Mesenchymal Stem Cells and Extracellular Vesicles as Next-Generation Therapeutics: Basic Concepts, Clinical Applications, and Cross-Disciplinary Innovations provides a comprehensive exploration of the groundbreaking roles stem cells and extracellular vesicles (EVs) play in regenerative medicine. The book examines the fundamental biology of stem cells and EVs, their therapeutic applications across tissues - including skin, neural, cardiac, ocular, and more and the innovative, interdisciplinary approaches shaping the future of healthcare. Sections cover Basic and Emerging Concepts, Therapeutic Applications and Disease Focus, and Cross-disciplinary Innovations and Future Directions the field will encounter in this rapidly growing branch of medicine.
Written by experts in the field for researchers and academics engaged in regenerative medicine, stem cell biology, and biomedical engineering, this book will be of interest to healthcare professionals such as physicians, surgeons, and specialists interested in tissue repair and regeneration.
1. Chapter 1. Introduction to mesenchymal stem cells and extracellular vesicles as next-generation therapeutics - p. 3 2. Chapter 2. Introduction to mesenchymal stem cell and extracellular vesicle biology - p. 9 3. Chapter 3. An overview on mesenchymal stem cells and extracellular vesicles in regenerative medicine - p. 39 4. Chapter 4. Engineering extracellular vesicles and mesenchymal stem cells for enhanced organ retention - p. 67 5. Chapter 5. Biomanufacturing of mesenchymal stem cells and extracellular vesicles: challenges and advances in isolation, scale-up, storage, transportation, and beyond - p. 85 6. Chapter 6. Quality, commercialization, and equity in mesenchymal stem cell and extracellular vesicle therapies - p. 121 7. Chapter 7. Regulatory pathways for mesenchymal stem cell and extracellular vesicle-based therapies: comparative perspectives from India, Europe, and the United States - p. 141 8. SECTION II: Therapeutic applications and disease focus - p. S163 9. Chapter 8. Mesenchymal stem cells and extracellular vesicles in skin regeneration - p. 165 10. Chapter 9. Mesenchymal stem cells and extracellular vesicles in neural regeneration - p. 203 11. Chapter 10. Mesenchymal stem cells and extracellular vesicles in neurodegenerative diseases - p. 231 12. Chapter 11. Mesenchymal stem cells and extracellular vesicles in cardiac regeneration - p. 271 13. Chapter 12. Mesenchymal stem cells and extracellular vesicles in ocular regeneration - p. 297 14. Chapter 13. Mesenchymal stem cells and extracellular vesicles in bone regeneration - p. 329 15. Chapter 14. Mesenchymal stem cells and extracellular vesicles in cartilage regeneration - p. 359 16. Chapter 15. Mesenchymal stem cells and extracellular vesicles in liver regeneration - p. 397 17. Chapter 16. Mesenchymal stem cells and their extracellular vesicles in pancreatic regeneration - p. 431 18. Chapter 17. Mesenchymal stem cells and extracellular vesicles in lung regeneration - p. 473 19. Chapter 18. Mesenchymal stem cell-derived extracellular vesicles in cancer immunotherapy - p. 513 20. SECTION III: Cross-disciplinary innovations and future directions - p. S565 21. Chapter 19. Biomaterials in mesenchymal stem cell and extracellular vesicle research - p. 567 22. Chapter 20. Bioreactors in mesenchymal stem cells and extracellular vesicles for therapeutic applications - p. 593 23. Chapter 21. Nanotechnology in mesenchymal stem cell and extracellular vesicle research - p. 623 24. Chapter 22. Microfluidics in mesenchymal stem cell and extracellular vesicle research - p. 663 25. Chapter 23. Artificial intelligence and machine learning in mesenchymal stem cell and extracellular vesicle research - p. 695 26. Chapter 24. Mesenchymal stem cells derived extracellular vesicles in radiation response - p. 733 27. Chapter 25. Mesenchymal stem cells and extracellular vesicles in space medicine - p. 755 28. Index - p. 783
Mesenchymal Stem Cells and Extracellular Vesicles as Next-Generation Therapeutics: Basic Concepts, Clinical Applications, and Cross-Disciplinary Innovations provides a comprehensive exploration of the groundbreaking roles stem cells and extracellular vesicles (EVs) play in regenerative medicine. The book examines the fundamental biology of stem cells and EVs, their therapeutic applications across tissues - including skin, neural, cardiac, ocular, and more and the innovative, interdisciplinary approaches shaping the future of healthcare. Sections cover Basic and Emerging Concepts, Therapeutic Applications and Disease Focus, and Cross-disciplinary Innovations and Future Directions the field will encounter in this rapidly growing branch of medicine.
