Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications is the first book to simultaneously cover the microbiome and the metabolome in relevant clinical conditions. In a pioneering fashion, it addresses not only the classic intestinal environment, but also the oral, gastric, lung, skin and vaginal microbiome that is in line with the latest investigations. Nonbacterial microbiomes, such as fungi and viruses are not overlooked, and the plasma microbiome is also discussed. As plasma, brain, placenta, tumor cells, and other sterile fluids and tissues, are increasingly recognized to potentially host a microbiome, albeit a limited one, this is a timely resource.
The book's editors were fortunate to have the input of renowned collaborators from nearly all continents. This is truly an international effort that brings the latest in the field to students and professionals alike.
1. Introduction to the Microbiome and Metabolome - p. xxiii 2. Useful Internet Sites - p. xxix 3. Block I. Tools, Toolstations and Models - p. xxxi 4. Chapter 1. Germ-Free Animals as a Tool to Study Indigenous Microbiota - p. 3 5. Chapter 2. Germ-Free Mouse Technology in Cardiovascular Research - p. 13 6. Chapter 3. The Gut Microbiome Beyond the Bacteriome—The Neglected Role of Virome and Mycobiome in Health and Disease - p. 27 7. Chapter 4. Techniques for Phenotyping the Gut Microbiota Metabolome - p. 33 8. Chapter 5. Metabolomics Tools and Information Retrieval in Microbiome Hacking - p. 43 9. Chapter 6. Laboratory Simulators of the Colon Microbiome - p. 61 10. Chapter 7. Potential of Metabolomics to Breath Tests - p. 69 11. Block II. Background Information - p. 81 12. Chapter 8. Metabolome and Microbiome From Infancy to Elderly - p. 85 13. Chapter 9. The Oral Microbiome - p. 91 14. Chapter 10. The Gastric Microbiome in Benign and Malignant Diseases - p. 101 15. Chapter 11. The Human Vaginal Microbiome - p. 109 16. Chapter 12. Bioactive Molecules of the Human Microbiome: Skin, Respiratory Tract, Intestine - p. 115 17. Chapter 13. Role of the Microbiome in Intestinal Barrier Function and Immune Defense - p. 127 18. Chapter 14. The Cross Talk Between Bile Acids and Intestinal Microbiota: Focus on Metabolic Diseases and Bariatric Surgery - p. 139 19. Block III. Established and Experimental Interventions - p. 145 20. Chapter 15. Use of Probiotics in Inflammatory Bowel Disease - p. 149 21. Chapter 16. Current Status of Fecal Microbiota Transplantation - p. 155 22. Chapter 17. Effects of Probiotics on Improvement of Metabolic Factors in Pregnant Women: A Metaanalysis of Randomized Placebo-Controlled Trials - p. 167 23. Chapter 18. Current Options for Fecal Transplantation in Clostridium difficile Infection - p. 177 24. Chapter 19. Targeted Delivery of Bacteriophages to the Gastrointestinal Tract and Their Controlled Release: Unleashing the Therapeutic Potential of Phage Therapy - p. 185 25. Chapter 20. The Unknown Effect of Antibiotic-Induced Dysbiosis on the Gut Microbiota - p. 195 26. Chapter 21. The Myth and Therapeutic Potentials of Postbiotics - p. 201 27. Block IV. Diagnostic and Therapeutical Applications - p. 211 28. Chapter 22. The Microbiome and Metabolome in Metabolic Syndrome - p. 215 29. Chapter 23. The Gut Microbiota as a Therapeutic Approach for Obesity - p. 227 30. Chapter 24. The Gut Microbiome After Bariatric Surgery - p. 235 31. Chapter 25. Gut Dysbiosis in Arterial Hypertension: A Candidate Therapeutic Target for Blood Pressure Management - p. 243 32. Chapter 26. The Emerging Role of Microbiome–Gut–Brain Axis in Functional Gastrointestinal Disorders - p. 251 33. Chapter 27. The Microbiome and Metabolome in Nonalcoholic Fatty Liver Disease - p. 265 34. Chapter 28. The Microbiome and Metabolome in Alcoholic Liver Disease - p. 271 35. Chapter 29. The Microbiome, Metabolome, and Proteome in Preterm Neonatal Sepsis - p. 279 36. Chapter 30. Gut Microbiome in the Elderly Hospitalized Patient: A Marker of Disease and Prognosis? - p. 287 37. Chapter 31. The Lung Microbiome, Metabolome, and Breath Volatolome in the Diagnosis of Pulmonary Disease - p. 297 38. Chapter 32. The Oral, Genital and Gut Microbiome in HIV Infection - p. 307 39. Chapter 33. The Gut Microbiome in Autoimmune Diseases - p. 325 40. Chapter 34. The Gut Microbiome and Metabolome in Multiple Sclerosis - p. 333 41. Chapter 35. Connections Between Gut Microbiota and Bone Health - p. 341 42. Chapter 36. The Gut Microbiome in Chronic Kidney Disease - p. 349 43. Chapter 37. Dysbiosis in Benign and Malignant Diseases of the Exocrine Pancreas - p. 357 44. Chapter 38. Importance of the Microbiome and the Metabolome in Cancer - p. 365 45. Chapter 39. The Microbiome in Graft Versus Host Disease - p. 373 46. Chapter 40. Impact of the Gut Microbiome on Behavior and Emotions - p. 379 47. Block V. Applications for Foods, Drugs, and Xenobiotics - p. 390 48. Chapter 41. The Gut Microbiome in Vegetarians - p. 393 49. Chapter 42. Metformin: A Candidate Drug to Control the Epidemic of Diabetes and Obesity by Way of Gut Microbiome Modification - p. 401 50. Chapter 43. Deleterious Impact of Smog on the Intestinal Bacteria - p. 409 51. Block VI. Challenges and Promises for the Future - p. 414 52. Chapter 44. New-Generation Probiotics: Perspectives and Applications - p. 417 53. Chapter 45. Fecal Microbiota Transfer and Inflammatory Bowel Disease: A Therapy or Risk? - p. 425 54. Chapter 46. Precision Medicine: The Microbiome and Metabolome - p. 435 55. Microbiome and Metabolome Glossary - p. 451 56. Index - p. 453
Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications is the first book to simultaneously cover the microbiome and the metabolome in relevant clinical conditions. In a pioneering fashion, it addresses not only the classic intestinal environment, but also the oral, gastric, lung, skin and vaginal microbiome that is in line with the latest investigations. Nonbacterial microbiomes, such as fungi and viruses are not overlooked, and the plasma microbiome is also discussed. As plasma, brain, placenta, tumor cells, and other sterile fluids and tissues, are increasingly recognized to potentially host a microbiome, albeit a limited one, this is a timely resource.
The book's editors were fortunate to have the input of renowned collaborators from nearly all continents. This is truly an international effort that brings the latest in the field to students and professionals alike.
1. Introduction to the Microbiome and Metabolome - p. xxiii 2. Useful Internet Sites - p. xxix 3. Block I. Tools, Toolstations and Models - p. xxxi 4. Chapter 1. Germ-Free Animals as a Tool to Study Indigenous Microbiota - p. 3 5. Chapter 2. Germ-Free Mouse Technology in Cardiovascular Research - p. 13 6. Chapter 3. The Gut Microbiome Beyond the Bacteriome—The Neglected Role of Virome and Mycobiome in Health and Disease - p. 27 7. Chapter 4. Techniques for Phenotyping the Gut Microbiota Metabolome - p. 33 8. Chapter 5. Metabolomics Tools and Information Retrieval in Microbiome Hacking - p. 43 9. Chapter 6. Laboratory Simulators of the Colon Microbiome - p. 61 10. Chapter 7. Potential of Metabolomics to Breath Tests - p. 69 11. Block II. Background Information - p. 81 12. Chapter 8. Metabolome and Microbiome From Infancy to Elderly - p. 85 13. Chapter 9. The Oral Microbiome - p. 91 14. Chapter 10. The Gastric Microbiome in Benign and Malignant