"**American Journal of Nursing (AJN) Book of the Year Awards, 2nd Place in Advanced Practice Nursing, 2025**
**Selected for 2026 Doody's Core Titles as an Essential Purchase in Advanced Practice**
Lehne's Pharmacotherapeutics for Advanced Practice Nurses and Physician Assistants, Third Edition builds on the same foundation of clearly explained, up-to-date, and clinically current content as Lehne’s trusted undergraduate text, while focusing on the information that advanced practice nurses and Physician Assistants specifically need for safe and effective prescribing. Introductory chapters provide foundational content in the areas of prescriptive authority, rational drug selection, prescription writing, and promoting positive outcomes of drug therapy. Core drug chapters focus on the drugs that you will most commonly see in clinical practice. Pharmacotherapeutic decision-making is emphasized, with Black Box Warnings and new Drug Decision Guide boxes. This edition features completely updated content with new chapters on drugs for sexual dysfunction and drugs for transgender health. It’s everything you need to be a safe and effective prescriber!"
1. Unit I Introduction - p. 1 2. 1 Prescriptive authority - p. 1 3. 2 Rational drug selection and prescription writing - p. 6 4. 3 Promoting positive outcomes of drug therapy - p. 10 5. Unit II Basic principles of pharmacology - p. 15 6. 4 Pharmacokinetics, pharmacodynamics, and drug interactions - p. 15 7. 5 Adverse drug reactions and medication errors - p. 36 8. 6 Individual variation in drug responses - p. 44 9. 7 Genetic and genomic considerations in pharmacotherapeutics - p. 48 10. Unit III Drug therapy across the life span - p. 53 11. 8 Drug therapy during pregnancy and breastfeeding - p. 53 12. 9 Drug therapy in pediatric patients - p. 59 13. 10 Drug therapy in geriatric patients - p. 63 14. Unit IV Peripheral nervous system drugs - p. 69 15. 11 Basic principles of neuropharmacology - p. 69 16. 12 Physiology of the peripheral nervous system - p. 73 17. 13 Muscarinic agonists and cholinesterase inhibitors - p. 83 18. 14 Muscarinic antagonists - p. 92 19. 15 Adrenergic agonists - p. 100 20. 16 Adrenergic antagonists - p. 109 21. 17 Indirect-acting antiadrenergic agents - p. 120 22. Unit V Central nervous system drugs - p. 125 23. 18 Introduction to central nervous system pharmacology - p. 125 24. 19 Drugs for parkinson disease - p. 127 25. 20 Drugs for Alzheimer disease - p. 144 26. 21 Drugs for seizure disorders - p. 152 27. 22 Drugs for muscle spasm and spasticity - p. 169 28. Unit VI Drugs for pain - p. 177 29. 23 Local anesthetics - p. 177 30. 24 Opioid analgesics, opioid antagonists, and nonopioid centrally acting analgesics - p. 181 31. 25 Drugs for headache - p. 192 32. Unit VII Psychotherapeutic drugs - p. 201 33. 26 Antipsychotic agents and their use in schizophrenia - p. 201 34. 27 Antidepressants - p. 212 35. 28 Drugs for bipolar disorder - p. 226 36. 29 Sedative-hypnotic drugs - p. 232 37. 30 Management of anxiety disorders - p. 241 38. 31 Central nervous system stimulants and attention-deficit/hyperactivity disorder - p. 246 39. Unit VIII Substance use disorders - p. 253 40. 32 Substance use disorders I: Basic considerations - p. 253 41. 33 Substance use disorders II: Alcohol - p. 258 42. 34 Substance use disorders III: Nicotine and smoking - p. 265 43. 35 Substance use disorders IV: Major drugs of misuse other than alcohol and nicotine - p. 270 44. Unit IX Drugs that affect the heart, blood vessels, blood, and blood volume - p. 281 45. 36 Review of hemodynamics - p. 281 46. 37 Diuretics - p. 286 47. 38 Drugs acting on the renin-angiotensin-aldosterone system - p. 293 48. 39 Calcium channel blockers - p. 304 49. 40 Vasodilators - p. 309 50. 41 Drugs for hypertension - p. 312 51. 42 Drugs for heart failure - p. 321 52. 43 Antidysrhythmic drugs - p. 333 53. 44 Prophylaxis of atherosclerotic cardiovascular disease: Drugs that help normalize cholesterol and triglyceride levels - p. 345 54. 45 Drugs for angina pectoris - p. 360 55. 46 Anticoagulant and antiplatelet drugs - p. 368 56. 47 Drugs for deficiency anemias - p. 385 57. Unit X Drugs for endocrine disorders - p. 393 58. 