Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions.Macrophages in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. ix 7. Chapter 1. Macrophages: From Metchnikoff to 2020 and ahead - p. 1 8. Chapter 2. Macrophage differentiation - p. 19 9. Chapter 3. Metabolic requirement for macrophages - p. 49 10. Chapter 4. Spleen, lymph nodes, and lymphoid tissues—Inflammatory system - p. 67 11. Chapter 5. Kidney—Inflammation and remodeling - p. 107 12. Chapter 6. Dermal macrophages in health and disease - p. 139 13. Chapter 7. Bone—From macrophage to osteoclast and osteolytic diseases - p. 161 14. Chapter 8. Microglia and border-associated macrophages in the central nervous system - p. 181 15. Chapter 9. Intestines—Inflammatory and digestive system - p. 213 16. Chapter 10. Lungs—Inflammatory and respiratory system - p. 231 17. Chapter 11. Macrophages in the immune-endocrine milieu of reproductive tissues - p. 243 18. Chapter 12. Macrophages at the maternal-fetal interface - p. 265 19. Chapter 13. Targeting macrophages in systemic diseases - p. 283 20. Index - p. 303
Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions.Macrophages in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. ix 7. Chapter 1. Macrophages: From Metchnikoff to 2020 and ahead - p. 1 8. Chapter 2. Macrophage differentiation - p. 19 9. Chapter 3. Metabolic requirement for macrophages - p. 49 10. Chapter 4. Spleen, lymph nodes, and lymphoid tissues—Inflammatory system - p. 67 11. Chapter 5. Kidney—Inflammation and remodeling - p. 107 12. Chapter 6. Dermal macrophages in health and disease - p. 139 13. Chapter 7. Bone—From macrophage to osteoclast and osteolytic diseases - p. 161 14. Chapter 8. Microglia and border-associated macrophages in the central nervous system - p. 181 15. Chapter 9. Intestines—Inflammatory and digestive system - p. 213 16. Chapter 10. Lungs—Inflammatory and respiratory system - p. 231 17. Chapter 11. Macrophages in the immune-endocrine milieu of reproductive tissues - p. 243 18. Chapter 12. Macrophages at the maternal-fetal interface - p. 265 19. Chapter 13. Targeting macrophages in systemic diseases - p. 283 20. Index - p. 303
