MicroRNA in Human Malignancies offers a deep overview of the role and translational significance of miRNAs in the development of cancer and other malignancies. The book establishes the foundations of the field by covering essential mechanisms and the translational potential of miRNAs in the field of oncology. Specific topics covered include invasion and metastasis, miRNAs and metabolism, and opportunities of miRNAs in therapeutics. Chapters on diseases include content on disease-related pathophysiology, as well as diagnostic, prognostic and predictive value. This book is an essential reference for students entering the field, as well as researchers and investigators.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xi 7. Section A: miRNAs involvement in basic mechanisms of cancer development - p. xiv 8. Chapter 1. Overview on miRNA classification, biogenesis, and functions - p. 3 9. Chapter 2. microRNA in cancer: An overview - p. 21 10. miR-15/16 in human malignancies - p. 29 11. Chapter 4. microRNAs and tumor suppressor p53 regulation - p. 37 12. Chapter 5. MicroRNA involvement in invasion and metastasis - p. 51 13. Chapter 6. microRNAs and metabolism - p. 71 14. Chapter 7. microRNAs in inflammation processes - p. 77 15. Section B: miRNAs methodologies - p. 90 16. Chapter 8. Wet-lab methods for miRNA analysis - p. 93 17. Chapter 9. Bioinformatics utilities, web resources and integrative strategies for the analysis of miRNA regulatory networks - p. 109 18. Chapter 10. Computational resources for analysis of miRNA targetome - p. 129 19. Chapter 11. miRNA bioinformatics and pathway analysis - p. 141 20. Section C: miRNAs involvement in therapeutics/ theranostics - p. 150 21. Chapter 12. Opportunities of miRNAs in cancer therapeutics - p. 153 22. Section D: miRNAs involvement in human cancer: Pathophysiology and translational opportunities - p. 164 23. Chapter 13. Pathophysiology roles and translational opportunities of miRNAs in acute leukemias - p. 167 24. Chapter 14. Pathophysiology roles and translational opportunities of miRNAs in CLL - p. 179 25. Chapter 15. Pathophysiology roles and translational opportunities of miRNAs in lymphoma - p. 187 26. Chapter 16. Pathophysiology rolesr and translational opportunities of miRNAs in breast cancer - p. 195 27. Chapter 17. Pathophysiology roles and translational opportunities of miRNAs in colorectal cancer - p. 218 28. Chapter 18. Pathophysiology roles and translational opportunities of miRNAs in lung cancer - p. 245 29. Chapter 19. Pathophysiology roles and translational opportunities of miRNAs in mesothelioma - p. 259 30. Chapter 20. Pathophysiology roles and translational opportunities of miRNAs in renal cancer - p. 271 31. Chapter 21. Pathophysiology roles and translational opportunities of miRNAs in pancreatic cancer - p. 281 32. Chapter 22. Extracellular vesicle-contained microRNAs in prostate cancer: From pathophysiology to emerging translational opportunities - p. 291 33. Chapter 23. Pathophysiology roles and translational opportunities of miRNAs in hepatocellular carcinoma - p. 301 34. Chapter 24. Pathophysiology roles and translational opportunities of miRNAs in ovarian cancer - p. 317 35. Chapter 25. Pathophysiology roles and translational opportunities of miRNAs in bladder cancer - p. 326 36. Chapter 26. Pathophysiology roles and translational opportunities of miRNAs in cutaneous melanoma - p. 368 37. Chapter 27. Pathophysiology roles and translational opportunities of miRNAs in brain tumors - p. 385 38. Chapter 28. Pathophysiology roles and translational opportunities of miRNAs in sarcomas - p. 395 39. Index - p. 411
MicroRNA in Human Malignancies offers a deep overview of the role and translational significance of miRNAs in the development of cancer and other malignancies. The book establishes the foundations of the field by covering essential mechanisms and the translational potential of miRNAs in the field of oncology. Specific topics covered include invasion and metastasis, miRNAs and metabolism, and opportunities of miRNAs in therapeutics. Chapters on diseases include content on disease-related pathophysiology, as well as diagnostic, prognostic and predictive value. This book is an essential reference for students entering the field, as well as researchers and investigators.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xi 7. Section A: miRNAs involvement in basic mechanisms of cancer development - p. xiv 8. Chapter 1. Overview on miRNA classification, biogenesis, and functions - p. 3 9. Chapter 2. microRNA in cancer: An overview - p. 21 10. miR-15/16 in human malignancies - p. 29 11. Chapter 4. microRNAs and tumor suppressor p53 regulation - p. 37 12. Chapter 5. MicroRNA involvement in invasion and metastasis - p. 51 13. Chapter 6. microRNAs and metabolism - p. 71 14. Chapter 7. microRNAs in inflammation processes - p. 77 15. Section B: miRNAs methodologies - p. 90 16. Chapter 8. Wet-lab methods for miRNA analysis - p. 93 17. Chapter 9. Bioinformatics utilities, web resources and integrative strategies for the analysis of miRNA regulatory networks - p. 109 18. Chapter 10. Computational resources for analysis of miRNA targetome - p. 129 19. Chapter 11. miRNA bioinformatics and pathway analysis - p. 141 20. Section C: miRNAs involvement in therapeutics/ theranostics - p. 150 21. Chapter 12. Opportunities of miRNAs in cancer therapeutics - p. 153 22. Section D: miRNAs involvement in human cancer: Pathophysiology and translational opportunities - p. 164 23. Chapter 13. Pathophysiology roles and translational opportunities of miRNAs in acute leukemias - p. 167 24. Chapter 14. Pathophysiology roles and translational opportunities of miRNAs in CLL - p. 179 25. Chapter 15. Pathophysiology roles and translational opportunities of miRNAs in lymphoma - p. 187 26. Chapter 16. Pathophysiology rolesr and translational opportunities of miRNAs in breast cancer - p. 195 27. Chapter 17. Pathophysiology roles and translational opportunities of miRNAs in colorectal cancer - p. 218 28. Chapter 18. Pathophysiology roles and translational opportunities of miRNAs in lung cancer - p. 245 29. Chapter 19. Pathophysiology roles and translational opportunities of miRNAs in mesothelioma - p. 259 30. Chapter 20. Pathophysiology roles and translational opportunities of miRNAs in renal cancer - p. 271 31. Chapter 21. Pathophysiology roles and translational opportunities of miRNAs in pancreatic cancer - p. 281 32. Chapter 22. Extracellular vesicle-contained microRNAs in prostate cancer: From pathophysiology to emerging translational opportunities - p. 291 33. Chapter 23. Pathophysiology roles and translational opportunities of miRNAs in hepatocellular carcinoma - p. 301 34. Chapter 24. Pathophysiology roles and translational opportunities of miRNAs in ovarian cancer - p. 317 35. Chapter 25. Pathophysiology roles and translational opportunities of miRNAs in bladder cancer - p. 326 36. Chapter 26. Pathophysiology roles and translational opportunities of miRNAs in cutaneous melanoma - p. 368 37. Chapter 27. Pathophysiology roles and translational opportunities of miRNAs in brain tumors - p. 385 38. Chapter 28. Pathophysiology roles and translational opportunities of miRNAs in sarcomas - p. 395 39. Index - p. 411
