A comprehensive, multidisciplinary resource for the entire radiation oncology team, Gunderson & Tepper’s Clinical Radiation Oncology, 5th Edition, thoroughly covers all aspects of this complex and dynamic field. Concise, templated chapters cover the basic biology of oncologic disease processes as well as updated treatment algorithms, the latest clinical guidelines, and state-of-the-art techniques and modalities. More than 1,000 images—detailed anatomy drawings, radiographic images, and more—provide outstanding visual support for every area of the text.
1. Introduction - p. 836 2. Etiology and Epidemiology - p. 837 3. Early Detection and Prevention - p. 837 4. Pathology and Molecular Biology of Lung Cancer - p. 838 5. Carcinogenesis and Pathways of Spread - p. 841 6. Clinical Manifestations, Patient Evaluation, and Staging - p. 843 7. Primary Therapy - p. 846 8. Radiotherapy Treatment Planning and Techniques - p. 858 9. Systemic and Local Management of Metastatic Disease - p. 862 10. Controversies - p. 866 11. Conclusions - p. 866 12. References - p. 867.e1 13. 52 Uncommon Thoracic Tumors - p. 868 14. Thymic Tumors - p. 868 15. Pulmonary Carcinoid Tumors - p. 879 16. Mesothelioma - p. 885 17. Summary - p. 895 18. Acknowledgments - p. 895 19. References - p. 897.e1 20. Part D Gastrointestinal Tumors - p. 897.e12 21. 53 Overview - p. 898 22. 54 Esophagus-Gastric Cancer - p. 908 23. Introduction - p. 909 24. Epidemiology and Etiology - p. 909 25. Prevention and Early Detection - p. 909.e1 26. Biological Characteristics and Molecular Biology - p. 909.e1 27. Pathology and Pathways of Spread - p. 913 28. Primary Therapy - p. 913.e1 29. Locally Advanced Disease and Palliation - p. 933 30. Irradiation Techniques and Tolerances - p. 934 31. Treatment Algorithm, Challenges, and Future Possibilities - p. 942 32. References - p. 945.e1 33. 55 Pancreatic Cancer - p. 946 34. Introduction - p. 947 35. Epidemiology and Etiology - p. 947 36. Prevention and Early Detection - p. 948 37. Biologic Characteristics and Molecular Biology - p. 948 38. Pathology and Pathways of Spread - p. 948.e1 39. Clinical Manifestations, Patient Evaluation, and Staging - p. 951 40. Primary Therapy - p. 954 41. Locally Advanced Disease - p. 960.e2 42. Metastatic Disease and Palliation - p. 964.e1 43. Irradiation Techniques and Tolerance - p. 965.e1 44. Treatment Algorithm, Challenges, and Future Directions - p. 970 45. References - p. 972.e1 46. 56 Hepatobiliary Cancer - p. 973 47. 57 Colon Cancer - p. 995 48. 58 Rectal Cancer - p. 1011 49. Etiology and Epidemiology - p. 1011 50. Prevention and Early Detection - p. 1012 51. Biological Characteristics and Molecular Biology - p. 1012 52. Pathology and Pathways of Spread - p. 1013 53. Clinical Manifestations, Patient Evaluation, and Staging - p. 1014 54. Posttreatment Assessment - p. 1017 55. Primary and Adjuvant Therapy for Resectable Disease - p. 1017 56. Locally Advanced Disease and Palliation - p. 1028 57. Irradiation Techniques and Tolerance - p. 1033 58. Conclusions - p. 1035 59. References - p. 1036.e1 60. 59 Anal Carcinoma - p. 1037 61. Part E Genitourinary Tumors - p. 1050.e4 62. 60 Overview - p. 1051 63. 