Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging.
This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.
1. Genome Stability - p. i 2. Cover - p. i 3. Title Page - p. ii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xvii 7. Chapter 1 Genome stability: An evolutionary perspective - p. 1 8. Chapter 2 Genetic instability of RNA viruses - p. 22 9. Chapter 3 Genome instability in DNA viruses - p. 39 10. Chapter 4 Genome instability in bacteria and archaea: Strategies for maintaining genome stability☆☆ Adapted from chapter “Genome Instability in Bacteria and Archaea: Strategies for Maintaining Genome Stability,” first edition, written by J.-E. Messling and A.B. Williams. - p. 53 11. Chapter 5 Genome instability in bacteria: Causes and consequencesaaAdopted from chapter “Genome instability in bacteria: causes and consequences”, first edition, written by Ashley B. Williams. - p. 72 12. Chapter 6 CRISPR – Bacterial immune system - p. 91 13. Chapter 7 From micronucleus to macronucleus: Programmed DNA rearrangement in ciliates is regulated by non-coding RNA molecules☆ - p. 108 14. Chapter 8 Homologous recombination and nonhomologous end-joining repair in yeast - p. 124 15. Chapter 9 Meiotic and mitotic recombination: First in flies - p. 150 16. Chapter 10 Genome stability in Drosophila: Mismatch repair and genome stability - p. 169 17. Chapter 11 Genome stability in Caenorhabditis elegans☆ - p. 177 18. Chapter 12 Plant genome stability—General mechanisms - p. 201 19. Chapter 13 Genetic engineering in plants using CRISPRs - p. 223 20. Chapter 14 Cell cycle control and DNA-damage signaling in mammals - p. 236 21. Chapter 15 The role of p53/p21/p16 in DNA damage signaling and DNA repair - p. 256 22. Chapter 16 Roles of RAD18 in DNA replication and post-replication repair (PRR)** Adapted from previous edition prepared by Cyrus Vaziri, Satoshi Tateishi, Liz Mutter-Rottmayer and Yanzhe Gao. - p. 275 23. Chapter 17 Base excision repair and nucleotide excision repair - p. 293 24. Chapter 18 DNA mismatch repair in mammals - p. 323 25. Chapter 19 Repair of double-strand breaks by nonhomologous end joining; Its components and their function - p. 348 26. Chapter 20 Homologous recombination in mammalian cells: From molecular mechanisms to pathology - p. 366 27. Chapter 21 Telomere maintenance and genome stability - p. 393 28. Chapter 22 Chromatin, nuclear organization and genome stability in mammals - p. 415 29. Chapter 23 Role of DNA methylation in genome stability☆☆ Dan Zhou and Keith D. Robertson are the authors of the original article published in the first edition. - p. 435 30. Chapter 24 Non-coding RNAs in genome integrity - p. 453 31. Chapter 25 Human diseases associated with genome instability☆☆ Original article in the 1st edition was prepared by Bruno César Feltes, Joice de Faria Poloni, Kendi Nishino Miyamoto, and Diego Bonatto. - p. 478 32. Chapter 26 Cancer and genomic instability☆ - p. 494 33. Chapter 27 Epigenetic regulation of the cell cycle & DNA-repair in cancer - p. 520 34. Chapter 28 Genomic instability and aging: Causes and consequences - p. 532 35. Chapter 29 The DNA damage response and neurodegeneration: Highlighting the role of the nucleolus in genome (in)stability☆ - p. 554 36. Chapter 30 Diet and nutrition - p. 574 37. Chapter 31 Chemical carcinogens and their effect on genome and epigenome stability - p. 589 38. Chapter 32 Modern sources of environmental ionizing radiation exposure and associated health consequences - p. 603 39. Chapter 33 Sins of fathers through a scientific lens: Transgenerational effects - p. 622 40. Chapter 34 Radiation and chemical induced genomic instability as a driver for environmental evolution - p. 638 41. Chapter 35 Transgenerational genome instability in plants - p. 659 42. Chapter 36 Methods for the detection of DNA damage - p. 679 43. Chapter 37 Conserved and divergent features of DNA repair. Future perspectives in genome stability research - p. 698 44. Chapter 38 Off-target effects in genome editing - p. 715 45. Index - p. 728
Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging.
