Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike.
1. INTRODUCTION - p. 65 2. BIOLOGICAL AND TECHNOLOGIC ISSUES - p. 65 3. LYMPHOID NEOPLASMS - p. 77 4. MYELOID NEOPLASMS - p. 91 5. POTENTIAL PITFALLS OF MOLECULAR TESTING - p. 105 6. SUMMARY AND CONCLUSIONS - p. 107 7. Acknowledgments - p. 107 8. Pearls and Pitfalls - p. 107 9. Chapter 6. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them - p. 108 10. TYPES OF CHROMOSOMAL ABERRATIONS IN HEMATOLOGIC MALIGNANCIES - p. 108 11. CONVENTIONAL CYTOGENETIC METHODS - p. 111 12. MOLECULAR CYTOGENETIC METHODS - p. 112 13. CLINICAL RELEVANCE OF CHROMOSOMAL ABNORMALITIES IN HEMATOLOGIC MALIGNANCIES - p. 118 14. CONCLUSION - p. 132 15. Pearls and Pitfalls - p. 132 16. Acknowledgments - p. 132 17. Part II. Normal and Reactive Conditions of Hematopoietic Tissues - p. 133 18. Chapter 7. Normal Lymphoid Organs and Tissues - p. 135 19. Chapter 8. Reactive Lymphadenopathies - p. 159 20. Chapter 9. The Normal Bone Marrow - p. 185 21. Chapter 10. Evaluation of Anemia, Leukopenia, and Thrombocytopenia - p. 205 22. EVALUATION OF ANEMIA - p. 205 23. EVALUATION OF LEUKOPENIA - p. 228 24. EVALUATION OF THROMBOCYTOPENIA - p. 237 25. EVALUATION OF SPECIFIC BONE MARROW FAILURE SYNDROMES - p. 245 26. Pearls and Pitfalls - p. 249 27. Chapter 11. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders - p. 250 28. Part III. Lymphoid Neoplasms - p. 267 29. Chapter 12. Principles of Classification of Lymphoid Neoplasms - p. 269 30. Section 1. MATURE B-CELL NEOPLASMS - p. 279.e3 31. Chapter 13. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia - p. 280 32. Chapter 14. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia - p. 310 33. Chapter 15. Hairy Cell Leukemia - p. 327 34. Chapter 16. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen - p. 338 35. Chapter 17. Follicular Lymphoma - p. 352 36. Chapter 18. Extranodal Marginal Zone Lymphoma: MALT Lymphoma - p. 383 37. Chapter 19. Primary Cutaneous B-Cell Lymphomas - p. 399 38. Chapter 20. Nodal Marginal Zone Lymphoma - p. 412 39. Chapter 21. Mantle Cell Lymphoma - p. 427 40. Chapter 22. Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas - p. 446 41. INTRODUCTION - p. 446 42. DEFINITIONS, SYNONYMS, AND TERMS - p. 446 43. DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED - p. 446 44. T-CELL/HISTIOCYTE–RICH LARGE B-CELL LYMPHOMA - p. 468 45. PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA - p. 472 46. INTRAVASCULAR LARGE B-CELL LYMPHOMA - p. 476 47. Pearls and Pitfalls - p. 479 48. Chapter 23. Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements - p. 482 49. Chapter 24. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma - p. 499 50. Chapter 25. Plasma Cell Neoplasms - p. 507 51. Classification Of Plasma Cell Neoplasms - p. 507 52. Pathogenesis of Plasma Cell Neoplasms - p. 507 53. Multiple Myeloma - p. 509 54. Monoclonal Gammopathy Of Undetermined Significance - p. 527 55. Plasmacytoma - p. 530 56. Immunoglobulin Deposition Diseases - p. 534 57. Plasma Cell Neoplasms With Associated Paraneoplastic Syndrome - p. 539 58. Pearls and Pitfalls - p. 542 59. Chapter 26. Nodular Lymphocyte-Predominant B-Cell Lymphoma - p. 544 60. Chapter 27. Classic Hodgkin Lymphoma - p. 563 61. Chapter 28. Virally Associated B-Cell Lymphoproliferative Disease - p. 585 62. Section 2. MATURE T-CELL AND NK-CELL NEOPLASMS - p. 608.e8 63. Chapter 29. Epstein-Barr Virus–Associated T-Cell and Natural Killer–Cell Lymphoproliferative Disorders - p. 610 64. INTRODUCTION - p. 610 65. Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis - p. 611 66. Chronic Active Epstein-Barr Virus Disease - p. 613 67. Severe Mosquito Bite Allergy - p. 616 68. Hydroa Vacciniforme Lymphoproliferative Disorder - p. 618 69. Systemic Epstein-Barr Virus–Positive T-Cell Lymphoma of Childhood - p. 620 70. Extranodal NK/T-Cell Lymphoma, Nasal Type - p. 624 71. Extranasal NK/T-Cell Lymphoma - p. 625 72. Aggressive Nk-Cell Leukemia - p. 634 73. Primary Nodal Epstein-Barr Virus–Positive T/Nk-Cell Lymphoma - p. 640 74. Pearls and Pitfalls - p. 642 75. Chapter 30. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations - p. 644 76. Chapter 31. T-Cell Prolymphocytic Leukemia - p. 655 77. Chapter 32. Adult T-Cell Leukemia/Lymphoma - p. 663 78. Chapter 33. Hepatosplenic T-Cell Lymphoma - p. 675 79. Chapter 34. Peripheral T-Cell Lymphoma, Not Otherwise Specified - p. 685 80. Chapter 35. Follicular Helper T-Cell Lymphoma - p. 701 81. Chapter 36. Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative - p. 716 82. Chapter 37. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas - p. 736 83. Chapter 38. Mycosis Fungoides and Sézary Syndrome - p. 758 84. Chapter 39. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders - p. 776 85. Chapter 40. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes - p. 792 86. Section 3. PRECURSOR B-AND T-CELL NEOPLASMS - p. 805.e4 87. Chapter 41. Precursor B-Cell and T-Cell Neoplasms - p. 806 88. Chapter 42. Acute Leukemias of Ambiguous Lineage - p. 821 89. Part IV. Myeloid, Histiocytic, and Related Proliferations - p. 829 90. Chapter 43. Principles of Classification of Myeloid Neoplasms - p. 831 91. Chapter 44. The Myelodysplastic Syndromes - p. 840 92. Incidence - p. 840 93. Synonyms and Related Terms - p. 840 94. Clinical Features - p. 840 95. Laboratory Features - p. 841 96. Diagnosis - p. 849 97. Classification - p. 850 98. Differential Diagnosis - p. 860 99. Etiology and Pathogenesis - p. 865 100. Conclusion - p. 865 101. Pearls and Pitfalls - p. 866 102. Chapter 45. Myeloid and Hematologic Neoplasms With Germline Predisposition - p. 867 103. Chapter 46. Acute Myeloid Leukemia - p. 889 104. Chapter 47. Myeloproliferative Neoplasms - p. 916 105. Introduction - p. 916 106. Etiology and Pathogenesis - p. 917 107. Chronic Myeloid Leukemia (CML) - p. 920 108. Chronic Neutrophilic Leukemia (CNL) - p. 929 109. Classic Bcr::Abl1-Negative Myeloproliferative Neoplasms - p. 932 110. Essential Thrombocythemia (ET) - p. 933 111. Primary Myelofibrosis (PMF) - p. 938 112. Polycythemia Vera - p. 944 113. Chronic Eosinophilic Leukemia, Not Otherwise Specified (CEL, NOS) - p. 950 114. Myeloproliferative Neoplasms, Unclassifiable (MPN-U) - p. 951 115. Conclusion - p. 951 116. Acknowledgments - p. 952 117. Pearls and Pitfalls - p. 952 118. Chapter 48. Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions - p. 953 119. Chapter 49. Mastocytosis - p. 975 120. Chapter 50. Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions - p. 999 121. Chapter 51. Blastic Plasmacytoid Dendritic Cell Neoplasm - p. 1022 122. Chapter 52. Histiocytic and Dendritic Cell Proliferations—Systemic and Neoplastic - p. 1034 123. Non-Neoplastic Histiocytic Disorders - p. 1034 124. Histiocytic and Dendritic Cell Neoplasms - p. 1048 125. Acknowledgment - p. 1081 126. Pearls and Pitfalls - p. 1081 127. Part V. Immunodeficiency Disorders - p. 1083 128. Chapter 53. The Pathology of Primary Immunodeficiencies - p. 1085 129. Chapter 54. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders - p. 1104 130. Part VI. Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia - p. 1123 131. Chapter 55. Bone Marrow Evaluation for Lymphoma - p. 1125 132. Chapter 56. Evaluation of the Bone Marrow After Therapy - p. 1158 133. Effects of Selected Therapies and Bone Marrow Transplantation - p. 1159 134. Acute Leukemia or Myelodysplastic Syndrome - p. 1163 135. Chronic Myeloid Leukemia - p. 1171 136. BCR::ABL1-Negative Myeloproliferative Neoplasms - p. 1175 137. Chronic Lymphoproliferative and Plasma Cell Disorders - p. 1177 138. Other Bone Marrow Changes after Therapy - p. 1181 139. Pearls and Pitfalls - p. 1186 140. Chapter 57. Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes - p. 1188 141. Chapter 58. Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions - p. 1210 142. Chapter 59. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin - p. 1228 143. Lymphomas of Immune-Privileged Sites - p. 1228 144. Lymphoma of The Nervous System and Meninges - p. 1228 145. Ocular Adnexal Lymphoma - p. 1233 146. Lymphomas of Waldeyer’s Ring - p. 1235 147. Lymphomas of The Nasal Cavity and Paranasal Sinuses - p. 1236 148. Salivary Gland Lymphomas - p. 1237 149. Lymphomas of The Oral Cavity - p. 1238 150. Thyroid Lymphomas - p. 1239 151. Laryngeal Lymphomas - p. 1240 152. Pulmonary Lymphomas - p. 1241 153. Lymphomas of The Pleura and Pleural Cavity - p. 1242 154. Lymphomas of The Thymus - p. 1242 155. Cardiac Lymphomas - p. 1242 156. Lymphomas of The Breast - p. 1243 157. Gastrointestinal Lymphomas - p. 1246 158. Gastric Lymphoma - p. 1246 159. Small and Large Intestinal Lymphomas - p. 1247 160. Lymphomas of The Liver and Pancreatobiliary Tract - p. 1248 161. Adrenal Lymphomas - p. 1249 162. Urinary Tract Lymphomas - p. 1249 163. Male Genital Tract Lymphomas - p. 1251 164. Lymphomas of The Female Genital Tract - p. 1253 165. Lymphomas of Bone - p. 1255 166. Pearls and Pitfalls - p. 1257 167. Appendix A. The International Consensus Classification of Myeloid, Lymphoid, and Histiocytic Neoplasms - p. 1258 168. Index - p. 1261
Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike.
1. INTRODUCTION - p. 65 2. BIOLOGICAL AND TECHNOLOGIC ISSUES - p. 65 3. LYMPHOID NEOPLASMS - p. 77 4. MYELOID NEOPLASMS - p. 91 5. POTENTIAL PITFALLS OF MOLECULAR TESTING - p. 105 6. SUMMARY AND CONCLUSIONS - p. 107 7. Acknowledgments - p. 107 8. Pearls and Pitfalls - p. 107 9. Chapter 6. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them - p. 108 10. TYPES OF CHROMOSOMAL ABERRATIONS IN HEMATOLOGIC MALIGNANCIES - p. 108 11. CONVENTIONAL CYTOGENETIC METHODS - p. 111 12. MOLECULAR CYTOGENETIC METHODS - p. 112 13. CLINICAL RELEVANCE OF CHROMOSOMAL ABNORMALITIES IN HEMATOLOGIC MALIGNANCIES - p. 118 14. CONCLUSION - p. 132 15. Pearls and Pitfalls - p. 132 16. Acknowledgments - p. 132 17. Part II. Normal and Reactive Conditions of Hematopoietic Tissues - p. 133 18. Chapter 7. Normal Lymphoid Organs and Tissues - p. 135 19. Chapter 8. Reactive Lymphadenopathies - p. 159 20. Chapter 9. The Normal Bone Marrow - p. 185 21. Chapter 10. Evaluation of Anemia, Leukopenia, and Thrombocytopenia - p. 205 22. EVALUATION OF ANEMIA - p. 205 23. EVALUATION OF LEUKOPENIA - p. 228 24. EVALUATION OF THROMBOCYTOPENIA - p. 237 25. EVALUATION OF SPECIFIC BONE MARROW FAILURE SYNDROMES - p. 245 26. Pearls and Pitfalls - p. 249 27. Chapter 11. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders - p. 250 28. Part III. Lymphoid Neoplasms - p. 267 29. Chapter 12. Principles of Classification of Lymphoid Neoplasms - p. 269 30. Section 1. MATURE B-CELL NEOPLASMS - p. 279.e3 31. Chapter 13. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia - p. 280 32. Chapter 14. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia - p. 310 33. Chapter 15. Hairy Cell Leukemia - p. 327 34. Chapter 16. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen - p. 338 35. Chapter 17. Follicular Lymphoma - p. 352 36. Chapter 18. Extranodal Marginal Zone Lymphoma: MALT Lymphoma - p. 383 37. Chapter 19. Primary Cutaneous B-Cell Lymphomas - p. 399 38. Chapter 20. Nodal Marginal Zone Lymphoma - p. 412 39. Chapter 21. Mantle Cell Lymphoma - p. 427 40. Chapter 22. Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas - p. 446 41. INTRODUCTION - p. 446 42. DEFINITIONS, SYNONYMS, AND TERMS - p. 446 43. DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED - p. 446 44. T-CELL/HISTIOCYTE–RICH LARGE B-CELL LYMPHOMA - p. 468 45. PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA - p. 472 46. INTRAVASCULAR LARGE B-CELL LYMPHOMA - p. 476 47. Pearls and Pitfalls - p. 479 48. Chapter 23. Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements - p. 482 49. Chapter 24. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma - p. 499 50. Chapter 25. Plasma Cell Neoplasms - p. 507 51. Classification Of Plasma Cell Neoplasms - p. 507 52. Pathogenesis of Plasma Cell Neoplasms - p. 507 53. Multiple Myeloma - p. 509 54. Monoclonal Gammopathy Of Undetermined Significance - p. 527 55. Plasmacytoma - p. 530 56. Immunoglobulin Deposition Diseases - p. 534 57. Plasma Cell Neoplasms With Associated Paraneoplastic Syndrome - p. 539 58. Pearls and Pitfalls - p. 542 59. Chapter 26. Nodular Lymphocyte-Predominant B-Cell Lymphoma - p. 544 60. Chapter 27. Classic Hodgkin Lymphoma - p. 563 61. Chapter 28. Virally Associated B-Cell Lymphoproliferative Disease - p. 585 62. Section 2. MATURE T-CELL AND NK-CELL NEOPLASMS - p. 608.e8 63. Chapter 29. Epstein-Barr Virus–Associated T-Cell and Natural Killer–Cell Lymphoproliferative Disorders - p. 610 64. INTRODUCTION - p. 610 65. Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis - p. 611 66. Chronic Active Epstein-Barr Virus Disease - p. 613 67. Severe Mosquito Bite Allergy - p. 616 68. Hydroa Vacciniforme Lymphoproliferative Disorder - p. 618 69. Systemic Epstein-Barr Virus–Positive T-Cell Lymphoma of Childhood - p. 620 70. Extranodal NK/T-Cell Lymphoma, Nasal Type - p. 624 71. Extranasal NK/T-Cell Lymphoma - p. 625 72. Aggressive Nk-Cell Leukemia - p. 634 73. Primary Nodal Epstein-Barr Virus–Positive T/Nk-Cell Lymphoma - p. 640 74. Pearls and Pitfalls - p. 642 75. Chapter 30. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations - p. 644 76. Chapter 31. T-Cell Prolymphocytic Leukemia - p. 655 77. Chapter 32. Adult T-Cell Leukemia/Lymphoma - p. 663 78. Chapter 33. Hepatosplenic T-Cell Lymphoma - p. 675 79. Chapter 34. Peripheral T-Cell Lymphoma, Not Otherwise Specified - p. 685 80. Chapter 35. Follicular Helper T-Cell Lymphoma - p. 701 81. Chapter 36. Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative - p. 716 82. Chapter 37. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas - p. 736 83. Chapter 38. Mycosis Fungoides and Sézary Syndrome - p. 758 84. Chapter 39. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders - p. 776 85. Chapter 40. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes - p. 792 86. Section 3. PRECURSOR B-AND T-CELL NEOPLASMS - p. 805.e4 87. Chapter 41. Precursor B-Cell and T-Cell Neoplasms - p. 806 88. Chapter 42. Acute Leukemias of Ambiguous Lineage - p. 821 89. Part IV. Myeloid, Histiocytic, and Related Proliferations - p. 829 90. Chapter 43. Principles of Classification of Myeloid Neoplasms - p. 831 91. Chapter 44. The Myelodysplastic Syndromes - p. 840 92. Incidence - p. 840 93. Synonyms and Related Terms - p. 840 94. Clinical Features - p. 840 95. Laboratory Features - p. 841 96. Diagnosis - p. 849 97. Classification - p. 850 98. Differential Diagnosis - p. 860 99. Etiology and