61 Prostate Cancer - p. 1054 64. Epidemiology and Etiology - p. 1054 65. Prevention and Early Detection - p. 1055.e1 66. Pathology and Pathways of Spread - p. 1057.e1 67. Histology - p. 1057.e1 68. Pathology of Prostate Cancer - p. 1057.e1 69. Clinical and Pathologic Stage Grouping - p. 1060 70. Predictive Factors - p. 1062 71. Clinical Manifestations, Patient Evaluation, Staging - p. 1067 72. Primary Therapy - p. 1072 73. Surgical Therapy - p. 1089.e1 74. Locally Advanced Disease - p. 1093 75. Adjuvant Versus Salvage Radiotherapy - p. 1102 76. Metastatic Disease - p. 1103 77. Irradiation Techniques - p. 1104.e1 78. Treatment Algorithm and Future Directions - p. 1112 79. References - p. 1114.e1 80. 62 Bladder Cancer - p. 1115 81. 63 Testicular Cancer - p. 1132 82. 64 Kidney and Ureteral Carcinoma - p. 1150 83. 65 Penile Cancer - p. 1170 84. Part F Gynecological Tumors - p. 1180.e2 85. 66 Overview - p. 1181 86. 67 Cervical Cancer - p. 1184 87. Epidemiology and Etiology - p. 1185 88. Prevention and Early Detection - p. 1185 89. Pathology and Pathways of Spread - p. 1186 90. Molecular Biology - p. 1187 91. Clinical Manifestations, Patient Evaluation, and Staging - p. 1188 92. Primary Therapy - p. 1190 93. Locally Advanced Disease and Palliation - p. 1199 94. Irradiation Techniques and Tolerance - p. 1200.e1 95. Treatment Algorithm, Conclusions, and FUTURE Possibilities - p. 1210 96. References - p. 1212.e1 97. 68 Endometrial Cancer - p. 1213 98. Epidemiology and Etiology - p. 1214 99. Prevention and Early Detection - p. 1215 100. Biological Characteristics/Molecular Biology - p. 1215 101. Pathology and Pathways of Spread - p. 1217 102. Clinical Manifestations, Patient Evaluation, and Staging - p. 1217.e1 103. Locally Advanced Disease and Palliation - p. 1229 104. Systemic Therapy for Recurrent or Metastatic Disease - p. 1231 105. Irradiation Techniques and Tolerance - p. 1234 106. Treatment Algorithm, Conclusions, and Challenges - p. 1240 107. References - p. 1242.e1 108. 69 Cancers of the Vulva and Vagina - p. 1243 109. Vulvar Cancer - p. 1245 110. Etiology and Epidemiology - p. 1245 111. Early Detection, Treatment and Prevention - p. 1245 112. Pathology and Pathways of Spread - p. 1246 113. Biology and Prognostic Factors - p. 1248 114. Clinical Manifestations, Patient Evaluation, and Staging - p. 1249 115. Primary Therapy - p. 1251 116. Locally Advanced Disease and Palliation - p. 1260 117. Irradiation Techniques and Tolerance - p. 1262 118. Challenges, Controversies, and Future Possibilities - p. 1264.e1 119. Miscellaneous Vulvar Malignancies - p. 1264.e1 120. Vaginal Cancer - p. 1267 121. Etiology and Epidemiology - p. 1266.e1 122. Prevention and Early Detection - p. 1266.e1 123. Pathology and Pathways of Spread - p. 1266.e1 124. Clinical Manifestations, Patient Evaluation, and Staging - p. 1266.e1 125. Primary Therapy - p. 1268 126. Locally Advanced Disease and Palliation - p. 1270 127. Irradiation Techniques and Tolerance - p. 1270 128. Treatment Algorithm and Future Possibilities - p. 1274 129. Nonsquamous Vaginal Malignancies - p. 1274 130. References - p. 1275.e1 131. 70 Ovarian Cancer - p. 1276 132. Part G Breast Cancer - p. 1296.e8 133. 71 Overview - p. 1297 134. 72 Noninvasive Breast Cancer - p. 1316 135. 