This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.
1. Genome Stability - p. i 2. Cover - p. i 3. Title Page - p. ii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xvii 7. Chapter 1 Genome stability: An evolutionary perspective - p. 1 8. Chapter 2 Genetic instability of RNA viruses - p. 22 9. Chapter 3 Genome instability in DNA viruses - p. 39 10. Chapter 4 Genome instability in bacteria and archaea: Strategies for maintaining genome stability☆☆ Adapted from chapter “Genome Instability in Bacteria and Archaea: Strategies for Maintaining Genome Stability,” first edition, written by J.-E. Messling and A.B. Williams. - p. 53 11. Chapter 5 Genome instability in bacteria: Causes and consequencesaaAdopted from chapter “Genome instability in bacteria: causes and consequences”, first edition, written by Ashley B. Williams. - p. 72 12. Chapter 6 CRISPR – Bacterial immune system - p. 91 13. Chapter 7 From micronucleus to macronucleus: Programmed DNA rearrangement in ciliates is regulated by non-coding RNA molecules☆ - p. 108 14. Chapter 8 Homologous recombination and nonhomologous end-joining repair in yeast - p. 124 15. Chapter 9 Meiotic and mitotic recombination: First in flies - p. 150 16. Chapter 10 Genome stability in Drosophila: Mismatch repair and genome stability - p. 169 17. Chapter 11 Genome stability in Caenorhabditis elegans☆ - p. 177 18. Chapter 12 Plant genome stability—General mechanisms - p. 201 19. Chapter 13 Genetic engineering in plants using CRISPRs - p. 223 20. Chapter 14 Cell cycle control and DNA-damage signaling in mammals - p. 236 21. Chapter 15 The role of p53/p21/p16 in DNA damage signaling and DNA repair - p. 256 22. Chapter 16 Roles of RAD18 in DNA replication and post-replication repair (PRR)** Adapted from previous edition prepared by Cyrus Vaziri, Satoshi Tateishi, Liz Mutter-Rottmayer and Yanzhe Gao. - p. 275 23. Chapter 17 Base excision repair and nucleotide excision repair - p. 293 24. Chapter 18 DNA mismatch repair in mammals - p. 323 25. Chapter 19 Repair of double-strand breaks by nonhomologous end joining; Its components and their function - p. 348 26. Chapter 20 Homologous recombination in mammalian cells: From molecular mechanisms to pathology - p. 366 27. Chapter 21 Telomere maintenance and genome stability - p. 393 28. Chapter 22 Chromatin, nuclear organization and genome stability in mammals - p. 415 29. Chapter 23 Role of DNA methylation in genome stability☆☆ Dan Zhou and Keith D. Robertson are the authors of the original article published in the first edition. - p. 435 30. Chapter 24 Non-coding RNAs in genome integrity - p. 453 31. Chapter 25 Human diseases associated with genome instability☆☆ Original article in the 1st edition was prepared by Bruno César Feltes, Joice de Faria Poloni, Kendi Nishino Miyamoto, and Diego Bonatto. - p. 478 32. Chapter 26 Cancer and genomic instability☆ - p. 494 33. Chapter 27 Epigenetic regulation of the cell cycle & DNA-repair in cancer - p. 520 34. Chapter 28 Genomic instability and aging: Causes and consequences - p. 532 35. Chapter 29 The DNA damage response and neurodegeneration: Highlighting the role of the nucleolus in genome (in)stability☆ - p. 554 36. Chapter 30 Diet and nutrition - p. 574 37. Chapter 31 Chemical carcinogens and their effect on genome and epigenome stability - p. 589 38. Chapter 32 Modern sources of environmental ionizing radiation exposure and associated health consequences - p. 603 39. Chapter 33 Sins of fathers through a scientific lens: Transgenerational effects - p. 622 40. Chapter 34 Radiation and chemical induced genomic instability as a driver for environmental evolution - p. 638 41. Chapter 35 Transgenerational genome instability in plants - p. 659 42. Chapter 36 Methods for the detection of DNA damage - p. 679 43. Chapter 37 Conserved and divergent features of DNA repair. Future perspectives in genome stability research - p. 698 44. Chapter 38 Off-target effects in genome editing - p. 715 45. Index - p. 728
