The Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition provides the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests. This classic clinical chemistry reference offers encyclopedic coverage detailing everything you need to know, including: analytical criteria for the medical usefulness of laboratory tests, variables that affect tests and results, laboratory medicine, applications of statistical methods, and most importantly clinical utility and interpretation of laboratory tests. It is THE definitive reference in clinical chemistry and molecular diagnostics, now fully searchable and with quarterly content updates, podcasts, clinical cases, animations, and extended content online through Expert Consult.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Associate Editors - p. iii 7. Reviewers - p. iii 8. Contributors - p. iii 9. Contributors to Expert Consult - p. iii 10. Foreword - p. iii 11. Preface - p. iii 12. List of Illustrations - p. iii 13. List of Tables - p. iii 14. Section I: Basics of Laboratory Medicine - p. iii 15. Chapter 1: Clinical Chemistry and Molecular Diagnostics - p. iii 16. Chapter 2: Statistical Methodologies in Laboratory Medicine: Analytical and Clinical Evaluation of Laboratory Tests - p. iii 17. Chapter 3: Quality Management in the Medical Laboratory - p. iii 18. Chapter 4: Specimen Collection and Processing - p. iii 19. Chapter 5: Preanalytical Variation and Preexamination Processes - p. iii 20. Chapter 6: Quality Control of the Analytical Examination Process - p. iii 21. Chapter 7: Biological Variation - p. iii 22. Chapter 8: Establishment and Use of Reference Intervals - p. iii 23. Chapter 9: Evidence-Based Laboratory Medicine - p. iii 24. Chapter 10: Biobanking - p. iii 25. Chapter 11: Laboratory Support of Pharmaceutical, In Vitro Diagnostics, and Epidemiologic Studies - p. iii 26. Section II: Analytical Techniques and Applications - p. iii 27. Chapter 12: Principles of Basic Techniques and Laboratory Safety - p. iii 28. Chapter 13: Optical Techniques - p. iii 29. Chapter 14: Electrochemistry and Chemical Sensors - p. iii 30. Chapter 15: Electrophoresis - p. iii 31. Chapter 16: Chromatography - p. iii 32. Chapter 17: Mass Spectrometry - p. iii 33. Chapter 18: Sample Preparation for Mass Spectrometry Applications - p. iii 34. Chapter 19: Mass Spectrometry Applications in Infectious Disease and Pathogens Identification - p. iii 35. Chapter 20: Development and Validation of Small Molecule Analytes by Liquid Chromatography-Tandem Mass Spectrometry - p. iii 36. Chapter 21: Proteomics - p. iii 37. Chapter 22: Enzyme and Rate Analysis - p. iii 38. Chapter 23: Immunochemical Techniques - p. iii 39. Chapter 24: Microfabrication and Microfluidics and Their Application in Clinical Diagnostics - p. iii 40. Chapter 25: Cytometry - p. iii 41. Chapter 26: Automation in the Clinical Laboratory - p. iii 42. Chapter 27: Point-of-Care Testing - p. iii 43. Section III: Analytes - p. iii 44. Chapter 28: Amino Acids, Peptides, and Proteins - p. iii 45. Chapter 29: Serum Enzymes - p. iii 46. Chapter 30: Enzymes of the Red Blood Cell - p. iii 47. Chapter 31: Tumor Markers - p. iii 48. Chapter 32: Kidney Function Tests - p. iii 49. Chapter 33: Carbohydrates - p. iii 50. Chapter 34: Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors - p. iii 51. Chapter 35: Electrolytes and Blood Gases - p. iii 52. Chapter 36: Hormones - p. iii 