Master an understanding of pharmacology — and apply that understanding to nursing practice! With an engaging approach that actually makes learning nursing pharmacology enjoyable, Lehne's Pharmacology for Nursing Care, 12th Edition makes it easier to understand difficult pharmacologic principles and the clinical use of drugs. The book discusses physiology and pathophysiology for each of the major drug families, using drug prototypes to simplify learning. What’s more, it focuses your attention on the most important content, limiting discussions of drug interactions and adverse effects to those that matter most. Written by nursing educators Jacqueline Rosenjack Burchum and Laura D. Rosenthal, this text emphasizes the understanding of drugs and drug therapy as opposed to simply memorizing drug facts.
1. Unit I. Introduction - p. ix 2. Chapter 1. Orientation to Pharmacology - p. 1 3. Chapter 2. Application of Pharmacology in Nursing Practice - p. 5 4. Chapter 3. Drug Regulation, Development, Names, and Information - p. 14 5. Unit II. Basic Principles of Pharmacology - p. 24 6. Chapter 4. Pharmacokinetics - p. 25 7. Chapter 5. Pharmacodynamics - p. 45 8. Chapter 6. Drug Interactions - p. 56 9. Chapter 7. Adverse Drug Reactions and Medication Errors - p. 64 10. Chapter 8. Individual Variation in Drug Responses - p. 76 11. Chapter 9. Genetic and Genomic Considerations - p. 81 12. Chapter 10. Introduction to Immunomodulators - p. 87 13. Unit III. Drug Therapy Across The Lifespan - p. 93 14. Chapter 11. Drug Therapy During Pregnancy and Breastfeeding - p. 94 15. Chapter 12. Drug Therapy in Pediatric Patients - p. 102 16. Chapter 13. Drug Therapy in Older Adults - p. 107 17. Unit IV. Peripheral Nervous System Drugs - p. 112 18. Chapter 14. Basic Principles of Neuropharmacology - p. 113 19. Chapter 15. Physiology of the Peripheral Nervous System - p. 119 20. Chapter 16. Muscarinic Agonists - p. 132 21. Chapter 17. Muscarinic Antagonists - p. 138 22. Chapter 18. Cholinesterase Inhibitors and Their Use in Myasthenia Gravis - p. 149 23. Chapter 19. Drugs That Block Nicotinic Cholinergic Transmission - p. 157 24. Chapter 20. Adrenergic Agonists - p. 167 25. Chapter 21. Adrenergic Antagonists - p. 181 26. Chapter 22. Indirect-Acting Antiadrenergic Agents - p. 198 27. Unit V. Central Nervous System Drugs - p. 203 28. Chapter 23. Introduction to Central Nervous System Pharmacology - p. 204 29. Chapter 24. Drugs for Parkinson Disease - p. 207 30. Chapter 25. Drugs for Alzheimer Disease - p. 226 31. Chapter 26. Drugs for Multiple Sclerosis - p. 237 32. Chapter 27. Drugs for Seizure Disorders - p. 254 33. Chapter 28. Drugs for Muscle Spasm and Spasticity - p. 283 34. Chapter 29. Local Anesthetics - p. 292 35. Chapter 30. General Anesthetics - p. 298 36. Chapter 31. Opioid Analgesics, Opioid Antagonists, and Nonopioid Centrally Acting Analgesics - p. 306 37. Chapter 32. Pain Management in Patients With Cancer - p. 327 38. Chapter 33. Drugs for Headache - p. 343 39. Chapter 34. Antipsychotic Agents and Their Use in Schizophrenia - p. 355 40. Chapter 35. Antidepressants - p. 372 41. Chapter 36. Drugs for Bipolar Disorder - p. 392 42. Chapter 37. Sedative-Hypnotic Drugs - p. 401 43. Chapter 38. Management of Anxiety Disorders - p. 416 44. Chapter 39. Central Nervous System Stimulants and Attention-Deficit/Hyperactivity Disorder - p. 423 45. Chapter 40. Substance Use Disorders I: Basic Considerations - p. 434 46. Chapter 41. Substance Use Disorders II: Alcohol - p. 441 47. Chapter 42. Substance Use Disorders III: Nicotine - p. 452 48. Chapter 43. Substance Use Disorders IV: Major Drugs of Abuse Other Than Alcohol and Nicotine - p. 459 