Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body’s toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies.
In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering.
Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xxxi 7. Part 1: Stem Cells - p. xxxix 8. Chapter 1. MicroRNA Biogenesis in Regenerative Medicine - p. 5 9. Chapter 2. Control of Pluripotency and Reprogramming - p. 49 10. Chapter 3. Epigenetic Modification of MicroRNAs - p. 79 11. Chapter 4. MicroRNAs and Mesenchymal Stem Cells in Diabetic Wound Healing - p. 111 12. Chapter 5. miRNAs in Cancer Stem Cells - p. 141 13. Chapter 6. MicroRNAs in Neural Stem Cells - p. 167 14. Chapter 7. MicroRNAs in Embryonic Stem Cells - p. 187 15. Chapter 8. MicroRNAs: Molecular Rheostats Regulating Stem Cells Self-Renewal and Therapeutic Implications - p. 217 16. Chapter 9. MicroRNAs in Endothelial Progenitor Cells - p. 243 17. Part 2: Development - p. 266 18. Chapter 10. MicroRNA Function in Muscle Homeostasis and Regenerative Medicine - p. 269 19. Chapter 11. MicroRNAs in Renal Development and Regeneration - p. 293 20. Chapter 12. MicroRNAs in Pancreas and Islet Development and Function - p. 315 21. Chapter 13. MicroRNAs in Skeletal Muscle Differentiation - p. 341 22. Chapter 14. MicroRNAs in Bone Formation and Homeostasis - p. 369 23. Part 3: Repair - p. 394 24. Chapter 15. MicroRNAs With Mega Functions in Cardiac Remodeling and Repair: The Micromanagement of Matters of the Heart - p. 397 25. Chapter 16. MicroRNAs in Liver Disease - p. 429 26. Chapter 17. Role of MicroRNAs in Vascular Remodeling and Repair - p. 453 27. Chapter 18. MicroRNAs in Skin Fibrosis - p. 489 28. Chapter 19. miRNAs in Bone Repair - p. 507 29. Chapter 20. MicroRNA Regulation of Angiogenesis - p. 539 30. Chapter 21. Micromanaging Inflammation and Tissue Repair - p. 573 31. Chapter 22. MicroRNA Regulation of mTOR Function - p. 593 32. Part 4: Regeneration - p. 626 33. Chapter 23. OxymiRs in Regenerative Medicine - p. 631 34. Chapter 24. miRNAs in Transitions: EMT, MET, and EndoMT - p. 659 35. Chapter 25. miRNA in Cardiac Regeneration - p. 694 36. Chapter 26. MicroRNAs in Liver Regeneration - p. 717 37. Chapter 27. Regulation of Bone Homeostasis and Regeneration by MicroRNAs - p. 741 38. Chapter 28. MitomiRs in Regenerative Medicine - p. 775 39. Part 5: Methodology - p. 787 40. Chapter 29. MicroRNA Bioinformatics - p. 799 41. Part 6: Intervention - p. 815 42. Chapter 30. MicroRNAs and Exosomes in Cancer Diagnosis and Therapy - p. 819 43. Chapter 31. Drug–MicroRNA Cross-Talk - p. 837 44. Chapter 32. Delivery and Biological Activity of Therapeutic miRNAs and miRNA Modifiers - p. 863 45. Chapter 33. Circulating MicroRNAs as Biomarkers and Diagnosis Tool for Diseases - p. 895 46. Chapter 34. MicroRNAs in Gut Health: Modulation of Host-Microbial Interactions in the Gastrointestinal Tract - p. 951 47. Part 7: Tissue Engineering - p. 970 48. Chapter 35. Nuclear Architecture and Transcriptional Regulation of MicroRNAs - p. 973 49. Chapter 36. MicroRNAs in Tissue Engineering and Regenerative Medicine - p. 1007 50. Chapter 37. Tissue Nanotransfection in Regenerative Medicine - p. 1051 51. Index - p. 1075
Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body’s toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies.
