In this issue of Otolaryngologic Clinics, guest editors Drs. Inna A. Husain and Nikki Johnston bring their considerable expertise to the topic of Laryngopharyngeal Reflux. Although it is suggested that laryngopharyngeal reflux disease (LPRD) accounts for up to 30% of outpatient otolaryngology visits, lack of formal diagnostic criteria, ease of testing, and varied treatment practices can lead to delay in care and high social/economic burden. In this edition, top experts review up-to-date information on pathophysiology of LPRD, including typical and atypical manifestations, role of diagnostic testing, updated treatment guidelines, and future directions of LPRD management.
1. Introduction to Laryngopharyngeal Reflux Disease - p. 399 2. Pathophysiology of Laryngopharyngeal Reflux Disease: The Reflux vs Reflex Theory - p. 403 3. Pepsin, Mucosal Injury, and Pathophysiology of Non-acid Reflux - p. 415 4. Microbiota, Gut Health, and Laryngopharyngeal Reflux Disease - p. 433 5. Diagnostic Testing for Laryngopharyngeal Reflux Disease: The Role of 24-hour Hypopharyngeal-Esophageal Multichannel Intraluminal Impedance-pH Monitoring - p. 441 6. Neural-Mediated Laryngopharyngeal Reflux Disease and the Role of Esophageal Dysmotility - p. 451 7. What's with the Lump in the Throat? Globus, Dysphagia, and the Role of the Upper Esophageal Sphincter in Laryngopharyngeal Reflux Disease - p. 465 8. Dysphonia and Laryngopharyngeal Reflux - p. 475 9. Chronic Cough and Pulmonary Manifestations of Laryngopharyngeal Reflux Disease - p. 485 10. Extralaryngeal Manifestations of Laryngopharyngeal Reflux Disease - p. 497 11. Pediatric Laryngopharyngeal Reflux: Epidemiology, Clinical Presentation, Diagnosis, and Therapeutic Outcomes - p. 507 12. Decision Making in the Managment of Laryngopharyngeal Reflux Disease: Antacids, Alginates, and the Role of Diet - p. 519 13. The Role of Surgical Intervention in Laryngopharyngeal Reflux Disease - p. 529 14. Future Directions in Managing and Treating Laryngopharyngeal Reflux Disease for Improving Patient Care - p. 537
In this issue of Otolaryngologic Clinics, guest editors Drs. Inna A. Husain and Nikki Johnston bring their considerable expertise to the topic of Laryngopharyngeal Reflux. Although it is suggested that laryngopharyngeal reflux disease (LPRD) accounts for up to 30% of outpatient otolaryngology visits, lack of formal diagnostic criteria, ease of testing, and varied treatment practices can lead to delay in care and high social/economic burden. In this edition, top experts review up-to-date information on pathophysiology of LPRD, including typical and atypical manifestations, role of diagnostic testing, updated treatment guidelines, and future directions of LPRD management.
1. Introduction to Laryngopharyngeal Reflux Disease - p. 399 2. Pathophysiology of Laryngopharyngeal Reflux Disease: The Reflux vs Reflex Theory - p. 403 3. Pepsin, Mucosal Injury, and Pathophysiology of Non-acid Reflux - p. 415 4. Microbiota, Gut Health, and Laryngopharyngeal Reflux Disease - p. 433 5. Diagnostic Testing for Laryngopharyngeal Reflux Disease: The Role of 24-hour Hypopharyngeal-Esophageal Multichannel Intraluminal Impedance-pH Monitoring - p. 441 6. Neural-Mediated Laryngopharyngeal Reflux Disease and the Role of Esophageal Dysmotility - p. 451 7. What's with the Lump in the Throat? Globus, Dysphagia, and the Role of the Upper Esophageal Sphincter in Laryngopharyngeal Reflux Disease - p. 465 8. Dysphonia and Laryngopharyngeal Reflux - p. 475 9. Chronic Cough and Pulmonary Manifestations of Laryngopharyngeal Reflux Disease - p. 485 10. Extralaryngeal Manifestations of Laryngopharyngeal Reflux Disease - p. 497 11. Pediatric Laryngopharyngeal Reflux: Epidemiology, Clinical Presentation, Diagnosis, and Therapeutic Outcomes - p. 507 12. Decision Making in the Managment of Laryngopharyngeal Reflux Disease: Antacids, Alginates, and the Role of Diet - p. 519 13. The Role of Surgical Intervention in Laryngopharyngeal Reflux Disease - p. 529 14. Future Directions in Managing and Treating Laryngopharyngeal Reflux Disease for Improving Patient Care - p. 537
