Histone Deacetylases in Neurodegenerative Disease, Part B, Volume 734 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on timely topics surrounding the Interaction of HDAC6 ZnF UBP with Tau affects its stability by NMR and Simulation studies, Protocols for In Vitro Analysis of Liquid-Liquid Phase Separation of Proteins, Histone deacetylases in NS, Histone Deacetylase 6 ZnF UBP domain enhances podosome formation in neuronal cells studied by high-resolution confocal microscopy, Methodological approach to Investigate Peroxiredoxin 1 Deacetylation by Histone Deacetylase 6, Critical structural features of HDAC11 inhibitors, and much more.
Additional chapters in this release include Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration, Elucidation of Site-Specific Ubiquitination on Chaperones in Response to Mutant Huntingtin, Protein acetylation dynamics (histone and non-histone) and role protein deacetylases in disease, Epigenetic Clues: Predicting Maternal Depression Through DNA Methylation, A short guide on in vivo transfection of flag-HDAC4 in dentate gyrus for study of adult neurogenesis in brain trauma, Decoding the Acetylation Journey from Neural Crest to Melanocyte, and more.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Series Page - p. iii 6. Copyright - p. iv 7. Contributors - p. xvii 8. Chapter One: Lysine methylation is an endogenous post-translational modifications of tau protein in human brain and a modulator of aggregation propensity - p. 0 9. Chapter Two: Experimental approaches for investigating sirtuin-mediated mitochondrial function, cellular metabolism, and epigenetic regulation - p. 28 10. Chapter Three: Methodological frameworks to probe histone acetylation–driven circuit plasticity in SYNGAP1–associated neurodevelopmental disorders - p. 55 11. Chapter Four: Mechanistic insights on HDAC6 ZnF UBP–Tau interaction through biophysical and computational approaches - p. 79 12. Chapter Five: Defining active and repressive chromatin states in neural crest cells using low-input CUT&RUN - p. 105 13. Chapter Six: Identification of 2,4-dihydroxy-azaflavanone as an allosteric activator of SIRT1 and its potential role in cellular models of Parkinson’s disease - p. 121 14. Chapter Seven: Epigenetic regulation of fatty acid chain elongation in MAFLD and its implications in the liver-brain axis dysfunction - p. 151 15. Chapter Eight: Critical structural features of HDAC11 inhibitors - p. 173 16. Chapter Nine: Mass spectrometry-based mapping of the ubiquitin chaperone code - p. 199 17. Chapter Ten: Evaluation of lysine modified peptides and their cell penetrating peptide conjugates with sirtuin activity inhibition properties and intracellular delivery - p. 217 18. Chapter Eleven: Epigenetic clues: Predicting maternal depression through DNA methylation - p. 235 19. Chapter Twelve: A short guide on in vivo transfection of flag-HDAC4 in dentate gyrus for study of adult neurogenesis in repetitive mild traumatic brain injury - p. 269 20. Chapter Thirteen: The extracellular Zinc-finger ubiquitin-binding domain of histone Deacetylase 6 enhances podosome formation in neuronal cells - p. 301 21. Chapter Fourteen: Histone deacetylases: From acetylation homeostasis to oncogenic and neurodegenerative disorders - p. 327 22. Chapter Fifteen: Experimental approaches to study histone deacetylation in Caenorhabditis elegans - p. 347 23. Chapter Sixteen: Protocols for in vitro analysis of liquid-liquid phase separation of proteins - p. 367 24. Chapter Seventeen: Methodological approach to investigate peroxiredoxin 1 deacetylation by histone deacetylase 6 - p. 381
Histone Deacetylases in Neurodegenerative Disease, Part B, Volume 734 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on timely topics surrounding the Interaction of HDAC6 ZnF UBP with Tau affects its stability by NMR and Simulation studies, Protocols for In Vitro Analysis of Liquid-Liquid Phase Separation of Proteins, Histone deacetylases in NS, Histone Deacetylase 6 ZnF UBP domain enhances podosome formation in neuronal cells studied by high-resolution confocal microscopy, Methodological approach to Investigate Peroxiredoxin 1 Deacetylation by Histone Deacetylase 6, Critical structural features of HDAC11 inhibitors, and much more.
Additional chapters in this release include Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration, Elucidation of Site-Specific Ubiquitination on Chaperones in Response to Mutant Huntingtin, Protein acetylation dynamics (histone and non-histone) and role protein deacetylases in disease, Epigenetic Clues: Predicting Maternal Depression Through DNA Methylation, A short guide on in vivo transfection of flag-HDAC4 in dentate gyrus for study of adult neurogenesis in brain trauma, Decoding the Acetylation Journey from Neural Crest to Melanocyte, and more.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Series Page - p. iii 6. Copyright - p. iv 7. Contributors - p. xvii 8. Chapter One: Lysine methylation is an endogenous post-translational modifications of tau protein in human brain and a modulator of aggregation propensity - p. 0 9. Chapter Two: Experimental approaches for investigating sirtuin-mediated mitochondrial function, cellular metabolism, and epigenetic regulation - p. 28 10. Chapter Three: Methodological frameworks to probe histone acetylation–driven circuit plasticity in SYNGAP1–associated neurodevelopmental disorders - p. 55 11. Chapter Four: Mechanistic insights on HDAC6 ZnF UBP–Tau interaction through biophysical and computational approaches - p. 79 12. Chapter Five: Defining active and repressive chromatin states in neural crest cells using low-input CUT&RUN - p. 105 13. Chapter Six: Identification of 2,4-dihydroxy-azaflavanone as an allosteric activator of SIRT1 and its potential role in cellular models of Parkinson’s disease - p. 121 14. Chapter Seven: Epigenetic regulation of fatty acid chain elongation in MAFLD and its implications in the liver-brain axis dysfunction - p. 151 15. Chapter Eight: Critical structural features of HDAC11 inhibitors - p. 173 16. Chapter Nine: Mass spectrometry-based mapping of the ubiquitin chaperone code - p. 199 17. Chapter Ten: Evaluation of lysine modified peptides and their cell penetrating peptide conjugates with sirtuin activity inhibition properties and intracellular delivery - p. 217 18. Chapter Eleven: Epigenetic clues: Predicting maternal depression through DNA methylation - p. 235 19. Chapter Twelve: A short guide on in vivo transfection of flag-HDAC4 in dentate gyrus for study of adult neurogenesis in repetitive mild traumatic brain injury - p. 269 20. Chapter Thirteen: The extracellular Zinc-finger ubiquitin-binding domain of histone Deacetylase 6 enhances podosome formation in neuronal cells - p. 301 21. Chapter Fourteen: Histone deacetylases: From acetylation homeostasis to oncogenic and neurodegenerative disorders - p. 327 22. Chapter Fifteen: Experimental approaches to study histone deacetylation in Caenorhabditis elegans - p. 347 23. Chapter Sixteen: Protocols for in vitro analysis of liquid-liquid phase separation of proteins - p. 367 24. Chapter Seventeen: Methodological approach to investigate peroxiredoxin 1 deacetylation by histone deacetylase 6 - p. 381
