A must-have resource for all members of the transplant team, Kidney Transplantation: Principles and Practice, 9th Edition, provides comprehensive, up-to-date information on every aspect of this complex field. Drs. Stuart J. Knechtle and Lorna P. Marson, along with a global team of internationally renowned surgeons and nephrologists, offer balanced coverage of both surgical techniques and medical considerations related to kidney transplantation. With updates from cover to cover, this core reference delivers the practical guidance you need to achieve optimal outcomes in both adults and children.
1. Introduction - p. 10 2. Activation of the Immune System Peri-Transplant - p. 11 3. Stimulation of Adaptive Alloimmunity - p. 17 4. T Cell–Mediated Rejection - p. 22 5. B-Cell Activation and Antibody-Mediated Rejection - p. 23 6. Transplant Tolerance - p. 28 7. Conclusion - p. 30 8. References - p. 30 9. 3. Chronic Kidney Failure: Renal Replacement Therapy - p. 40 10. 4. The Recipient of a Renal Transplant - p. 55 11. 5. Access for Renal Replacement Therapy - p. 76 12. 6. Brain Death and Cardiac Death: Donor Criteria and Care of Deceased Donor - p. 101 13. 7. Medical Evaluation of the Living Donor - p. 116 14. 8. Donor Nephrectomy - p. 128 15. 9. Kidney Preservation - p. 140 16. 10. Histocompatability in Kidney Transplantation - p. 150 17. 11. Surgical Techniques of Kidney Transplantation - p. 171 18. 12. Urological Complications After Kidney Transplant and Transplantation Into an Abnormal Bladder - p. 188 19. 13. Perioperative Care of Patients Undergoing Kidney Transplantation - p. 201 20. 14. Early Course of the Patient With a Kidney Transplant - p. 215 21. 15. Azathioprine and Mycophenolates - p. 229 22. 16. Steroids - p. 249 23. 17. Calcineurin Inhibitors - p. 261 24. 18. mTOR Inhibitors: Sirolimus and Everolimus - p. 277 25. 19. Antilymphocyte Globulin, Monoclonal Antibodies, and Fusion Proteins - p. 302 26. Abstract - p. 302 27. CHAPTER OUTLINE - p. 302 28. Introduction - p. 302 29. Historical Perspective - p. 303 30. Antibody Structure and Function - p. 304 31. Fusion Protein Structure and Function - p. 304 32. General Clinical Considerations for the Use of Antibody and Fusion Protein Preparations - p. 305 33. Polyclonal Antibody Preparations - p. 306 34. Specific Clinical Applications of Polyclonal Antibody Preparations - p. 307 35. Monoclonal Antibody and Fusion Protein Preparations - p. 309 36. Monoclonal Antibodies and Fusion Proteins in Clinical Transplantation Practice - p. 309 37. Monoclonal Antibodies and Fusion Proteins in Clinical Transplantation Investigation - p. 315 38. Conclusions - p. 319 39. References - p. 320 40. 20. Other Forms of Immunosuppression - p. 330 41. Abstract - p. 330 42. CHAPTER OUTLINE - p. 330 43. Small Molecules - p. 330 44. Total Lymphoid Irradiation - p. 341 45. Photopheresis - p. 342 46. Splenectomy - p. 343 47. Plasmapheresis - p. 343 48. References - p. 344 49. 21. Approaches to the Induction of Tolerance - p. 353 50. 22. Transplantation in the Sensitized Recipient and Across ABO Blood Groups - p. 374 51. 23. Paired Exchange Programs for Living Donors - p. 388 52. 24. Kidney Allocation - p. 395 53. 25. Pathology of Kidney Transplantation - p. 407 54. Abstract - p. 407 55. CHAPTER OUTLINE - p. 407 56. Abbreviations [selected] - p. 407 57. Kidney Allograft Biopsy - p. 408 58. Donor Kidney Biopsy - p. 408 59. Hyperacute Rejection - p. 410 60. Acute Kidney Allograft Rejection - p. 410 61. Late Graft Diseases - p. 421 62. Protocol Biopsies - p. 425 63. Acute Tubular Necrosis - p. 426 64. Calcineurin Inhibitor Nephrotoxicity - p. 426 65. Target of Rapamycin Inhibitor Toxicity - p. 429 66. Drug-Induced Acute Tubulointerstitial Nephritis - p. 429 67. Infections - p. 430 68. Major Kidney Vascular Disease - p. 431 69. De Novo Glomerular Disease - p. 431 70. Recurrent Kidney Disease - p. 433 71. Posttransplant Malignancy and Posttransplant Lymphoproliferative Disease/Lymphoid Proliferations and Lymphomas Associated With Immune Deficiency and Dysregulation - p. 433 72. Future Directions in Biopsy Assessment - p. 435 73. Acknowledgments - p. 436 74. References - p. 436 75. 