The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common.
This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.
1. Introduction - p. 189 2. Prion-Like Proteins in Neurodegenerative Diseases - p. 196 3. Mechanistic, Functional, and Pathogenic Properties of Prions - p. 206 4. Mechanisms of Transport and Cell-to-Cell Propagation - p. 209 5. The Strain Hypothesis - p. 214 6. How Prion Strains Might Come to Our Aid - p. 219 7. The Issue of Communicability of “Prion-Like” Diseases - p. 223 8. Conclusions - p. 226 9. References - p. 227 10. Chapter 9. Neurodegenerative Diseases as Protein Folding Disorders - p. 243 11. Chapter 10. Heat Shock Proteins and Protein Quality Control in Alzheimer’s Disease - p. 269 12. Chapter 11. Neurodegenerative Diseases and Autophagy - p. 299 13. Chapter 12. Neurodegenerative Diseases and Axonal Transport - p. 345 14. Chapter 13. Mitochondrial Function and Neurodegenerative Diseases - p. 369 15. Abstract - p. 369 16. Acknowledgment - p. 369 17. Introduction - p. 369 18. Mitochondria and Bioenergetics - p. 370 19. Mitochondria in Neurodegenerative Diseases - p. 382 20. Therapeutic Targeting of Mitochondria - p. 392 21. Conclusions - p. 394 22. References - p. 395 23. Chapter 14. Non-cell Autonomous Degeneration: Role of Astrocytes in Neurodegenerative Diseases - p. 415 24. Chapter 15. Neurodegenerative Diseases and RNA-Mediated Toxicity - p. 441 25. Chapter 16. Neuroinflammation in Age-Related Neurodegenerative Diseases - p. 477 26. Chapter 17. Neurodegenerative Diseases and the Aging Brain - p. 509 27. Index - p. 527
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common.
This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.
1. Introduction - p. 189 2. Prion-Like Proteins in Neurodegenerative Diseases - p. 196 3. Mechanistic, Functional, and Pathogenic Properties of Prions - p. 206 4. Mechanisms of Transport and Cell-to-Cell Propagation - p. 209 5. The Strain Hypothesis - p. 214 6. How Prion Strains Might Come to Our Aid - p. 219 7. The Issue of Communicability of “Prion-Like” Diseases - p. 223 8. Conclusions - p. 226 9. References - p. 227 10. Chapter 9. Neurodegenerative Diseases as Protein Folding Disorders - p. 243 11. Chapter 10. Heat Shock Proteins and Protein Quality Control in Alzheimer’s Disease - p. 269 12. Chapter 11. Neurodegenerative Diseases and Autophagy - p. 299 13. Chapter 12. Neurodegenerative Diseases and Axonal Transport - p. 345 14. Chapter 13. Mitochondrial Function and Neurodegenerative Diseases - p. 369 15. Abstract - p. 369 16. Acknowledgment - p. 369 17. Introduction - p. 369 18. Mitochondria and Bioenergetics - p. 370 19. Mitochondria in Neurodegenerative Diseases - p. 382 20. Therapeutic Targeting of Mitochondria - p. 392 21. Conclusions - p. 394 22. References - p. 395 23. Chapter 14. Non-cell Autonomous Degeneration: Role of Astrocytes in Neurodegenerative Diseases - p. 415 24. Chapter 15. Neurodegenerative Diseases and RNA-Mediated Toxicity - p. 441 25. Chapter 16. Neuroinflammation in Age-Related Neurodegenerative Diseases - p. 477 26. Chapter 17. Neurodegenerative Diseases and the Aging Brain - p. 509 27. Index - p. 527