Pathogenesis - p. 865 100. Conclusion - p. 865 101. Pearls and Pitfalls - p. 866 102. Chapter 45. Myeloid and Hematologic Neoplasms With Germline Predisposition - p. 867 103. Chapter 46. Acute Myeloid Leukemia - p. 889 104. Chapter 47. Myeloproliferative Neoplasms - p. 916 105. Introduction - p. 916 106. Etiology and Pathogenesis - p. 917 107. Chronic Myeloid Leukemia (CML) - p. 920 108. Chronic Neutrophilic Leukemia (CNL) - p. 929 109. Classic Bcr::Abl1-Negative Myeloproliferative Neoplasms - p. 932 110. Essential Thrombocythemia (ET) - p. 933 111. Primary Myelofibrosis (PMF) - p. 938 112. Polycythemia Vera - p. 944 113. Chronic Eosinophilic Leukemia, Not Otherwise Specified (CEL, NOS) - p. 950 114. Myeloproliferative Neoplasms, Unclassifiable (MPN-U) - p. 951 115. Conclusion - p. 951 116. Acknowledgments - p. 952 117. Pearls and Pitfalls - p. 952 118. Chapter 48. Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions - p. 953 119. Chapter 49. Mastocytosis - p. 975 120. Chapter 50. Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions - p. 999 121. Chapter 51. Blastic Plasmacytoid Dendritic Cell Neoplasm - p. 1022 122. Chapter 52. Histiocytic and Dendritic Cell Proliferations—Systemic and Neoplastic - p. 1034 123. Non-Neoplastic Histiocytic Disorders - p. 1034 124. Histiocytic and Dendritic Cell Neoplasms - p. 1048 125. Acknowledgment - p. 1081 126. Pearls and Pitfalls - p. 1081 127. Part V. Immunodeficiency Disorders - p. 1083 128. Chapter 53. The Pathology of Primary Immunodeficiencies - p. 1085 129. Chapter 54. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders - p. 1104 130. Part VI. Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia - p. 1123 131. Chapter 55. Bone Marrow Evaluation for Lymphoma - p. 1125 132. Chapter 56. Evaluation of the Bone Marrow After Therapy - p. 1158 133. Effects of Selected Therapies and Bone Marrow Transplantation - p. 1159 134. Acute Leukemia or Myelodysplastic Syndrome - p. 1163 135. Chronic Myeloid Leukemia - p. 1171 136. BCR::ABL1-Negative Myeloproliferative Neoplasms - p. 1175 137. Chronic Lymphoproliferative and Plasma Cell Disorders - p. 1177 138. Other Bone Marrow Changes after Therapy - p. 1181 139. Pearls and Pitfalls - p. 1186 140. Chapter 57. Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes - p. 1188 141. Chapter 58. Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions - p. 1210 142. Chapter 59. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin - p. 1228 143. Lymphomas of Immune-Privileged Sites - p. 1228 144. Lymphoma of The Nervous System and Meninges - p. 1228 145. Ocular Adnexal Lymphoma - p. 1233 146. Lymphomas of Waldeyer’s Ring - p. 1235 147. Lymphomas of The Nasal Cavity and Paranasal Sinuses - p. 1236 148. Salivary Gland Lymphomas - p. 1237 149. Lymphomas of The Oral Cavity - p. 1238 150. Thyroid Lymphomas - p. 1239 151. Laryngeal Lymphomas - p. 1240 152. Pulmonary Lymphomas - p. 1241 153. Lymphomas of The Pleura and Pleural Cavity - p. 1242 154. Lymphomas of The Thymus - p. 1242 155. Cardiac Lymphomas - p. 1242 156. Lymphomas of The Breast - p. 1243 157. Gastrointestinal Lymphomas - p. 1246 158. Gastric Lymphoma - p. 1246 159. Small and Large Intestinal Lymphomas - p. 1247 160. Lymphomas of The Liver and Pancreatobiliary Tract - p. 1248 161. Adrenal Lymphomas - p. 1249 162. Urinary Tract Lymphomas - p. 1249 163. Male Genital Tract Lymphomas - p. 1251 164. Lymphomas of The Female Genital Tract - p. 1253 165. Lymphomas of Bone - p. 1255 166. Pearls and Pitfalls - p. 1257 167. Appendix A. The International Consensus Classification of Myeloid, Lymphoid, and Histiocytic Neoplasms - p. 1258 168. Index - p. 1261