Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses.
In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xiii 7. Section I: Overview - p. xv 8. Chapter 1. Epigenetics Overview - p. 3 9. Section II: Molecular Mechanisms of Epigenetics - p. 8 10. Chapter 2. Mechanisms of DNA Methylation and Demethylation During Mammalian Development - p. 11 11. Chapter 3. Mechanisms of Histone Modifications - p. 27 12. Chapter 4. The Epigenetics of Noncoding RNA - p. 55 13. Chapter 5. Prions and prion-like phenomena in epigenetic inheritance - p. 73 14. Chapter 6. Higher-order Chromatin Organization in Diseases, from Chromosomal Position Effect to Phenotype Variegation - p. 89 15. Chapter 7. Polycomb-group proteins and epigenetic control of gene activity - p. 111 16. Section III: Methods in Epigenetics - p. 118 17. Chapter 8. Methods for Analyzing DNA Cytosine Modifications Genome-wide - p. 123 18. Chapter 9. Genome-wide Analyses of Histone Modifications in the Mammalian Genome - p. 137 19. Chapter 10. Techniques for Analyzing Genome-wide Expression of Non-coding RNA - p. 163 20. Chapter 11. Computational Epigenetics: The Competitive Endogenous RNAs Network Analysis - p. 185 21. Section IV: Model Organisms of Epigenetics - p. 196 22. Chapter 12. Epigenetic Mechanisms in Bacteria Bridge Physiology, Growth and Host–Pathogen Interactions - p. 201 23. Drosophila Epigenetics - p. 215 24. Chapter 14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies - p. 249 25. Chapter 15. Plant Epigenomics - p. 263 26. Section V: Factors Influencing Epigenetic Changes - p. 279 27. Chapter 16. Dynamic Changes in Epigenetic Modifications During Mammalian Early Embryo Development - p. 289 28. Chapter 17. Epigenetic Biomarkers - p. 303 29. Chapter 18. Transposable Elements Shaping the Epigenome - p. 323 30. Chapter 19. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications - p. 357 31. Chapter 20. Epigenetics, Stem Cells, Cellular Differentiation, and Associated Neurological Disorders and Brain Cancer - p. 381 32. Chapter 21. Epigenetic Regulation of Skeletal Muscle Regeneration - p. 403 33. Chapter 22. Epigenetics of X-chromosome Inactivation - p. 419 34. Chapter 23. Epigenetics of Memory Processes - p. 443 35. Chapter 24. Transgenerational Epigenetics - p. 465 36. Chapter 25. DNA Methylation Clocks in Age-related Disease - p. 479 37. Section VI: Evolutionary Epigenetics - p. 491 38. Chapter 26. Evolution of Epigenetic Mechanisms in Plants: Insights from H3K4 and H3K27 Methyltransferases - p. 499 39. Chapter 27. Evolution, Functions and Dynamics of Epigenetic Mechanisms in Animals - p. 521 40. Chapter 28. Adaptive evolution and epigenetics - p. 551 41. Section VII: Epigenetic Epidemiology - p. 561 42. Chapter 29. Epigenetics of Livestock Health, Production, and Breeding - p. 569 43. Chapter 30. Nutritional Epigenetics and Fetal Metabolic Programming - p. 611 44. Chapter 31. Epigenetics of Drug Addiction - p. 625 45. Chapter 32. Environmental Influence on Epigenetics - p. 639 46. Chapter 33. Gut Microbiome Influence on Human Epigenetics, Health, and Disease - p. 669 47. Chapter 34. Population Pharmacoepigenomics - p. 687 48. Section VIII: Epigenetics and Human Disease - p. 693 49. Chapter 35. Cancer Epigenetics - p. 697 50. Chapter 36. The Role of Epigenetics in Autoimmune Disorders - p. 715 51. Chapter 37. Epigenetics of Brain Disorders - p. 737 52. Chapter 38. Epigenetics of Metabolic Diseases - p. 761 53. Chapter 39. Imprinting Disorders in Humans - p. 779 54. Section IX: Epigenetic Therapy - p. 787 55. Chapter 40. Clinical Applications of Histone Deacetylase Inhibitors - p. 793 56. Chapter 41. Combination Epigenetic Therapy - p. 821 57. Section X: The Future of Epigenetics - p. 837 58. Chapter 42. New Directions for Epigenetics: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research - p. 843 59. Index - p. 869
Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses.
