Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. List of Contributors - p. vii 7. Preface: Mechanobiology, why not? - p. xi 8. Section I. Mechanobiological Basis of Diseases - p. xv 9. Chapter 1.1. Osteocyte Mechanobiology in Aging and Disease - p. 1 10. Chapter 1.2. Cardiovascular Mechanics and Disease - p. 23 11. Chapter 1.3. Mechanobiology of the Optic Nerve Head in Primary Open-Angle Glaucoma - p. 47 12. Chapter 1.4. The Role of Mechanobiology in Cancer Metastasis - p. 65 13. Section II. Cellular Basis of Mechanobiology - p. 78 14. Chapter 2.1. Cells as Functional Load Sensors and Drivers of Adaptation - p. 79 15. Chapter 2.2. Primary Cilia Mechanobiology - p. 99 16. Chapter 2.3. In Vivo Models of Muscle Stimulation and Mechanical Loading in Bone Mechanobiology - p. 117 17. Section III. Experimental Methods - p. 136 18. Chapter 3.1. Mechanobiology in Soft Tissue Engineering - p. 137 19. Chapter 3.2. Intracellular Force Measurements in Live Cells With Förster Resonance Energy Transfer–Based Molecular Tension Sensors - p. 161 20. Section IV. Computational Simulations in Mechanobiology - p. 171 21. Chapter 4.1. Multiscale Models Coupling Chemical Signaling and Mechanical Properties for Studying Tissue Growth - p. 173 22. Chapter 4.2. Computational Morphogenesis of Embryonic Bone Development: Past, Present, and Future - p. 197 23. Chapter 5. Future Prospects and Challenges - p. 221 24. Glossary - p. 229 25. Index - p. 231
Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. List of Contributors - p. vii 7. Preface: Mechanobiology, why not? - p. xi 8. Section I. Mechanobiological Basis of Diseases - p. xv 9. Chapter 1.1. Osteocyte Mechanobiology in Aging and Disease - p. 1 10. Chapter 1.2. Cardiovascular Mechanics and Disease - p. 23 11. Chapter 1.3. Mechanobiology of the Optic Nerve Head in Primary Open-Angle Glaucoma - p. 47 12. Chapter 1.4. The Role of Mechanobiology in Cancer Metastasis - p. 65 13. Section II. Cellular Basis of Mechanobiology - p. 78 14. Chapter 2.1. Cells as Functional Load Sensors and Drivers of Adaptation - p. 79 15. Chapter 2.2. Primary Cilia Mechanobiology - p. 99 16. Chapter 2.3. In Vivo Models of Muscle Stimulation and Mechanical Loading in Bone Mechanobiology - p. 117 17. Section III. Experimental Methods - p. 136 18. Chapter 3.1. Mechanobiology in Soft Tissue Engineering - p. 137 19. Chapter 3.2. Intracellular Force Measurements in Live Cells With Förster Resonance Energy Transfer–Based Molecular Tension Sensors - p. 161 20. Section IV. Computational Simulations in Mechanobiology - p. 171 21. Chapter 4.1. Multiscale Models Coupling Chemical Signaling and Mechanical Properties for Studying Tissue Growth - p. 173 22. Chapter 4.2. Computational Morphogenesis of Embryonic Bone Development: Past, Present, and Future - p. 197 23. Chapter 5. Future Prospects and Challenges - p. 221 24. Glossary - p. 229 25. Index - p. 231
