Heart Failure in the Child and Young Adult: From Bench to Bedside, Second Edition highlights unique aspects of heart failure in the young. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure and then progresses through diagnosis, management, treatment, and surgery, finally concluding with advanced special topics, including genetics, self-management, and nanomedicine.
This new edition covers advancements in the field, including additional chapters and discussion on biomarkers, neuromuscular disease, quality of life, palliative care, and the impact of COVID-19 in myocarditis and multisystem inflammatory syndrome in children. It will serve as an indispensable reference to basic science researchers in cardiology, pediatrics, cardiologists, and pediatric cardiologists.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. ix 7. Section I. Basic science of heart failure - p. S1 8. Chapter 1. From molecular and cellular mechanisms to models of heart failure - p. 3 9. Chapter 2. Cardiovascular receptors and signaling in heart failure - p. 23 10. Chapter 3. Heart failure in the child and young adult: From bench to bedside: Inflammatory mediators in heart failure - p. 37 11. Chapter 4. Transcriptional regulation, epigenetic regulation, and transcriptomics of pediatric heart failure - p. 59 12. Chapter 5. Mechanisms of hypertrophy in heart failure - p. 75 13. Chapter 6. Hemodynamic adaptive mechanisms in heart failure - p. 85 14. Chapter 7. Neurohormonal axis and natriuretic peptides in heart failure - p. 103 15. Chapter 8. Novel biomarkers in heart failure - p. 117 16. Chapter 9. Systolic and diastolic function - p. 137 17. Chapter 10. Echocardiographic quantitation of ventricular function - p. 147 18. Chapter 11. MRI assessment of heart failure - p. 171 19. Chapter 12. Assessment of heart failure by invasive methods - p. 183 20. Chapter 13. The lymphatic system in heart failure - p. 199 21. Chapter 14. Endothelial dysfunction in heart failure in the child and young adult - p. 211 22. Section II. Clinical diagnosis and management of pediatric heart failure - p. S2 23. Chapter 15. Epidemiology and economics of pediatric heart failure - p. 223 24. Chapter 16. Clinical recognition of heart failure in children - p. 231 25. Chapter 17. Classification of pediatric heart failure - p. 237 26. Chapter 18. Right ventricular dysfunction - p. 247 27. Chapter 19. Pediatric myocarditis - p. 255 28. Chapter 20. Dilated cardiomyopathy - p. 285 29. Chapter 21. Clinical features of restrictive cardiomyopathy and constrictive pericarditis - p. 299 30. Chapter 22. Hypertrophic cardiomyopathy - p. 321 31. Chapter 23. Left ventricular noncompaction cardiomyopathy - p. 355 32. Chapter 24. Arrhythmogenic cardiomyopathies - p. 375 33. Chapter 25. Valvular insufficiency and heart failure - p. 387 34. Chapter 26. Valvular stenosis and heart failure - p. 397 35. Chapter 27. Coronary artery disease in children and young adults - p. 407 36. Chapter 28. Chronic heart failure in congenital heart disease including single ventricle circulation - p. 413 37. Chapter 29. Heart failure in adults with congenital heart disease - p. 421 38. Chapter 30. Dysrhythmias and ventricular dysfunction and heart failure - p. 447 39. Chapter 31. Fetal heart failure - p. 465 40. Chapter 32. Heart failure in the neonate - p. 481 41. Chapter 33. Heart failure in pediatric pulmonary diseases - p. 499 42. Chapter 34. Pediatric cardiorenal syndrome - p. 519 43. Chapter 35. Heart failure in pediatric oncologic disease - p. 531 44. Chapter 36. Neuromuscular disorders - p. 547 45. Chapter 37. Sickle cell disease - p. 569 46. Chapter 38. The cardiovascular system in systemic inflammatory syndromes - p. 577 47. Chapter 39. Outpatient management of pediatric heart failure - p. 593 48. Chapter 40. Cardiac intensive care and inpatient management of heart failure - p. 611 49. Chapter 41. Quality of life, neurodevelopmental and psychosocial outcomes in pediatric heart failure - p. 619 50. Chapter 42. Palliative care - p. 631 51. Chapter 43. Quality metrics and quality improvement in pediatric heart failure - p. 643 52. Chapter 44. Nursing