrophic Fat Versus Adenocarcinoma - p. 233 81. 3.11 Well-Differentiated Neuroendocrine Tumor Versus Neuroendocrine Carcinoma - p. 237 82. 3.12 Multilocular Peritoneal Inclusion Cyst Versus Malignant Mesothelioma - p. 243 83. 3.13 Gangliocytic Paraganglioma Versus Well-Differentiated Neuroendocrine Tumor of the Small Intestine - p. 247 84. 3.14 Ampullary Adenocarcinoma (pT2 Vs pT3) - p. 252 85. 3.15 Small Intestinal Adenocarcinoma Versus Metastatic Adenocarcinoma - p. 257 86. Part 4 Appendix - p. p263 87. 4.1 Acute Appendicitis With Diverticulitis Versus Low-Grade Appendiceal Mucinous Neoplasm - p. 263 88. 4.2 Sessile Serrated Adenoma Versus Mucosal Hyperplasia - p. 266 89. 4.3 Benign Subserosal Glands (Endosalpingiosis) Versus Adenocarcinoma - p. 269 90. 4.4 Low-Grade Appendiceal Mucinous Neoplasm Versus Appendiceal Adenoma - p. 272 91. 4.5 Low-Grade Appendiceal Mucinous Neoplasm Versus Distended Appendix With Mucin - p. 274 92. 4.6 Low-Grade Appendiceal Mucinous Neoplasm With Serosal Acellular Mucin and Other Risk Factors in Low-Grade Appendiceal Mucinous Neoplasm - p. 278 93. 4.7 Low-Grade Appendiceal Mucinous Neoplasm Versus High-Grade Appendiceal Mucinous Neoplasm - p. 282 94. 4.8 Mucinous Carcinoma Peritonei (Pseudomyxoma Peritonei), Low Grade (Grade 1) Versus High Grade (Grade 2) - p. 286 95. 4.9 Mucinous Carcinoma Peritonei (Pseudomyxoma Peritonei), Grade 2 Versus Grade 3 - p. 292 96. 4.10 Goblet Cell Adenocarcinoma Versus Neuroendocrine Neoplasms and Conventional Adenocarcinoma - p. 295 97. 4.11 Appendiceal Neuroendocrine Tumor: Low- Versus High-Risk Features - p. 300 98. 4.12 Tubular Neuroendocrine Tumor Versus Adenocarcinoma - p. 304 99. Part 5 Colon - p. p307 100. 5.1 Infectious Colitis Versus Inflammatory Bowel Disease - p. 307 101. 5.2 Ischemic Versus Pseudomembranous Colitis - p. 312 102. 5.3 Graft-Versus-Host Disease Versus Bowel Prep Effect - p. 316 103. 5.4 Eosinophilic Colitis Versus Infiltrative Disorders With Prominent Eosinophils - p. 318 104. 5.5 Enterocolic Lymphocytic Phlebitis Versus Inflammatory Bowel Disease - p. 322 105. 5.6 Lymphocytic Versus Collagenous Colitis - p. 326 106. 5.7 Diverticular Disease-Associated Colitis Versus Inflammatory Bowel Disease - p. 330 107. 5.8 Diversion Colitis Versus Inflammatory Bowel Disease - p. 333 108. 5.9 Isolated Asymptomatic Chronic Colitis and Ileitis Versus Inflammatory Bowel Disease - p. 336 109. 5.10 Drug-Induced Colitis Versus Inflammatory Bowel Disease - p. 339 110. 5.11 Radiation Colitis Versus Inflammatory Bowel Disease - p. 343 111. 5.12 Solitary Rectal Ulcer Syndrome Versus Inflammatory Bowel Disease - p. 346 112. 5.13 Ulcerative Colitis Versus Crohn’s Disease - p. 348 113. 5.14 Fulminant Colitis Versus Infectious Colitis - p. 353 114. 5.15 Crohn’s Disease Versus Sarcoidosis - p. 356 115. 5.16 Pouchitis Versus Crohn’s Disease - p. 359 116. 5.17 Isolated and Multiple Ulcers: Crohn’s Disease Versus Drug Versus Other Etiologies - p. 362 117. 5.18 Reactive Epithelial Changes Versus Dysplasia in Inflammatory Bowel Disease - p. 364 118. 5.19 Conventional Low- Versus High-Grade Dysplasia in Inflammatory Bowel Disease - p. 367 119. 5.20 Conventional Dysplasia Versus Dysplasia Variants in Inflammatory Bowel Disease - p. 369 120. 5.21 Microscopic Colitis and Inflammatory Bowel Disease Overlap - p. 373 121. 5.22 Kayexelate Versus Other Crystals - p. 375 122. 5.23 Chronic Intestinal Pseudo-obstruction Versus Hirschsprung Disease - p. 379 123. 