49. Unit VI. Drugs That Affect Fluid and Electrolyte Balance - p. 475 50. Chapter 44. Diuretics - p. 476 51. Chapter 45. Agents Affecting the Volume and Ion Content of Body Fluids - p. 488 52. Unit VII. Drugs That Affect The Heart, Blood Vessels, and Blood - p. 492 53. Chapter 46. Review of Hemodynamics - p. 493 54. Chapter 47. Drugs Acting on the Renin-Angiotensin-Aldosterone System - p. 500 55. Chapter 48. Calcium Channel Blockers - p. 516 56. Chapter 49. Vasodilators - p. 525 57. Chapter 50. Drugs for Hypertension - p. 531 58. Chapter 51. Drugs for Heart Failure - p. 550 59. Chapter 52. Antidysrhythmic Drugs - p. 568 60. Chapter 53. Drugs That Help Normalize Cholesterol and Triglyceride Levels - p. 587 61. Chapter 54. Drugs for Angina Pectoris - p. 609 62. Chapter 55. Anticoagulant, Antiplatelet, and Thrombolytic Drugs - p. 622 63. Chapter 56. Management of ST-Elevation Myocardial Infarction - p. 649 64. Chapter 57. Drugs for Hemophilia - p. 656 65. Chapter 58. Drugs for Deficiency Anemias - p. 665 66. Chapter 59. Hematopoietic Agents - p. 680 67. Unit VIII. Drugs for Endocrine Disorders - p. 689 68. Chapter 60. Drugs for Diabetes Mellitus - p. 690 69. Chapter 61. Drugs for Thyroid Disorders - p. 727 70. Chapter 62. Drugs Related to Hypothalamic and Pituitary Function - p. 739 71. Chapter 63. Drugs for Disorders of the Adrenal Cortex - p. 748 72. Unit IX. Reproductive Health - p. 755 73. Chapter 64. Estrogens and Progestins: Basic Pharmacology and Noncontraceptive Applications - p. 756 74. Chapter 65. Birth Control - p. 771 75. Chapter 66. Drug Therapy for Infertility - p. 786 76. Chapter 67. Drugs That Affect Uterine Function - p. 795 77. Chapter 68. Androgens - p. 807 78. Chapter 69. Drugs for Erectile Dysfunction and Benign Prostatic Hyperplasia - p. 816 79. Chapter 70. Transgender Health - p. 829 80. Unit X. Anti-Inflammatory, Antiallergic, and Immunologic Drugs - p. 841 81. Chapter 71. Review of the Immune System - p. 842 82. Chapter 72. Childhood Immunization - p. 853 83. Chapter 73. Immunosuppressants - p. 871 84. Chapter 74. Antihistamines - p. 882 85. Chapter 75. Cyclooxygenase Inhibitors: Nonsteroidal Antiinflammatory Drugs and Acetaminophen - p. 890 86. Chapter 76. Glucocorticoids in Nonendocrine Disorders - p. 908 87. Unit XI. Drugs for Bone and Joint Disorders - p. 918 88. Chapter 77. Drug Therapy for Rheumatoid Arthritis - p. 919 89. Chapter 78. Drug Therapy for Gout - p. 936 90. Chapter 79. Drugs Affecting Calcium Levels and Bone Mineralization - p. 943 91. Unit XII. Respiratory Tract Drugs - p. 967 92. Chapter 80. Drugs for Asthma and Chronic Obstructive Pulmonary Disease - p. 968 93. Chapter 81. Drugs for Allergic Rhinitis, Cough, and Colds - p. 999 94. Unit XIII. Gastrointestinal Drugs - p. 1006 95. Chapter 82. Drugs for Peptic Ulcer Disease - p. 1007 96. Chapter 83. Laxatives - p. 1021 97. Chapter 84. Other Gastrointestinal Drugs - p. 1031 98. Unit XIV. Nutrition and Complementary Therapy - p. 1044 99. Chapter 85. Vitamins - p. 1045 100. Chapter 86. Drugs for Weight Loss - p. 1058 101. Chapter 87. Complementary and Alternative Therapy - p. 1067 102. Unit XV. Therapy of Infectious Diseases - p. 1083 103. Chapter 88. Basic Principles of Antimicrobial Therapy - p. 1084 104. Chapter 89. Drugs That Weaken the Bacterial Cell Wall I: Penicillins - p. 1099 105. Chapter 90. Drugs That Weaken the Bacterial Cell Wall II: Other Drugs - p. 1108 106. Chapter 91. Bacteriostatic Inhibitors of Protein Synthesis: Tetracyclines, Macrolides, and Others - p. 1119 107. Chapter 92. Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis - p. 1129 108. Chapter 93. Sulfonamide Antibiotics and Trimethoprim - p. 1136 109. Chapter 94. Drug Therapy for Urinary Tract Infections - p. 1146 110. Chapter 95. Antimycobacterial Agents: Drugs for Tuberculosis - p. 1152 111. Chapter 96. Miscellaneous Antibacterial Drugs: Fluoroquinolones, Metronidazole, Daptomycin, Rifampin, Rifaximin, and Fidaxomicin - p. 1168 112. Chapter 97. Antifungal Agents - p. 1174 113. Chapter 98. Antiviral Agents I: Drugs for Non-HIV Viral Infections - p. 1186 114. Chapter 99. Antiviral Agents II: Drugs for HIV Infection and Related Opportunistic Infections - p. 1212 115. Chapter 100. Drug Therapy for Sexually Transmitted Infections - p. 1248 116. Chapter 101. Antiseptics and Disinfectants - p. 1260 117. Unit XVI. Chemotherapy of Parasitic Diseases - p. 1266 118. Chapter 102. Anthelmintics - p. 1267 119. Chapter 103. Antiprotozoal Drugs I: Antimalarial Agents - p. 1274 120. Chapter 104. Antiprotozoal Drugs II: Miscellaneous Agents - p. 1283 121. Chapter 105. Ectoparasiticides - p. 1288 122. Unit XVII. Cancer Chemotherapy - p. 1292 123. Chapter 106. Basic Principles of Cancer Treatment - p. 1293 124. Chapter 107. Anticancer Drugs I: Cytotoxic Agents - p. 1307 125. Chapter 108. Anticancer Drugs II: Hormonal Agents, Targeted Drugs, and Other Noncytotoxic Anticancer Drugs - p. 1326 126. Unit XVIII. Miscellaneous Drugs and Therapies - p. 1347 127. Chapter 109. Drugs for Eye Conditions and Diseases - p. 1348 128. Chapter 110. Drugs for Skin Conditions - p. 1362 129. Chapter 111. Drugs for Ear Conditions - p. 1388 130. Unit XIX. Toxicology - p. 1394 131. Chapter 112. Management of Poisoning - p. 1395 132. Chapter 113. Potential Weapons of Biologic, Radiologic, and Chemical Terrorism - p. 1400 133. Appendix A. Canadian Drug Information - p. 1410 134. Appendix B. Prototype Drugs and Their Major Uses - p. 1414 135. Index - p. 1423 136. Special Interest Topics - p. 1477
Master an understanding of pharmacology — and apply that understanding to nursing practice! With an engaging approach that actually makes learning nursing pharmacology enjoyable, Lehne's Pharmacology for Nursing Care, 12th Edition makes it easier to understand difficult pharmacologic principles and the clinical use of drugs. The book discusses physiology and pathophysiology for each of the major drug families, using drug prototypes to simplify learning. What’s more, it focuses your attention on the most important content, limiting discussions of drug interactions and adverse effects to those that matter most. Written by nursing educators Jacqueline Rosenjack Burchum and Laura D. Rosenthal, this text emphasizes the understanding of drugs and drug therapy as opposed to simply memorizing drug facts.
1. Unit I. Introduction - p. ix 2. Chapter 1. Orientation to Pharmacology - p. 1 3. Chapter 2. Application of Pharmacology in Nursing Practice - p. 5 4. Chapter 3. Drug Regulation, Development, Names, and Information - p. 14 5. Unit II. Basic Principles of Pharmacology - p. 24 6. Chapter 4. Pharmacokinetics - p. 25 7. Chapter 5. Pharmacodynamics - p. 45 8. Chapter 6. Drug Interactions - p. 56 9. Chapter 7. Adverse Drug Reactions and Medication Errors - p. 64 10. Chapter 8. Individual Variation in Drug Responses - p. 76 11. Chapter 9. Genetic and Genomic Considerations - p. 81 12. Chapter 10. Introduction to Immunomodulators - p. 87 13. Unit III. Drug Therapy Across The Lifespan - p. 93 14. Chapter 11. Drug Therapy During Pregnancy and Breastfeeding - p. 94 15. Chapter 12. Drug Therapy in Pediatric Patients - p. 102 16. Chapter 13. Drug Therapy in Older Adults - p. 107 17. Unit IV. Peripheral Nervous System Drugs - p. 112 18. Chapter 14. Basic Principles of Neuropharmacology - p. 113 19. Chapter 15. Physiology of the