73 Breast Cancer - p. 1325 136. Introduction - p. 1325 137. Pretreatment Evaluation - p. 1326 138. Surgical Techniques - p. 1325.e1 139. Breast-Conserving Surgery With Radiotherapy - p. 1325.e1 140. When to Use Nodal Irradiation - p. 1328.e1 141. Treatment Techniques - p. 1331 142. Radiotherapy Dose and Schedule Parameters - p. 1334 143. Accelerated Partial-Breast Irradiation - p. 1333.e1 144. Acute and Chronic Complications and Cosmetic Results - p. 1336 145. Patient Follow-Up - p. 1339 146. Treatment of Locoregional Failure - p. 1338.e1 147. Conclusions - p. 1338.e1 148. References - p. 1341.e1 149. 74 Locally Advanced and Inflammatory Breast Cancer - p. 1342 150. Part H Sarcoma and Benign Disease - p. 1358.e2 151. 75 Soft-Tissue Sarcoma - p. 1359 152. 76 Benign Diseases - p. 1386 153. Part I Childhood Cancers - p. 1397.e8 154. 77 Overview - p. 1398 155. 78 Central Nervous System Tumors in Children - p. 1403 156. 79 Pediatric Soft-Tissue Sarcomas - p. 1421 157. 80 Pediatric Sarcomas of Bone - p. 1431 158. 81 Wilms Tumor - p. 1442 159. 82 Retinoblastoma - p. 1453 160. 83 Neuroblastoma - p. 1460 161. 84 Pediatric Leukemia and Lymphoma - p. 1468 162. 85 Pediatric Hodgkin Lymphoma - p. 1477 163. 86 Rare Pediatric Tumors - p. 1497 164. Part J Lymphoma and Hematological Malignancies - p. 1510.e6 165. 87 Overview - p. 1511 166. 88 Hodgkin Lymphoma - p. 1516 167. 89 Non-Hodgkin Lymphoma - p. 1531 168. Introduction - p. 1531 169. Etiology and Epidemiology - p. 1531 170. Prevention and Early Detection - p. 1532 171. Biological Characteristics and Pathology - p. 1533 172. Clinical Manifestations, Patient Evaluation, and Staging Classification - p. 1537 173. Prognostic Factors - p. 1539 174. Principles of Management - p. 1539 175. Management of Distinct Disease Entities - p. 1541 176. Conclusion - p. 1553 177. References - p. 1554.e1 178. 90 Multiple Myeloma and Other Plasma Cell Neoplasms - p. 1555 179. 91 Mycosis Fungoides - p. 1564 180. Index - p. 1587
A comprehensive, multidisciplinary resource for the entire radiation oncology team, Gunderson & Tepper’s Clinical Radiation Oncology, 5th Edition, thoroughly covers all aspects of this complex and dynamic field. Concise, templated chapters cover the basic biology of oncologic disease processes as well as updated treatment algorithms, the latest clinical guidelines, and state-of-the-art techniques and modalities. More than 1,000 images—detailed anatomy drawings, radiographic images, and more—provide outstanding visual support for every area of the text.
1. Introduction - p. 836 2. Etiology and Epidemiology - p. 837 3. Early Detection and Prevention - p. 837 4. Pathology and Molecular Biology of Lung Cancer - p. 838 5. Carcinogenesis and Pathways of Spread - p. 841 6. Clinical Manifestations, Patient Evaluation, and Staging - p. 843 7. Primary Therapy - p. 846 8. Radiotherapy Treatment Planning and Techniques - p. 858 9. Systemic and Local Management of Metastatic Disease - p. 862 10. Controversies - p. 866 11. Conclusions - p. 866 12. References - p. 867.e1 13. 52 Uncommon Thoracic Tumors - p. 868 14. Thymic Tumors - p. 868 15. Pulmonary Carcinoid Tumors - p. 879 16. Mesothelioma - p. 885 17. Summary - p. 895 18. Acknowledgments - p. 895 19. References - p. 897.e1 20. Part D Gastrointestinal Tumors - p. 897.e12 21. 53 Overview - p. 898 22. 54 Esophagus-Gastric Cancer - p. 908 23. Introduction - p. 909 24. Epidemiology and Etiology - p. 909 25. Prevention and Early Detection - p. 909.e1 26. Biological Characteristics and Molecular Biology - p. 909.e1 27. Pathology and Pathways of Spread - p. 913 28. Primary Therapy - p. 913.e1 29. Locally Advanced Disease and Palliation - p. 933 30. Irradiation Techniques and Tolerances - p. 934 31. Treatment Algorithm, Challenges, and Future Possibilities - p. 942 32. References - p. 945.e1 33. 