26. Biomarkers for Posttransplant Allograft Monitoring - p. 449 76. 27. Chronic Allograft Failure - p. 461 77. 28. Vascular and Lymphatic Complications After Kidney Transplantation - p. 486 78. 29. Cardiovascular Disease in Renal Transplantation - p. 516 79. 30. Infection in Kidney Transplant Recipients - p. 540 80. CHAPTER OUTLINE - p. 540 81. Overview - p. 540 82. Risk of Infection - p. 540 83. Timeline of Infection - p. 544 84. Assessment of Infectious Diseases in Recipients and Potential Donors Before Transplantation - p. 548 85. Selected Infections of Importance - p. 551 86. Conclusions - p. 561 87. References - p. 561 88. 31. Transplantation in a Pandemic: Lessons Learned From COVID-19 - p. 568 89. 32. Liver Disease Among Renal Transplant Recipients - p. 578 90. Abstract - p. 578 91. CHAPTER OUTLINE - p. 578 92. Overview of Incidence and Clinicopathological Associations - p. 578 93. Combined Liver and Kidney Diseases - p. 579 94. Specific Immunosuppressive Agents in Renal Transplantation and Hepatotoxicity - p. 581 95. Hepatitis Viruses Associated With Renal Transplantation - p. 582 96. Nonalcoholic Fatty Liver Disease and Renal Transplant - p. 595 97. Hepatocellular Carcinoma After Renal Transplantation - p. 597 98. Systemic Infections Resulting in Hepatitis and Liver Disease - p. 598 99. References - p. 600 100. 33. Neurological Complications After Kidney Transplantation - p. 607 101. 34. Cutaneous Disease in Kidney Transplantation Patients - p. 621 102. 35. Cancer in Kidney Failure and Kidney Transplantation - p. 636 103. 36. Pancreas and Kidney Transplantation for Diabetic Nephropathy - p. 653 104. 37. Kidney Transplantation in Children - p. 679 105. Abstract - p. 679 106. CHAPTER OUTLINE - p. 679 107. Introduction - p. 679 108. Epidemiology of End-Stage Kidney Disease in Children - p. 680 109. Access to Transplantation - p. 681 110. Timing of Transplantation - p. 684 111. Patient and Graft Survival - p. 684 112. Contraindications to Transplantation - p. 688 113. Recurrence of Original Disease - p. 688 114. Pretransplant Evaluation - p. 695 115. Perioperative Management of Pediatric Renal Transplant Recipients - p. 699 116. Immunosuppressive Protocols and Drugs - p. 700 117. Acute Rejection in Pediatric Transplantation - p. 705 118. Long-Term Management Posttransplant - p. 707 119. References - p. 710 120. 38. Advancing Kidney Transplantation in Low- and Middle-Income Countries: Challenges and Strategies - p. 721 121. 39. Results of Kidney Transplantation - p. 733 122. 40. Psychosocial Aspects of Kidney Transplantation and Living Kidney Donation - p. 760 123. 41. Ethical and Legal Aspects of Kidney Donation - p. 775 124. 42. Xenotransplantation - p. 791 125. 43. Evidence in Transplantation - p. 803 126. Index - p. 813 127. Confidence is ClinicalKey - p. 838
A must-have resource for all members of the transplant team, Kidney Transplantation: Principles and Practice, 9th Edition, provides comprehensive, up-to-date information on every aspect of this complex field. Drs. Stuart J. Knechtle and Lorna P. Marson, along with a global team of internationally renowned surgeons and nephrologists, offer balanced coverage of both surgical techniques and medical considerations related to kidney transplantation. With updates from cover to cover, this core reference delivers the practical guidance you need to achieve optimal outcomes in both adults and children.