Peripheral Nervous System - p. 119 20. Chapter 16. Muscarinic Agonists - p. 132 21. Chapter 17. Muscarinic Antagonists - p. 138 22. Chapter 18. Cholinesterase Inhibitors and Their Use in Myasthenia Gravis - p. 149 23. Chapter 19. Drugs That Block Nicotinic Cholinergic Transmission - p. 157 24. Chapter 20. Adrenergic Agonists - p. 167 25. Chapter 21. Adrenergic Antagonists - p. 181 26. Chapter 22. Indirect-Acting Antiadrenergic Agents - p. 198 27. Unit V. Central Nervous System Drugs - p. 203 28. Chapter 23. Introduction to Central Nervous System Pharmacology - p. 204 29. Chapter 24. Drugs for Parkinson Disease - p. 207 30. Chapter 25. Drugs for Alzheimer Disease - p. 226 31. Chapter 26. Drugs for Multiple Sclerosis - p. 237 32. Chapter 27. Drugs for Seizure Disorders - p. 254 33. Chapter 28. Drugs for Muscle Spasm and Spasticity - p. 283 34. Chapter 29. Local Anesthetics - p. 292 35. Chapter 30. General Anesthetics - p. 298 36. Chapter 31. Opioid Analgesics, Opioid Antagonists, and Nonopioid Centrally Acting Analgesics - p. 306 37. Chapter 32. Pain Management in Patients With Cancer - p. 327 38. Chapter 33. Drugs for Headache - p. 343 39. Chapter 34. Antipsychotic Agents and Their Use in Schizophrenia - p. 355 40. Chapter 35. Antidepressants - p. 372 41. Chapter 36. Drugs for Bipolar Disorder - p. 392 42. Chapter 37. Sedative-Hypnotic Drugs - p. 401 43. Chapter 38. Management of Anxiety Disorders - p. 416 44. Chapter 39. Central Nervous System Stimulants and Attention-Deficit/Hyperactivity Disorder - p. 423 45. Chapter 40. Substance Use Disorders I: Basic Considerations - p. 434 46. Chapter 41. Substance Use Disorders II: Alcohol - p. 441 47. Chapter 42. Substance Use Disorders III: Nicotine - p. 452 48. Chapter 43. Substance Use Disorders IV: Major Drugs of Abuse Other Than Alcohol and Nicotine - p. 459 49. Unit VI. Drugs That Affect Fluid and Electrolyte Balance - p. 475 50. Chapter 44. Diuretics - p. 476 51. Chapter 45. Agents Affecting the Volume and Ion Content of Body Fluids - p. 488 52. Unit VII. Drugs That Affect The Heart, Blood Vessels, and Blood - p. 492 53. Chapter 46. Review of Hemodynamics - p. 493 54. Chapter 47. Drugs Acting on the Renin-Angiotensin-Aldosterone System - p. 500 55. Chapter 48. Calcium Channel Blockers - p. 516 56. Chapter 49. Vasodilators - p. 525 57. Chapter 50. Drugs for Hypertension - p. 531 58. Chapter 51. Drugs for Heart Failure - p. 550 59. Chapter 52. Antidysrhythmic Drugs - p. 568 60. Chapter 53. Drugs That Help Normalize Cholesterol and Triglyceride Levels - p. 587 61. Chapter 54. Drugs for Angina Pectoris - p. 609 62. Chapter 55. Anticoagulant, Antiplatelet, and Thrombolytic Drugs - p. 622 63. Chapter 56. Management of ST-Elevation Myocardial Infarction - p. 649 64. Chapter 57. Drugs for Hemophilia - p. 656 65. Chapter 58. Drugs for Deficiency Anemias - p. 665 66. Chapter 59. Hematopoietic Agents - p. 680 67. Unit VIII. Drugs for Endocrine Disorders - p. 689 68. Chapter 60. Drugs for Diabetes Mellitus - p. 690 69. Chapter 61. Drugs for Thyroid Disorders - p. 727 70. Chapter 62. Drugs Related to Hypothalamic and Pituitary Function - p. 739 71. Chapter 63. Drugs for Disorders of the Adrenal Cortex - p. 748 72. Unit IX. Reproductive Health - p. 755 73. Chapter 64. Estrogens and Progestins: Basic Pharmacology and Noncontraceptive Applications - p. 756 74. Chapter 65. Birth Control - p. 771 75. Chapter 66. Drug Therapy for Infertility - p. 786 76. Chapter 67. Drugs That Affect Uterine Function - p. 795 77. Chapter 68. Androgens - p. 807 78. Chapter 69. Drugs for Erectile Dysfunction and Benign Prostatic Hyperplasia - p. 816 79. Chapter 70. Transgender Health - p. 829 80. Unit