Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 5 of the Fourth Edition continues coverage of Organ-Specific Toxicologic Pathology and major organ systems not covered in Volume 4. Completely revised, Volume 5 of the Handbook of Toxicologic Pathology is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.
1. 1 Introduction - p. 2 2. Part I: Heart - p. 2 3. 2 Structure and Function - p. 3 4. 3 Evaluation of Toxicity - p. 11 5. 4 Responses to Injury - p. 25 6. 5 Mechanisms of Toxicity - p. 50 7. 6 Cardiotoxicity Issues in Drug Development - p. 57 8. Part II: Blood Vessels - p. 59 9. 7 Structure and Function - p. 60 10. 8 Evaluation of Toxicity: Vasotoxic Effects - p. 66 11. 9 Responses to Injury - p. 73 12. 10 Vascular Toxicity in Specific Organs - p. 79 13. 11 Conclusion - p. 81 14. Chapter 2. Kidney - p. 87 15. 1 Introduction - p. 87 16. 2 Structure, Function, and Cell Biology - p. 89 17. 3 Evaluation of Toxicity - p. 113 18. 4 Responses to Injury - p. 147 19. 5 Mechanisms of Toxicity - p. 157 20. 6 Issues in Drug Development - p. 199 21. 7 Conclusion - p. 206 22. Chapter 3. Lower Urinary Tract - p. 213 23. Chapter 4. Respiratory System - p. 235 24. 1 Introduction - p. 235 25. 2 Structure, Function, and Cell Biology - p. 237 26. 3 Testing for Toxicity - p. 261 27. 4 Responses to Injury - p. 287 28. 5 Mechanisms of Toxicity - p. 316 29. 6 Conclusion - p. 328 30. Chapter 5. Hematopoietic System - p. 337 31. 1 Introduction - p. 337 32. 2 Phylogenesis and Ontogenesis - p. 339 33. 3 Structure, Function, and Cell Biology - p. 345 34. 4 Evaluation of Hematotoxicity - p. 360 35. 5 Responses to Injury - p. 372 36. 6 Mechanisms of Hematotoxicity - p. 392 37. 7 Issues in Drug Development and Regulatory Considerations - p. 418 38. 8 Conclusion - p. 421 39. Glossary - p. 421 40. Chapter 6. Immune System - p. 437 41. 1 Introduction and Background - p. 437 42. 2 Function - p. 438 43. 3 Development, Structure, and Physiology - p. 444 44. 4 Physiological Influences on the Immune System Throughout the Lifespan - p. 463 45. 5 Immunomodulation, Immune Systems Responses, and Mechanisms of Toxicity - p. 466 46. 6 Evaluation of Changes and Toxicity - p. 476 47. 7 Responses to Injury - p. 490 48. 8 Preneoplastic Changes and Neoplasia - p. 495 49. 9 Best Practices and Regulatory Considerations on Evaluation of Toxicity and Adversity in the Immune System - p. 497 50. 10 Conclusion - p. 499 51. Chapter 7. Integument - p. 505 52. 1 Introduction - p. 505 53. 2 Structure and Function - p. 506 54. 3 Evaluation of Toxicity - p. 523 55. 4 Responses to Injury - p. 536 56. 5 Mechanisms of Toxicity - p. 559 57. 6 Conclusion - p. 576 58. Chapter 8. Mammary Gland - p. 583 59. Chapter 9. Male Reproductive System - p. 635 60. 1 Introduction - p. 635 61. 2 Structure, Function, and Cell Biology - p. 636 62. 3 Evaluation of Toxicity - p. 665 63. 4 Response to Injury - p. 680 64. 5 Mechanisms and Patterns of Toxicity - p. 708 65. 6 Conclusion - p. 727 66. Chapter 10. Female Reproductive System - p. 743 67. 1 Introduction - p. 743 68. 2 Structure, Function, and Cell Biology - p. 746 69. 3 Evaluation of Female Reproductive System Toxicity - p. 775 70. 4 Responses to Injury - p. 779 71. 5 Mechanisms of Toxicity in the Female Reproductive System - p. 783 72. 6 Carcinogenesis in the Female Reproductive System - p. 797 73. 7 Conclusion - p. 810 74. Chapter 11. Embryo, Fetus, and Placenta - p. 819 75. 1 Introduction - p. 819 76. 2 Fundamentals of Developmental Toxicologic Pathology - p. 821 77. 3 Structure, Function, and Cell Biology—Embryo and Fetus - p. 823 78. 4 Structure, Function, and Cell Biology—Placenta - p. 833 79. 5 Evaluation of Toxicity - p. 838 80. 6 Responses to Injury - p. 847 81. 7 Mechanisms of Developmental Toxicity - p. 876 82. 8 Developmental Toxicity Issues in Product Development - p. 883 83. 9 Regulatory Considerations - p. 902 84. 10 Conclusion - p. 904 85. Glossary - p. 905 86. Index - p. 919
Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 5 of the Fourth Edition continues coverage of Organ-Specific Toxicologic Pathology and major organ systems not covered in Volume 4. Completely revised, Volume 5 of the Handbook of Toxicologic Pathology is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.
