Genomic and Precision Medicine: Infectious and Inflammatory Disease, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.
1. Genomic and Precision Medicine - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. Acknowledgments - p. Page viii 8. List of Illustrations - p. Page ix 9. List of Tables - p. Page x 10. Chapter 1 : Overview: Genomic and precision medicine for infectious and inflammatory disease - p. Page x 11. Chapter 2 : The human genome as a foundation for genomic and precision health - p. Page 6 12. Chapter 3 : Data analytics for precision medicine - p. Page 22 13. Chapter 4 : Clinical metagenomics for infection diagnosis - p. Page 31 14. Chapter 5 : Host-pathogen interactions - p. Page 52 15. Chapter 6 : Sepsis genomics and precision medicine - p. Page 73 16. Chapter 7 : Sepsis: Metabolomics and proteomics - p. Page 91 17. Chapter 8 : Aspiring to precision medicine for infectious diseases in resource limited settings - p. Page 101 18. Chapter 9 : Respiratory viral infections - p. Page 113 19. Chapter 10 : Emerging viral infections - p. Page 131 20. Chapter 11 : Viral hepatitis - p. Page 149 21. Chapter 12 : Vaccine development - p. Page 163 22. Chapter 13 : HIV pharmacogenetics and pharmacogenomics: From bench to bedside - p. Page 177 23. Chapter 14 : Genomics and precision medicine for malaria: A dream come true? - p. Page 214 24. Chapter 15 : The role of disease surveillance in precision public health - p. Page 244 25. Chapter 16 : Multiple sclerosis - p. Page 264 26. Chapter 17 : Systemic sclerosis - p. Page 276 27. Chapter 18 : Leveraging genomics to uncover the genetic, environmental and age-related factors leading to asthma - p. Page 317 28. Chapter 19 : Chronic obstructive pulmonary disease - p. Page 368 29. Chapter 20 : Precision medicine in solid organ transplantation - p. Page 397 30. Chapter 21 : Molecular prognosis in liver cirrhosis - p. Page 408 31. Chapter 22 : Biomarkers and osteoarthritis☆ - p. Page 420 32. Chapter 23 : The microbiota and infectious diseases - p. Page 439 33. Index - p. Page 453
Genomic and Precision Medicine: Infectious and Inflammatory Disease, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.
1. Genomic and Precision Medicine - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. Acknowledgments - p. Page viii 8. List of Illustrations - p. Page ix 9. List of Tables - p. Page x 10. Chapter 1 : Overview: Genomic and precision medicine for infectious and inflammatory disease - p. Page x 11. Chapter 2 : The human genome as a foundation for genomic and precision health - p. Page 6 12. Chapter 3 : Data analytics for precision medicine - p. Page 22 13. Chapter 4 : Clinical metagenomics for infection diagnosis - p. Page 31 14. Chapter 5 : Host-pathogen interactions - p. Page 52 15. Chapter 6 : Sepsis genomics and precision medicine - p. Page 73 16. Chapter 7 : Sepsis: Metabolomics and proteomics - p. Page 91 17. Chapter 8 : Aspiring to precision medicine for infectious diseases in resource limited settings - p. Page 101 18. Chapter 9 : Respiratory viral infections - p. Page 113 19. Chapter 10 : Emerging viral infections - p. Page 131 20. Chapter 11 : Viral hepatitis - p. Page 149 21. Chapter 12 : Vaccine development - p. Page 163 22. Chapter 13 : HIV pharmacogenetics and pharmacogenomics: From bench to bedside - p. Page 177 23. Chapter 14 : Genomics and precision medicine for malaria: A dream come true? - p. Page 214 24. Chapter 15 : The role of disease surveillance in precision public health - p. Page 244 25. Chapter 16 : Multiple sclerosis - p. Page 264 26. Chapter 17 : Systemic sclerosis - p. Page 276 27. Chapter 18 : Leveraging genomics to uncover the genetic, environmental and age-related factors leading to asthma - p. Page 317 28. Chapter 19 : Chronic obstructive pulmonary disease - p. Page 368 29. Chapter 20 : Precision medicine in solid organ transplantation - p. Page 397 30. Chapter 21 : Molecular prognosis in liver cirrhosis - p. Page 408 31. Chapter 22 : Biomarkers and osteoarthritis☆ - p. Page 420 32. Chapter 23 : The microbiota and infectious diseases - p. Page 439 33. Index - p. Page 453