aspects of heart failure - p. 651 53. Section III. Medical treatment for pediatric heart failure - p. S3 54. Chapter 45. Diuretic and invasive fluid management strategies - p. 665 55. Chapter 46. Inotropic agents in heart failure - p. 681 56. Chapter 47. Phosphodiesterase inhibitors - p. 691 57. Chapter 48. Use of vasodilators in heart failure - p. 699 58. Chapter 49. Recognition and treatment of low cardiac output states in pediatric cardiac intensive care - p. 717 59. Chapter 50. New therapeutic strategies for heart failure - p. 743 60. Chapter 51. Electrophysiologic devices in heart failure - p. 751 61. Chapter 52. Catheter device therapies for heart failure - p. 761 62. Section IV. Cardiac surgery and pediatric heart failure - p. S4 63. Chapter 53. Posttransplant heart failure - p. 795 64. Chapter 54. Surgical strategies for the failing single ventricle - p. 811 65. Chapter 55. Valve interventions for heart failure - p. 835 66. Chapter 56. Principles of mechanical cardiopulmonary support - p. 871 67. Chapter 57. Future of mechanical circulatory support devices in children and young adults - p. 879 68. Chapter 58. Short-term mechanical cardiopulmonary support devices - p. 887 69. Chapter 59. Decision-making in ventricular assist device support in pediatric advanced heart failure patients - p. 899 70. Chapter 60. Long-term ventricular assist devices in children - p. 909 71. Section V. Special topics - p. S5 72. Chapter 61. Genetics and genomics - p. 923 73. Chapter 62. Genetic testing - p. 931 74. Chapter 63. Big data and artificial intelligence in pediatric heart failure - p. 937 75. Chapter 64. Outpatient monitoring and self-care - p. 949 76. Chapter 65. Cardiac regenerative medicine for congenital heart defects - p. 969 77. Chapter 66. Development of digital twin models for heart failure patient treatment - p. 979 78. Chapter 67. Nutritional assessment and management in pediatric heart failure - p. 985 79. Chapter 68. The role of wearable technology in improving the care of pediatric heart failure - p. 991 80. Index - p. 1001
Heart Failure in the Child and Young Adult: From Bench to Bedside, Second Edition highlights unique aspects of heart failure in the young. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure and then progresses through diagnosis, management, treatment, and surgery, finally concluding with advanced special topics, including genetics, self-management, and nanomedicine.
This new edition covers advancements in the field, including additional chapters and discussion on biomarkers, neuromuscular disease, quality of life, palliative care, and the impact of COVID-19 in myocarditis and multisystem inflammatory syndrome in children. It will serve as an indispensable reference to basic science researchers in cardiology, pediatrics, cardiologists, and pediatric cardiologists.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. ix 7. Section I. Basic science of heart failure - p. S1 8. Chapter 1. From molecular and cellular mechanisms to models of heart failure - p. 3 9. Chapter 2. Cardiovascular receptors and signaling in heart failure - p. 23 10. Chapter 3. Heart failure in the child and young adult: From bench to bedside: Inflammatory mediators in heart failure - p. 37 11. Chapter 4. Transcriptional regulation, epigenetic regulation, and transcriptomics of pediatric heart failure - p. 59 12. Chapter 5. Mechanisms of hypertrophy in heart failure - p. 75 13. Chapter 6. Hemodynamic adaptive mechanisms in heart failure - p. 85 14. Chapter 7. Neurohormonal axis and natriuretic peptides in heart failure - p. 103 15. Chapter 8. Novel biomarkers in heart failure - p. 117 16. Chapter 9. Systolic and diastolic function - p. 137 17. Chapter 10. Echocardiographic quantitation of ventricular function - p. 147 18. Chapter 11. MRI assessment of heart failure - p. 171 19. Chapter 12. Assessment of heart failure by invasive methods - p. 183 20. Chapter 13. The lymphatic system in heart failure - p. 199 21. Chapter 14. Endothelial dysfunction in heart failure in the child and young adult - p. 211 22. Section II. Clinical diagnosis and management of pediatric