1. 1 Introduction - p. 2 2. Part I: Heart - p. 2 3. 2 Structure and Function - p. 3 4. 3 Evaluation of Toxicity - p. 11 5. 4 Responses to Injury - p. 25 6. 5 Mechanisms of Toxicity - p. 50 7. 6 Cardiotoxicity Issues in Drug Development - p. 57 8. Part II: Blood Vessels - p. 59 9. 7 Structure and Function - p. 60 10. 8 Evaluation of Toxicity: Vasotoxic Effects - p. 66 11. 9 Responses to Injury - p. 73 12. 10 Vascular Toxicity in Specific Organs - p. 79 13. 11 Conclusion - p. 81 14. Chapter 2. Kidney - p. 87 15. 1 Introduction - p. 87 16. 2 Structure, Function, and Cell Biology - p. 89 17. 3 Evaluation of Toxicity - p. 113 18. 4 Responses to Injury - p. 147 19. 5 Mechanisms of Toxicity - p. 157 20. 6 Issues in Drug Development - p. 199 21. 7 Conclusion - p. 206 22. Chapter 3. Lower Urinary Tract - p. 213 23. Chapter 4. Respiratory System - p. 235 24. 1 Introduction - p. 235 25. 2 Structure, Function, and Cell Biology - p. 237 26. 3 Testing for Toxicity - p. 261 27. 4 Responses to Injury - p. 287 28. 5 Mechanisms of Toxicity - p. 316 29. 6 Conclusion - p. 328 30. Chapter 5. Hematopoietic System - p. 337 31. 1 Introduction - p. 337 32. 2 Phylogenesis and Ontogenesis - p. 339 33. 3 Structure, Function, and Cell Biology - p. 345 34. 4 Evaluation of Hematotoxicity - p. 360 35. 5 Responses to Injury - p. 372 36. 6 Mechanisms of Hematotoxicity - p. 392 37. 7 Issues in Drug Development and Regulatory Considerations - p. 418 38. 8 Conclusion - p. 421 39. Glossary - p. 421 40. Chapter 6. Immune System - p. 437 41. 1 Introduction and Background - p. 437 42. 2 Function - p. 438 43. 3 Development, Structure, and Physiology - p. 444 44. 4 Physiological Influences on the Immune System Throughout the Lifespan - p. 463 45. 5 Immunomodulation, Immune Systems Responses, and Mechanisms of Toxicity - p. 466 46. 6 Evaluation of Changes and Toxicity - p. 476 47. 7 Responses to Injury - p. 490 48. 8 Preneoplastic Changes and Neoplasia - p. 495 49. 9 Best Practices and Regulatory Considerations on Evaluation of Toxicity and Adversity in the Immune System - p. 497 50. 10 Conclusion - p. 499 51. Chapter 7. Integument - p. 505 52. 1 Introduction - p. 505 53. 2 Structure and Function - p. 506 54. 3 Evaluation of Toxicity - p. 523 55. 4 Responses to Injury - p. 536 56. 5 Mechanisms of Toxicity - p. 559 57. 6 Conclusion - p. 576 58. Chapter 8. Mammary Gland - p. 583 59. Chapter 9. Male Reproductive System - p. 635 60. 1 Introduction - p. 635 61. 2 Structure, Function, and Cell Biology - p. 636 62. 3 Evaluation of Toxicity - p. 665 63. 4 Response to Injury - p. 680 64. 5 Mechanisms and Patterns of Toxicity - p. 708 65. 6 Conclusion - p. 727 66. Chapter 10. Female Reproductive System - p. 743 67. 1 Introduction - p. 743 68. 2 Structure, Function, and Cell Biology - p. 746 69. 3 Evaluation of Female Reproductive System Toxicity - p. 775 70. 4 Responses to Injury - p. 779 71. 5 Mechanisms of Toxicity in the Female Reproductive System - p. 783 72. 6 Carcinogenesis in the Female Reproductive System - p. 797 73. 7 Conclusion - p. 810 74. Chapter 11. Embryo, Fetus, and Placenta - p. 819 75. 1 Introduction - p. 819 76. 2 Fundamentals of Developmental Toxicologic Pathology - p. 821 77. 3 Structure, Function, and Cell Biology—Embryo and Fetus - p. 823 78. 4 Structure, Function, and Cell Biology—Placenta - p. 833 79. 5 Evaluation of Toxicity - p. 838 80. 6 Responses to Injury - p. 847 81. 7 Mechanisms of Developmental Toxicity - p. 876 82. 8 Developmental Toxicity Issues in Product Development - p. 883 83. 9 Regulatory Considerations - p. 902 84. 10 Conclusion - p. 904 85. Glossary - p. 905 86. Index - p. 919
