Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xiii 7. 1. Inflammation, symptoms, benefits, reaction, and biochemistry - p. 1 8. REMOVED: Natural products as modulators of signaling in inflammation - p. 19 9. 2. Natural products with antiinflammatory activities against autoimmune myocarditis - p. 21 10. 3. Multitarget approach for natural products in inflammation - p. 39 11. 4. Antiinflammatory activity of natural dietary flavonoids - p. 69 12. Antiinflammatory effects of turmeric (Curcuma longa) and ginger (Zingiber officinale) - p. 83 13. Antiinflammatory activity of Boswellia - p. 103 14. 7. Antiinflammatory activity of galangal - p. 119 15. 8. Antiinflammatory natural products from marine algae - p. 131 16. 9. Medicinal plants and their potential use in the treatment of rheumatic diseases - p. 161 17. 10. Natural product–derived drugs for the treatment of inflammatory bowel diseases (IBD) - p. 191 18. 11. Smart drug delivery systems of natural products for inflammation: From fundamentals to the clinic - p. 218 19. 12. Systems pharmacology and molecular docking strategies prioritize natural molecules as antiinflammatory agents - p. 241 20. 13. Bioavailability, pharmacokinetic, pharmacodynamic, and clinical studies of natural products on their antiinflammatory activities - p. 279 21. 14. Supplements and diets for antiinflammation - p. 315 22. 15. Values of natural products to future antiinflammatory pharmaceutical discovery - p. 333 23. 16. Identification of toxicology biomarker and evaluation of toxicity of natural products by metabolomic applications - p. 375 24. Index - p. 393
Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xiii 7. 1. Inflammation, symptoms, benefits, reaction, and biochemistry - p. 1 8. REMOVED: Natural products as modulators of signaling in inflammation - p. 19 9. 2. Natural products with antiinflammatory activities against autoimmune myocarditis - p. 21 10. 3. Multitarget approach for natural products in inflammation - p. 39 11. 4. Antiinflammatory activity of natural dietary flavonoids - p. 69 12. Antiinflammatory effects of turmeric (Curcuma longa) and ginger (Zingiber officinale) - p. 83 13. Antiinflammatory activity of Boswellia - p. 103 14. 7. Antiinflammatory activity of galangal - p. 119 15. 8. Antiinflammatory natural products from marine algae - p. 131 16. 9. Medicinal plants and their potential use in the treatment of rheumatic diseases - p. 161 17. 10. Natural product–derived drugs for the treatment of inflammatory bowel diseases (IBD) - p. 191 18. 11. Smart drug delivery systems of natural products for inflammation: From fundamentals to the clinic - p. 218 19. 12. Systems pharmacology and molecular docking strategies prioritize natural molecules as antiinflammatory agents - p. 241 20. 13. Bioavailability, pharmacokinetic, pharmacodynamic, and clinical studies of natural products on their antiinflammatory activities - p. 279 21. 14. Supplements and diets for antiinflammation - p. 315 22. 15. Values of natural products to future antiinflammatory pharmaceutical discovery - p. 333 23. 16. Identification of toxicology biomarker and evaluation of toxicity of natural products by metabolomic applications - p. 375 24. Index - p. 393
