Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity.
This protein’s diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion.
This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease.
1. Introduction - p. xvii 2. Section I. The Role of Moonlighting GAPDH in Normal Cell Function - p. xvii 3. Chapter 1. The Role of Moonlighting GAPDH in Cell Proliferation: The Dynamic Nature of GAPDH Expression and Subcellular Localization - p. 3 4. Chapter 2. Moonlighting GAPDH and the Transcriptional Regulation of Gene Expression: Multiprotein Complex Formation and Mechanisms of Nuclear Translocation - p. 21 5. Chapter 3. The Diversity of Moonlighting GAPDH Function in Posttranscriptional RNA Regulation: mRNA Stability, tRNA Processing, and Viral Pathogenesis - p. 35 6. Chapter 4. The Role of Moonlighting GAPDH in Membrane Structure and Function: Membrane Fusion and Iron Metabolism - p. 57 7. Chapter 5. The Role of Moonlighting GAPDH in Intracellular Membrane Trafficking: Tubulin Regulation and Modulation of Cytoskeletal Structure - p. 77 8. Chapter 6. Moonlighting GAPDH and the Maintenance of DNA Integrity: Preservation of Genetic Information and Cancer Facilitation - p. 97 9. Chapter 7. Moonlighting GAPDH in Neuronal Structure and Function: Regulation of Ion Channels and Signal Transduction - p. 113 10. Section II. Physiological Stress and GAPDH Functional Diversity - p. 128 11. Chapter 8. The Significance of Nitric Oxide–Modified GAPDH: Regulation of Apoptosis, Cell Signaling, and Heme Metabolism - p. 131 12. Chapter 9. GAPDH and Hypoxia: Mechanisms of Cell Survival During Oxygen Deprivation - p. 155 13. Chapter 10. Moonlighting GAPDH and Ischemia: Cellular and Molecular Effects of Oxygen Deprivation and Reperfusion - p. 167 14. Section III. The Pathology of GAPDH Functional Diversity - p. 178 15. Chapter 11. GAPDH and Tumorigenesis: Molecular Mechanisms of Cancer Development and Survival - p. 181 16. Chapter 12. Moonlighting GAPDH and Age-Related Neurodegenerative Disease: Diversity of Protein Interactions and Complexity of Function - p. 199 17. Chapter 13. Functional Diversity of GAPDH in Infection and Immunity: The Complexity of “Simple” Organisms - p. 221 18. Chapter 14. Moonlighting GAPDH and Diabetes: Pleiotropic Effects of Perturbations in GAPDH Structure and Function - p. 241 19. Section IV. The Pharmacology of Moonlighting GAPDH - p. 259 20. Section V. The Unique Role of Sperm-Specific GAPDH - p. 279 21. Section VI. Discussion - p. 297 22. Index - p. 299
Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity.
This protein’s diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion.
This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease.
1. Introduction - p. xvii 2. Section I. The Role of Moonlighting GAPDH in Normal Cell Function - p. xvii 3. Chapter 1. The Role of Moonlighting GAPDH in Cell Proliferation: The Dynamic Nature of GAPDH Expression and Subcellular Localization - p. 3 4. Chapter 2. Moonlighting GAPDH and the Transcriptional Regulation of Gene Expression: Multiprotein Complex Formation and Mechanisms of Nuclear Translocation - p. 21 5. Chapter 3. The Diversity of Moonlighting GAPDH Function in Posttranscriptional RNA Regulation: mRNA Stability, tRNA Processing, and Viral Pathogenesis - p. 35 6. Chapter 4. The Role of Moonlighting GAPDH in Membrane Structure and Function: Membrane Fusion and Iron Metabolism - p. 57 7. Chapter 5. The Role of Moonlighting GAPDH in Intracellular Membrane Trafficking: Tubulin Regulation and Modulation of Cytoskeletal Structure - p. 77 8. Chapter 6. Moonlighting GAPDH and the Maintenance of DNA Integrity: Preservation of Genetic Information and Cancer Facilitation - p. 97 9. Chapter 7. Moonlighting GAPDH in Neuronal Structure and Function: Regulation of Ion Channels and Signal Transduction - p. 113 10. Section II. Physiological Stress and GAPDH Functional Diversity - p. 128 11. Chapter 8. The Significance of Nitric Oxide–Modified GAPDH: Regulation of Apoptosis, Cell Signaling, and Heme Metabolism - p. 131 12. Chapter 9. GAPDH and Hypoxia: Mechanisms of Cell Survival During Oxygen Deprivation - p. 155 13. Chapter 10. Moonlighting GAPDH and Ischemia: Cellular and Molecular Effects of Oxygen Deprivation and Reperfusion - p. 167 14. Section III. The Pathology of GAPDH Functional Diversity - p. 178 15. Chapter 11. GAPDH and Tumorigenesis: Molecular Mechanisms of Cancer Development and Survival - p. 181 16. Chapter 12. Moonlighting GAPDH and Age-Related Neurodegenerative Disease: Diversity of Protein Interactions and Complexity of Function - p. 199 17. Chapter 13. Functional Diversity of GAPDH in Infection and Immunity: The Complexity of “Simple” Organisms - p. 221 18. Chapter 14. Moonlighting GAPDH and Diabetes: Pleiotropic Effects of Perturbations in GAPDH Structure and Function - p. 241 19. Section IV. The Pharmacology of Moonlighting GAPDH - p. 259 20. Section V. The Unique Role of Sperm-Specific GAPDH - p. 279 21. Section VI. Discussion - p. 297 22. Index - p. 299
