Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose.
The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient.
1. Introduction: Don’t Just Dose—Choose a Specific Target Goal, Suited to the Patient’s Need, and Dose to Hit it Most Precisely - p. xxv 2. Section I: Basic Techniques for Individualized Therapy - p. xxxiv 3. Chapter 1. Basic Pharmacokinetics and Dynamics for Clinicians - p. 3 4. Chapter 2. Describing Drug Behavior in Groups of Patients - p. 19 5. Chapter 3. Developing Maximally Precise Dosage Regimens for Patients—Multiple Model (MM) Dosage Design - p. 27 6. Chapter 4. Optimizing Laboratory Assay Methods for Individualized Therapy - p. 33 7. Chapter 5. Evaluation of Renal Function - p. 47 8. Section II: The Clinical Software - p. 56 9. Chapter 6. Using the BestDose Clinical Software—Examples With Aminoglycosides - p. 59 10. Chapter 7. Monitoring the Patient: Four Different Bayesian Methods to Make Individual Patient Drug Models - p. 77 11. Chapter 8. Monitoring Each Patient Optimally: When to Obtain the Best Samples for Therapeutic Drug Monitoring - p. 91 12. Chapter 9. Optimizing Individualized Drug Therapy in the ICU - p. 103 13. Chapter 10. Quantitative Modeling of Diffusion Into Endocardial Vegetations, the Postantibiotic Effect, and Bacterial Growth and Kill - p. 115 14. Chapter 11. Individualizing Digoxin Therapy - p. 135 15. Section III: Clinical Applications of Individualized Therapy - p. 154 16. Chapter 12. Optimizing Single-Drug Antibacterial and Antifungal Therapy - p. 157 17. Chapter 13. Combination Chemotherapy With Anti-Infective Agents - p. 181 18. Chapter 14. Controlling Antiretroviral Therapy in Children and Adolescents with HIV Infection - p. 207 19. Chapter 15. Individualizing Tuberculosis Therapy - p. 239 20. Chapter 16. Individualizing Transplant Therapy - p. 255 21. Chapter 17. Individualizing Dosage Regimens of Antineoplastic Agents - p. 281 22. Chapter 18. Controlling Busulfan Therapy in Children - p. 307 23. Chapter 19. Individualizing Antiepileptic Therapy for Patients - p. 327 24. Chapter 20. Individualizing Drug Therapy in the Elderly - p. 373 25. Chapter 21. The Present and Future State of Individualized Therapy - p. 383 26. Index - p. 393
Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose.
The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient.
1. Introduction: Don’t Just Dose—Choose a Specific Target Goal, Suited to the Patient’s Need, and Dose to Hit it Most Precisely - p. xxv 2. Section I: Basic Techniques for Individualized Therapy - p. xxxiv 3. Chapter 1. Basic Pharmacokinetics and Dynamics for Clinicians - p. 3 4. Chapter 2. Describing Drug Behavior in Groups of Patients - p. 19 5. Chapter 3. Developing Maximally Precise Dosage Regimens for Patients—Multiple Model (MM) Dosage Design - p. 27 6. Chapter 4. Optimizing Laboratory Assay Methods for Individualized Therapy - p. 33 7. Chapter 5. Evaluation of Renal Function - p. 47 8. Section II: The Clinical Software - p. 56 9. Chapter 6. Using the BestDose Clinical Software—Examples With Aminoglycosides - p. 59 10. Chapter 7. Monitoring the Patient: Four Different Bayesian Methods to Make Individual Patient Drug Models - p. 77 11. Chapter 8. Monitoring Each Patient Optimally: When to Obtain the Best Samples for Therapeutic Drug Monitoring - p. 91 12. Chapter 9. Optimizing Individualized Drug Therapy in the ICU - p. 103 13. Chapter 10. Quantitative Modeling of Diffusion Into Endocardial Vegetations, the Postantibiotic Effect, and Bacterial Growth and Kill - p. 115 14. Chapter 11. Individualizing Digoxin Therapy - p. 135 15. Section III: Clinical Applications of Individualized Therapy - p. 154 16. Chapter 12. Optimizing Single-Drug Antibacterial and Antifungal Therapy - p. 157 17. Chapter 13. Combination Chemotherapy With Anti-Infective Agents - p. 181 18. Chapter 14. Controlling Antiretroviral Therapy in Children and Adolescents with HIV Infection - p. 207 19. Chapter 15. Individualizing Tuberculosis Therapy - p. 239 20. Chapter 16. Individualizing Transplant Therapy - p. 255 21. Chapter 17. Individualizing Dosage Regimens of Antineoplastic Agents - p. 281 22. Chapter 18. Controlling Busulfan Therapy in Children - p. 307 23. Chapter 19. Individualizing Antiepileptic Therapy for Patients - p. 327 24. Chapter 20. Individualizing Drug Therapy in the Elderly - p. 373 25. Chapter 21. The Present and Future State of Individualized Therapy - p. 383 26. Index - p. 393