53. Chapter 37: Vitamins and Trace Elements - p. iii 54. Chapter 38: Hemoglobin, Iron, Bilirubin - p. iii 55. Chapter 39: Porphyrins and the Porphyrias - p. iii 56. Chapter 40: Therapeutic Drugs and Their Management - p. iii 57. Chapter 41: Clinical Toxicology - p. iii 58. Chapter 42: Toxic Elements - p. iii 59. Chapter 43: Body Fluids - p. iii 60. Section IV: Molecular Diagnostics - p. iii 61. Chapter 44: Principles of Molecular Biology - p. iii 62. Chapter 45: Genomes and Variants - p. iii 63. Chapter 46: Nucleic Acid Isolation - p. iii 64. Chapter 47: Nucleic Acid Techniques - p. iii 65. Chapter 48: Molecular Microbiology - p. iii 66. Chapter 49: Genetics - p. iii 67. Chapter 50: Solid Tumor Genomics - p. iii 68. Chapter 51: Genetic Aspects of Hematopoietic Malignancies - p. iii 69. Chapter 52: Circulating Tumor Cells and Circulating Tumor DNA - p. iii 70. Chapter 53: Circulating Nucleic Acids for Prenatal Diagnostics - p. iii 71. Chapter 54: Pharmacogenetics - p. iii 72. Chapter 55: Identity Testing - p. iii 73. Section V: Pathophysiology - p. iii 74. Chapter 56: Nutrition: Laboratory and Clinical Aspects - p. iii 75. Chapter 57: Diabetes Mellitus - p. iii 76. Chapter 58: Cardiac Function - p. iii 77. Chapter 59: Kidney Disease - p. iii 78. Chapter 60: Disorders of Water, Electrolytes, and Acid–Base Metabolism - p. iii 79. Chapter 61: Liver Disease - p. iii 80. Chapter 62: Gastric, Pancreatic, and Intestinal Function - p. iii 81. Chapter 63: Monoamine-Producing Tumors - p. iii 82. Chapter 64: Bone and Mineral Metabolism - p. iii 83. Chapter 65: Pituitary Function and Pathophysiology - p. iii 84. Chapter 66: Adrenal Cortex - p. iii 85. Chapter 67: Thyroid Disorders - p. iii 86. Chapter 68: Reproductive Endocrinology and Related Disorders - p. iii 87. Chapter 69: Pregnancy and Its Disorders - p. iii 88. Chapter 70: Newborn Screening and Inborn Errors of Metabolism - p. g0015 89. Section VI: Hematology and Coagulation - p. g0015 90. Chapter 71: Hemostasis - p. g0015 91. Chapter 72: Red Blood Cell Morphology and Indices With Clinical Chemistry Interface - p. g0015 92. Chapter 73: Automated Hematology - p. g0015 93. Section VII: Microbiology - p. g0015 94. Chapter 74: Bacteriology - p. g0015 95. Chapter 75: Antimicrobial Susceptibility Testing - p. g0015 96. Chapter 76: Mycobacteriology - p. g0015 97. Chapter 77: Mycology - p. g0015 98. Chapter 78: Parasitology - p. g0015 99. Chapter 79: Virology - p. g0015 100. Section VIII: Transfusion Medicine - p. g0015 101. Chapter 80: Blood Groups, Pretransfusion Testing, and Red Blood Cell Transfusion - p. g0015 102. Chapter 81: Blood Components, Blood Donor Screening, and Transfusion Reactions - p. g0015 103. Chapter 82: Reference Information for the Clinical Laboratory - p. g0015 104. Chapter 83: Tietz Atlas of Biochemical Genetics: The Roy Peake Collection - p. g0015 105. Chapter 84: Tietz Atlas of Electrophoretic Patterns - p. g0015 106. Chapter 85: Atlas of Electrophoretic Patterns - p. g0015 107. Chapter 86: Atlas of Biochemical Genetics - p. g0015 108. Chapter 87: Tietz Clinical Vignettes: The Coakley Collection and Other Short Cases - p. g0015 109. Chapter 88: Tietz Biochemical Calculations: Deacon's Challenge - p. g0015 110. Chapter 89: Tietz Teasers in Parasitology: The Bobbi Pritt Collection - p. g0015 111. Free-Living Amebae: Acanthamoeba species/Balamuthia mandrillaris - p. g0015 112. Acanthocephalans - p. g0015 113. Ascaris lumbricoides - p. g0015 114. Babesia species - p. g0015 115. Balantidium coli - p. g0015 116. Blastocystis hominis - p. g0015 117. Brugia malayi - p. g0015 118. Capillaria species - p. g0015 119. Non-Parasitic Stool Objects - p. g0015 120. Clonorchis sinensis - p. g0015 121. Cyclospora cayetanensis - p. g0015 122. Demodex species - p. g0015 123. Bot Flies - p. g0015 124. Diphyllobothrium species - p. g0015 125. Dipylidium caninum - p. g0015 126. Echinococcus species - p. g0015 127. Entamoeba coli - p. g0015 128. Entamoeba histolytica/Entamoeba dispar - p. g0015 129. Enterobius vermicularis (Pinworm) - p. g0015 130. Fasciola hepatica - p. g0015 131. Giardia duodenalis (a.k.a., G. lamblia, G. intestinalis) - p. g0015 132. Gordian Worm - p. g0015 133. Hard Ticks - p. g0015 134. Hookworm - p. g0015 135. Howell-Jolly Bodies - p. g0015 136. Hymenolepis nana - p. g0015 137. Iodamoeba buetschlii - p. g0015 138. Leishmania species - p. g0015 139. Microsporidia - p. g0015 140. Mosquitoes - p. g0015 141. Onchocerca volvulus - p. g0015 142. Paragonimus species - p. g0015 143. Pediculus humanus - p. g0015 144. Plasmodium species (Malaria) - p. g0015 145. Pthirus pubis (Pubic Louse) - p. g0015 146. Sarcocystis species - p. g0015 147. Sarcoptes scabei - p. g0015 148. Schistosoma species - p. g0015 149. Strongyloides stercoralis - p. g0015 150. Taenia species - p. g0015 151. Toxocara species - p. g0015 152. Toxoplasma gondii - p. g0015 153. Trichinella species - p. g0015 154. Trichuris trichiura (whipworm) - p. g0015 155. Trypanosomes - p. g0015 156. Tunga penetrans - p. g0015 157. Wuchereria bancrofti - p. g0015 158. Zoonotic Mite - p. g0015 159. Index - p. g0015
The Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition provides the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests. This classic clinical chemistry reference offers encyclopedic coverage detailing everything you need to know, including: analytical criteria for the medical usefulness of laboratory tests, variables that affect tests and results, laboratory medicine, applications of statistical methods, and most importantly clinical utility and interpretation of laboratory tests. It is THE definitive reference in clinical chemistry and molecular diagnostics, now fully searchable and with quarterly content updates, podcasts, clinical cases, animations, and extended content online through Expert Consult.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Associate Editors - p. iii 7. Reviewers - p. iii 8. Contributors - p. iii 9. Contributors to Expert Consult - p. iii 10. Foreword - p. iii 11. Preface - p. iii 12. List of Illustrations - p. iii 13. List of Tables - p. iii 14. Section I: Basics of Laboratory Medicine - p. iii 15. Chapter 1: Clinical Chemistry and Molecular Diagnostics - p. iii 16. Chapter 2: Statistical Methodologies in Laboratory Medicine: Analytical and Clinical Evaluation of Laboratory Tests - p. iii 17. Chapter 3: Quality Management in the Medical Laboratory - p. iii 18. Chapter 4: Specimen Collection and Processing - p. iii 19. Chapter 5: Preanalytical Variation and Preexamination Processes - p. iii 20. Chapter 6: Quality Control of the Analytical Examination Process - p. iii 21. Chapter 7: Biological Variation - p. iii 22. Chapter 8: Establishment and Use of Reference Intervals - p. iii 23. Chapter 9: Evidence-Based Laboratory Medicine - p. iii 