X. Anti-Inflammatory, Antiallergic, and Immunologic Drugs - p. 841 81. Chapter 71. Review of the Immune System - p. 842 82. Chapter 72. Childhood Immunization - p. 853 83. Chapter 73. Immunosuppressants - p. 871 84. Chapter 74. Antihistamines - p. 882 85. Chapter 75. Cyclooxygenase Inhibitors: Nonsteroidal Antiinflammatory Drugs and Acetaminophen - p. 890 86. Chapter 76. Glucocorticoids in Nonendocrine Disorders - p. 908 87. Unit XI. Drugs for Bone and Joint Disorders - p. 918 88. Chapter 77. Drug Therapy for Rheumatoid Arthritis - p. 919 89. Chapter 78. Drug Therapy for Gout - p. 936 90. Chapter 79. Drugs Affecting Calcium Levels and Bone Mineralization - p. 943 91. Unit XII. Respiratory Tract Drugs - p. 967 92. Chapter 80. Drugs for Asthma and Chronic Obstructive Pulmonary Disease - p. 968 93. Chapter 81. Drugs for Allergic Rhinitis, Cough, and Colds - p. 999 94. Unit XIII. Gastrointestinal Drugs - p. 1006 95. Chapter 82. Drugs for Peptic Ulcer Disease - p. 1007 96. Chapter 83. Laxatives - p. 1021 97. Chapter 84. Other Gastrointestinal Drugs - p. 1031 98. Unit XIV. Nutrition and Complementary Therapy - p. 1044 99. Chapter 85. Vitamins - p. 1045 100. Chapter 86. Drugs for Weight Loss - p. 1058 101. Chapter 87. Complementary and Alternative Therapy - p. 1067 102. Unit XV. Therapy of Infectious Diseases - p. 1083 103. Chapter 88. Basic Principles of Antimicrobial Therapy - p. 1084 104. Chapter 89. Drugs That Weaken the Bacterial Cell Wall I: Penicillins - p. 1099 105. Chapter 90. Drugs That Weaken the Bacterial Cell Wall II: Other Drugs - p. 1108 106. Chapter 91. Bacteriostatic Inhibitors of Protein Synthesis: Tetracyclines, Macrolides, and Others - p. 1119 107. Chapter 92. Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis - p. 1129 108. Chapter 93. Sulfonamide Antibiotics and Trimethoprim - p. 1136 109. Chapter 94. Drug Therapy for Urinary Tract Infections - p. 1146 110. Chapter 95. Antimycobacterial Agents: Drugs for Tuberculosis - p. 1152 111. Chapter 96. Miscellaneous Antibacterial Drugs: Fluoroquinolones, Metronidazole, Daptomycin, Rifampin, Rifaximin, and Fidaxomicin - p. 1168 112. Chapter 97. Antifungal Agents - p. 1174 113. Chapter 98. Antiviral Agents I: Drugs for Non-HIV Viral Infections - p. 1186 114. Chapter 99. Antiviral Agents II: Drugs for HIV Infection and Related Opportunistic Infections - p. 1212 115. Chapter 100. Drug Therapy for Sexually Transmitted Infections - p. 1248 116. Chapter 101. Antiseptics and Disinfectants - p. 1260 117. Unit XVI. Chemotherapy of Parasitic Diseases - p. 1266 118. Chapter 102. Anthelmintics - p. 1267 119. Chapter 103. Antiprotozoal Drugs I: Antimalarial Agents - p. 1274 120. Chapter 104. Antiprotozoal Drugs II: Miscellaneous Agents - p. 1283 121. Chapter 105. Ectoparasiticides - p. 1288 122. Unit XVII. Cancer Chemotherapy - p. 1292 123. Chapter 106. Basic Principles of Cancer Treatment - p. 1293 124. Chapter 107. Anticancer Drugs I: Cytotoxic Agents - p. 1307 125. Chapter 108. Anticancer Drugs II: Hormonal Agents, Targeted Drugs, and Other Noncytotoxic Anticancer Drugs - p. 1326 126. Unit XVIII. Miscellaneous Drugs and Therapies - p. 1347 127. Chapter 109. Drugs for Eye Conditions and Diseases - p. 1348 128. Chapter 110. Drugs for Skin Conditions - p. 1362 129. Chapter 111. Drugs for Ear Conditions - p. 1388 130. Unit XIX. Toxicology - p. 1394 131. Chapter 112. Management of Poisoning - p. 1395 132. Chapter 113. Potential Weapons of Biologic, Radiologic, and Chemical Terrorism - p. 1400 133. Appendix A. Canadian Drug Information - p. 1410 134. Appendix B. Prototype Drugs and Their Major Uses - p. 1414 135. Index - p. 1423 136. Special Interest Topics - p. 1477