5.24 Serrated Polyps Versus Adenomas - p. 386 124. 5.25 Tubular Adenoma With Squamoid Morules Versus Composite Adenoma-Microcarcinoid - p. 392 125. 5.26 Tubular Adenoma Versus Endometriosis and Mucosal Colonization by Cancer - p. 395 126. 5.27 Adenoma With Misplaced Epithelium (“Pseudoinvasion”) Versus Adenocarcinoma - p. 397 127. 5.28 Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection Reporting of Adenocarcinoma in Polyp - p. 400 128. 5.29 Familial Adenomatous Polyposis Versus Other Adenomatous Polyposis Syndromes - p. 403 129. 5.30 Serrated Polyposis Syndrome Versus Multiple Hyperplastic Polyps - p. 407 130. 5.31 Mucosal Prolapse Versus Peutz-Jeghers Polyp - p. 410 131. 5.32 Juvenile Polyps Versus Inflammatory Polyps - p. 413 132. 5.33 Cowden Syndrome Versus Cronkhite-Canada Syndrome - p. 416 133. 5.34 Tailgut Cyst Versus Other Retrorectal Cysts - p. 420 134. 5.35 Adenocarcinoma Not Otherwise Specified Versus Special Types - p. 423 135. 5.36 Well- Versus Moderately Versus Poorly Differentiated Adenocarcinoma - p. 428 136. 5.37 pT3 Versus pT4a Colorectal Cancer - p. 432 137. 5.38 Lymphovascular Invasion in Colorectal Carcinoma - p. 436 138. 5.39 Tumor Deposits Versus Nodal Metastasis Versus Venous Invasion - p. 440 139. 5.40 Poorly Differentiated Neuroendocrine Carcinomas Versus Well-Differentiated Neuroendocrine Tumors Versus Mixed Neuroendocrine–Nonneuroendocrine Neoplasm - p. 444 140. 5.41 Primary Versus Metastatic Carcinoma - p. 448 141. 5.42 Isolated Tumor Cells Versus Micrometastasis Versus Positive Lymph Nodes - p. 452 142. 5.43 Positive Versus Negative Radial Margins - p. 455 143. Part 6 Anal Canal - p. p459 144. 6.1 Treponema pallidum Versus Other Infections - p. 459 145. 6.2 Condyloma Versus Reactive Changes - p. 463 146. 6.3 Low-Grade Versus High-Grade Squamous Intraepithelial Lesion - p. 467 147. 6.4 High-Grade Squamous Intraepithelial Lesion Versus Superficially Invasive Squamous Cell Carcinoma - p. 471 148. 6.5 Squamous Cell Carcinoma Versus Basal Cell Carcinoma - p. 473 149. 6.6 Squamous Cell Carcinoma Versus Neuroendocrine Carcinoma - p. 477 150. 6.7 Anal Gland Adenocarcinoma Versus Rectal Adenocarcinoma - p. 479 151. 6.8 Paget Disease Versus High-Grade Squamous Intraepithelial Lesion - p. 482 152. 6.9 Anal Melanoma - p. 485 153. Part 7 Hematopoietic Neoplasms and Mimics - p. p489 154. 7.1 Gastric Extranodal Marginal Zone Lymphoma Versus Helicobacter pylori Gastritis With Lymphoid Hyperplasia - p. 489 155. 7.2 Colonic Polypoid Extranodal Marginal Zone Lymphoma Versus Reactive Lymphoid Hyperplasia - p. 495 156. 7.3 Mantle Cell Lymphoma - p. 499 157. 7.4 Duodenal Follicular Lymphoma Versus Reactive Follicles - p. 502 158. 7.5 Colonic Polypoid Follicular Lymphoma Versus Reactive Lymphoid Infiltrates - p. 505 159. 7.6 Diffuse Large B-Cell Lymphoma Versus Other Large B-Cell Lymphomas - p. 508 160. 7.7 High-Grade B-Cell Lymphoma Versus Other High-Grade Neoplasms - p. 511 161. 7.8 Enteropathy-Associated T-Cell Lymphoma Versus Other Lymphoma - p. 514 162. 7.9 Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma Versus Other Lymphoma - p. 517 163. 7.10 Indolent Clonal T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract Versus Lymphoma - p. 522 164. 7.11 Systemic T-Cell Lymphoma Involvement of the Gastrointestinal Tract Versus Primary Gastrointestinal Lymphoma - p. 525 165. 7.12 Reactive Marginal Zone Hyperplasia Versus Extranodal Marginal Zone Lymphoma - p. 529 166. 