Handbook of Endocannabinoid Function in the Central Nervous System, a new release in the Handbook of Behavioral Neuroscience series, offers a comprehensive, interdisciplinary approach to understanding the role of the endocannabinoid system in functions of the central nervous system. This new volume brings together the most influential and internally recognized experts in the field to provide a detailed overview of the physiological and pathophysiological roles of endocannabinoids in CNS activity. It covers the history, functional anatomy, and neurophysiology of the endocannabinoid system, moving on to assess endocannabinoid roles across human lifespans, and in behavioral control.
Final sections of the book explore the use of endocannabinoids in psychiatric and neurological disorders. This is a vital resource for neuroscientists, neuropharmacologists, and neuropathologists, as well as any researcher seeking detailed discussions of brain endocannabinoid functions.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xiii 7. Acknowledgments - p. xv 8. Section 1 History of the endocannabinoid system - p. P1 9. Chapter 1. The day anandamide almost died, and other endocannabinoid stories - p. 3 10. Section 2 Functional anatomy of the endocannabinoid system - p. P2 11. Chapter 2. The endocannabinoid signalosome - p. 21 12. Chapter 3. Endocannabinoid signaling in glial cells - p. 37 13. Chapter 4. Endocannabinoid in nonneuronal cells of the CNS - p. 55 14. Chapter 5. Cannabinoid modulation of brain mitochondria - p. 65 15. Section 3 The neurophysiology of the endocannabinoid system - p. P3 16. Chapter 6. Cellular effects of endocannabinoids in the CNS - p. 89 17. Chapter 7. The endocannabinoid-mediated control of neuronal excitability - p. 103 18. Chapter 8. Potential mechanisms of endocannabinoid release - p. 111 19. Chapter 9. Endocannabinoids in pain modulation - p. 123 20. Chapter 10. Endocannabinoid regulation of hippocampal circuits - p. 143 21. Chapter 11. Endocannabinoids regulation of the mesolimbic system - p. 153 22. Chapter 12. Endocannabinoid regulation of cortical functions - p. 173 23. Chapter 13. The endocannabinoidome and its role in the central and peripheral control of food intake - p. 197 24. Section 4 Endocannabinoids in development and lifetime - p. P4 25. Chapter 14. Roles of eCB in adolescence and sensitive periods - p. 223 26. Chapter 15. Roles of endocannabinoid in aging - p. 231 27. Chapter 16. Epigenetic modulation by the endocannabinoid system in the central nervous system - p. 247 28. Chapter 17. Perinatal cannabinoid exposure - p. 261 29. Section 5 Endocannabinoids and behavioral control - p. P5 30. Chapter 18. Endocannabinoids and sensory processing - p. 275 31. Chapter 19. Endocannabinoids and the neurobiology of emotional states - p. 291 32. Chapter 20. Endocannabinoids and social behavior - p. 311 33. Chapter 21. The complex interplay between stress and the endocannabinoid system in the modulation of memory function - p. 327 34. Section 6 Endocannabinoids in psychiatric disorders - p. P6 35. Chapter 22. Role of the endocannabinoid system in schizophrenia: From preclinical to human evidence - p. 339 36. 1 Schizophrenia - p. 339 37. 2 Cannabis and schizophrenia - p. 340 38. 3 The endocannabinoid system: A brief overview - p. 341 39. 4 The endocannabinoid system in schizophrenia - p. 342 40. 5 Preclinical models resembling schizophrenia-like phenotype - p. 347 41. 6 Pharmacological modulation of the endocannabinoid system: Preclinical and clinical evidence - p. 348 42. 7 Conclusions and future perspective - p. 359 43. Chapter 23. The role of endocannabinoids in nonpharmacological addiction - p. 371 44. Chapter 24. The endocannabinoid system in autism spectrum disorder - p. 389 45. Chapter 25. The endocannabinoid system in intellectual disability - p. 409 46. Section 7 Endocannabinoids in neurological disorders - p. P7 47. Chapter 26. Neurodegeneration and the endocannabinoid system: Toward the development of cannabinoid-based therapies for Parkinson's disease, amyotrophic lateral sclerosis and spinocerebellar ataxias - p. 425 48. Chapter 27. Endocannabinoids and Alzheimer's disease - p. 451 49. Index - p. 471
Handbook of Endocannabinoid Function in the Central Nervous System, a new release in the Handbook of Behavioral Neuroscience series, offers a comprehensive, interdisciplinary approach to understanding the role of the endocannabinoid system in functions of the central nervous system. This new volume brings together the most influential and internally recognized experts in the field to provide a detailed overview of the physiological and pathophysiological roles of endocannabinoids in CNS activity. It covers the history, functional anatomy, and neurophysiology of the endocannabinoid system, moving on to assess endocannabinoid roles across human lifespans, and in behavioral control.
