Genomics-Guided Natural Products Discovery, Volume 717 focuses on how the genomics revolution has catalyzed a resurgence of interest in natural products research. With the explosion of new sequencing data to analyze, “genome-mining” tools have grown in sophistication. Hence, this volume captures the utility of these tools, serving as a how-to guide to lower the entry barrier for newcomers. Topics covered in this new release include Merging RODEO with genomic enzymology workflows to guide RiPP discovery, Exploring Ribosomally Synthesized and Post-translationally Modified Peptides through SPECO-Based Genome Mining, Genome Mining for Natural Products Made by Multinuclear Iron-dependent Oxidation Enzymes (MNIOs), and much more.
Additional sections explore Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases, Global genome mining in fungi using FunBGCe, Plant genome mining of burpitides from fused precursor peptides, Determining biosynthetic gene cluster boundaries thru comparative bioinformatics, Genome mining for bacterial terpenoids, Bioinformatics guided synthesis of natural product cyclic peptides, Overview of Genome Mining Strategies for Natural Products Discovery, and much more.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Series Page - p. iii 5. Copyright - p. iv 6. Contributors - p. xv 7. Chapter One: Using antiSMASH - p. 1 8. Chapter Two: Merging RODEO with genomic enzymology workflows to guide RiPP discovery - p. 29 9. Chapter Three: Exploring ribosomally synthesized and post-translationally modified peptides through SPECO-based genome mining - p. 67 10. Chapter Four: Genome mining for natural products made by multinuclear iron-dependent oxidation enzymes (MNIOs) - p. 89 11. Chapter Five: Genome mining and in vivo characterization of triceptides - p. 119 12. Chapter Six: Plant genome mining of burpitides from fused precursor peptides - p. 141 13. Chapter Seven: Genome mining of RiPPs driven by highly efficient pathway reconstruction methods - p. 175 14. Chapter Eight: Genome mining with hypothetical proteins - p. 199 15. Chapter Nine: Determining biosynthetic gene cluster boundaries through comparative bioinformatics - p. 241 16. Chapter Ten: Targeted genome mining for natural product discovery - p. 267 17. Chapter Eleven: Global genome mining in fungi using FunBGCeX - p. 299 18. Chapter Twelve: Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases - p. 317 19. Chapter Thirteen: Discovery of bacterial terpenoids by genome mining - p. 349 20. Chapter Fourteen: Bioinformatics guided synthesis of natural product cyclic peptides - p. 387 21. Chapter Fifteen: Genome mining for the discovery of peptide halogenases and their biochemical characterization - p. 413 22. Chapter Sixteen: Harnessing membrane vesicles to activate silent bacterial metabolite production - p. 437
Genomics-Guided Natural Products Discovery, Volume 717 focuses on how the genomics revolution has catalyzed a resurgence of interest in natural products research. With the explosion of new sequencing data to analyze, “genome-mining” tools have grown in sophistication. Hence, this volume captures the utility of these tools, serving as a how-to guide to lower the entry barrier for newcomers. Topics covered in this new release include Merging RODEO with genomic enzymology workflows to guide RiPP discovery, Exploring Ribosomally Synthesized and Post-translationally Modified Peptides through SPECO-Based Genome Mining, Genome Mining for Natural Products Made by Multinuclear Iron-dependent Oxidation Enzymes (MNIOs), and much more.
Additional sections explore Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases, Global genome mining in fungi using FunBGCe, Plant genome mining of burpitides from fused precursor peptides, Determining biosynthetic gene cluster boundaries thru comparative bioinformatics, Genome mining for bacterial terpenoids, Bioinformatics guided synthesis of natural product cyclic peptides, Overview of Genome Mining Strategies for Natural Products Discovery, and much more.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Series Page - p. iii 5. Copyright - p. iv 6. Contributors - p. xv 7. Chapter One: Using antiSMASH - p. 1 8. Chapter Two: Merging RODEO with genomic enzymology workflows to guide RiPP discovery - p. 29 9. Chapter Three: Exploring ribosomally synthesized and post-translationally modified peptides through SPECO-based genome mining - p. 67 10. Chapter Four: Genome mining for natural products made by multinuclear iron-dependent oxidation enzymes (MNIOs) - p. 89 11. Chapter Five: Genome mining and in vivo characterization of triceptides - p. 119 12. Chapter Six: Plant genome mining of burpitides from fused precursor peptides - p. 141 13. Chapter Seven: Genome mining of RiPPs driven by highly efficient pathway reconstruction methods - p. 175 14. Chapter Eight: Genome mining with hypothetical proteins - p. 199 15. Chapter Nine: Determining biosynthetic gene cluster boundaries through comparative bioinformatics - p. 241 16. Chapter Ten: Targeted genome mining for natural product discovery - p. 267 17. Chapter Eleven: Global genome mining in fungi using FunBGCeX - p. 299 18. Chapter Twelve: Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases - p. 317 19. Chapter Thirteen: Discovery of bacterial terpenoids by genome mining - p. 349 20. Chapter Fourteen: Bioinformatics guided synthesis of natural product cyclic peptides - p. 387 21. Chapter Fifteen: Genome mining for the discovery of peptide halogenases and their biochemical characterization - p. 413 22. Chapter Sixteen: Harnessing membrane vesicles to activate silent bacterial metabolite production - p. 437