7.13 Natural Killer Cell Enteropathy Versus Extranodal Natural Killer/T-Cell Lymphoma - p. 532 167. 7.14 Myeloid Sarcoma Versus Other Hematopoietic or Small Round Blue Cell Tumors - p. 536 168. 7.15 Systemic Mastocytosis Versus Benign Mast Cells - p. 541 169. 7.16 Classic Hodgkin Lymphoma Versus Mimics - p. 544 170. 7.17 Langerhans Cell Histiocytosis Versus Langerhans Cell Sarcoma - p. 547 171. 7.18 Burkitt Lymphoma Versus Other Lymphoma - p. 550 172. 7.19 Plasmablastic Lymphoma Versus Other Lymphoma - p. 553 173. 7.20 Posttransplant Lymphoproliferative Disorder Versus Reactive Lymphoid Lesions - p. 555 174. 7.21 Rectal Tonsil or Reactive Lymphoid Aggregate Versus Rectal Lymphoma - p. 559 175. Part 8 Mesenchymal Tumors - p. p561 176. 8.1 Gastrointestinal Stromal Tumor Versus Smooth Muscle or Neurogenic Tumor - p. 561 177. 8.2 Inflammatory Myofibroblastic Tumor Versus Other Spindle Cell Neoplasms - p. 568 178. 8.3 Intraabdominal Desmoid (Mesenteric Fibromatosis) Versus Gastrointestinal Stromal Tumor - p. 571 179. 8.4 Solitary Fibrous Tumor Versus Other Spindle Cell Neoplasms - p. 575 180. 8.5 Lipoma Versus Liposarcoma - p. 579 181. 8.6 Inflammatory Fibroid Polyp (Gastric or Small Intestine) Versus Other Spindle Cell Polyps - p. 584 182. 8.7 Plexiform Fibromyxoma (Gastric or Duodenum) Versus Other Spindle Cell Lesions - p. 589 183. 8.8 Leiomyoma and Atypical Smooth Muscle Tumor - p. 593 184. 8.9 Leiomyosarcoma Versus Other Spindle Cell Neoplasms - p. 597 185. 8.10 Hemangioma or Arteriovenous Malformation Versus Other Vascular Lesions - p. 600 186. 8.11 Kaposi Sarcoma (Any Gastrointestinal Site) Versus Other Spindle Cell Lesions - p. 604 187. 8.12 Angiosarcoma (Any Gastrointestinal Site) Versus Other Sarcomas - p. 607 188. 8.13 Glomus Tumor (Stomach) Versus Other Neoplasms - p. 611 189. 8.14 Vascular Malformations (Lymphatic, Venous, Arteriovenous) Versus Hemangioma - p. 614 190. 8.15 Schwannoma (Stomach) Versus Other Spindle Cell Lesions - p. 619 191. 8.16 Granular Cell Tumor Versus Atypical Granular Cell Tumor (Esophagus or Large Bowel) - p. 622 192. 8.17 Perineurioma or Benign Fibroblastic Polyp (Large Bowel) - p. 627 193. 8.18 Ganglioneuroma and Ganglioneuromatosis (Large Bowel) - p. 631 194. 8.19 Perivascular Epithelioid Cell Tumor or Angiomyolipoma Versus Other Neoplasms - p. 634 195. 8.20 Synovial Sarcoma (Stomach) Versus Other Sarcomas - p. 638 196. 8.21 Malignant Gastrointestinal Neuroectodermal Tumor and Gastrointestinal Clear Cell Sarcoma (Small Intestine, Stomach, Large Intestine) Versus Melanoma - p. 642 197. 8.22 Colonic Ulceration With Pseudomalignant Change - p. 648 198. 8.23 Endometrial Lesions and Their Mimics in the Gastrointestinal Tract - p. 651 199. Part 9 Systemic Disorders Involving the Gastrointestinal Tract - p. p659 200. 9.1 Amyloidosis Versus Normal Biopsy - p. 659 201. 9.2 Graft-Versus-Host Disease Versus Mycophenolate Injury - p. 665 202. 9.3 Scleroderma Versus Other Autoimmune Disorders - p. 669 203. 9.4 Human Immunodeficiency Virus Enteritis Versus Other Immune Deficiency Disorders - p. 672 204. 9.5 Esophageal Stricture Versus Immunoglobulin G4 Disease - p. 675 205. Part 10 Liver Metastasis - p. p677 206. 10.1 Metastatic Adenocarcinoma Versus Intrahepatic Cholangiocarcinoma - p. 677 207. 10.2 Resection of Colorectal Cancer Metastasis - p. 684 208. 10.3 Metastatic Small Intestinal Well-Differentiated NET Versus HCC Versus Other Neoplasms - p. 691 209. 10.4 Metastatic Neuroendocrine Carcinoma Versus Adenocarcinoma With Neuroendocrine Features - p. 699 210. 10.5 Metastatic Hepatoid Carcinoma Versus Yolk Sac Tumor Versus HCC - p. 705 211. 10.6 Metastatic Epithelioid GIST Versus Primary/Metastatic Carcinoma - p. 710 212. 10.7 Metastatic Anorectal Melanoma Versus Primary/Metastatic Tumors - p. 716 213. Index - p. 720