24. Chapter 10: Biobanking - p. iii 25. Chapter 11: Laboratory Support of Pharmaceutical, In Vitro Diagnostics, and Epidemiologic Studies - p. iii 26. Section II: Analytical Techniques and Applications - p. iii 27. Chapter 12: Principles of Basic Techniques and Laboratory Safety - p. iii 28. Chapter 13: Optical Techniques - p. iii 29. Chapter 14: Electrochemistry and Chemical Sensors - p. iii 30. Chapter 15: Electrophoresis - p. iii 31. Chapter 16: Chromatography - p. iii 32. Chapter 17: Mass Spectrometry - p. iii 33. Chapter 18: Sample Preparation for Mass Spectrometry Applications - p. iii 34. Chapter 19: Mass Spectrometry Applications in Infectious Disease and Pathogens Identification - p. iii 35. Chapter 20: Development and Validation of Small Molecule Analytes by Liquid Chromatography-Tandem Mass Spectrometry - p. iii 36. Chapter 21: Proteomics - p. iii 37. Chapter 22: Enzyme and Rate Analysis - p. iii 38. Chapter 23: Immunochemical Techniques - p. iii 39. Chapter 24: Microfabrication and Microfluidics and Their Application in Clinical Diagnostics - p. iii 40. Chapter 25: Cytometry - p. iii 41. Chapter 26: Automation in the Clinical Laboratory - p. iii 42. Chapter 27: Point-of-Care Testing - p. iii 43. Section III: Analytes - p. iii 44. Chapter 28: Amino Acids, Peptides, and Proteins - p. iii 45. Chapter 29: Serum Enzymes - p. iii 46. Chapter 30: Enzymes of the Red Blood Cell - p. iii 47. Chapter 31: Tumor Markers - p. iii 48. Chapter 32: Kidney Function Tests - p. iii 49. Chapter 33: Carbohydrates - p. iii 50. Chapter 34: Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors - p. iii 51. Chapter 35: Electrolytes and Blood Gases - p. iii 52. Chapter 36: Hormones - p. iii 53. Chapter 37: Vitamins and Trace Elements - p. iii 54. Chapter 38: Hemoglobin, Iron, Bilirubin - p. iii 55. Chapter 39: Porphyrins and the Porphyrias - p. iii 56. Chapter 40: Therapeutic Drugs and Their Management - p. iii 57. Chapter 41: Clinical Toxicology - p. iii 58. Chapter 42: Toxic Elements - p. iii 59. Chapter 43: Body Fluids - p. iii 60. Section IV: Molecular Diagnostics - p. iii 61. Chapter 44: Principles of Molecular Biology - p. iii 62. Chapter 45: Genomes and Variants - p. iii 63. Chapter 46: Nucleic Acid Isolation - p. iii 64. Chapter 47: Nucleic Acid Techniques - p. iii 65. Chapter 48: Molecular Microbiology - p. iii 66. Chapter 49: Genetics - p. iii 67. Chapter 50: Solid Tumor Genomics - p. iii 68. Chapter 51: Genetic Aspects of Hematopoietic Malignancies - p. iii 69. Chapter 52: Circulating Tumor Cells and Circulating Tumor DNA - p. iii 70. Chapter 53: Circulating Nucleic Acids for Prenatal Diagnostics - p. iii 71. Chapter 54: Pharmacogenetics - p. iii 72. Chapter 55: Identity Testing - p. iii 73. Section V: Pathophysiology - p. iii 74. Chapter 56: Nutrition: Laboratory and Clinical Aspects - p. iii 75. Chapter 57: Diabetes Mellitus - p. iii 76. Chapter 58: Cardiac Function - p. iii 77. Chapter 59: Kidney Disease - p. iii 78. Chapter 60: Disorders of Water, Electrolytes, and Acid–Base Metabolism - p. iii 79. Chapter 61: Liver Disease - p. iii 80. Chapter 62: Gastric, Pancreatic, and Intestinal Function - p. iii 81. Chapter 63: Monoamine-Producing Tumors - p. iii 82. Chapter 64: Bone and Mineral Metabolism - p. iii 83. Chapter 65: Pituitary Function and Pathophysiology - p. iii 84. Chapter 66: Adrenal Cortex - p. iii 85. Chapter 67: Thyroid Disorders - p. iii 