Diseases - p. 101 15. Chapter 11. The Human Vaginal Microbiome - p. 109 16. Chapter 12. Bioactive Molecules of the Human Microbiome: Skin, Respiratory Tract, Intestine - p. 115 17. Chapter 13. Role of the Microbiome in Intestinal Barrier Function and Immune Defense - p. 127 18. Chapter 14. The Cross Talk Between Bile Acids and Intestinal Microbiota: Focus on Metabolic Diseases and Bariatric Surgery - p. 139 19. Block III. Established and Experimental Interventions - p. 145 20. Chapter 15. Use of Probiotics in Inflammatory Bowel Disease - p. 149 21. Chapter 16. Current Status of Fecal Microbiota Transplantation - p. 155 22. Chapter 17. Effects of Probiotics on Improvement of Metabolic Factors in Pregnant Women: A Metaanalysis of Randomized Placebo-Controlled Trials - p. 167 23. Chapter 18. Current Options for Fecal Transplantation in Clostridium difficile Infection - p. 177 24. Chapter 19. Targeted Delivery of Bacteriophages to the Gastrointestinal Tract and Their Controlled Release: Unleashing the Therapeutic Potential of Phage Therapy - p. 185 25. Chapter 20. The Unknown Effect of Antibiotic-Induced Dysbiosis on the Gut Microbiota - p. 195 26. Chapter 21. The Myth and Therapeutic Potentials of Postbiotics - p. 201 27. Block IV. Diagnostic and Therapeutical Applications - p. 211 28. Chapter 22. The Microbiome and Metabolome in Metabolic Syndrome - p. 215 29. Chapter 23. The Gut Microbiota as a Therapeutic Approach for Obesity - p. 227 30. Chapter 24. The Gut Microbiome After Bariatric Surgery - p. 235 31. Chapter 25. Gut Dysbiosis in Arterial Hypertension: A Candidate Therapeutic Target for Blood Pressure Management - p. 243 32. Chapter 26. The Emerging Role of Microbiome–Gut–Brain Axis in Functional Gastrointestinal Disorders - p. 251 33. Chapter 27. The Microbiome and Metabolome in Nonalcoholic Fatty Liver Disease - p. 265 34. Chapter 28. The Microbiome and Metabolome in Alcoholic Liver Disease - p. 271 35. Chapter 29. The Microbiome, Metabolome, and Proteome in Preterm Neonatal Sepsis - p. 279 36. Chapter 30. Gut Microbiome in the Elderly Hospitalized Patient: A Marker of Disease and Prognosis? - p. 287 37. Chapter 31. The Lung Microbiome, Metabolome, and Breath Volatolome in the Diagnosis of Pulmonary Disease - p. 297 38. Chapter 32. The Oral, Genital and Gut Microbiome in HIV Infection - p. 307 39. Chapter 33. The Gut Microbiome in Autoimmune Diseases - p. 325 40. Chapter 34. The Gut Microbiome and Metabolome in Multiple Sclerosis - p. 333 41. Chapter 35. Connections Between Gut Microbiota and Bone Health - p. 341 42. Chapter 36. The Gut Microbiome in Chronic Kidney Disease - p. 349 43. Chapter 37. Dysbiosis in Benign and Malignant Diseases of the Exocrine Pancreas - p. 357 44. Chapter 38. Importance of the Microbiome and the Metabolome in Cancer - p. 365 45. Chapter 39. The Microbiome in Graft Versus Host Disease - p. 373 46. Chapter 40. Impact of the Gut Microbiome on Behavior and Emotions - p. 379 47. Block V. Applications for Foods, Drugs, and Xenobiotics - p. 390 48. Chapter 41. The Gut Microbiome in Vegetarians - p. 393 49. Chapter 42. Metformin: A Candidate Drug to Control the Epidemic of Diabetes and Obesity by Way of Gut Microbiome Modification - p. 401 50. Chapter 43. Deleterious Impact of Smog on the Intestinal Bacteria - p. 409 51. Block VI. Challenges and Promises for the Future - p. 414 52. Chapter 44. New-Generation Probiotics: Perspectives and Applications - p. 417 53. Chapter 45. Fecal Microbiota Transfer and Inflammatory Bowel Disease: A Therapy or Risk? - p. 425 54. Chapter 46. Precision Medicine: The Microbiome and Metabolome - p. 435 55. Microbiome and Metabolome Glossary - p. 451 56. Index - p. 453
