Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xi 7. Chapter 1. Sample preparation for the analysis of drugs in biological fluids - p. 1 8. Chapter 2. Drug analyses in human plasma by chromatography - p. 15 9. Chapter 3. Mass spectrometry for the quantification of drugs in biosamples - p. 47 10. Chapter 4. Capillary electrophoresis for the determination of drugs in biological fluids - p. 81 11. Chapter 5. Immunoassays for therapeutic drug monitoring and clinical toxicology - p. 97 12. Chapter 6. Validation of bioanalytical chromatographic methods for the quantification of drugs in biological fluids - p. 115 13. Chapter 7. Pharmacokinetic methods for TDM data analysis and optimal individualization of drug dosage regimens - p. 135 14. Chapter 8. Therapeutic drug monitoring of antibiotics in critically ill patients - p. 169 15. Chapter 9. Therapeutic drug monitoring for antifungal triazoles: pharmacologic background and current status - p. 185 16. Chapter 10. Therapeutic monitoring of antiepileptic drugs - p. 225 17. Chapter 11. Therapeutic drug monitoring of antidepressant and antipsychotic drugs - p. 257 18. Chapter 12. Assessing immunosuppressive drug concentrations in clinical practice - p. 277 19. Chapter 13. Dose and therapy individualization in cancer chemotherapy - p. 291 20. Chapter 14. Pharmacogenomics - p. 321 21. Index - p. 355
Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xi 7. Chapter 1. Sample preparation for the analysis of drugs in biological fluids - p. 1 8. Chapter 2. Drug analyses in human plasma by chromatography - p. 15 9. Chapter 3. Mass spectrometry for the quantification of drugs in biosamples - p. 47 10. Chapter 4. Capillary electrophoresis for the determination of drugs in biological fluids - p. 81 11. Chapter 5. Immunoassays for therapeutic drug monitoring and clinical toxicology - p. 97 12. Chapter 6. Validation of bioanalytical chromatographic methods for the quantification of drugs in biological fluids - p. 115 13. Chapter 7. Pharmacokinetic methods for TDM data analysis and optimal individualization of drug dosage regimens - p. 135 14. Chapter 8. Therapeutic drug monitoring of antibiotics in critically ill patients - p. 169 15. Chapter 9. Therapeutic drug monitoring for antifungal triazoles: pharmacologic background and current status - p. 185 16. Chapter 10. Therapeutic monitoring of antiepileptic drugs - p. 225 17. Chapter 11. Therapeutic drug monitoring of antidepressant and antipsychotic drugs - p. 257 18. Chapter 12. Assessing immunosuppressive drug concentrations in clinical practice - p. 277 19. Chapter 13. Dose and therapy individualization in cancer chemotherapy - p. 291 20. Chapter 14. Pharmacogenomics - p. 321 21. Index - p. 355