48 Drugs for diabetes - p. 393 59. 49 Drugs for thyroid disorders - p. 416 60. Unit XI Reproductive health - p. 425 61. 50 Estrogens and progestins: Basic pharmacology and noncontraceptive applications - p. 425 62. 51 Birth control - p. 437 63. 52 Androgens - p. 447 64. 53 Drugs for benign prostatic hyperplasia - p. 453 65. 54 Drugs for sexual dysfunction - p. 457 66. 55 Transgender health - p. 466 67. Unit XII Antiinflammatory, antiallergic, and immunologic drugs - p. 475 68. 56 Review of the immune system - p. 475 69. 57 Childhood immunization - p. 484 70. 58 Antihistamines - p. 495 71. 59 Cyclooxygenase inhibitors, nonsteroidal antiinflammatory drugs, and acetaminophen - p. 500 72. 60 Glucocorticoids in nonendocrine disorders - p. 510 73. Unit XIII Drugs for bone and joint disorders - p. 519 74. 61 Drug therapy for rheumatoid arthritis - p. 519 75. 62 Drug therapy for gout - p. 534 76. 63 Drugs affecting calcium levels and bone mineralization - p. 540 77. Unit XIV Respiratory tract drugs - p. 557 78. 64 Drugs for asthma and chronic obstructive pulmonary disease - p. 557 79. 65 Drugs for allergic rhinitis, cough, and colds - p. 577 80. Unit XV Gastrointestinal drugs - p. 585 81. 66 Drugs for peptic ulcer disease - p. 585 82. 67 Laxatives - p. 594 83. 68 Other gastrointestinal drugs - p. 601 84. Unit XVI Nutrition and complementary therapies - p. 611 85. 69 Vitamins - p. 611 86. 70 Drugs for obesity - p. 621 87. 71 Complementary and alternative therapy - p. 630 88. Unit XVII Therapy for infectious and parasitic diseases - p. 645 89. 72 Basic principles of antimicrobial therapy - p. 645 90. 73 Drugs that weaken the bacterial cell wall I: Penicillins - p. 656 91. 74 Drugs that weaken the bacterial cell wall II: Other drugs - p. 663 92. 75 Bacteriostatic inhibitors of protein synthesis - p. 670 93. 76 Aminoglycosides: Bactericidal inhibitors of protein synthesis - p. 677 94. 77 Sulfonamide antibiotics and trimethoprim - p. 682 95. 78 Drug therapy for urinary tract infections - p. 689 96. 79 Drug therapy for tuberculosis - p. 694 97. 80 Miscellaneous antibacterial drugs - p. 707 98. 81 Antifungal agents - p. 711 99. 82 Antiviral agents I: Drugs for non-hiv viral infections - p. 721 100. 83 Antiviral agents II: Drugs for HIV infection - p. 745 101. 84 Drug therapy for sexually transmitted infections - p. 764 102. 85 Anthelmintics - p. 773 103. Unit XVIII Cancer therapy - p. 779 104. 86 Introduction to immunomodulators - p. 779 105. 87 Supportive care of patients receiving anticancer drugs - p. 782 106. 88 Drugs for cancer pain - p. 811 107. Unit XIX Drugs for eyes, ears, and skin - p. 819 108. 89 Drugs for disorders of the eye - p. 819 109. 90 Drugs for disorders of the skin - p. 830 110. 91 Drugs for disorders of the ear - p. 855 111. Unit XX Drug therapy in acute care - p. 863 112. 92 Agents affecting the volume and ion content of body fluids - p. 863 113. 93 Management of ST-Elevation myocardial infarction - p. 867 114. 94 Drugs for acute care - p. 872 115. Appendix Canadian drug information - p. 883 116. Index - p. 887
"**American Journal of Nursing (AJN) Book of the Year Awards, 2nd Place in Advanced Practice Nursing, 2025**
**Selected for 2026 Doody's Core Titles as an Essential Purchase in Advanced Practice**
Lehne's Pharmacotherapeutics for Advanced Practice Nurses and Physician Assistants, Third Edition builds on the same foundation of clearly explained, up-to-date, and clinically current content as Lehne’s trusted undergraduate text, while focusing on the information that advanced practice nurses and Physician Assistants specifically need for safe and effective prescribing. Introductory chapters provide foundational content in the areas of prescriptive authority, rational drug selection, prescription writing, and promoting positive outcomes of drug therapy. Core drug chapters focus on the drugs that you will most commonly see in clinical practice. Pharmacotherapeutic decision-making is emphasized, with Black Box Warnings and new Drug Decision Guide boxes. This edition features completely updated content with new chapters on drugs for sexual dysfunction and drugs for transgender health. It’s everything you need to be a safe and effective prescriber!"