The first title in the new Case-Based Approach to Diagnosis series, Gastrointestinal Pathology and Liver Metastasis offers a practical, real-world approach to this complex area of surgical pathology. Actual cases, highlighted by hundreds of high-quality clinical and histologic photographs, help you learn and retain key information, including which pathologic findings are clinically significant and which are not. Useful as both an everyday bench-side reference and as an authoritative review for certification and recertification exams, this new volume uses diagnostically relevant cases to teach how to evaluate and interpret even the most challenging lesions.
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Dedications - p. v 5. Contributors - p. vi 6. Preface - p. x 7. Contents - p. xi 8. Part 1 Esophagus - p. p1 9. 1.1 Eosinophilic Esophagitis Versus Reflux Esophagitis - p. 1 10. 1.2 Lymphocytic Esophagitis Versus Candida Esophagitis Versus Lichen Planus Esophagitis - p. 7 11. 1.3 Candida Esophagitis Versus Other Neutrophil-Predominant Esophagitis - p. 12 12. 1.4 Viral Esophagitis Versus Pill and Corrosive Esophagitis - p. 15 13. 1.5 Epidermoid Metaplasia Versus Glycogenic Acanthosis - p. 19 14. 1.6 Melanosis or Melanocytosis (“Brown” Esophagus) Versus Acute Necrosis (“Black” Esophagus) - p. 22 15. 1.7 Columnar-Lined Esophagus Versus Barrett’s Esophagus - p. 25 16. 1.8 Multilayered Epithelium Versus Barrett’s Esophagus - p. 29 17. 1.9 Ancillary Stains for the Diagnosis of Barrett’s Esophagus - p. 30 18. 1.10 Barrett’s Esophagus Versus Carditis With Intestinal Metaplasia - p. 33 19. 1.11 Reactive Changes Versus Dysplasia (Including “Crypt Dysplasia”) in Barrett’s Esophagus - p. 36 20. 1.12 Low-Grade Versus High-Grade Conventional Dysplasia - p. 39 21. 1.13 Conventional Versus Foveolar Dysplasia - p. 41 22. 1.14 p53 Immunohistochemistry for Diagnosis of Dysplasia in Barrett’s Esophagus - p. 43 23. 1.15 High-Grade Dysplasia Versus Intramucosal Adenocarcinoma - p. 46 24. 1.16 Early Adenocarcinoma Reporting in Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection Specimens - p. 48 25. 1.17 Esophageal Adenocarcinoma Variants - p. 51 26. 1.18 Grading and Management of Squamous Dysplasia - p. 54 27. 1.19 Typical and Variant Squamous Cell Carcinoma - p. 57 28. 1.20 Giant Fibrovascular Polyp Versus Atypical Lipomatous Tumor - p. 60 29. 1.21 Leiomyoma Versus Granular Cell Tumor - p. 63 30. 1.22 Poorly Differentiated and Undifferentiated Esophageal Carcinomas - p. 66 31. 1.23 Diagnostic Challenges in Post-neoadjuvant Esophageal Cancer Resection Specimens - p. 70 32. 1.24 Esophageal Adenocarcinoma Versus Salivary Gland–Type Tumors - p. 74 33. 1.25 Primary Versus Secondary Esophageal Carcinomas - p. 77 34. Part 2 Stomach - p. p81 35. 2.1 Normal Stomach Versus Chronic Gastritis - p. 81 36. 2.2 Chronic Gastritis Versus Reactive Gastropathy - p. 86 37. 2.3 Helicobacter Pylori Gastritis: To Stain or Not to Stain - p. 88 38. 2.4 Autoimmune Gastritis Versus Helicobacter Gastritis - p. 93 39. 