55 Pancreatic Cancer - p. 946 34. Introduction - p. 947 35. Epidemiology and Etiology - p. 947 36. Prevention and Early Detection - p. 948 37. Biologic Characteristics and Molecular Biology - p. 948 38. Pathology and Pathways of Spread - p. 948.e1 39. Clinical Manifestations, Patient Evaluation, and Staging - p. 951 40. Primary Therapy - p. 954 41. Locally Advanced Disease - p. 960.e2 42. Metastatic Disease and Palliation - p. 964.e1 43. Irradiation Techniques and Tolerance - p. 965.e1 44. Treatment Algorithm, Challenges, and Future Directions - p. 970 45. References - p. 972.e1 46. 56 Hepatobiliary Cancer - p. 973 47. 57 Colon Cancer - p. 995 48. 58 Rectal Cancer - p. 1011 49. Etiology and Epidemiology - p. 1011 50. Prevention and Early Detection - p. 1012 51. Biological Characteristics and Molecular Biology - p. 1012 52. Pathology and Pathways of Spread - p. 1013 53. Clinical Manifestations, Patient Evaluation, and Staging - p. 1014 54. Posttreatment Assessment - p. 1017 55. Primary and Adjuvant Therapy for Resectable Disease - p. 1017 56. Locally Advanced Disease and Palliation - p. 1028 57. Irradiation Techniques and Tolerance - p. 1033 58. Conclusions - p. 1035 59. References - p. 1036.e1 60. 59 Anal Carcinoma - p. 1037 61. Part E Genitourinary Tumors - p. 1050.e4 62. 60 Overview - p. 1051 63. 61 Prostate Cancer - p. 1054 64. Epidemiology and Etiology - p. 1054 65. Prevention and Early Detection - p. 1055.e1 66. Pathology and Pathways of Spread - p. 1057.e1 67. Histology - p. 1057.e1 68. Pathology of Prostate Cancer - p. 1057.e1 69. Clinical and Pathologic Stage Grouping - p. 1060 70. Predictive Factors - p. 1062 71. Clinical Manifestations, Patient Evaluation, Staging - p. 1067 72. Primary Therapy - p. 1072 73. Surgical Therapy - p. 1089.e1 74. Locally Advanced Disease - p. 1093 75. Adjuvant Versus Salvage Radiotherapy - p. 1102 76. Metastatic Disease - p. 1103 77. Irradiation Techniques - p. 1104.e1 78. Treatment Algorithm and Future Directions - p. 1112 79. References - p. 1114.e1 80. 62 Bladder Cancer - p. 1115 81. 63 Testicular Cancer - p. 1132 82. 64 Kidney and Ureteral Carcinoma - p. 1150 83. 65 Penile Cancer - p. 1170 84. Part F Gynecological Tumors - p. 1180.e2 85. 66 Overview - p. 1181 86. 67 Cervical Cancer - p. 1184 87. Epidemiology and Etiology - p. 1185 88. Prevention and Early Detection - p. 1185 89. Pathology and Pathways of Spread - p. 1186 90. Molecular Biology - p. 1187 91. Clinical Manifestations, Patient Evaluation, and Staging - p. 1188 92. Primary Therapy - p. 1190 93. Locally Advanced Disease and Palliation - p. 1199 94. Irradiation Techniques and Tolerance - p. 1200.e1 95. Treatment Algorithm, Conclusions, and FUTURE Possibilities - p. 1210 96. References - p. 1212.e1 97. 68 Endometrial Cancer - p. 1213 98. Epidemiology and Etiology - p. 1214 99. Prevention and Early Detection - p. 1215 100. Biological Characteristics/Molecular Biology - p. 1215 101. Pathology and Pathways of Spread - p. 1217 102. Clinical Manifestations, Patient Evaluation, and Staging - p. 1217.e1 103. Locally Advanced Disease and Palliation - p. 1229 104. Systemic Therapy for Recurrent or Metastatic Disease - p. 1231 105. Irradiation Techniques and Tolerance - p. 1234 106. Treatment Algorithm, Conclusions, and Challenges - p. 1240 107. References - p. 1242.e1 108. 