In Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies. Finite element method-based models of all hyperthermia processes of liver, brain and breast tumors are simulated on COMSOL Multiphysics software. Problems of constant versus variable heat sources, the backflow problem, the enhanced permeation and retention effect, the flow around Happel’s sphere in cells model structure, the deformation effect in poroelastic brain tumor, 3D flow through porous tissue, the reacting nanofluid flows, and optimization of parameters have been simulated for quantitative analysis.
This important reference aids in hyperthermia treatment planning in clinical applications and provides an important compendium for practitioners as well as non-medical practicing scientists and engineers and is resource for both research and medical practice in hyperthermia treatment planning in clinical applications.
1. Cover - p. i 2. Title Page - p. iii 3. Copyright - p. iv 4. Table of Contents - p. iv 5. Chapter 1 Basics of magnetic fluid hyperthermia - p. 1 6. Chapter 2 Historical background of magnetic fluid hyperthermia - p. 17 7. Chapter 3 The phenomena of heat dissipation by magnetic nanoparticles under applied magnetic field - p. 37 8. Chapter 4 Mathematical models of physical processes involved in magnetic fluid hyperthermia - p. 47 9. Chapter 5 Mathematical modeling and simulation of magnetic fluid hyperthermia of liver tumor - p. 53 10. Chapter 6 Modeling thermal therapy of poroelastic brain tumor using magnetic nanoparticles - p. 73 11. Chapter 7 Finite element modeling analysis of hyperthermia of female breast cancer in three dimensions - p. 95 12. Chapter 8 Mathematical modeling and simulation of enhanced permeation and retention (EPR) effect with thermal analysis - p. 115 13. Chapter 9 Simulating the nanoflow around Happel's sphere in the porous tumor carrying the cell-model structure - p. 127 14. Chapter 10 Computational analysis of the reacting nanofluid in the porous tumor - p. 139 15. Chapter 11 Thermal therapy of cylindrical tumor with optimization using Nelder-Mead method - p. 151 16. Supplementary material: Appendix A - p. 165 17. Supplementary material: Appendix B - p. 167 18. Supplementary material: Appendix C - p. 169 19. Supplementary material: Appendix D - p. 173 20. Supplementary material: Appendix E - p. 177 21. Conclusions - p. 183 22. Future work - p. 187 23. Index - p. 189
In Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies. Finite element method-based models of all hyperthermia processes of liver, brain and breast tumors are simulated on COMSOL Multiphysics software. Problems of constant versus variable heat sources, the backflow problem, the enhanced permeation and retention effect, the flow around Happel’s sphere in cells model structure, the deformation effect in poroelastic brain tumor, 3D flow through porous tissue, the reacting nanofluid flows, and optimization of parameters have been simulated for quantitative analysis.
This important reference aids in hyperthermia treatment planning in clinical applications and provides an important compendium for practitioners as well as non-medical practicing scientists and engineers and is resource for both research and medical practice in hyperthermia treatment planning in clinical applications.
1. Cover - p. i 2. Title Page - p. iii 3. Copyright - p. iv 4. Table of Contents - p. iv 5. Chapter 1 Basics of magnetic fluid hyperthermia - p. 1 6. Chapter 2 Historical background of magnetic fluid hyperthermia - p. 17 7. Chapter 3 The phenomena of heat dissipation by magnetic nanoparticles under applied magnetic field - p. 37 8. Chapter 4 Mathematical models of physical processes involved in magnetic fluid hyperthermia - p. 47 9. Chapter 5 Mathematical modeling and simulation of magnetic fluid hyperthermia of liver tumor - p. 53 10. Chapter 6 Modeling thermal therapy of poroelastic brain tumor using magnetic nanoparticles - p. 73 11. Chapter 7 Finite element modeling analysis of hyperthermia of female breast cancer in three dimensions - p. 95 12. Chapter 8 Mathematical modeling and simulation of enhanced permeation and retention (EPR) effect with thermal analysis - p. 115 13. Chapter 9 Simulating the nanoflow around Happel's sphere in the porous tumor carrying the cell-model structure - p. 127 14. Chapter 10 Computational analysis of the reacting nanofluid in the porous tumor - p. 139 15. Chapter 11 Thermal therapy of cylindrical tumor with optimization using Nelder-Mead method - p. 151 16. Supplementary material: Appendix A - p. 165 17. Supplementary material: Appendix B - p. 167 18. Supplementary material: Appendix C - p. 169 19. Supplementary material: Appendix D - p. 173 20. Supplementary material: Appendix E - p. 177 21. Conclusions - p. 183 22. Future work - p. 187 23. Index - p. 189