2.5 Iron Pill Gastropathy Versus Other Gastric Siderosis - p. 98 40. 2.6 Doxycycline Injury Versus Nonspecific Erosion - p. 100 41. 2.7 Lanthanum Injury Versus Other Histiocytic Infiltration - p. 102 42. 2.8 Lymphocytic Versus Collagenous Gastritis - p. 105 43. 2.9 Gastric Biopsy With Increase in Eosinophils - p. 108 44. 2.10 Acute Gastritis With Ulcer Versus Cytomegalovirus Gastritis - p. 110 45. 2.11 Acute Gastritis With Ulcer Versus Adenovirus Gastritis - p. 113 46. 2.12 Phlegmonous Gastritis - p. 115 47. 2.13 Chronic Gastritis With Intestinal Metaplasia: To Type or Not to Type - p. 117 48. 2.14 Chronic Gastritis With Reactive Changes Versus Intestinal-Type Dysplasia - p. 121 49. 2.15 Chronic Gastritis With Reactive Changes Versus Foveolar Dysplasia - p. 125 50. 2.16 High-Grade Dysplasia Versus Intramucosal Adenocarcinoma - p. 128 51. 2.17 Hyperplastic Polyp Versus Fundic Gland Polyp - p. 130 52. 2.18 Hyperplastic Polyp With Dysplasia Versus Intestinal-Type Adenoma - p. 133 53. 2.19 Pyloric Gland Adenoma Versus Foveolar-Type Adenoma - p. 135 54. 2.20 Oxyntic Gland Adenoma Versus Other Adenomas - p. 139 55. 2.21 Hyperplastic Polyp Versus Peutz-Jeghers Polyp - p. 142 56. 2.22 Multiple Fundic Polyps Versus Gastric Adenocarcinoma and Proximal Polyposis of the Stomach - p. 144 57. 2.23 Gastric Adenocarcinoma: Intestinal Versus Diffuse Type - p. 147 58. 2.24 Lymphocyte-Rich/Epstein-Barr Virus-Positive Versus Mismatch Repair Deficient Adenocarcinoma - p. 151 59. 2.25 Hepatoid Carcinoma Versus Poorly-Differentiated Adenocarcinoma - p. 155 60. 2.26 Enteroblastic Adenocarcinoma Versus Conventional Adenocarcinoma - p. 158 61. 2.27 Signet Ring Cell Carcinoma Versus Pseudo Signet Ring Cells - p. 161 62. 2.28 Signet Ring Cell Carcinoma: Sporadic Versus Familial - p. 164 63. 2.29 Signet Ring Cell Carcinoma: Primary Versus Metastatic - p. 168 64. 2.30 Sarcomatoid Carcinoma Versus Sarcoma - p. 171 65. 2.31 Gastroblastoma Versus Adenocarcinoma - p. 173 66. 2.32 Gastric Adenocarcinoma With HER2 Staining - p. 175 67. 2.33 Gastric Adenocarcinoma With Programmed Cell Death Ligand 1 Staining - p. 178 68. 2.34 Well-Differentiated Neuroendocrine Tumor in Autoimmune Gastritis (Type 1) Versus Neuroendocrine Hyperplasia - p. 181 69. 2.35 Well-Differentiated Neuroendocrine Tumor: Sporadic (Type 3) Versus Other Types (Types 1 and 2) and Neuroendocrine Carcinoma - p. 184 70. Part 3 Small Intestine - p. p189 71. 3.1 Gastric Heterotopia Versus Neoplasm - p. 189 72. 3.2 Pediatric Small Intestinal Biopsies in Intractable Diarrhea - p. 193 73. 3.3 Small Bowel Disorders: Celiac Disease and Mimics - p. 197 74. 3.4 Small Bowel Infection: Protozoal, Microsporidial, Viral - p. 208 75. 3.5 Macrophage Infiltrates: Infectious Versus Non-Infectious Etiologies - p. 214 76. 3.6 Heterotopic Pancreas Versus Neoplasm - p. 220 77. 3.7 Active Ileitis With Crystals Versus Crohn’s Disease - p. 223 78. 3.8 Adenoma With High-Grade Dysplasia Versus Invasive Adenocarcinoma - p. 226 79. 3.9 Pyloric Gland Adenoma Versus Brunner Gland Hamartoma - p. 229 80. 3.10 Dystrophic Fat Versus Adenocarcinoma - p. 233 81. 3.11 Well-Differentiated Neuroendocrine Tumor Versus Neuroendocrine Carcinoma - p. 237 82. 3.12 Multilocular Peritoneal Inclusion Cyst Versus Malignant Mesothelioma - p. 243 83. 3.13 Gangliocytic Paraganglioma Versus Well-Differentiated Neuroendocrine Tumor of the Small Intestine - p. 247 84. 3.14 Ampullary Adenocarcinoma (pT2 Vs pT3) - p. 252 85. 