The extremely popular textbook Immunology & Serology in Laboratory Medicine, 8th Edition provides the foundation you need to master the relevant competencies demanded in today’s clinical laboratory. Immunology & Serology helps you gain the knowledge required by medical laboratory technician (MLT) and medical laboratory scientist (MLS) students to achieve excellent scores on national board certification upon graduation and to display entry-level professional competencies for career success. Featuring a straightforward presentation, each chapter in this edition presents state-of-the-art content in subject areas such as Molecular Diagnostics. A problem-based case study approach that stimulates critical thinking makes it easier to integrate the concepts of theory with laboratory procedures that generate diagnostic information in cases of infectious diseases, immune disorders, tumor immunology, and tissue transplantation. Immunology & Serology is a distinctly unique textbook because the author recognizes the importance of robust professional knowledge and the practice guidelines developed by the American Society for Clinical Pathology (ASCP) Board of Certification Examination Immunology Content Outlines for MLT and MLS certification levels and the American Society for Clinical Laboratory Science (ASCLS) Professional Body of Knowledge.
1. Title of Book - p. ii 2. Cover image - p. ii 3. Title page - p. ii 4. Table of Contents - p. ii 5. Quick Reference - p. i 6. Copyright - p. vi 7. Dedication - p. vii 8. Reviewers - p. viii 9. Preface - p. ix 10. Acknowledgments - p. xii 11. About the Author - p. xiii 12. Part I. Basic Immunologic Mechanisms - p. 1 13. 1. Foundations of Innate and Adaptive Immune Systems - p. 2 14. 2. Soluble Mediators of the Immune System - p. 28 15. 3. Antigens and Antibodies - p. 47 16. 4. Cellular Activities and Clinical Disorders of Innate and Adaptive Immunity - p. 67 17. Part II. The Theory of Immunologic and Serologic Procedures - p. 96.e1 18. 5. Basic Safety in the Immunology-Serology Laboratory - p. 98 19. 6. Basic Quality Control and Quality Assurance Practices - p. 107 20. 7. Basic Serologic Laboratory: Techniques and Clinical Applications - p. 117 21. 8. Precipitation and Particle Agglutination Methods - p. 128 22. 9. Electrophoresis Techniques and Chromatography - p. 143 23. 10. Labeling Techniques in Immunoassay - p. 150 24. 11. Flow Cytometry - p. 159 25. 12. Molecular Laboratory Techniques - p. 168 26. Part III. Immunologic Manifestations of Infectious Diseases - p. 187.e1 27. 13. Infectious Diseases: Overview and TORCH Diseases - p. 190 28. 14. Streptococcal Infections - p. 221 29. 15. Syphilis - p. 228 30. 16. Vector-Borne Diseases - p. 240 31. 17. Infectious Mononucleosis - p. 267 32. 18. Viral Hepatitis - p. 273 33. Part IV. Immune Disorders - p. 297.e1 34. 19. Primary and Acquired Immunodeficiency Syndromes - p. 300 35. Primary Immunodeficiency Disorders - p. 302 36. Characteristics of Primary Immunodeficiency Disorders - p. 304 37. General Laboratory Evaluation - p. 304 38. T-Cell Immunodeficiency Disorders - p. 306 39. Digeorge Syndrome - p. 307 40. Severe Combined Immunodeficiency (SCID) - p. 307 41. Chronic Mucocutaneous Candidiasis - p. 308 42. Bruton X-Linked Agammaglobulinemia (XLA) - p. 309 43. Immunologic Manifestations - p. 310 44. Common Variable Immunodeficiency - p. 310 45. Transient Hypogammaglobulinemia of Infancy - p. 311 46. Immunodeficiency With Elevated Immunoglobulin M (Hyper-IgM) - p. 311 47. Selective Immunoglobulin A Deficiency - p. 311 48. Hyper-E Syndrome (HIES) - p. 311 49. X-Linked Lymphoproliferative Disease (XLP) Syndromes 1 and 2 (Duncan Disease) - p. 312 50. Combined Cellular Immunodeficiency Disorders - p. 312 51. Partial Combined Immune Deficiency Disorders - p. 312 52. Other Primary Immune Disorders - p. 313 53. Acquired (Secondary) Immunodeficiency Disorders - p. 313 54. Acquired Immunodeficiency Syndrome - p. 313 55. Viral Characteristics - p. 314 56. Viral Structure - p. 314 57. Viral Replication - p. 315 58. Epidemiology - p. 316 59. Infectious Patterns - p. 317 60. Modes of Transmission - p. 318 61. Signs and Symptoms - p. 318 62. Opportunistic Infections - p. 319 63. Disease Progression - p. 321 64. Immunologic Manifestations - p. 321 65. Serologic Markers - p. 322 66. Diagnostic Evaluation and Monitoring - p. 322 67. Testing Methods - p. 322 68. HIV-1 Antibody Assays - p. 322 69. HIV Antigen and Genome Testing - p. 324 70. Alternative Screening for HIV - p. 324 71. Fourth-Generation Testing - p. 326 72. Pediatric Testing - p. 326 73. Rapid Testing - p. 326 74. Tests for Therapeutic Monitoring - p. 326 75. Prevention - p. 326 76. Treatment - p. 326 77. Drug Therapy - p. 327 78. Actions of Mechanistic Classes of Antiretroviral Drugs - p. 328 79. Investigational Drugs - p. 331 80. Preexposure and Postexposure Prophylaxis - p. 332 81. 20. Hypersensitivity Reactions - p. 337 82. 21. Plasma Cell Neoplasms and Other Diseases With Paraproteins - p. 353 83. 22. Tolerance, Autoimmunity, and Autoimmune Disorders - p. 369 84. 23. Systemic Lupus Erythematosus - p. 396 85. 24. Rheumatoid Arthritis - p. 414 86. Part V. Transplantation and Tumor Immunology - p. 425.e1 87. 25. Transplantation: Human Leukocyte Antigens, Solid Organ, Tissues, and Hematopoietic Stem Cells - p. 428 88. 26. Tumor Immunology and Applications of Massive Parallel Sequencing/Next-Generation Sequencing - p. 454 89. Part VI. Vaccines - p. 476.e1 90. 27. Vaccines: Development and Applications - p. 478 91. Appendix A. Answers to Case Study Multiple-Choice Questions - p. 500 92. Appendix B. Answers to Review Questions - p. 503 93. Appendix C. Origin and Immunoregulatory Activity of Cytokines - p. 510 94. Appendix D. Coronavirus Disease 2019 (COVID-19) - p. 514 95. Appendix E. Vaccines Licensed for Use in the United States by the Federal Drug Administration - p. 516 96. Bibliography - p. 518 97. Glossary - p. 528 98. Index - p. 550
The extremely popular textbook Immunology & Serology in Laboratory Medicine, 8th Edition provides the foundation you need to master the relevant competencies demanded in today’s clinical laboratory. Immunology & Serology helps you gain the knowledge required by medical laboratory technician (MLT) and medical laboratory scientist (MLS) students to achieve excellent scores on national board certification upon graduation and to display entry-level professional competencies for career success. Featuring a straightforward presentation, each chapter in this edition presents state-of-the-art content in subject areas such as Molecular Diagnostics. A problem-based case study approach that stimulates critical thinking makes it easier to integrate the concepts of theory with laboratory procedures that generate diagnostic information in cases of infectious diseases, immune disorders, tumor immunology, and tissue transplantation. Immunology & Serology is a distinctly unique textbook because the author recognizes the importance of robust professional knowledge and the practice guidelines developed by the American Society for Clinical Pathology (ASCP) Board of Certification Examination Immunology Content Outlines for MLT and MLS certification levels and the American Society for Clinical Laboratory Science (ASCLS) Professional Body of Knowledge.