In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering.
Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xxxi 7. Part 1: Stem Cells - p. xxxix 8. Chapter 1. MicroRNA Biogenesis in Regenerative Medicine - p. 5 9. Chapter 2. Control of Pluripotency and Reprogramming - p. 49 10. Chapter 3. Epigenetic Modification of MicroRNAs - p. 79 11. Chapter 4. MicroRNAs and Mesenchymal Stem Cells in Diabetic Wound Healing - p. 111 12. Chapter 5. miRNAs in Cancer Stem Cells - p. 141 13. Chapter 6. MicroRNAs in Neural Stem Cells - p. 167 14. Chapter 7. MicroRNAs in Embryonic Stem Cells - p. 187 15. Chapter 8. MicroRNAs: Molecular Rheostats Regulating Stem Cells Self-Renewal and Therapeutic Implications - p. 217 16. Chapter 9. MicroRNAs in Endothelial Progenitor Cells - p. 243 17. Part 2: Development - p. 266 18. Chapter 10. MicroRNA Function in Muscle Homeostasis and Regenerative Medicine - p. 269 19. Chapter 11. MicroRNAs in Renal Development and Regeneration - p. 293 20. Chapter 12. MicroRNAs in Pancreas and Islet Development and Function - p. 315 21. Chapter 13. MicroRNAs in Skeletal Muscle Differentiation - p. 341 22. Chapter 14. MicroRNAs in Bone Formation and Homeostasis - p. 369 23. Part 3: Repair - p. 394 24. Chapter 15. MicroRNAs With Mega Functions in Cardiac Remodeling and Repair: The Micromanagement of Matters of the Heart - p. 397 25. Chapter 16. MicroRNAs in Liver Disease - p. 429 26. Chapter 17. Role of MicroRNAs in Vascular Remodeling and Repair - p. 453 27. Chapter 18. MicroRNAs in Skin Fibrosis - p. 489 28. Chapter 19. miRNAs in Bone Repair - p. 507 29. Chapter 20. MicroRNA Regulation of Angiogenesis - p. 539 30. Chapter 21. Micromanaging Inflammation and Tissue Repair - p. 573 31. Chapter 22. MicroRNA Regulation of mTOR Function - p. 593 32. Part 4: Regeneration - p. 626 33. Chapter 23. OxymiRs in Regenerative Medicine - p. 631 34. Chapter 24. miRNAs in Transitions: EMT, MET, and EndoMT - p. 659 35. Chapter 25. miRNA in Cardiac Regeneration - p. 694 36. Chapter 26. MicroRNAs in Liver Regeneration - p. 717 37. Chapter 27. Regulation of Bone Homeostasis and Regeneration by MicroRNAs - p. 741 38. Chapter 28. MitomiRs in Regenerative Medicine - p. 775 39. Part 5: Methodology - p. 787 40. Chapter 29. MicroRNA Bioinformatics - p. 799 41. Part 6: Intervention - p. 815 42. Chapter 30. MicroRNAs and Exosomes in Cancer Diagnosis and Therapy - p. 819 43. Chapter 31. Drug–MicroRNA Cross-Talk - p. 837 44. Chapter 32. Delivery and Biological Activity of Therapeutic miRNAs and miRNA Modifiers - p. 863 45. Chapter 33. Circulating MicroRNAs as Biomarkers and Diagnosis Tool for Diseases - p. 895 46. Chapter 34. MicroRNAs in Gut Health: Modulation of Host-Microbial Interactions in the Gastrointestinal Tract - p. 951 47. Part 7: Tissue Engineering - p. 970 48. Chapter 35. Nuclear Architecture and Transcriptional Regulation of MicroRNAs - p. 973 49. Chapter 36. MicroRNAs in Tissue Engineering and Regenerative Medicine - p. 1007 50. Chapter 37. Tissue Nanotransfection in Regenerative Medicine - p. 1051 51. Index - p. 1075