Final sections of the book explore the use of endocannabinoids in psychiatric and neurological disorders. This is a vital resource for neuroscientists, neuropharmacologists, and neuropathologists, as well as any researcher seeking detailed discussions of brain endocannabinoid functions.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xiii 7. Acknowledgments - p. xv 8. Section 1 History of the endocannabinoid system - p. P1 9. Chapter 1. The day anandamide almost died, and other endocannabinoid stories - p. 3 10. Section 2 Functional anatomy of the endocannabinoid system - p. P2 11. Chapter 2. The endocannabinoid signalosome - p. 21 12. Chapter 3. Endocannabinoid signaling in glial cells - p. 37 13. Chapter 4. Endocannabinoid in nonneuronal cells of the CNS - p. 55 14. Chapter 5. Cannabinoid modulation of brain mitochondria - p. 65 15. Section 3 The neurophysiology of the endocannabinoid system - p. P3 16. Chapter 6. Cellular effects of endocannabinoids in the CNS - p. 89 17. Chapter 7. The endocannabinoid-mediated control of neuronal excitability - p. 103 18. Chapter 8. Potential mechanisms of endocannabinoid release - p. 111 19. Chapter 9. Endocannabinoids in pain modulation - p. 123 20. Chapter 10. Endocannabinoid regulation of hippocampal circuits - p. 143 21. Chapter 11. Endocannabinoids regulation of the mesolimbic system - p. 153 22. Chapter 12. Endocannabinoid regulation of cortical functions - p. 173 23. Chapter 13. The endocannabinoidome and its role in the central and peripheral control of food intake - p. 197 24. Section 4 Endocannabinoids in development and lifetime - p. P4 25. Chapter 14. Roles of eCB in adolescence and sensitive periods - p. 223 26. Chapter 15. Roles of endocannabinoid in aging - p. 231 27. Chapter 16. Epigenetic modulation by the endocannabinoid system in the central nervous system - p. 247 28. Chapter 17. Perinatal cannabinoid exposure - p. 261 29. Section 5 Endocannabinoids and behavioral control - p. P5 30. Chapter 18. Endocannabinoids and sensory processing - p. 275 31. Chapter 19. Endocannabinoids and the neurobiology of emotional states - p. 291 32. Chapter 20. Endocannabinoids and social behavior - p. 311 33. Chapter 21. The complex interplay between stress and the endocannabinoid system in the modulation of memory function - p. 327 34. Section 6 Endocannabinoids in psychiatric disorders - p. P6 35. Chapter 22. Role of the endocannabinoid system in schizophrenia: From preclinical to human evidence - p. 339 36. 1 Schizophrenia - p. 339 37. 2 Cannabis and schizophrenia - p. 340 38. 3 The endocannabinoid system: A brief overview - p. 341 39. 4 The endocannabinoid system in schizophrenia - p. 342 40. 5 Preclinical models resembling schizophrenia-like phenotype - p. 347 41. 6 Pharmacological modulation of the endocannabinoid system: Preclinical and clinical evidence - p. 348 42. 7 Conclusions and future perspective - p. 359 43. Chapter 23. The role of endocannabinoids in nonpharmacological addiction - p. 371 44. Chapter 24. The endocannabinoid system in autism spectrum disorder - p. 389 45. Chapter 25. The endocannabinoid system in intellectual disability - p. 409 46. Section 7 Endocannabinoids in neurological disorders - p. P7 47. Chapter 26. Neurodegeneration and the endocannabinoid system: Toward the development of cannabinoid-based therapies for Parkinson's disease, amyotrophic lateral sclerosis and spinocerebellar ataxias - p. 425 48. Chapter 27. Endocannabinoids and Alzheimer's disease - p. 451 49. Index - p. 471