1. Title of Book - p. ii 2. Cover image - p. ii 3. Title page - p. ii 4. Table of Contents - p. ii 5. Quick Reference - p. i 6. Copyright - p. vi 7. Dedication - p. vii 8. Reviewers - p. viii 9. Preface - p. ix 10. Acknowledgments - p. xii 11. About the Author - p. xiii 12. Part I. Basic Immunologic Mechanisms - p. 1 13. 1. Foundations of Innate and Adaptive Immune Systems - p. 2 14. 2. Soluble Mediators of the Immune System - p. 28 15. 3. Antigens and Antibodies - p. 47 16. 4. Cellular Activities and Clinical Disorders of Innate and Adaptive Immunity - p. 67 17. Part II. The Theory of Immunologic and Serologic Procedures - p. 96.e1 18. 5. Basic Safety in the Immunology-Serology Laboratory - p. 98 19. 6. Basic Quality Control and Quality Assurance Practices - p. 107 20. 7. Basic Serologic Laboratory: Techniques and Clinical Applications - p. 117 21. 8. Precipitation and Particle Agglutination Methods - p. 128 22. 9. Electrophoresis Techniques and Chromatography - p. 143 23. 10. Labeling Techniques in Immunoassay - p. 150 24. 11. Flow Cytometry - p. 159 25. 12. Molecular Laboratory Techniques - p. 168 26. Part III. Immunologic Manifestations of Infectious Diseases - p. 187.e1 27. 13. Infectious Diseases: Overview and TORCH Diseases - p. 190 28. 14. Streptococcal Infections - p. 221 29. 15. Syphilis - p. 228 30. 16. Vector-Borne Diseases - p. 240 31. 17. Infectious Mononucleosis - p. 267 32. 18. Viral Hepatitis - p. 273 33. Part IV. Immune Disorders - p. 297.e1 34. 19. Primary and Acquired Immunodeficiency Syndromes - p. 300 35. Primary Immunodeficiency Disorders - p. 302 36. Characteristics of Primary Immunodeficiency Disorders - p. 304 37. General Laboratory Evaluation - p. 304 38. T-Cell Immunodeficiency Disorders - p. 306 39. Digeorge Syndrome - p. 307 40. Severe Combined Immunodeficiency (SCID) - p. 307 41. Chronic Mucocutaneous Candidiasis - p. 308 42. Bruton X-Linked Agammaglobulinemia (XLA) - p. 309 43. Immunologic Manifestations - p. 310 44. Common Variable Immunodeficiency - p. 310 45. Transient Hypogammaglobulinemia of Infancy - p. 311 46. Immunodeficiency With Elevated Immunoglobulin M (Hyper-IgM) - p. 311 47. Selective Immunoglobulin A Deficiency - p. 311 48. Hyper-E Syndrome (HIES) - p. 311 49. X-Linked Lymphoproliferative Disease (XLP) Syndromes 1 and 2 (Duncan Disease) - p. 312 50. Combined Cellular Immunodeficiency Disorders - p. 312 51. Partial Combined Immune Deficiency Disorders - p. 312 52. Other Primary Immune Disorders - p. 313 53. Acquired (Secondary) Immunodeficiency Disorders - p. 313 54. Acquired Immunodeficiency Syndrome - p. 313 55. Viral Characteristics - p. 314 56. Viral Structure - p. 314 57. Viral Replication - p. 315 58. Epidemiology - p. 316 59. Infectious Patterns - p. 317 60. Modes of Transmission - p. 318 61. Signs and Symptoms - p. 318 62. Opportunistic Infections - p. 319 63. Disease Progression - p. 321 64. Immunologic Manifestations - p. 321 65. Serologic Markers - p. 322 66. Diagnostic Evaluation and Monitoring - p. 322 67. Testing Methods - p. 322 68. HIV-1 Antibody Assays - p. 322 69. HIV Antigen and Genome Testing - p. 324 70. Alternative Screening for HIV - p. 324 71. Fourth-Generation Testing - p. 326 72. Pediatric Testing - p. 326 73. Rapid Testing - p. 326 74. Tests for Therapeutic Monitoring - p. 326 75. Prevention - p. 326 76. Treatment - p. 326 77. Drug Therapy - p. 327 78. Actions of Mechanistic Classes of Antiretroviral Drugs - p. 328 79. Investigational Drugs - p. 331 80. Preexposure and Postexposure Prophylaxis - p. 332 81. 20. Hypersensitivity Reactions - p. 337 82. 21. Plasma Cell Neoplasms and Other Diseases With Paraproteins - p. 353 83. 22. Tolerance, Autoimmunity, and Autoimmune Disorders - p. 369 84. 23. Systemic Lupus Erythematosus - p. 396 85. 24. Rheumatoid Arthritis - p. 414 86. Part V. Transplantation and Tumor Immunology - p. 425.e1 87. 25. Transplantation: Human Leukocyte Antigens, Solid Organ, Tissues, and Hematopoietic Stem Cells - p. 428 88. 26. Tumor Immunology and Applications of Massive Parallel Sequencing/Next-Generation Sequencing - p. 454 89. Part VI. Vaccines - p. 476.e1 90. 27. Vaccines: Development and Applications - p. 478 91. Appendix A. Answers to Case Study Multiple-Choice Questions - p. 500 92. Appendix B. Answers to Review Questions - p. 503 93. Appendix C. Origin and Immunoregulatory Activity of Cytokines - p. 510 94. Appendix D. Coronavirus Disease 2019 (COVID-19) - p. 514 95. Appendix E. Vaccines Licensed for Use in the United States by the Federal Drug Administration - p. 516 96. Bibliography - p. 518 97. Glossary - p. 528 98. Index - p. 550
