**Selected for Doody’s Core Titles® 2024 in Clinical Genetics**
Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic.
This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications.
1. Title of Book - p. Cover 2. Cover image - p. Cover 3. Title page - p. ii 4. Table of Contents - p. iv 5. Front Matter - p. i 6. Copyright - p. iii 7. Contributors - p. xiii 8. Preface - p. xxi 9. Part I: Reproductive tract development and gametogenesis - p. xxii 10. Chapter 1. Developmental genetics of the male reproductive system - p. 17 11. Chapter 2. Developmental genetics of the female reproductive tract - p. 29 12. Chapter 3. Genetics and genomics of early gonad development - p. 61 13. Chapter 4. Effects of aging on sperm chromatin - p. 93 14. Chapter 5. In vitro spermatogenesis from pluripotent stem cells - p. 119 15. Chapter 6. The molecular genetics of oogenesis - p. 145 16. Chapter 7. Growth of the mammalian oocyte: Focus on intercellular contact and communication - p. 165 17. Chapter 8. In vitro activation of ovarian follicles - p. 189 18. Part II: Embryo implantation, placenta development and pregnancy - p. 207 19. Chapter 9. Interaction of sperm and embryo with the female reproductive tract - p. 211 20. Chapter 10. MicroRNAs in gametes and preimplantation embryos: Clinical implications - p. 251 21. Chapter 11. Epigenetic modifications in the human placenta - p. 289 22. Chapter 12. In vitro models of human blastocysts and early embryogenesis - p. 311 23. Chapter 13. microRNAs in pregnancy: Implications for basic research and clinical management - p. 329 24. Chapter 14. Human X-chromosome inactivation: Complexity and clinical implications - p. 355 25. Chapter 15. The intergenerational effects on fetal programming - p. 387 26. Part III: Infertility and assisted reproductive technology - p. 407 27. Chapter 16. Theoretical and experimental strategies for preservation and restoration of male fertility - p. 411 28. Chapter 17. Update on the genetics and genomics of premature ovarian insufficiency - p. 441 29. Chapter 18. Premature ovarian insufficiency - p. 463 30. Chapter 19. Genetics of polycystic ovary syndrome - p. 485 31. Chapter 20. Developmental origins and genetic basis of polycystic ovary syndrome - p. 505 32. Chapter 21. Genetic basis of metabolism and inflammation in PCOS - p. 531 33. Chapter 22. Genetics and genomics of recurrent pregnancy loss - p. 565 34. Genetics and genomics of endometriosis☆ - p. 599 35. Chapter 24. Human genetics and assisted reproduction in endometriosis - p. 633 36. Chapter 25. Uterus transplantation as an infertility treatment - p. 675 37. Chapter 26. Impacts of COVID-19 on reproductive health and prenatal genetics - p. 679 38. Part IV: Preimplantation/prenatal genetic diagnosis and screening - p. 691 39. Chapter 27. Genomics in reproductive medicine: Current and future applications - p. 695 40. Chapter 28. Molecular cytogenomics of human genetic disorders - p. 724 41. Chapter 29. Next-generation sequencing for gene panels, clinical exome, and whole-genome analysis - p. 743 42. Chapter 30. Chromosomal microarrays and next-generation sequencing for diagnosis of fetal abnormalities - p. 776 43. Chapter 31. Noninvasive prenatal testing for genetic diseases - p. 789 44. Chapter 32. Noninvasive prenatal testing/screening by circulating cell-free DNA - p. 823 45. Chapter 33. Application of new technologies in embryos: From gene editing to synthetic embryos - p. 853 46. Index - p. 887
**Selected for Doody’s Core Titles® 2024 in Clinical Genetics**
Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic.
This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications.
1. Title of Book - p. Cover 2. Cover image - p. Cover 3. Title page - p. ii 4. Table of Contents - p. iv 5. Front Matter - p. i 6. Copyright - p. iii 7. Contributors - p. xiii 8. Preface - p. xxi 9. Part I: Reproductive tract development and gametogenesis - p. xxii 10. Chapter 1. Developmental genetics of the male reproductive system - p. 17 11. Chapter 2. Developmental genetics of the female reproductive tract - p. 29 12. Chapter 3. Genetics and genomics of early gonad development - p. 61 13. Chapter 4. Effects of aging on sperm chromatin - p. 93 14. Chapter 5. In vitro spermatogenesis from pluripotent stem cells - p. 119 15. Chapter 6. The molecular genetics of oogenesis - p. 145 16. Chapter 7. Growth of the mammalian oocyte: Focus on intercellular contact and communication - p. 165 17. Chapter 8. In vitro activation of ovarian follicles - p. 189 18. Part II: Embryo implantation, placenta development and pregnancy - p. 207 19. Chapter 9. Interaction of sperm and embryo with the female reproductive tract - p. 211 20. Chapter 10. MicroRNAs in gametes and preimplantation embryos: Clinical implications - p. 251 21. Chapter 11. Epigenetic modifications in the human placenta - p. 289 22. Chapter 12. In vitro models of human blastocysts and early embryogenesis - p. 311 23. Chapter 13. microRNAs in pregnancy: Implications for basic research and clinical management - p. 329 24. Chapter 14. Human X-chromosome inactivation: Complexity and clinical implications - p. 355 25. Chapter 15. The intergenerational effects on fetal programming - p. 387 26. Part III: Infertility and assisted reproductive technology - p. 407 27. Chapter 16. Theoretical and experimental strategies for preservation and restoration of male fertility - p. 411 28. Chapter 17. Update on the genetics and genomics of premature ovarian insufficiency - p. 441 29. Chapter 18. Premature ovarian insufficiency - p. 463 30. Chapter 19. Genetics of polycystic ovary syndrome - p. 485 31. Chapter 20. Developmental origins and genetic basis of polycystic ovary syndrome - p. 505 32. Chapter 21. Genetic basis of metabolism and inflammation in PCOS - p. 531 33. Chapter 22. Genetics and genomics of recurrent pregnancy loss - p. 565 34. Genetics and genomics of endometriosis☆ - p. 599 35. Chapter 24. Human genetics and assisted reproduction in endometriosis - p. 633 36. Chapter 25. Uterus transplantation as an infertility treatment - p. 675 37. Chapter 26. Impacts of COVID-19 on reproductive health and prenatal genetics - p. 679 38. Part IV: Preimplantation/prenatal genetic diagnosis and screening - p. 691 39. Chapter 27. Genomics in reproductive medicine: Current and future applications - p. 695 40. Chapter 28. Molecular cytogenomics of human genetic disorders - p. 724 41. Chapter 29. Next-generation sequencing for gene panels, clinical exome, and whole-genome analysis - p. 743 42. Chapter 30. Chromosomal microarrays and next-generation sequencing for diagnosis of fetal abnormalities - p. 776 43. Chapter 31. Noninvasive prenatal testing for genetic diseases - p. 789 44. Chapter 32. Noninvasive prenatal testing/screening by circulating cell-free DNA - p. 823 45. Chapter 33. Application of new technologies in embryos: From gene editing to synthetic embryos - p. 853 46. Index - p. 887