69 Cancers of the Vulva and Vagina - p. 1243 109. Vulvar Cancer - p. 1245 110. Etiology and Epidemiology - p. 1245 111. Early Detection, Treatment and Prevention - p. 1245 112. Pathology and Pathways of Spread - p. 1246 113. Biology and Prognostic Factors - p. 1248 114. Clinical Manifestations, Patient Evaluation, and Staging - p. 1249 115. Primary Therapy - p. 1251 116. Locally Advanced Disease and Palliation - p. 1260 117. Irradiation Techniques and Tolerance - p. 1262 118. Challenges, Controversies, and Future Possibilities - p. 1264.e1 119. Miscellaneous Vulvar Malignancies - p. 1264.e1 120. Vaginal Cancer - p. 1267 121. Etiology and Epidemiology - p. 1266.e1 122. Prevention and Early Detection - p. 1266.e1 123. Pathology and Pathways of Spread - p. 1266.e1 124. Clinical Manifestations, Patient Evaluation, and Staging - p. 1266.e1 125. Primary Therapy - p. 1268 126. Locally Advanced Disease and Palliation - p. 1270 127. Irradiation Techniques and Tolerance - p. 1270 128. Treatment Algorithm and Future Possibilities - p. 1274 129. Nonsquamous Vaginal Malignancies - p. 1274 130. References - p. 1275.e1 131. 70 Ovarian Cancer - p. 1276 132. Part G Breast Cancer - p. 1296.e8 133. 71 Overview - p. 1297 134. 72 Noninvasive Breast Cancer - p. 1316 135. 73 Breast Cancer - p. 1325 136. Introduction - p. 1325 137. Pretreatment Evaluation - p. 1326 138. Surgical Techniques - p. 1325.e1 139. Breast-Conserving Surgery With Radiotherapy - p. 1325.e1 140. When to Use Nodal Irradiation - p. 1328.e1 141. Treatment Techniques - p. 1331 142. Radiotherapy Dose and Schedule Parameters - p. 1334 143. Accelerated Partial-Breast Irradiation - p. 1333.e1 144. Acute and Chronic Complications and Cosmetic Results - p. 1336 145. Patient Follow-Up - p. 1339 146. Treatment of Locoregional Failure - p. 1338.e1 147. Conclusions - p. 1338.e1 148. References - p. 1341.e1 149. 74 Locally Advanced and Inflammatory Breast Cancer - p. 1342 150. Part H Sarcoma and Benign Disease - p. 1358.e2 151. 75 Soft-Tissue Sarcoma - p. 1359 152. 76 Benign Diseases - p. 1386 153. Part I Childhood Cancers - p. 1397.e8 154. 77 Overview - p. 1398 155. 78 Central Nervous System Tumors in Children - p. 1403 156. 79 Pediatric Soft-Tissue Sarcomas - p. 1421 157. 80 Pediatric Sarcomas of Bone - p. 1431 158. 81 Wilms Tumor - p. 1442 159. 82 Retinoblastoma - p. 1453 160. 83 Neuroblastoma - p. 1460 161. 84 Pediatric Leukemia and Lymphoma - p. 1468 162. 85 Pediatric Hodgkin Lymphoma - p. 1477 163. 86 Rare Pediatric Tumors - p. 1497 164. Part J Lymphoma and Hematological Malignancies - p. 1510.e6 165. 87 Overview - p. 1511 166. 88 Hodgkin Lymphoma - p. 1516 167. 89 Non-Hodgkin Lymphoma - p. 1531 168. Introduction - p. 1531 169. Etiology and Epidemiology - p. 1531 170. Prevention and Early Detection - p. 1532 171. Biological Characteristics and Pathology - p. 1533 172. Clinical Manifestations, Patient Evaluation, and Staging Classification - p. 1537 173. Prognostic Factors - p. 1539 174. Principles of Management - p. 1539 175. Management of Distinct Disease Entities - p. 1541 176. Conclusion - p. 1553 177. References - p. 1554.e1 178. 90 Multiple Myeloma and Other Plasma Cell Neoplasms - p. 1555 179. 91 Mycosis Fungoides - p. 1564 180. Index - p. 1587