3.15 Small Intestinal Adenocarcinoma Versus Metastatic Adenocarcinoma - p. 257 86. Part 4 Appendix - p. p263 87. 4.1 Acute Appendicitis With Diverticulitis Versus Low-Grade Appendiceal Mucinous Neoplasm - p. 263 88. 4.2 Sessile Serrated Adenoma Versus Mucosal Hyperplasia - p. 266 89. 4.3 Benign Subserosal Glands (Endosalpingiosis) Versus Adenocarcinoma - p. 269 90. 4.4 Low-Grade Appendiceal Mucinous Neoplasm Versus Appendiceal Adenoma - p. 272 91. 4.5 Low-Grade Appendiceal Mucinous Neoplasm Versus Distended Appendix With Mucin - p. 274 92. 4.6 Low-Grade Appendiceal Mucinous Neoplasm With Serosal Acellular Mucin and Other Risk Factors in Low-Grade Appendiceal Mucinous Neoplasm - p. 278 93. 4.7 Low-Grade Appendiceal Mucinous Neoplasm Versus High-Grade Appendiceal Mucinous Neoplasm - p. 282 94. 4.8 Mucinous Carcinoma Peritonei (Pseudomyxoma Peritonei), Low Grade (Grade 1) Versus High Grade (Grade 2) - p. 286 95. 4.9 Mucinous Carcinoma Peritonei (Pseudomyxoma Peritonei), Grade 2 Versus Grade 3 - p. 292 96. 4.10 Goblet Cell Adenocarcinoma Versus Neuroendocrine Neoplasms and Conventional Adenocarcinoma - p. 295 97. 4.11 Appendiceal Neuroendocrine Tumor: Low- Versus High-Risk Features - p. 300 98. 4.12 Tubular Neuroendocrine Tumor Versus Adenocarcinoma - p. 304 99. Part 5 Colon - p. p307 100. 5.1 Infectious Colitis Versus Inflammatory Bowel Disease - p. 307 101. 5.2 Ischemic Versus Pseudomembranous Colitis - p. 312 102. 5.3 Graft-Versus-Host Disease Versus Bowel Prep Effect - p. 316 103. 5.4 Eosinophilic Colitis Versus Infiltrative Disorders With Prominent Eosinophils - p. 318 104. 5.5 Enterocolic Lymphocytic Phlebitis Versus Inflammatory Bowel Disease - p. 322 105. 5.6 Lymphocytic Versus Collagenous Colitis - p. 326 106. 5.7 Diverticular Disease-Associated Colitis Versus Inflammatory Bowel Disease - p. 330 107. 5.8 Diversion Colitis Versus Inflammatory Bowel Disease - p. 333 108. 5.9 Isolated Asymptomatic Chronic Colitis and Ileitis Versus Inflammatory Bowel Disease - p. 336 109. 5.10 Drug-Induced Colitis Versus Inflammatory Bowel Disease - p. 339 110. 5.11 Radiation Colitis Versus Inflammatory Bowel Disease - p. 343 111. 5.12 Solitary Rectal Ulcer Syndrome Versus Inflammatory Bowel Disease - p. 346 112. 5.13 Ulcerative Colitis Versus Crohn’s Disease - p. 348 113. 5.14 Fulminant Colitis Versus Infectious Colitis - p. 353 114. 5.15 Crohn’s Disease Versus Sarcoidosis - p. 356 115. 5.16 Pouchitis Versus Crohn’s Disease - p. 359 116. 5.17 Isolated and Multiple Ulcers: Crohn’s Disease Versus Drug Versus Other Etiologies - p. 362 117. 5.18 Reactive Epithelial Changes Versus Dysplasia in Inflammatory Bowel Disease - p. 364 118. 5.19 Conventional Low- Versus High-Grade Dysplasia in Inflammatory Bowel Disease - p. 367 119. 5.20 Conventional Dysplasia Versus Dysplasia Variants in Inflammatory Bowel Disease - p. 369 120. 5.21 Microscopic Colitis and Inflammatory Bowel Disease Overlap - p. 373 121. 5.22 Kayexelate Versus Other Crystals - p. 375 122. 5.23 Chronic Intestinal Pseudo-obstruction Versus Hirschsprung Disease - p. 379 123. 5.24 Serrated Polyps Versus Adenomas - p. 386 124. 5.25 Tubular Adenoma With Squamoid Morules Versus Composite Adenoma-Microcarcinoid - p. 392 125. 5.26 Tubular Adenoma Versus Endometriosis and Mucosal Colonization by Cancer - p. 395 126. 5.27 Adenoma With Misplaced Epithelium (“Pseudoinvasion”) Versus Adenocarcinoma - p. 397 127. 