Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.
1. 1 Introduction - p. 1 2. 2 Structure and Function of the Digestive Tract - p. 2 3. 3 Evaluation of Digestive Toxicity - p. 44 4. 4 Response of the Digestive Tract to Injury - p. 75 5. 5 Mechanisms of Digestive Toxicity - p. 112 6. 6 Issues in Drug Development - p. 128 7. 7 Regulatory Issues - p. 133 8. 8 Conclusion - p. 134 9. References - p. 134 10. Chapter 2. Liver and Gall Bladder - p. 149 11. Chapter 3. Bones, Joints, and Teeth - p. 249 12. Chapter 4. Muscle and Tendon - p. 361 13. Chapter 5. Exocrine Pancreas - p. 417 14. Chapter 6. Adipose Tissues - p. 469 15. Chapter 7. Endocrine System - p. 517 16. Abstract - p. 517 17. Acknowledgments - p. 517 18. 1 Introduction - p. 518 19. 2 Adrenal Cortex - p. 518 20. 3 Adrenal Medulla - p. 543 21. 4 Pituitary Gland - p. 551 22. 5 Thyroid C Cells - p. 562 23. 6 Thyroid Follicular Cells - p. 567 24. 7 Parathyroid Gland - p. 586 25. 8 Endocrine Pancreas - p. 596 26. 9 Endocrine Disruption and Endocrine-Disrupting Compounds - p. 606 27. References - p. 620 28. Chapter 8. Nervous System - p. 633 29. Chapter 9. The Eye - p. 739 30. Chapter 10. Ear - p. 833 31. Index - p. 871
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.
1. 1 Introduction - p. 1 2. 2 Structure and Function of the Digestive Tract - p. 2 3. 3 Evaluation of Digestive Toxicity - p. 44 4. 4 Response of the Digestive Tract to Injury - p. 75 5. 5 Mechanisms of Digestive Toxicity - p. 112 6. 6 Issues in Drug Development - p. 128 7. 7 Regulatory Issues - p. 133 8. 8 Conclusion - p. 134 9. References - p. 134 10. Chapter 2. Liver and Gall Bladder - p. 149 11. Chapter 3. Bones, Joints, and Teeth - p. 249 12. Chapter 4. Muscle and Tendon - p. 361 13. Chapter 5. Exocrine Pancreas - p. 417 14. Chapter 6. Adipose Tissues - p. 469 15. Chapter 7. Endocrine System - p. 517 16. Abstract - p. 517 17. Acknowledgments - p. 517 18. 1 Introduction - p. 518 19. 2 Adrenal Cortex - p. 518 20. 3 Adrenal Medulla - p. 543 21. 4 Pituitary Gland - p. 551 22. 5 Thyroid C Cells - p. 562 23. 6 Thyroid Follicular Cells - p. 567 24. 7 Parathyroid Gland - p. 586 25. 8 Endocrine Pancreas - p. 596 26. 9 Endocrine Disruption and Endocrine-Disrupting Compounds - p. 606 27. References - p. 620 28. Chapter 8. Nervous System - p. 633 29. Chapter 9. The Eye - p. 739 30. Chapter 10. Ear - p. 833 31. Index - p. 871