1. Unit I Introduction - p. 1 2. 1 Prescriptive authority - p. 1 3. 2 Rational drug selection and prescription writing - p. 6 4. 3 Promoting positive outcomes of drug therapy - p. 10 5. Unit II Basic principles of pharmacology - p. 15 6. 4 Pharmacokinetics, pharmacodynamics, and drug interactions - p. 15 7. 5 Adverse drug reactions and medication errors - p. 36 8. 6 Individual variation in drug responses - p. 44 9. 7 Genetic and genomic considerations in pharmacotherapeutics - p. 48 10. Unit III Drug therapy across the life span - p. 53 11. 8 Drug therapy during pregnancy and breastfeeding - p. 53 12. 9 Drug therapy in pediatric patients - p. 59 13. 10 Drug therapy in geriatric patients - p. 63 14. Unit IV Peripheral nervous system drugs - p. 69 15. 11 Basic principles of neuropharmacology - p. 69 16. 12 Physiology of the peripheral nervous system - p. 73 17. 13 Muscarinic agonists and cholinesterase inhibitors - p. 83 18. 14 Muscarinic antagonists - p. 92 19. 15 Adrenergic agonists - p. 100 20. 16 Adrenergic antagonists - p. 109 21. 17 Indirect-acting antiadrenergic agents - p. 120 22. Unit V Central nervous system drugs - p. 125 23. 18 Introduction to central nervous system pharmacology - p. 125 24. 19 Drugs for parkinson disease - p. 127 25. 20 Drugs for Alzheimer disease - p. 144 26. 21 Drugs for seizure disorders - p. 152 27. 22 Drugs for muscle spasm and spasticity - p. 169 28. Unit VI Drugs for pain - p. 177 29. 23 Local anesthetics - p. 177 30. 24 Opioid analgesics, opioid antagonists, and nonopioid centrally acting analgesics - p. 181 31. 25 Drugs for headache - p. 192 32. Unit VII Psychotherapeutic drugs - p. 201 33. 26 Antipsychotic agents and their use in schizophrenia - p. 201 34. 27 Antidepressants - p. 212 35. 28 Drugs for bipolar disorder - p. 226 36. 29 Sedative-hypnotic drugs - p. 232 37. 30 Management of anxiety disorders - p. 241 38. 31 Central nervous system stimulants and attention-deficit/hyperactivity disorder - p. 246 39. Unit VIII Substance use disorders - p. 253 40. 32 Substance use disorders I: Basic considerations - p. 253 41. 33 Substance use disorders II: Alcohol - p. 258 42. 34 Substance use disorders III: Nicotine and smoking - p. 265 43. 35 Substance use disorders IV: Major drugs of misuse other than alcohol and nicotine - p. 270 44. Unit IX Drugs that affect the heart, blood vessels, blood, and blood volume - p. 281 45. 36 Review of hemodynamics - p. 281 46. 37 Diuretics - p. 286 47. 38 Drugs acting on the renin-angiotensin-aldosterone system - p. 293 48. 39 Calcium channel blockers - p. 304 49. 40 Vasodilators - p. 309 50. 41 Drugs for hypertension - p. 312 51. 42 Drugs for heart failure - p. 321 52. 43 Antidysrhythmic drugs - p. 333 53. 44 Prophylaxis of atherosclerotic cardiovascular disease: Drugs that help normalize cholesterol and triglyceride levels - p. 345 54. 45 Drugs for angina pectoris - p. 360 55. 46 Anticoagulant and antiplatelet drugs - p. 368 56. 47 Drugs for deficiency anemias - p. 385 57. Unit X Drugs for endocrine disorders - p. 393 58. 