5.28 Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection Reporting of Adenocarcinoma in Polyp - p. 400 128. 5.29 Familial Adenomatous Polyposis Versus Other Adenomatous Polyposis Syndromes - p. 403 129. 5.30 Serrated Polyposis Syndrome Versus Multiple Hyperplastic Polyps - p. 407 130. 5.31 Mucosal Prolapse Versus Peutz-Jeghers Polyp - p. 410 131. 5.32 Juvenile Polyps Versus Inflammatory Polyps - p. 413 132. 5.33 Cowden Syndrome Versus Cronkhite-Canada Syndrome - p. 416 133. 5.34 Tailgut Cyst Versus Other Retrorectal Cysts - p. 420 134. 5.35 Adenocarcinoma Not Otherwise Specified Versus Special Types - p. 423 135. 5.36 Well- Versus Moderately Versus Poorly Differentiated Adenocarcinoma - p. 428 136. 5.37 pT3 Versus pT4a Colorectal Cancer - p. 432 137. 5.38 Lymphovascular Invasion in Colorectal Carcinoma - p. 436 138. 5.39 Tumor Deposits Versus Nodal Metastasis Versus Venous Invasion - p. 440 139. 5.40 Poorly Differentiated Neuroendocrine Carcinomas Versus Well-Differentiated Neuroendocrine Tumors Versus Mixed Neuroendocrine–Nonneuroendocrine Neoplasm - p. 444 140. 5.41 Primary Versus Metastatic Carcinoma - p. 448 141. 5.42 Isolated Tumor Cells Versus Micrometastasis Versus Positive Lymph Nodes - p. 452 142. 5.43 Positive Versus Negative Radial Margins - p. 455 143. Part 6 Anal Canal - p. p459 144. 6.1 Treponema pallidum Versus Other Infections - p. 459 145. 6.2 Condyloma Versus Reactive Changes - p. 463 146. 6.3 Low-Grade Versus High-Grade Squamous Intraepithelial Lesion - p. 467 147. 6.4 High-Grade Squamous Intraepithelial Lesion Versus Superficially Invasive Squamous Cell Carcinoma - p. 471 148. 6.5 Squamous Cell Carcinoma Versus Basal Cell Carcinoma - p. 473 149. 6.6 Squamous Cell Carcinoma Versus Neuroendocrine Carcinoma - p. 477 150. 6.7 Anal Gland Adenocarcinoma Versus Rectal Adenocarcinoma - p. 479 151. 6.8 Paget Disease Versus High-Grade Squamous Intraepithelial Lesion - p. 482 152. 6.9 Anal Melanoma - p. 485 153. Part 7 Hematopoietic Neoplasms and Mimics - p. p489 154. 7.1 Gastric Extranodal Marginal Zone Lymphoma Versus Helicobacter pylori Gastritis With Lymphoid Hyperplasia - p. 489 155. 7.2 Colonic Polypoid Extranodal Marginal Zone Lymphoma Versus Reactive Lymphoid Hyperplasia - p. 495 156. 7.3 Mantle Cell Lymphoma - p. 499 157. 7.4 Duodenal Follicular Lymphoma Versus Reactive Follicles - p. 502 158. 7.5 Colonic Polypoid Follicular Lymphoma Versus Reactive Lymphoid Infiltrates - p. 505 159. 7.6 Diffuse Large B-Cell Lymphoma Versus Other Large B-Cell Lymphomas - p. 508 160. 7.7 High-Grade B-Cell Lymphoma Versus Other High-Grade Neoplasms - p. 511 161. 7.8 Enteropathy-Associated T-Cell Lymphoma Versus Other Lymphoma - p. 514 162. 7.9 Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma Versus Other Lymphoma - p. 517 163. 7.10 Indolent Clonal T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract Versus Lymphoma - p. 522 164. 7.11 Systemic T-Cell Lymphoma Involvement of the Gastrointestinal Tract Versus Primary Gastrointestinal Lymphoma - p. 525 165. 7.12 Reactive Marginal Zone Hyperplasia Versus Extranodal Marginal Zone Lymphoma - p. 529 166. 7.13 Natural Killer Cell Enteropathy Versus Extranodal Natural Killer/T-Cell Lymphoma - p. 532 167. 7.14 Myeloid Sarcoma Versus Other Hematopoietic or Small Round Blue Cell Tumors - p. 536 168. 7.15 Systemic Mastocytosis Versus Benign Mast Cells - p. 541 169. 7.16 Classic Hodgkin Lymphoma Versus Mimics - p. 544 170. 7.17 Langerhans Cell Histiocytosis Versus Langerhans Cell Sarcoma - p. 547 171. 