1. Introduction - p. 10 2. Activation of the Immune System Peri-Transplant - p. 11 3. Stimulation of Adaptive Alloimmunity - p. 17 4. T Cell–Mediated Rejection - p. 22 5. B-Cell Activation and Antibody-Mediated Rejection - p. 23 6. Transplant Tolerance - p. 28 7. Conclusion - p. 30 8. References - p. 30 9. 3. Chronic Kidney Failure: Renal Replacement Therapy - p. 40 10. 4. The Recipient of a Renal Transplant - p. 55 11. 5. Access for Renal Replacement Therapy - p. 76 12. 6. Brain Death and Cardiac Death: Donor Criteria and Care of Deceased Donor - p. 101 13. 7. Medical Evaluation of the Living Donor - p. 116 14. 8. Donor Nephrectomy - p. 128 15. 9. Kidney Preservation - p. 140 16. 10. Histocompatability in Kidney Transplantation - p. 150 17. 11. Surgical Techniques of Kidney Transplantation - p. 171 18. 12. Urological Complications After Kidney Transplant and Transplantation Into an Abnormal Bladder - p. 188 19. 13. Perioperative Care of Patients Undergoing Kidney Transplantation - p. 201 20. 14. Early Course of the Patient With a Kidney Transplant - p. 215 21. 15. Azathioprine and Mycophenolates - p. 229 22. 16. Steroids - p. 249 23. 17. Calcineurin Inhibitors - p. 261 24. 18. mTOR Inhibitors: Sirolimus and Everolimus - p. 277 25. 19. Antilymphocyte Globulin, Monoclonal Antibodies, and Fusion Proteins - p. 302 26. Abstract - p. 302 27. CHAPTER OUTLINE - p. 302 28. Introduction - p. 302 29. Historical Perspective - p. 303 30. Antibody Structure and Function - p. 304 31. Fusion Protein Structure and Function - p. 304 32. General Clinical Considerations for the Use of Antibody and Fusion Protein Preparations - p. 305 33. Polyclonal Antibody Preparations - p. 306 34. Specific Clinical Applications of Polyclonal Antibody Preparations - p. 307 35. Monoclonal Antibody and Fusion Protein Preparations - p. 309 36. Monoclonal Antibodies and Fusion Proteins in Clinical Transplantation Practice - p. 309 37. Monoclonal Antibodies and Fusion Proteins in Clinical Transplantation Investigation - p. 315 38. Conclusions - p. 319 39. References - p. 320 40. 20. Other Forms of Immunosuppression - p. 330 41. Abstract - p. 330 42. CHAPTER OUTLINE - p. 330 43. Small Molecules - p. 330 44. Total Lymphoid Irradiation - p. 341 45. Photopheresis - p. 342 46. Splenectomy - p. 343 47. Plasmapheresis - p. 343 48. References - p. 344 49. 21. Approaches to the Induction of Tolerance - p. 353 50. 22. Transplantation in the Sensitized Recipient and Across ABO Blood Groups - p. 374 51. 23. Paired Exchange Programs for Living Donors - p. 388 52. 24. Kidney Allocation - p. 395 53. 25. Pathology of Kidney Transplantation - p. 407 54. Abstract - p. 407 55. CHAPTER OUTLINE - p. 407 56. Abbreviations [selected] - p. 407 57. Kidney Allograft Biopsy - p. 408 58. Donor Kidney Biopsy - p. 408 59. Hyperacute Rejection - p. 410 60. Acute Kidney Allograft Rejection - p. 410 61. Late Graft Diseases - p. 421 62. Protocol Biopsies - p. 425 63. Acute Tubular Necrosis - p. 426 64. Calcineurin Inhibitor Nephrotoxicity - p. 426 65. Target of Rapamycin Inhibitor Toxicity - p. 429 66. Drug-Induced Acute Tubulointerstitial Nephritis - p. 429 67. Infections - p. 430 68. Major Kidney Vascular Disease - p. 431 69. De Novo Glomerular Disease - p. 431 70. Recurrent Kidney Disease - p. 433 71. Posttransplant Malignancy and Posttransplant Lymphoproliferative Disease/Lymphoid Proliferations and Lymphomas Associated With Immune Deficiency and Dysregulation - p. 433 72. Future Directions in Biopsy Assessment - p. 435 73. Acknowledgments - p. 436 74. References - p. 436 75. 