Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.
1. Mechanisms of Disease Pathogenesis in Multiple Sclerosis - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. List of Illustrations - p. Page vi 8. List of Tables - p. Page vii 9. Chapter 1 : Multiple sclerosis: Clinical course, open questions, unmet clinical needs - p. Page vii 10. Chapter 2 : Novel imaging approaches in multiple sclerosis - p. Page 19 11. Chapter 3 : Effect of infections on multiple sclerosis - p. Page 73 12. Chapter 4 : T cells in multiple sclerosis - p. Page 112 13. Chapter 5 : B cells in multiple sclerosis - p. Page 141 14. Chapter 6 : Microglia in multiple sclerosis - p. Page 180 15. Chapter 7 : Monocytes in multiple sclerosis - p. Page 212 16. Chapter 8 : Antigen presenting cells in multiple sclerosis - p. Page 238 17. Chapter 9 : Oligodendrocytes in multiple sclerosis - p. Page 256 18. Chapter 10 : Astrocytes in multiple sclerosis - p. Page 278 19. Chapter 11 : The blood-brain barrier in multiple sclerosis - p. Page 300 20. Chapter 12 : Microbiome in multiple sclerosis - p. Page 333 21. Index - p. Page 375
Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.
1. Mechanisms of Disease Pathogenesis in Multiple Sclerosis - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. List of Illustrations - p. Page vi 8. List of Tables - p. Page vii 9. Chapter 1 : Multiple sclerosis: Clinical course, open questions, unmet clinical needs - p. Page vii 10. Chapter 2 : Novel imaging approaches in multiple sclerosis - p. Page 19 11. Chapter 3 : Effect of infections on multiple sclerosis - p. Page 73 12. Chapter 4 : T cells in multiple sclerosis - p. Page 112 13. Chapter 5 : B cells in multiple sclerosis - p. Page 141 14. Chapter 6 : Microglia in multiple sclerosis - p. Page 180 15. Chapter 7 : Monocytes in multiple sclerosis - p. Page 212 16. Chapter 8 : Antigen presenting cells in multiple sclerosis - p. Page 238 17. Chapter 9 : Oligodendrocytes in multiple sclerosis - p. Page 256 18. Chapter 10 : Astrocytes in multiple sclerosis - p. Page 278 19. Chapter 11 : The blood-brain barrier in multiple sclerosis - p. Page 300 20. Chapter 12 : Microbiome in multiple sclerosis - p. Page 333 21. Index - p. Page 375