48 Drugs for diabetes - p. 393 59. 49 Drugs for thyroid disorders - p. 416 60. Unit XI Reproductive health - p. 425 61. 50 Estrogens and progestins: Basic pharmacology and noncontraceptive applications - p. 425 62. 51 Birth control - p. 437 63. 52 Androgens - p. 447 64. 53 Drugs for benign prostatic hyperplasia - p. 453 65. 54 Drugs for sexual dysfunction - p. 457 66. 55 Transgender health - p. 466 67. Unit XII Antiinflammatory, antiallergic, and immunologic drugs - p. 475 68. 56 Review of the immune system - p. 475 69. 57 Childhood immunization - p. 484 70. 58 Antihistamines - p. 495 71. 59 Cyclooxygenase inhibitors, nonsteroidal antiinflammatory drugs, and acetaminophen - p. 500 72. 60 Glucocorticoids in nonendocrine disorders - p. 510 73. Unit XIII Drugs for bone and joint disorders - p. 519 74. 61 Drug therapy for rheumatoid arthritis - p. 519 75. 62 Drug therapy for gout - p. 534 76. 63 Drugs affecting calcium levels and bone mineralization - p. 540 77. Unit XIV Respiratory tract drugs - p. 557 78. 64 Drugs for asthma and chronic obstructive pulmonary disease - p. 557 79. 65 Drugs for allergic rhinitis, cough, and colds - p. 577 80. Unit XV Gastrointestinal drugs - p. 585 81. 66 Drugs for peptic ulcer disease - p. 585 82. 67 Laxatives - p. 594 83. 68 Other gastrointestinal drugs - p. 601 84. Unit XVI Nutrition and complementary therapies - p. 611 85. 69 Vitamins - p. 611 86. 70 Drugs for obesity - p. 621 87. 71 Complementary and alternative therapy - p. 630 88. Unit XVII Therapy for infectious and parasitic diseases - p. 645 89. 72 Basic principles of antimicrobial therapy - p. 645 90. 73 Drugs that weaken the bacterial cell wall I: Penicillins - p. 656 91. 74 Drugs that weaken the bacterial cell wall II: Other drugs - p. 663 92. 75 Bacteriostatic inhibitors of protein synthesis - p. 670 93. 76 Aminoglycosides: Bactericidal inhibitors of protein synthesis - p. 677 94. 77 Sulfonamide antibiotics and trimethoprim - p. 682 95. 78 Drug therapy for urinary tract infections - p. 689 96. 79 Drug therapy for tuberculosis - p. 694 97. 80 Miscellaneous antibacterial drugs - p. 707 98. 81 Antifungal agents - p. 711 99. 82 Antiviral agents I: Drugs for non-hiv viral infections - p. 721 100. 83 Antiviral agents II: Drugs for HIV infection - p. 745 101. 84 Drug therapy for sexually transmitted infections - p. 764 102. 85 Anthelmintics - p. 773 103. Unit XVIII Cancer therapy - p. 779 104. 86 Introduction to immunomodulators - p. 779 105. 87 Supportive care of patients receiving anticancer drugs - p. 782 106. 88 Drugs for cancer pain - p. 811 107. Unit XIX Drugs for eyes, ears, and skin - p. 819 108. 89 Drugs for disorders of the eye - p. 819 109. 90 Drugs for disorders of the skin - p. 830 110. 91 Drugs for disorders of the ear - p. 855 111. Unit XX Drug therapy in acute care - p. 863 112. 92 Agents affecting the volume and ion content of body fluids - p. 863 113. 93 Management of ST-Elevation myocardial infarction - p. 867 114. 94 Drugs for acute care - p. 872 115. Appendix Canadian drug information - p. 883 116. Index - p. 887