86. Chapter 68: Reproductive Endocrinology and Related Disorders - p. iii 87. Chapter 69: Pregnancy and Its Disorders - p. iii 88. Chapter 70: Newborn Screening and Inborn Errors of Metabolism - p. g0015 89. Section VI: Hematology and Coagulation - p. g0015 90. Chapter 71: Hemostasis - p. g0015 91. Chapter 72: Red Blood Cell Morphology and Indices With Clinical Chemistry Interface - p. g0015 92. Chapter 73: Automated Hematology - p. g0015 93. Section VII: Microbiology - p. g0015 94. Chapter 74: Bacteriology - p. g0015 95. Chapter 75: Antimicrobial Susceptibility Testing - p. g0015 96. Chapter 76: Mycobacteriology - p. g0015 97. Chapter 77: Mycology - p. g0015 98. Chapter 78: Parasitology - p. g0015 99. Chapter 79: Virology - p. g0015 100. Section VIII: Transfusion Medicine - p. g0015 101. Chapter 80: Blood Groups, Pretransfusion Testing, and Red Blood Cell Transfusion - p. g0015 102. Chapter 81: Blood Components, Blood Donor Screening, and Transfusion Reactions - p. g0015 103. Chapter 82: Reference Information for the Clinical Laboratory - p. g0015 104. Chapter 83: Tietz Atlas of Biochemical Genetics: The Roy Peake Collection - p. g0015 105. Chapter 84: Tietz Atlas of Electrophoretic Patterns - p. g0015 106. Chapter 85: Atlas of Electrophoretic Patterns - p. g0015 107. Chapter 86: Atlas of Biochemical Genetics - p. g0015 108. Chapter 87: Tietz Clinical Vignettes: The Coakley Collection and Other Short Cases - p. g0015 109. Chapter 88: Tietz Biochemical Calculations: Deacon's Challenge - p. g0015 110. Chapter 89: Tietz Teasers in Parasitology: The Bobbi Pritt Collection - p. g0015 111. Free-Living Amebae: Acanthamoeba species/Balamuthia mandrillaris - p. g0015 112. Acanthocephalans - p. g0015 113. Ascaris lumbricoides - p. g0015 114. Babesia species - p. g0015 115. Balantidium coli - p. g0015 116. Blastocystis hominis - p. g0015 117. Brugia malayi - p. g0015 118. Capillaria species - p. g0015 119. Non-Parasitic Stool Objects - p. g0015 120. Clonorchis sinensis - p. g0015 121. Cyclospora cayetanensis - p. g0015 122. Demodex species - p. g0015 123. Bot Flies - p. g0015 124. Diphyllobothrium species - p. g0015 125. Dipylidium caninum - p. g0015 126. Echinococcus species - p. g0015 127. Entamoeba coli - p. g0015 128. Entamoeba histolytica/Entamoeba dispar - p. g0015 129. Enterobius vermicularis (Pinworm) - p. g0015 130. Fasciola hepatica - p. g0015 131. Giardia duodenalis (a.k.a., G. lamblia, G. intestinalis) - p. g0015 132. Gordian Worm - p. g0015 133. Hard Ticks - p. g0015 134. Hookworm - p. g0015 135. Howell-Jolly Bodies - p. g0015 136. Hymenolepis nana - p. g0015 137. Iodamoeba buetschlii - p. g0015 138. Leishmania species - p. g0015 139. Microsporidia - p. g0015 140. Mosquitoes - p. g0015 141. Onchocerca volvulus - p. g0015 142. Paragonimus species - p. g0015 143. Pediculus humanus - p. g0015 144. Plasmodium species (Malaria) - p. g0015 145. Pthirus pubis (Pubic Louse) - p. g0015 146. Sarcocystis species - p. g0015 147. Sarcoptes scabei - p. g0015 148. Schistosoma species - p. g0015 149. Strongyloides stercoralis - p. g0015 150. Taenia species - p. g0015 151. Toxocara species - p. g0015 152. Toxoplasma gondii - p. g0015 153. Trichinella species - p. g0015 154. Trichuris trichiura (whipworm) - p. g0015 155. Trypanosomes - p. g0015 156. Tunga penetrans - p. g0015 157. Wuchereria bancrofti - p. g0015 158. Zoonotic Mite - p. g0015 159. Index - p. g0015