Written by experts in the field for researchers and academics engaged in regenerative medicine, stem cell biology, and biomedical engineering, this book will be of interest to healthcare professionals such as physicians, surgeons, and specialists interested in tissue repair and regeneration.
1. Chapter 1. Introduction to mesenchymal stem cells and extracellular vesicles as next-generation therapeutics - p. 3 2. Chapter 2. Introduction to mesenchymal stem cell and extracellular vesicle biology - p. 9 3. Chapter 3. An overview on mesenchymal stem cells and extracellular vesicles in regenerative medicine - p. 39 4. Chapter 4. Engineering extracellular vesicles and mesenchymal stem cells for enhanced organ retention - p. 67 5. Chapter 5. Biomanufacturing of mesenchymal stem cells and extracellular vesicles: challenges and advances in isolation, scale-up, storage, transportation, and beyond - p. 85 6. Chapter 6. Quality, commercialization, and equity in mesenchymal stem cell and extracellular vesicle therapies - p. 121 7. Chapter 7. Regulatory pathways for mesenchymal stem cell and extracellular vesicle-based therapies: comparative perspectives from India, Europe, and the United States - p. 141 8. SECTION II: Therapeutic applications and disease focus - p. S163 9. Chapter 8. Mesenchymal stem cells and extracellular vesicles in skin regeneration - p. 165 10. Chapter 9. Mesenchymal stem cells and extracellular vesicles in neural regeneration - p. 203 11. Chapter 10. Mesenchymal stem cells and extracellular vesicles in neurodegenerative diseases - p. 231 12. Chapter 11. Mesenchymal stem cells and extracellular vesicles in cardiac regeneration - p. 271 13. Chapter 12. Mesenchymal stem cells and extracellular vesicles in ocular regeneration - p. 297 14. Chapter 13. Mesenchymal stem cells and extracellular vesicles in bone regeneration - p. 329 15. Chapter 14. Mesenchymal stem cells and extracellular vesicles in cartilage regeneration - p. 359 16. Chapter 15. Mesenchymal stem cells and extracellular vesicles in liver regeneration - p. 397 17. Chapter 16. Mesenchymal stem cells and their extracellular vesicles in pancreatic regeneration - p. 431 18. Chapter 17. Mesenchymal stem cells and extracellular vesicles in lung regeneration - p. 473 19. Chapter 18. Mesenchymal stem cell-derived extracellular vesicles in cancer immunotherapy - p. 513 20. SECTION III: Cross-disciplinary innovations and future directions - p. S565 21. Chapter 19. Biomaterials in mesenchymal stem cell and extracellular vesicle research - p. 567 22. Chapter 20. Bioreactors in mesenchymal stem cells and extracellular vesicles for therapeutic applications - p. 593 23. Chapter 21. Nanotechnology in mesenchymal stem cell and extracellular vesicle research - p. 623 24. Chapter 22. Microfluidics in mesenchymal stem cell and extracellular vesicle research - p. 663 25. Chapter 23. Artificial intelligence and machine learning in mesenchymal stem cell and extracellular vesicle research - p. 695 26. Chapter 24. Mesenchymal stem cells derived extracellular vesicles in radiation response - p. 733 27. Chapter 25. Mesenchymal stem cells and extracellular vesicles in space medicine - p. 755 28. Index - p. 783
