Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype.
Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition.
There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response.
The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines.
1. Immunomodulatory Biomaterials - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. Preface - p. Page vi 8. List of Illustrations - p. Page viii 9. List of Tables - p. Page ix 10. 1 : Engineering physical biomaterial properties to manipulate macrophage phenotype: From bench to bedside - p. Page ix 11. 2 : Early factors in the immune response to biomaterials - p. Page 17 12. 3 : Nanotechnology and biomaterials for immune modulation and monitoring - p. Page 39 13. 4 : Immune-instructive materials and surfaces for medical applications - p. Page 59 14. 5 : Electrospun tissue regeneration biomaterials for immunomodulation - p. Page 81 15. 6 : Biomaterials and immunomodulation for spinal cord repair - p. Page 107 16. 7 : Biomaterial strategies to treat autoimmunity and unwanted immune responses to drugs and transplanted tissues - p. Page 129 17. 8 : Lipids as regulators of inflammation and tissue regeneration - p. Page 164 18. 9 : Biomaterials modulation of the tumor immune environment for cancer immunotherapy - p. Page 186 19. 10 : Circumventing immune rejection and foreign body response to therapeutics of type 1 diabetes - p. Page 210 20. 11 : Machine learning and mechanistic computational modeling of inflammation as tools for designing immunomodulatory biomaterials - p. Page 241 21. Index - p. Page 264
Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype.
Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition.
There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response.
The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines.
1. Immunomodulatory Biomaterials - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. Preface - p. Page vi 8. List of Illustrations - p. Page viii 9. List of Tables - p. Page ix 10. 1 : Engineering physical biomaterial properties to manipulate macrophage phenotype: From bench to bedside - p. Page ix 11. 2 : Early factors in the immune response to biomaterials - p. Page 17 12. 3 : Nanotechnology and biomaterials for immune modulation and monitoring - p. Page 39 13. 4 : Immune-instructive materials and surfaces for medical applications - p. Page 59 14. 5 : Electrospun tissue regeneration biomaterials for immunomodulation - p. Page 81 15. 6 : Biomaterials and immunomodulation for spinal cord repair - p. Page 107 16. 7 : Biomaterial strategies to treat autoimmunity and unwanted immune responses to drugs and transplanted tissues - p. Page 129 17. 8 : Lipids as regulators of inflammation and tissue regeneration - p. Page 164 18. 9 : Biomaterials modulation of the tumor immune environment for cancer immunotherapy - p. Page 186 19. 10 : Circumventing immune rejection and foreign body response to therapeutics of type 1 diabetes - p. Page 210 20. 11 : Machine learning and mechanistic computational modeling of inflammation as tools for designing immunomodulatory biomaterials - p. Page 241 21. Index - p. Page 264
