This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language.
This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis.
The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance.
1. Introduction - p. xiii 2. Chapter 1. Chemical composition of living beings - p. 1 3. Chapter 2. Water - p. 5 4. Chapter 3. Proteins - p. 21 5. Chapter 4. Carbohydrates - p. 77 6. Chapter 5. Lipids - p. 105 7. Chapter 6. Nucleic acids - p. 131 8. Chapter 7. Elements of thermodynamics and biochemical kinetics - p. 153 9. Chapter 8. Enzymes - p. 166 10. Chapter 9. Biological oxidations: Bioenergetics - p. 191 11. Chapter 10. Antioxidants - p. 221 12. Chapter 11. Membranes - p. 264 13. Chapter 12. Digestion—Absorption - p. 281 14. Chapter 13. Metabolism - p. 307 15. Chapter 14. Carbohydrate metabolism - p. 324 16. Chapter 15. Lipid metabolism - p. 359 17. Chapter 16. Amino acid metabolism - p. 401 18. Chapter 17. Heme metabolism - p. 437 19. Chapter 18. Purine and pyrimidine metabolism - p. 449 20. Chapter 19. Integration and regulation of metabolism - p. 461 21. Chapter 20. Metabolism in some tissues - p. 483 22. Chapter 21. The genetic information (I) - p. 501 23. Chapter 22. The genetic information (II) - p. 535 24. Chapter 23. Regulation of gene expression - p. 569 25. Chapter 24. Posttranslational protein modifications - p. 583 26. Chapter 25. Biochemical basis of endocrinology (I) receptors and signal transduction - p. 611 27. Chapter 26. Biochemical bases of endocrinology (II) hormones and other chemical intermediates - p. 632 28. Chapter 27. Vitamins - p. 709 29. Chapter 28. Water and acid-base balance - p. 753 30. Chapter 29. Essential minerals - p. 780 31. Chapter 30. Molecular basis of immunity - p. 811 32. Chapter 31. Hemostasis - p. 851 33. Chapter 32. Cell death - p. 861 34. Index - p. 871
This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language.
This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis.
The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance.
1. Introduction - p. xiii 2. Chapter 1. Chemical composition of living beings - p. 1 3. Chapter 2. Water - p. 5 4. Chapter 3. Proteins - p. 21 5. Chapter 4. Carbohydrates - p. 77 6. Chapter 5. Lipids - p. 105 7. Chapter 6. Nucleic acids - p. 131 8. Chapter 7. Elements of thermodynamics and biochemical kinetics - p. 153 9. Chapter 8. Enzymes - p. 166 10. Chapter 9. Biological oxidations: Bioenergetics - p. 191 11. Chapter 10. Antioxidants - p. 221 12. Chapter 11. Membranes - p. 264 13. Chapter 12. Digestion—Absorption - p. 281 14. Chapter 13. Metabolism - p. 307 15. Chapter 14. Carbohydrate metabolism - p. 324 16. Chapter 15. Lipid metabolism - p. 359 17. Chapter 16. Amino acid metabolism - p. 401 18. Chapter 17. Heme metabolism - p. 437 19. Chapter 18. Purine and pyrimidine metabolism - p. 449 20. Chapter 19. Integration and regulation of metabolism - p. 461 21. Chapter 20. Metabolism in some tissues - p. 483 22. Chapter 21. The genetic information (I) - p. 501 23. Chapter 22. The genetic information (II) - p. 535 24. Chapter 23. Regulation of gene expression - p. 569 25. Chapter 24. Posttranslational protein modifications - p. 583 26. Chapter 25. Biochemical basis of endocrinology (I) receptors and signal transduction - p. 611 27. Chapter 26. Biochemical bases of endocrinology (II) hormones and other chemical intermediates - p. 632 28. Chapter 27. Vitamins - p. 709 29. Chapter 28. Water and acid-base balance - p. 753 30. Chapter 29. Essential minerals - p. 780 31. Chapter 30. Molecular basis of immunity - p. 811 32. Chapter 31. Hemostasis - p. 851 33. Chapter 32. Cell death - p. 861 34. Index - p. 871
