Immunological Aspects of Preterm Birth, a volume in the Reproductive Immunology book series, bridges reproductive
immunology of preterm birth to subtypes, phenotypes, and bedside prevention and treatment. This book reviews the
role of the different immune mechanisms during pregnancy leading to preterm birth and fetal programming effects that
are connected to maternal immune activation. This book also discusses immune cells and their products, cytokines and
chemokines, as central for the success of the pregnancy, from the process of implantation to parturition and the effects of
the changes on fetal programming.
While our knowledge on the role of immune cells and the inflammatory process in preterm birth has grown exponentially
in the last 10 years, connecting basic science to clinical science and development of new therapeutics has not progressed
as rapidly. This book assists researchers in understanding the basic immunologic mechanisms and inflammatory processes
associated with preterm birth and fills an urgent need for the development of therapeutics in this space.
1. Introduction - p. xxix 2. Chapter 1. Preterm labor, preterm birth, and prematurity: Molecular and clinical phenotypes - p. 1 3. Chapter 2. Screening, diagnosis, and therapeutic approaches to preterm labor - p. 41 4. Chapter 3. Cellular immunology of preterm labor and birth and its potential utility for biomarker discovery - p. 69 5. Chapter 4. Understanding preterm birth: The role of infection and inflammation - p. 149 6. Chapter 5. The role of macrophages in preterm birth - p. 203 7. Chapter 6. T cells, placentation, gestational length and an evolutionary perspective relevant to preterm birth - p. 237 8. Chapter 7. Spontaneous preterm birth: Immunoperinatology perspective - p. 277 9. Chapter 8. Exosomes in reproductive biology and medicine - p. 303 10. Chapter 9. Vaginal microbiome and preterm birth - p. 327 11. Chapter 10. Viral infections and preterm birth - p. 337 12. Chapter 11. Environment and immune interactions in preterm birth - p. 361 13. Chapter 12. Placenta: Window into neonatal health - p. 377 14. Chapter 13. Spontaneous preterm birth: Current therapies and opportunities for the future - p. 419 15. Chapter 14. Special considerations: Transplant in pregnancy - p. 459 16. Index - p. 495
Immunological Aspects of Preterm Birth, a volume in the Reproductive Immunology book series, bridges reproductive
immunology of preterm birth to subtypes, phenotypes, and bedside prevention and treatment. This book reviews the
role of the different immune mechanisms during pregnancy leading to preterm birth and fetal programming effects that
are connected to maternal immune activation. This book also discusses immune cells and their products, cytokines and
chemokines, as central for the success of the pregnancy, from the process of implantation to parturition and the effects of
the changes on fetal programming.
While our knowledge on the role of immune cells and the inflammatory process in preterm birth has grown exponentially
in the last 10 years, connecting basic science to clinical science and development of new therapeutics has not progressed
as rapidly. This book assists researchers in understanding the basic immunologic mechanisms and inflammatory processes
associated with preterm birth and fills an urgent need for the development of therapeutics in this space.
1. Introduction - p. xxix 2. Chapter 1. Preterm labor, preterm birth, and prematurity: Molecular and clinical phenotypes - p. 1 3. Chapter 2. Screening, diagnosis, and therapeutic approaches to preterm labor - p. 41 4. Chapter 3. Cellular immunology of preterm labor and birth and its potential utility for biomarker discovery - p. 69 5. Chapter 4. Understanding preterm birth: The role of infection and inflammation - p. 149 6. Chapter 5. The role of macrophages in preterm birth - p. 203 7. Chapter 6. T cells, placentation, gestational length and an evolutionary perspective relevant to preterm birth - p. 237 8. Chapter 7. Spontaneous preterm birth: Immunoperinatology perspective - p. 277 9. Chapter 8. Exosomes in reproductive biology and medicine - p. 303 10. Chapter 9. Vaginal microbiome and preterm birth - p. 327 11. Chapter 10. Viral infections and preterm birth - p. 337 12. Chapter 11. Environment and immune interactions in preterm birth - p. 361 13. Chapter 12. Placenta: Window into neonatal health - p. 377 14. Chapter 13. Spontaneous preterm birth: Current therapies and opportunities for the future - p. 419 15. Chapter 14. Special considerations: Transplant in pregnancy - p. 459 16. Index - p. 495
