Hyponatremia and 40 Years of Controversy: Looking Back and Moving Forward traces and probes the prolonged, contentious debate surrounding the treatment of severe hyponatremia, a low-sodium concentration in the blood that can result in severe brain damage if managed incorrectly.
A mix of memoir and science, the book explains how slow correction of hyponatremia became accepted and how consensus was disrupted by assertions that caution was unnecessary and harmful. It scrutinizes the controversy, offers an approach to management, and unpacks research limitations – reminding us that what is believed true today may change tomorrow.
Hyponatremia and 40 Years of Controversy: Looking Back and Moving Forward is a vital resource for both experienced medical specialists and novice trainees. It explains the physiology of how hyponatremia happens and how it hurts. By offering historical insights, scientific rigor, and practical guidance, this book promises to enhance clinical decision making, foster new research, and improve outcomes in patients with hyponatremia.
1. Introduction to part one: Memoir of an accidental expert - p. 3 2. Chapter 1. From Central Pontine Myelinolysis (CPM) to Osmotic Demyelination Syndrome (ODS) - p. 43 3. Chapter 2. What is rapid correction? - p. 73 4. Chapter 3. Osmotic stress and demyelination - p. 97 5. Chapter 4. Hyponatremic encephalopathy: Age, sex, hormones, and oxygen - p. 119 6. Chapter 5. Speed limits and how to obey them - p. 153 7. Part II. Climbing the ladder and finding the ground - p. P2 8. Introduction to part two: Turning points - p. 183 9. Chapter 6. New evidence: Rare or just not well done? - p. 197 10. Chapter 7. The court's in session - p. 213 11. Chapter 8. Primum non nocere - p. 231 12. Chapter 9. Beyond osmosis: malnutrition, alcoholism, and the liver - p. 247 13. Chapter 10. A toolbox for managing hyponatremia - p. 259 14. Conclusion: Looking back and moving forward - p. 279 15. Index - p. 283
Hyponatremia and 40 Years of Controversy: Looking Back and Moving Forward traces and probes the prolonged, contentious debate surrounding the treatment of severe hyponatremia, a low-sodium concentration in the blood that can result in severe brain damage if managed incorrectly.
A mix of memoir and science, the book explains how slow correction of hyponatremia became accepted and how consensus was disrupted by assertions that caution was unnecessary and harmful. It scrutinizes the controversy, offers an approach to management, and unpacks research limitations – reminding us that what is believed true today may change tomorrow.
Hyponatremia and 40 Years of Controversy: Looking Back and Moving Forward is a vital resource for both experienced medical specialists and novice trainees. It explains the physiology of how hyponatremia happens and how it hurts. By offering historical insights, scientific rigor, and practical guidance, this book promises to enhance clinical decision making, foster new research, and improve outcomes in patients with hyponatremia.
1. Introduction to part one: Memoir of an accidental expert - p. 3 2. Chapter 1. From Central Pontine Myelinolysis (CPM) to Osmotic Demyelination Syndrome (ODS) - p. 43 3. Chapter 2. What is rapid correction? - p. 73 4. Chapter 3. Osmotic stress and demyelination - p. 97 5. Chapter 4. Hyponatremic encephalopathy: Age, sex, hormones, and oxygen - p. 119 6. Chapter 5. Speed limits and how to obey them - p. 153 7. Part II. Climbing the ladder and finding the ground - p. P2 8. Introduction to part two: Turning points - p. 183 9. Chapter 6. New evidence: Rare or just not well done? - p. 197 10. Chapter 7. The court's in session - p. 213 11. Chapter 8. Primum non nocere - p. 231 12. Chapter 9. Beyond osmosis: malnutrition, alcoholism, and the liver - p. 247 13. Chapter 10. A toolbox for managing hyponatremia - p. 259 14. Conclusion: Looking back and moving forward - p. 279 15. Index - p. 283