7.18 Burkitt Lymphoma Versus Other Lymphoma - p. 550 172. 7.19 Plasmablastic Lymphoma Versus Other Lymphoma - p. 553 173. 7.20 Posttransplant Lymphoproliferative Disorder Versus Reactive Lymphoid Lesions - p. 555 174. 7.21 Rectal Tonsil or Reactive Lymphoid Aggregate Versus Rectal Lymphoma - p. 559 175. Part 8 Mesenchymal Tumors - p. p561 176. 8.1 Gastrointestinal Stromal Tumor Versus Smooth Muscle or Neurogenic Tumor - p. 561 177. 8.2 Inflammatory Myofibroblastic Tumor Versus Other Spindle Cell Neoplasms - p. 568 178. 8.3 Intraabdominal Desmoid (Mesenteric Fibromatosis) Versus Gastrointestinal Stromal Tumor - p. 571 179. 8.4 Solitary Fibrous Tumor Versus Other Spindle Cell Neoplasms - p. 575 180. 8.5 Lipoma Versus Liposarcoma - p. 579 181. 8.6 Inflammatory Fibroid Polyp (Gastric or Small Intestine) Versus Other Spindle Cell Polyps - p. 584 182. 8.7 Plexiform Fibromyxoma (Gastric or Duodenum) Versus Other Spindle Cell Lesions - p. 589 183. 8.8 Leiomyoma and Atypical Smooth Muscle Tumor - p. 593 184. 8.9 Leiomyosarcoma Versus Other Spindle Cell Neoplasms - p. 597 185. 8.10 Hemangioma or Arteriovenous Malformation Versus Other Vascular Lesions - p. 600 186. 8.11 Kaposi Sarcoma (Any Gastrointestinal Site) Versus Other Spindle Cell Lesions - p. 604 187. 8.12 Angiosarcoma (Any Gastrointestinal Site) Versus Other Sarcomas - p. 607 188. 8.13 Glomus Tumor (Stomach) Versus Other Neoplasms - p. 611 189. 8.14 Vascular Malformations (Lymphatic, Venous, Arteriovenous) Versus Hemangioma - p. 614 190. 8.15 Schwannoma (Stomach) Versus Other Spindle Cell Lesions - p. 619 191. 8.16 Granular Cell Tumor Versus Atypical Granular Cell Tumor (Esophagus or Large Bowel) - p. 622 192. 8.17 Perineurioma or Benign Fibroblastic Polyp (Large Bowel) - p. 627 193. 8.18 Ganglioneuroma and Ganglioneuromatosis (Large Bowel) - p. 631 194. 8.19 Perivascular Epithelioid Cell Tumor or Angiomyolipoma Versus Other Neoplasms - p. 634 195. 8.20 Synovial Sarcoma (Stomach) Versus Other Sarcomas - p. 638 196. 8.21 Malignant Gastrointestinal Neuroectodermal Tumor and Gastrointestinal Clear Cell Sarcoma (Small Intestine, Stomach, Large Intestine) Versus Melanoma - p. 642 197. 8.22 Colonic Ulceration With Pseudomalignant Change - p. 648 198. 8.23 Endometrial Lesions and Their Mimics in the Gastrointestinal Tract - p. 651 199. Part 9 Systemic Disorders Involving the Gastrointestinal Tract - p. p659 200. 9.1 Amyloidosis Versus Normal Biopsy - p. 659 201. 9.2 Graft-Versus-Host Disease Versus Mycophenolate Injury - p. 665 202. 9.3 Scleroderma Versus Other Autoimmune Disorders - p. 669 203. 9.4 Human Immunodeficiency Virus Enteritis Versus Other Immune Deficiency Disorders - p. 672 204. 9.5 Esophageal Stricture Versus Immunoglobulin G4 Disease - p. 675 205. Part 10 Liver Metastasis - p. p677 206. 10.1 Metastatic Adenocarcinoma Versus Intrahepatic Cholangiocarcinoma - p. 677 207. 10.2 Resection of Colorectal Cancer Metastasis - p. 684 208. 10.3 Metastatic Small Intestinal Well-Differentiated NET Versus HCC Versus Other Neoplasms - p. 691 209. 10.4 Metastatic Neuroendocrine Carcinoma Versus Adenocarcinoma With Neuroendocrine Features - p. 699 210. 10.5 Metastatic Hepatoid Carcinoma Versus Yolk Sac Tumor Versus HCC - p. 705 211. 10.6 Metastatic Epithelioid GIST Versus Primary/Metastatic Carcinoma - p. 710 212. 10.7 Metastatic Anorectal Melanoma Versus Primary/Metastatic Tumors - p. 716 213. Index - p. 720