In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xiii 7. Section I: Overview - p. xv 8. Chapter 1. Epigenetics Overview - p. 3 9. Section II: Molecular Mechanisms of Epigenetics - p. 8 10. Chapter 2. Mechanisms of DNA Methylation and Demethylation During Mammalian Development - p. 11 11. Chapter 3. Mechanisms of Histone Modifications - p. 27 12. Chapter 4. The Epigenetics of Noncoding RNA - p. 55 13. Chapter 5. Prions and prion-like phenomena in epigenetic inheritance - p. 73 14. Chapter 6. Higher-order Chromatin Organization in Diseases, from Chromosomal Position Effect to Phenotype Variegation - p. 89 15. Chapter 7. Polycomb-group proteins and epigenetic control of gene activity - p. 111 16. Section III: Methods in Epigenetics - p. 118 17. Chapter 8. Methods for Analyzing DNA Cytosine Modifications Genome-wide - p. 123 18. Chapter 9. Genome-wide Analyses of Histone Modifications in the Mammalian Genome - p. 137 19. Chapter 10. Techniques for Analyzing Genome-wide Expression of Non-coding RNA - p. 163 20. Chapter 11. Computational Epigenetics: The Competitive Endogenous RNAs Network Analysis - p. 185 21. Section IV: Model Organisms of Epigenetics - p. 196 22. Chapter 12. Epigenetic Mechanisms in Bacteria Bridge Physiology, Growth and Host–Pathogen Interactions - p. 201 23. Drosophila Epigenetics - p. 215 24. Chapter 14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies - p. 249 25. Chapter 15. Plant Epigenomics - p. 263 26. Section V: Factors Influencing Epigenetic Changes - p. 279 27. Chapter 16. Dynamic Changes in Epigenetic Modifications During Mammalian Early Embryo Development - p. 289 28. Chapter 17. Epigenetic Biomarkers - p. 303 29. Chapter 18. Transposable Elements Shaping the Epigenome - p. 323 30. Chapter 19. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications - p. 357 31. Chapter 20. Epigenetics, Stem Cells, Cellular Differentiation, and Associated Neurological Disorders and Brain Cancer - p. 381 32. Chapter 21. Epigenetic Regulation of Skeletal Muscle Regeneration - p. 403 33. Chapter 22. Epigenetics of X-chromosome Inactivation - p. 419 34. Chapter 23. Epigenetics of Memory Processes - p. 443 35. Chapter 24. Transgenerational Epigenetics - p. 465 36. Chapter 25. DNA Methylation Clocks in Age-related Disease - p. 479 37. Section VI: Evolutionary Epigenetics - p. 491 38. Chapter 26. Evolution of Epigenetic Mechanisms in Plants: Insights from H3K4 and H3K27 Methyltransferases - p. 499 39. Chapter 27. Evolution, Functions and Dynamics of Epigenetic Mechanisms in Animals - p. 521 40. Chapter 28. Adaptive evolution and epigenetics - p. 551 41. Section VII: Epigenetic Epidemiology - p. 561 42. Chapter 29. Epigenetics of Livestock Health, Production, and Breeding - p. 569 43. Chapter 30. Nutritional Epigenetics and Fetal Metabolic Programming - p. 611 44. Chapter 31. Epigenetics of Drug Addiction - p. 625 45. Chapter 32. Environmental Influence on Epigenetics - p. 639 46. Chapter 33. Gut Microbiome Influence on Human Epigenetics, Health, and Disease - p. 669 47. Chapter 34. Population Pharmacoepigenomics - p. 687 48. Section VIII: Epigenetics and Human Disease - p. 693 49. Chapter 35. Cancer Epigenetics - p. 697 50. Chapter 36. The Role of Epigenetics in Autoimmune Disorders - p. 715 51. Chapter 37. Epigenetics of Brain Disorders - p. 737 52. Chapter 38. Epigenetics of Metabolic Diseases - p. 761 53. Chapter 39. Imprinting Disorders in Humans - p. 779 54. Section IX: Epigenetic Therapy - p. 787 55. Chapter 40. Clinical Applications of Histone Deacetylase Inhibitors - p. 793 56. Chapter 41. Combination Epigenetic Therapy - p. 821 57. Section X: The Future of Epigenetics - p. 837 58. Chapter 42. New Directions for Epigenetics: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research - p. 843 59. Index - p. 869