heart failure - p. S2 23. Chapter 15. Epidemiology and economics of pediatric heart failure - p. 223 24. Chapter 16. Clinical recognition of heart failure in children - p. 231 25. Chapter 17. Classification of pediatric heart failure - p. 237 26. Chapter 18. Right ventricular dysfunction - p. 247 27. Chapter 19. Pediatric myocarditis - p. 255 28. Chapter 20. Dilated cardiomyopathy - p. 285 29. Chapter 21. Clinical features of restrictive cardiomyopathy and constrictive pericarditis - p. 299 30. Chapter 22. Hypertrophic cardiomyopathy - p. 321 31. Chapter 23. Left ventricular noncompaction cardiomyopathy - p. 355 32. Chapter 24. Arrhythmogenic cardiomyopathies - p. 375 33. Chapter 25. Valvular insufficiency and heart failure - p. 387 34. Chapter 26. Valvular stenosis and heart failure - p. 397 35. Chapter 27. Coronary artery disease in children and young adults - p. 407 36. Chapter 28. Chronic heart failure in congenital heart disease including single ventricle circulation - p. 413 37. Chapter 29. Heart failure in adults with congenital heart disease - p. 421 38. Chapter 30. Dysrhythmias and ventricular dysfunction and heart failure - p. 447 39. Chapter 31. Fetal heart failure - p. 465 40. Chapter 32. Heart failure in the neonate - p. 481 41. Chapter 33. Heart failure in pediatric pulmonary diseases - p. 499 42. Chapter 34. Pediatric cardiorenal syndrome - p. 519 43. Chapter 35. Heart failure in pediatric oncologic disease - p. 531 44. Chapter 36. Neuromuscular disorders - p. 547 45. Chapter 37. Sickle cell disease - p. 569 46. Chapter 38. The cardiovascular system in systemic inflammatory syndromes - p. 577 47. Chapter 39. Outpatient management of pediatric heart failure - p. 593 48. Chapter 40. Cardiac intensive care and inpatient management of heart failure - p. 611 49. Chapter 41. Quality of life, neurodevelopmental and psychosocial outcomes in pediatric heart failure - p. 619 50. Chapter 42. Palliative care - p. 631 51. Chapter 43. Quality metrics and quality improvement in pediatric heart failure - p. 643 52. Chapter 44. Nursing aspects of heart failure - p. 651 53. Section III. Medical treatment for pediatric heart failure - p. S3 54. Chapter 45. Diuretic and invasive fluid management strategies - p. 665 55. Chapter 46. Inotropic agents in heart failure - p. 681 56. Chapter 47. Phosphodiesterase inhibitors - p. 691 57. Chapter 48. Use of vasodilators in heart failure - p. 699 58. Chapter 49. Recognition and treatment of low cardiac output states in pediatric cardiac intensive care - p. 717 59. Chapter 50. New therapeutic strategies for heart failure - p. 743 60. Chapter 51. Electrophysiologic devices in heart failure - p. 751 61. Chapter 52. Catheter device therapies for heart failure - p. 761 62. Section IV. Cardiac surgery and pediatric heart failure - p. S4 63. Chapter 53. Posttransplant heart failure - p. 795 64. Chapter 54. Surgical strategies for the failing single ventricle - p. 811 65. Chapter 55. Valve interventions for heart failure - p. 835 66. Chapter 56. Principles of mechanical cardiopulmonary support - p. 871 67. Chapter 57. Future of mechanical circulatory support devices in children and young adults - p. 879 68. Chapter 58. Short-term mechanical cardiopulmonary support devices - p. 887 69. Chapter 59. Decision-making in ventricular assist device support in pediatric advanced heart failure patients - p. 899 70. Chapter 60. Long-term ventricular assist devices in children - p. 909 71. Section V. Special topics - p. S5 72. Chapter 61. Genetics and genomics - p. 923 73. Chapter 62. Genetic testing - p. 931 74. Chapter 63. Big data and artificial intelligence in pediatric heart failure - p. 937 75. Chapter 64. Outpatient monitoring and self-care - p. 949 76. Chapter 65. Cardiac regenerative medicine for congenital heart defects - p. 969 77. Chapter 66. Development of digital twin models for heart failure patient treatment - p. 979 78. Chapter 67. Nutritional assessment and management in pediatric heart failure - p. 985 79. Chapter 68. The role of wearable technology in improving the care of pediatric heart failure - p. 991 80. Index - p. 1001