26. Biomarkers for Posttransplant Allograft Monitoring - p. 449 76. 27. Chronic Allograft Failure - p. 461 77. 28. Vascular and Lymphatic Complications After Kidney Transplantation - p. 486 78. 29. Cardiovascular Disease in Renal Transplantation - p. 516 79. 30. Infection in Kidney Transplant Recipients - p. 540 80. CHAPTER OUTLINE - p. 540 81. Overview - p. 540 82. Risk of Infection - p. 540 83. Timeline of Infection - p. 544 84. Assessment of Infectious Diseases in Recipients and Potential Donors Before Transplantation - p. 548 85. Selected Infections of Importance - p. 551 86. Conclusions - p. 561 87. References - p. 561 88. 31. Transplantation in a Pandemic: Lessons Learned From COVID-19 - p. 568 89. 32. Liver Disease Among Renal Transplant Recipients - p. 578 90. Abstract - p. 578 91. CHAPTER OUTLINE - p. 578 92. Overview of Incidence and Clinicopathological Associations - p. 578 93. Combined Liver and Kidney Diseases - p. 579 94. Specific Immunosuppressive Agents in Renal Transplantation and Hepatotoxicity - p. 581 95. Hepatitis Viruses Associated With Renal Transplantation - p. 582 96. Nonalcoholic Fatty Liver Disease and Renal Transplant - p. 595 97. Hepatocellular Carcinoma After Renal Transplantation - p. 597 98. Systemic Infections Resulting in Hepatitis and Liver Disease - p. 598 99. References - p. 600 100. 33. Neurological Complications After Kidney Transplantation - p. 607 101. 34. Cutaneous Disease in Kidney Transplantation Patients - p. 621 102. 35. Cancer in Kidney Failure and Kidney Transplantation - p. 636 103. 36. Pancreas and Kidney Transplantation for Diabetic Nephropathy - p. 653 104. 37. Kidney Transplantation in Children - p. 679 105. Abstract - p. 679 106. CHAPTER OUTLINE - p. 679 107. Introduction - p. 679 108. Epidemiology of End-Stage Kidney Disease in Children - p. 680 109. Access to Transplantation - p. 681 110. Timing of Transplantation - p. 684 111. Patient and Graft Survival - p. 684 112. Contraindications to Transplantation - p. 688 113. Recurrence of Original Disease - p. 688 114. Pretransplant Evaluation - p. 695 115. Perioperative Management of Pediatric Renal Transplant Recipients - p. 699 116. Immunosuppressive Protocols and Drugs - p. 700 117. Acute Rejection in Pediatric Transplantation - p. 705 118. Long-Term Management Posttransplant - p. 707 119. References - p. 710 120. 38. Advancing Kidney Transplantation in Low- and Middle-Income Countries: Challenges and Strategies - p. 721 121. 39. Results of Kidney Transplantation - p. 733 122. 40. Psychosocial Aspects of Kidney Transplantation and Living Kidney Donation - p. 760 123. 41. Ethical and Legal Aspects of Kidney Donation - p. 775 124. 42. Xenotransplantation - p. 791 125. 43. Evidence in Transplantation - p. 803 126. Index - p. 813 127. Confidence is ClinicalKey - p. 838
